Diuretics, Osmotic

Name
Diuretics, Osmotic
Accession Number
DBCAT001104
Description

Compounds that increase urine volume by increasing the amount of osmotically active solute in the urine. Osmotic diuretics also increase the osmolarity of plasma.

Drugs
DrugDrug Description
MannitolA sugar alcohol used to test for asthma, to reduce intracranial and intraocular pressure, to measure glomerular filtration rate, and to manage pulmonary symptoms associated with cystic fibrosis.
IsosorbideA vasodilator used for the prevention and treatment of angina pectoris due to coronary artery disease. It was previously used to reduce intraocular pressure.
UreaA keratolytic emollient used to treat hyperkeratotic lesions and moisturize the skin.
Drugs & Drug Targets
DrugTargetType
MannitolMannitol dehydrogenaseenzyme
IsosorbideGuanylate cyclasetarget
UreaArginase-1target
UreaCarbonic anhydrase 2target
UreaCatenin beta-1target
UreaSulfoxide reductase catalytic subunit YedYtarget
UreaUrea transporter 2transporter
UreaUrea transporter 1transporter
UreaDihydrofolate reductasetarget