Pyridazines

Six-membered rings with two adjacent nitrogen atoms also called 1,2-diazine.
DrugDrug NameDrug Description
DB00972AzelastineA histamine H1-receptor antagonist used intranasally to treat allergic and vasomotor rhinitis and in an ophthalmic solution to treat allergic conjunctivitis.
DB01275HydralazineAn antihypertensive agent used for the management of essential hypertension or severe hypertension associated with conditions requiring immediate action, heart failure, and pre-eclampsia or eclampsia .
DB01340CilazaprilAn ACE inhibitor used for the management of hypertension and heart failure.
DB02041IsoluminolNot Available
DB04879VatalanibUsed in combination with first- and second-line chemotherapy for the treatment of metastatic colorectal cancer and non-small cell lung cancer (NSCLC).
DB09074OlaparibA chemotherapeutic agent used to treat recurrent or advanced ovarian cancer and metastatic breast cancer in patients with specific mutations and prior history of chemotherapy.
DB11760TalazoparibA poly-ADP ribose polymerase inhibitor used to treat HER2-, BRCA mutated locally advanced or metastatic breast cancer.
DB12550TaladegibTaladegib has been used in trials studying the treatment of Solid Tumor, COLON CANCER, BREAST CANCER, Advanced Cancer, and Rhabdomyosarcoma, among others.
DB12806GSK-1004723Gsk1004723 has been investigated for the treatment of Allergic Rhinitis and Rhinitis, Allergic, Seasonal.
DB12945DihydralazineDihydralazine is under investigation in clinical trial NCT00311974 (The Effect of Dihydralazine on Kidney Function and Hormones in Healthy Individuals).
DB13349TalastineNot Annotated
DB00922LevosimendanFor short term treatment of acutely decompensated severe chronic heart failure (CHF). Also being investigated for use/treatment in heart disease.
DB12286SimendanSimendan is under investigation in clinical trial NCT00527059 (Renal Effects of Levosimendan in Patients Admitted With Acute Decompensated Heart Failure).
DB15565CilazaprilatNot Annotated
DrugDrug NameTargetType
DB00972AzelastineHistamine H1 receptortarget
DB00972AzelastineCytochrome P450 1A2enzyme
DB00972AzelastineCytochrome P450 2D6enzyme
DB00972AzelastineCytochrome P450 3A4enzyme
DB00972AzelastineCytochrome P450 2C19enzyme
DB00972AzelastineCytochrome P450 1A1enzyme
DB00972AzelastineCytochrome P450 3A5enzyme
DB00972AzelastineCytochrome P450 2C9enzyme
DB00972AzelastineCytochrome P450 2C8enzyme
DB00972AzelastineP-glycoprotein 1transporter
DB00972AzelastineCytochrome P450 2A6enzyme
DB00972AzelastineCytochrome P450 2E1enzyme
DB00972AzelastineHistamine H2 receptortarget
DB00972AzelastinePhospholipase A2target
DB00972AzelastineLeukotriene C4 synthasetarget
DB00972AzelastineCytochrome P450 2B6enzyme
DB01275HydralazineMembrane primary amine oxidasetarget
DB01275HydralazineProlyl 4-hydroxylase subunit alpha-1target
DB01275HydralazineCytochrome P450 3A4enzyme
DB01275HydralazineSerum albumincarrier
DB01275HydralazineHypoxia-inducible factor 1-alphatarget
DB01340CilazaprilAngiotensin-converting enzymetarget
DB01340CilazaprilP-glycoprotein 1transporter
DB01340CilazaprilSolute carrier family 15 member 1transporter
DB01340CilazaprilSolute carrier family 15 member 2transporter
DB02041IsoluminolQueuine tRNA-ribosyltransferasetarget
DB04879VatalanibVascular endothelial growth factor receptor 1target
DB04879VatalanibVascular endothelial growth factor receptor 2target
DB04879VatalanibVascular endothelial growth factor receptor 3target
DB09074OlaparibPoly [ADP-ribose] polymerase 1target
DB09074OlaparibCytochrome P450 3A4enzyme
DB09074OlaparibCytochrome P450 2B6enzyme
DB09074OlaparibPoly [ADP-ribose] polymerase 2target
DB09074OlaparibPoly [ADP-ribose] polymerase 3target
DB09074OlaparibCytochrome P450 3A5enzyme
DB09074OlaparibP-glycoprotein 1transporter
DB09074OlaparibATP-binding cassette sub-family G member 2transporter
DB11760TalazoparibPoly [ADP-ribose] polymerase 1target
DB11760TalazoparibPoly [ADP-ribose] polymerase 2target
DB11760TalazoparibP-glycoprotein 1transporter
DB11760TalazoparibATP-binding cassette sub-family G member 2transporter
DB12945DihydralazineCytochrome P450 1A2enzyme
DB00922LevosimendanTroponin C, slow skeletal and cardiac musclestarget
DB00922LevosimendanATP-sensitive inward rectifier potassium channel 11target
DB00922LevosimendanATP-sensitive inward rectifier potassium channel 8target
DB00922LevosimendancGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
DB15565CilazaprilatAngiotensin-converting enzymetarget