Pyridazines

Name
Pyridazines
Accession Number
DBCAT001326
Description

Six-membered rings with two adjacent nitrogen atoms also called 1,2-diazine.

Drugs
DrugDrug Description
AzelastineA histamine H1-receptor antagonist used intranasally to treat allergic and vasomotor rhinitis and in an ophthalmic solution to treat allergic conjunctivitis.
HydralazineAn antihypertensive agent used for the management of essential hypertension or severe hypertension associated with conditions requiring immediate action, heart failure, and pre-eclampsia or eclampsia .
CilazaprilAn ACE inhibitor used for the management of hypertension and heart failure.
IsoluminolNot Available
VatalanibUsed in combination with first- and second-line chemotherapy for the treatment of metastatic colorectal cancer and non-small cell lung cancer (NSCLC).
OlaparibA chemotherapeutic agent used to treat recurrent or advanced ovarian cancer and metastatic breast cancer in patients with specific mutations and prior history of chemotherapy.
TalazoparibA poly-ADP ribose polymerase inhibitor used to treat HER2-, BRCA mutated locally advanced or metastatic breast cancer.
TaladegibTaladegib has been used in trials studying the treatment of Solid Tumor, COLON CANCER, BREAST CANCER, Advanced Cancer, and Rhabdomyosarcoma, among others.
GSK-1004723Gsk1004723 has been investigated for the treatment of Allergic Rhinitis and Rhinitis, Allergic, Seasonal.
DihydralazineDihydralazine is under investigation in clinical trial NCT00311974 (The Effect of Dihydralazine on Kidney Function and Hormones in Healthy Individuals).
TalastineNot Annotated
LevosimendanFor short term treatment of acutely decompensated severe chronic heart failure (CHF). Also being investigated for use/treatment in heart disease.
SimendanSimendan is under investigation in clinical trial NCT00527059 (Renal Effects of Levosimendan in Patients Admitted With Acute Decompensated Heart Failure).
CilazaprilatNot Annotated
ZopolrestatNot Available
Drugs & Drug Targets
DrugTargetType
AzelastineHistamine H1 receptortarget
AzelastineCytochrome P450 1A2enzyme
AzelastineCytochrome P450 2D6enzyme
AzelastineCytochrome P450 3A4enzyme
AzelastineCytochrome P450 2C19enzyme
AzelastineCytochrome P450 1A1enzyme
AzelastineCytochrome P450 3A5enzyme
AzelastineCytochrome P450 2C9enzyme
AzelastineCytochrome P450 2C8enzyme
AzelastineP-glycoprotein 1transporter
AzelastineCytochrome P450 2A6enzyme
AzelastineCytochrome P450 2E1enzyme
AzelastineHistamine H2 receptortarget
AzelastinePhospholipase A2target
AzelastineLeukotriene C4 synthasetarget
AzelastineCytochrome P450 2B6enzyme
HydralazineMembrane primary amine oxidasetarget
HydralazineProlyl 4-hydroxylase subunit alpha-1target
HydralazineCytochrome P450 3A4enzyme
HydralazineSerum albumincarrier
HydralazineHypoxia-inducible factor 1-alphatarget
CilazaprilAngiotensin-converting enzymetarget
CilazaprilP-glycoprotein 1transporter
CilazaprilSolute carrier family 15 member 1transporter
CilazaprilSolute carrier family 15 member 2transporter
IsoluminolQueuine tRNA-ribosyltransferasetarget
VatalanibVascular endothelial growth factor receptor 1target
VatalanibVascular endothelial growth factor receptor 2target
VatalanibVascular endothelial growth factor receptor 3target
OlaparibPoly [ADP-ribose] polymerase 1target
OlaparibCytochrome P450 3A4enzyme
OlaparibCytochrome P450 2B6enzyme
OlaparibPoly [ADP-ribose] polymerase 2target
OlaparibPoly [ADP-ribose] polymerase 3target
OlaparibCytochrome P450 3A5enzyme
OlaparibP-glycoprotein 1transporter
OlaparibATP-binding cassette sub-family G member 2transporter
TalazoparibPoly [ADP-ribose] polymerase 1target
TalazoparibPoly [ADP-ribose] polymerase 2target
TalazoparibP-glycoprotein 1transporter
TalazoparibATP-binding cassette sub-family G member 2transporter
DihydralazineCytochrome P450 1A2enzyme
LevosimendanTroponin C, slow skeletal and cardiac musclestarget
LevosimendanATP-sensitive inward rectifier potassium channel 11target
LevosimendanATP-sensitive inward rectifier potassium channel 8target
LevosimendancGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
CilazaprilatAngiotensin-converting enzymetarget
ZopolrestatAldo-keto reductase family 1 member B10target
ZopolrestatAldose reductasetarget