Radiation-Protective Agents

Drugs used to protect against ionizing radiation. They are usually of interest for use in radiation therapy but have been considered for other, e.g. military, purposes.
DrugDrug NameDrug Indication
DB00806PentoxifyllineFor the treatment of patients with intermittent lameness or immobility arising from chronic occlusive arterial disease of the limbs.
DB01143AmifostineFor reduction in the cumulative renal toxicity in patients with ovarian cancer (using cisplatin) and moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer.
DB01428OxybenzoneUsed as an ingredient in sunscreen and other cosmetics.
DB03006Arsanilic acidNot Available
DB04744LawsoneNot Available
DB09321Zinc oxideFor adjunctive treatment of diaper dermatitis. Also, it can be used to treat minor skin irritations (eg, cuts, burns, and scrapes, poison ivy). Zinc oxide can be used in ointments, creams, and lotions to protect against sunburn and other damage to the skin caused by ultraviolet light.
DB09495AvobenzoneSun protection factor, added in the sunscreen products for its wide spectrum ultraviolet absorption properties.
DB09496OctinoxateAs an active ingredient in sunscreens and lip balms. Used for protection against damaging effects of sun rays.
DB09526HydroquinoneHydroquinone is used as an OTC topical lightening agent for disorders of hyperpigmentation including melasma, post-inflammatory hyperpigmention, sunspots and freckles.
DB09534EcamsuleApplied topically to filter out UVA rays.
DB09536Titanium dioxideIn the pharmaceutical industry, titanium dioxide is used in most sunscreens to block UVA and UVB rays, similar to zinc oxide. It is also commonly used as pigment for pharmaceutical products such as gelatin capsules, tablet coatings and syrups.
DB11231LycopeneNot Available
DB11570Padimate OIndicated as an active UV-B filter to prevent photodamage.
DB12116Epigallocatechin gallateNot Available
DB12449TempolNot Available
DB12692GusperimusNot Available
DB12870Buthionine SulfoximineNot Available
DB12991DeoxyspergualinNot Available
DB13056IrsogladineNot Available
DB13124TroxerutinNot Available
DB05389TetrachlorodecaoxideInvestigated for use/treatment in acquired immune deficiency syndrome (AIDS) and aids-related infections, cancer/tumors (unspecified), HIV infection, and inflammatory disorders (unspecified).
DB08900TeduglutideTreatment of short bowel syndrome (SBS), malabsorption associated with the removal of the intestine, in adults patients who are dependent on parenteral support.
DB11062OctisalateIngredient in sunscreens for protection against damage effects of sun light, provides protection from sunburns, aging and skin cancer.
DB11064HomosalateAs ingredient in many sunscreen for protection against sunburn, skin aging and skin cancer.
DrugDrug NameTargetType
DB00806PentoxifyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB00806PentoxifyllinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DB00806PentoxifyllinecGMP-specific 3',5'-cyclic phosphodiesterasetarget
DB00806PentoxifyllineAdenosine receptor A1target
DB00806PentoxifyllineAdenosine receptor A2atarget
DB00806PentoxifyllineCytochrome P450 1A2enzyme
DB01143AmifostineEctonucleotide pyrophosphatase/phosphodiesterase family member 1target
DB01143AmifostineAlkaline phosphatase, placental-liketarget
DB01143AmifostineAlkaline phosphatase, tissue-nonspecific isozymeenzyme
DB01428OxybenzoneProgesterone receptortarget
DB01428OxybenzoneAndrogen receptortarget
DB01428OxybenzoneEstrogen receptor alphatarget
DB01428OxybenzoneEstrogen receptor betatarget
DB03006Arsanilic acidLysozyme Ctarget
DB09526HydroquinoneSerum albumincarrier
DB09536Titanium dioxideMacrophage receptor MARCOtarget
DB12116Epigallocatechin gallateAryl hydrocarbon receptortarget
DB12116Epigallocatechin gallateDNA (cytosine-5)-methyltransferase 1target
DB12116Epigallocatechin gallateDihydrofolate reductase, mitochondrialtarget
DB05389TetrachlorodecaoxideMacrophage erythroblast attachertarget
DB05389TetrachlorodecaoxideScavenger receptor cysteine-rich type 1 protein M130target
DB08900TeduglutideGlucagon-like peptide 2 receptortarget
DB11064HomosalateProgesterone receptortarget
DB11064HomosalateAndrogen receptortarget
DB11064HomosalateEstrogen receptor alphatarget