DrugDrug NameDrug Indication
DB00886OmapatrilatFor the treatment of hypertension.
DB01224QuetiapineFor the treatment of schizophrenia and related psychotic disorders.
DB08836TemocaprilTemocapril is an ACE inhibitor primarily indicated in the treatment of hypertension and congestive heart failure, diabetic nephropathy, and improvement of prognosis for coronary artery diseases (including acute myocardial infarction).
DB09167DosulepinIndicated in the treatment of symptoms of depressive illness, especially where an anti-anxiety effect is required.
DB09225ZotepineZotepine, like other atypical antipsychotics, is considered as the first-line treatment in newly diagnosed schizophrenia. It is usually thought to be an option of choice for managing acute schizophrenic episodes when discussion with the patient is not possible. Zotepine, as an atypical antipsychotic, is used in patients who are suffering unacceptable side effects from conventional antipsychotics or in relapse patients that were inadequately controlled.[T108] It is important to consider that the indications stated above are related to atypical antipsychotics, that zotepine is not currently FDA, Canada or EMA approved and that studies have not shown any additional benefit when compared with other approved atypical antipsychotics.[A31857] Schizophrenia is a chronic and severe mental disorder that affects how a person thinks, feels and behaves. It is usually marked for a loose reality perspective delineated by hallucinations, delusions and thought and movement disorders.[L1320]
DB09289TianeptineUsed primarily in the treatment of major depressive disorder and anxiety [A31969]. It is currently being studied for fibromyalgia pain treatment [L1426].
DB11729GSK-2330672Not Available
DB12486ElobixibatNot Available
DB13252TropatepineNot Available
DB13256ClothiapineNot Available
DrugDrug NameTargetType
DB00886OmapatrilatNeprilysintarget
DB00886OmapatrilatAngiotensin-converting enzymetarget
DB01224Quetiapine5-hydroxytryptamine receptor 2Atarget
DB01224Quetiapine5-hydroxytryptamine receptor 2Ctarget
DB01224QuetiapineD(2) dopamine receptortarget
DB01224Quetiapine5-hydroxytryptamine receptor 1Atarget
DB01224QuetiapineHistamine H1 receptortarget
DB01224QuetiapineCytochrome P450 3A4enzyme
DB01224QuetiapineAlpha-1A adrenergic receptortarget
DB01224QuetiapineAlpha-1B adrenergic receptortarget
DB01224QuetiapineAlpha-1D adrenergic receptortarget
DB01224QuetiapineAlpha-2A adrenergic receptortarget
DB01224QuetiapineAlpha-2B adrenergic receptortarget
DB01224QuetiapineAlpha-2C adrenergic receptortarget
DB01224Quetiapine5-hydroxytryptamine receptor 1Dtarget
DB01224QuetiapineMuscarinic acetylcholine receptor M1target
DB01224QuetiapineMuscarinic acetylcholine receptor M2target
DB01224QuetiapineMuscarinic acetylcholine receptor M3target
DB01224QuetiapineMuscarinic acetylcholine receptor M4target
DB01224QuetiapineMuscarinic acetylcholine receptor M5target
DB01224Quetiapine5-hydroxytryptamine receptor 1Btarget
DB01224Quetiapine5-hydroxytryptamine receptor 1Etarget
DB01224Quetiapine5-hydroxytryptamine receptor 3Atarget
DB01224Quetiapine5-hydroxytryptamine receptor 6target
DB01224Quetiapine5-hydroxytryptamine receptor 7target
DB01224QuetiapineD(1B) dopamine receptortarget
DB01224QuetiapineD(1A) dopamine receptortarget
DB01224QuetiapineD(3) dopamine receptortarget
DB01224QuetiapineD(4) dopamine receptortarget
DB01224QuetiapineCytochrome P450 3A5enzyme
DB01224QuetiapineCytochrome P450 3A7enzyme
DB01224QuetiapineMultidrug resistance protein 1transporter
DB01224QuetiapineCytochrome P450 2C19enzyme
DB01224QuetiapineCytochrome P450 2D6enzyme
DB08836TemocaprilSolute carrier family 15 member 1transporter
DB08836TemocaprilSolute carrier organic anion transporter family member 1A2transporter
DB08836TemocaprilAngiotensin-converting enzymetarget
DB09167Dosulepin5-hydroxytryptamine receptor 1Atarget
DB09167Dosulepin5-hydroxytryptamine receptor 2Atarget
DB09167DosulepinCytochrome P450 2D6enzyme
DB09167DosulepinCytochrome P450 1A2enzyme
DB09167DosulepinCytochrome P450 2C19enzyme
DB09167DosulepinCytochrome P450 2C9enzyme
DB09167DosulepinHistamine H1 receptortarget
DB09167DosulepinMuscarinic acetylcholine receptor M1target
DB09167DosulepinMuscarinic acetylcholine receptor M2target
DB09167DosulepinMuscarinic acetylcholine receptor M3target
DB09167DosulepinMuscarinic acetylcholine receptor M4target
DB09167DosulepinMuscarinic acetylcholine receptor M5target
DB09167DosulepinSodium-dependent noradrenaline transportertarget
DB09167DosulepinSodium-dependent serotonin transportertarget
DB09167DosulepinAlpha-1 adrenergic receptorstarget
DB09167DosulepinAlpha-2 adrenergic receptorstarget
DB09225ZotepineD(1) dopamine receptortarget
DB09225ZotepineD(2) dopamine receptortarget
DB09225Zotepine5-hydroxytryptamine receptor 2Atarget
DB09225Zotepine5-hydroxytryptamine receptor 6target
DB09225Zotepine5-hydroxytryptamine receptor 7target
DB09225ZotepineSodium-dependent noradrenaline transportertarget
DB09225ZotepineSodium-dependent serotonin transportertarget
DB09225ZotepineCytochrome P450 1A2enzyme
DB09225ZotepineCytochrome P450 3A4enzyme
DB09289TianeptineGlutamate receptor 1target
DB09289TianeptineMu-type opioid receptortarget
DB09289Tianeptine5-hydroxytryptamine receptor 1Atarget
DB09289TianeptineD(3) dopamine receptortarget
DB09289TianeptineCytochrome P450 3A4enzyme