A 30-kDa protein synthesized primarily in the ANTERIOR PITUITARY GLAND and the HYPOTHALAMUS. It is also found in the skin and other peripheral tissues. Depending on species and tissues, POMC is cleaved by PROHORMONE CONVERTASES yielding various active peptides including ACTH; BETA-LIPOTROPIN; ENDORPHINS; MELANOCYTE-STIMULATING HORMONES; and others (GAMMA-LPH; CORTICOTROPIN-LIKE INTERMEDIATE LOBE PEPTIDE; N-terminal peptide of POMC or NPP).
|Drug||Drug Name||Drug Indication|
|DB01284||Tetracosactide||For use as a diagnostic agent in the screening of patients presumed to have adrenocortical insufficiency.|
|DB01285||Corticotropin||For use as a diagnostic agent in the screening of patients presumed to have adrenocortical insufficiency.|
|DB04931||Afamelanotide||Investigated for use/treatment in actinic keratosis, keratoses, skin cell studies, and skin infections/disorders.|
|DB11653||Bremelanotide||Bremelanotide is indicated to treat premenopausal women with hypoactive sexual desire disorder that is not due to a medical or psychiatric condition, problems with the relationship, or the effects of a medication or drug.[L4894]|