Metals, Alkaline Earth

Name
Metals, Alkaline Earth
Accession Number
DBCAT001352
Description

Metals that constitute the group 2 (formerly group IIa) of the periodic table.

Drugs
DrugDrug Description
CalciumA mineral found in over-the-counter supplements or prescription formulations used for the treatment of specific medical conditions related to calcium deficiency.
Radium Ra 223 dichlorideA radiopharmaceutical agent used to treat patients with castration-resistant prostate cancer, symptomatic bone metastases and no known visceral metastatic disease.
Magnesium carbonateAn antacid used for symptomatic relief of heartburn, indigestion, and upset stomach.
Strontium chloride Sr-89A radiopharmaceutical agent used for the relief of bone pain in patients with painful skeletal metastases.
BariumBarium is under investigation for the diagnostic of Known or Suspected Abdominal Disease.
Strontium chlorideA medication used to treat bone pain in skeletal metastases.
MagnesiumA medication used for many purposes including constipation, indigestion, magnesium deficiency, and pre-eclampsia.
Radium Ra-223Radium 223 is under investigation in clinical trial NCT02463799 (Ph 2 Study of Sipuleucel-T W/ or W/O Radium-223 in Men With Asymptomatic or Minimally Symptomatic Bone-MCRPC).
Drugs & Drug Targets
DrugTargetType
CalciumProtein S100-Btarget
CalciumCalpastatintarget
CalciumCartilage oligomeric matrix proteintarget
CalciumCalmodulintarget
CalciumSpectrin beta chain, non-erythrocytic 1target
CalciumVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
CalciumTroponin C, skeletal muscletarget
CalciumTroponin C, slow skeletal and cardiac musclestarget
CalciumCalcium-transporting ATPase type 2C member 1target
CalciumAmiloride-sensitive amine oxidase [copper-containing]target
CalciumProtein S100-A13target
CalciumAlkaline phosphatase, placental typetarget
CalciumProtein S100-A8target
CalciumProtein S100-A9target
CalciumProtein S100-A2target
CalciumCeruloplasmintarget
CalciumBone morphogenetic protein 4target
CalciumMatrix Gla proteintarget
CalciumProtocadherin-19target
CalciumProgrammed cell death protein 6target
Magnesium carbonateTransient receptor potential cation channel subfamily M member 6transporter
Magnesium carbonateSolute carrier family 41 member 3transporter
Magnesium carbonateMetal transporter CNNM2transporter
Magnesium carbonateTransient receptor potential cation channel subfamily M member 7transporter
Magnesium carbonateGlutamate (NMDA) receptortarget
Strontium chloride Sr-89Alkaline phosphatase, placental-likeenzyme
Strontium chloride Sr-89Alkaline phosphatase, tissue-nonspecific isozymeenzyme
Strontium chloride Sr-89Adenosine triphosphate (ATP)enzyme
Strontium chloride Sr-89Sodium/calcium exchanger 1transporter
Strontium chloride Sr-89Voltage-dependent T-type calcium channel subunit alpha-1Itransporter
MagnesiumSerum albumincarrier
MagnesiumClaudin-16transporter
MagnesiumTransient receptor potential cation channel subfamily M member 6transporter
MagnesiumTransient receptor potential cation channel subfamily M member 7transporter
MagnesiumSolute carrier family 41 member 1transporter
MagnesiumSolute carrier family 41 member 3transporter
MagnesiumMagnesium transporter MRS2 homolog, mitochondrialtransporter