Trypanocidal Agents

Agents destructive to the protozoal organisms belonging to the suborder TRYPANOSOMATINA.
DrugDrug NameDrug Indication
DB00738PentamidineFor the treatment of pneumonia due to Pneumocystis carinii.
DB01263PosaconazoleFor prophylaxis of invasive Aspergillus and Candida infections in patients, 13 years of age and older, who are at high risk of developing these infections due to being severely immunocompromised as a result of procedures such as hematopoietic stem cell transplant (HSCT) recipients with graft-versus-host disease (GVHD), or due to hematologic malignancies with prolonged neutropenia from chemotherapy. Also for the treatment of oropharyngeal candidiasis, including oropharyngeal candidiasis refractory to itraconazole and/or fluconazole. Posaconazole is used as an alternative treatment for invasive aspergillosis, Fusarium infections, and zygomycosis in patients who are intolerant of, or whose disease is refractory to, other antifungals.
DB03608DiminazeneNot Available
DB03819Salicylhydroxamic AcidNot Available
DB04786SuraminFor treatment of human sleeping sickness, onchocerciasis and other diseases caused by trypanosomes and worms.
DB06243EflornithineEflornithine is indicated in the treatment of facial hirsutism (excessive hair growth).
DB06266LonidamineInvestigated for use/treatment in benign prostatic hyperplasia, prostate disorders, and cancer/tumors (unspecified).
DB08437PuromycinNot Available
DB11820NifurtimoxNot Available
DB11989BenznidazoleFor use in the treatment of Chagas disease in children 2-12 years of age [L939].
DB12864MelarsoprolNot Available
DB06532PafuramidineInvestigated for use/treatment in pneumonia, trypanosomiasis, malaria, HIV infection, and infectious and parasitic disease (unspecified).
DrugDrug NameTargetType
DB00738PentamidineDNAtarget
DB00738PentamidineCytochrome P450 2C19enzyme
DB00738PentamidinetRNA (cytosine(38)-C(5))-methyltransferasetarget
DB00738PentamidineCytochrome P450 2D6enzyme
DB00738PentamidineCytochrome P450 1A1enzyme
DB00738PentamidineCytochrome P450 3A5enzyme
DB00738PentamidineCytochrome P450 4A11enzyme
DB01263PosaconazoleCytochrome P450 3A4enzyme
DB01263PosaconazoleMultidrug resistance protein 1transporter
DB01263PosaconazoleCytochrome P450 51target
DB03608DiminazenePeroxiredoxin-5, mitochondrialtarget
DB03608DiminazeneHTH-type transcriptional regulator QacRtarget
DB03608DiminazeneTrypsin-1target
DB03608DiminazeneAmiloride-sensitive amine oxidase [copper-containing]target
DB04786SuraminNAD-dependent protein deacylase sirtuin-5, mitochondrialtarget
DB04786SuraminComplement control protein C3target
DB04786SuraminPhospholipase A2, membrane associatedtarget
DB04786SuraminProthrombintarget
DB04786SuraminP2Y purinoceptor 2target
DB04786SuraminFollicle-stimulating hormone receptortarget
DB04786SuraminRyanodine receptor 1target
DB04786SuraminArylsulfatase Aenzyme
DB04786SuraminCytosolic phospholipase A2enzyme
DB06243EflornithineOrnithine decarboxylasetarget
DB06266LonidamineCystic fibrosis transmembrane conductance regulatortarget
DB06266LonidamineHexokinase-1target
DB08437Puromycin60S ribosomal protein L10-liketarget
DB08437Puromycin60S ribosomal protein L13atarget
DB08437Puromycin60S ribosomal protein L23target
DB08437Puromycin60S ribosomal protein L15target
DB08437Puromycin60S ribosomal protein L19target
DB08437Puromycin60S ribosomal protein L23atarget
DB08437PuromycinProbable ribosome biogenesis protein RLP24target
DB08437Puromycin60S ribosomal protein L26-like 1target
DB08437Puromycin60S ribosomal protein L8target
DB08437Puromycin60S ribosomal protein L37target
DB08437Puromycin60S ribosomal protein L3target
DB08437Puromycin60S ribosomal protein L11target
DB08437PuromycinLeucyl/phenylalanyl-tRNA--protein transferasetarget