Naphthyridines
- Name
- Naphthyridines
- Accession Number
- DBCAT001128
- Description
QUINOLONES containing a 4-oxo (a carbonyl in the para position to the nitrogen). They inhibit the A subunit of DNA GYRASE and are used as antimicrobials. Second generation 4-quinolones are also substituted with a 1-piperazinyl group at the 7-position and a fluorine at the 6-position.
- Drugs
Drug Drug Description Nalidixic acid A quinolone antibiotic used to treat urinary tract infections. Gemifloxacin A quinolone antibacterial agent used for the treatment of acute bacterial exacerbation of chronic bronchitis and mild to moderate community-acquired pneumonia caused by susceptible bacteria. - Drugs & Drug Targets
Drug Target Type Nalidixic acid DNA target Nalidixic acid Solute carrier family 22 member 6 transporter Nalidixic acid Tryptophan 2,3-dioxygenase enzyme Nalidixic acid Cytochrome P450 1A2 enzyme Gemifloxacin DNA gyrase subunit A target Gemifloxacin DNA topoisomerase 4 subunit A target Gemifloxacin Cytochrome P450 1A2 enzyme