5-alpha Reductase Inhibitors

Name
5-alpha Reductase Inhibitors
Accession Number
DBCAT001276  (DBCAT002511, DBCAT003749)
Description

Drugs that inhibit 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE. They are commonly used to reduce the production of DIHYDROTESTOSTERONE.

ATC Classification
Drugs
DrugDrug Description
DutasterideAn antiandrogenic compound that is used for the treatment of symptomatic benign prostatic hyperplasia (BPH) in adult males by inhibiting 5-alpha reductase.
FinasterideAn antiandrogenic compound that is used for the treatment of symptomatic benign prostatic hyperplasia (BPH) and male pattern hair loss in adult males by inhibiting Type II 5-alpha reductase.
Drugs & Drug Targets
DrugTargetType
Dutasteride3-oxo-5-alpha-steroid 4-dehydrogenase 1target
Dutasteride3-oxo-5-alpha-steroid 4-dehydrogenase 2target
DutasterideSodium-dependent dopamine transportertransporter
DutasterideSynaptic vesicular amine transportertransporter
DutasterideSerum albumincarrier
DutasterideAlpha-1-acid glycoprotein 1carrier
DutasterideCytochrome P450 3A5enzyme
Finasteride3-oxo-5-alpha-steroid 4-dehydrogenase 1target
FinasterideCytochrome P450 3A4enzyme
Finasteride3-oxo-5-alpha-steroid 4-dehydrogenase 2target
Finasteride3-oxo-5-beta-steroid 4-dehydrogenasetarget
FinasterideCytochrome P450 3A5enzyme
FinasterideCytochrome P450 3A7enzyme
FinasterideSolute carrier family 12 member 5transporter