beta-Lactamase Inhibitors

Endogenous substances and drugs that inhibit or block the activity of BETA-LACTAMASES.
DrugDrug NameDrug Description
DB01606TazobactamA beta lactamase inhibitor administered with antibiotics such as piperacillin and ceftolozane to prevent their degradation, resulting in increased efficacy.
DB09324SulbactamAn beta-lactamase inhibitor antibiotic combined with other antibiotics to treat a variety of susceptible bacterial infections.
DB00766Clavulanic acidA beta lactamase inhibitor used to enhance the effectiveness of beta lactam antibiotics.
DB09060AvibactamA non-β-lactam β-lactamase inhibitor used in combination with ceftazidime for the treatment of complicated intra-abdominal infections, complicated urinary tract infections, and hospital or ventilator-acquired pneumonia.
DB11593Isatoic anhydrideNot Available
DB12377RelebactamA beta-lactamase inhibitor used to prevent hydrolysis of beta-lactam antibiotics, leading to increased effectiveness.
DB12107VaborbactamA beta lactamase inhibitor used to treat complicated urinary tract infections.
DrugDrug NameTargetType
DB01606TazobactamBeta-lactamase TEMtarget
DB01606TazobactamSolute carrier family 22 member 6transporter
DB01606TazobactamSolute carrier family 22 member 8transporter
DB01606TazobactamBeta-lactamase Ohio-1target
DB01606TazobactamBeta-lactamase SHV-1target
DB09324SulbactamBeta-lactamasetarget
DB00766Clavulanic acidBacterial beta-lactamase enzymesenzyme
DB00766Clavulanic acidBacterial beta-lactamase enzymestarget
DB00766Clavulanic acidSodium/glucose cotransporter 1transporter
DB09060AvibactamCanalicular multispecific organic anion transporter 1transporter
DB09060AvibactamSolute carrier family 22 member 8transporter
DB09060AvibactamBeta-lactamase TEMtarget
DB09060AvibactamBeta-lactamase CTX-Mtarget
DB09060AvibactamBeta-lactamasetarget
DB09060AvibactamBeta-lactamase SHV-1target
DB09060AvibactamBeta-lactamase SHV-2target
DB09060AvibactamBeta-lactamase SHV-1target
DB09060AvibactamClass D OXA-48 carbapenemasetarget
DB09060AvibactamCarbapenem-hydrolyzing beta-lactamase KPCtarget
DB09060AvibactamBeta-lactamase CTX-M-15target
DB09060AvibactamExtended-spectrum beta-lactamase PER-1target
DB12377RelebactamSolute carrier family 22 member 8transporter
DB12377RelebactamSolute carrier family 22 member 11transporter
DB12377RelebactamMultidrug and toxin extrusion protein 1transporter
DB12377RelebactamMultidrug and toxin extrusion protein 2transporter
DB12377RelebactamBeta-lactamase TEMtarget
DB12377RelebactamBeta-lactamase SHV-1target
DB12377RelebactamBeta-lactamase CTX-Mtarget
DB12377RelebactamBeta-lactamase (KPC-2)target
DB12377RelebactamBeta-lactamasetarget
DB12107VaborbactamBeta-lactamasetarget
DB12107VaborbactamCarbapenem-hydrolyzing beta-lactamase KPCtarget
DB12107VaborbactamBeta-lactamase (KPC-2)target
DB12107VaborbactamBeta-lactamase CTX-Mtarget
DB12107VaborbactamBeta-lactamase (blaSHV)target
DB12107VaborbactamBeta-lactamase SHV-1target
DB12107VaborbactamBeta-lactamase TEMtarget
DB12107VaborbactamBeta-lactamase (MIR-1)target
DB12107VaborbactamBeta-lactamasetarget