Deoxycholic Acid

A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.
DrugDrug NameDrug Indication
DB01586Ursodeoxycholic acidThe drug decreases the absorption of cholesterol and is used to dissolve (cholesterol) gallstones in patients as an alternative to a surgical procedure to remove the gallstones.
DB02123Glycochenodeoxycholic AcidNot Available
DB05990Obeticholic acidIndicated for the treatment of primary biliary cholangitis in combination with ursodeoxycholic acid (UDCA) in adults with an inadequate response to UDCA, or as monotherapy in adults unable to tolerate UDCA.
DB06777Chenodeoxycholic acidChenodiol is indicated for patients with radiolucent stones in well-opacifying gallbladders, in whom selective surgery would be undertaken except for the presence of increased surgical risk due to systemic disease or age. Chenodiol will not dissolve calcified (radiopaque) or radiolucent bile pigment stones.
DB08833Taurochenodeoxycholic acidTaurochenodeoxycholic acid is likely indicated as a choleretic and cholagogue. It is also being investigated for its role in inflammation and cancer therapy.
DB08834Tauroursodeoxycholic acidUsed in the treatment of cholesterol gallstones. Tauroursodeoxycholic acid is also being investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis, and Amyotrophic Lateral Sclerosis.
DB08857Bamet-UD2Not Available
DB08858cis-Diamminechlorocholylglycinateplatinum(II)Not Available
DB03619Deoxycholic acidFor improvement in appearance of moderate to severe fullness associated with submental fat in adults.
DrugDrug NameTargetType
DB01586Ursodeoxycholic acidAldo-keto reductase family 1 member C2target
DB01586Ursodeoxycholic acidBile salt export pumptransporter
DB01586Ursodeoxycholic acidSolute carrier organic anion transporter family member 1A2transporter
DB01586Ursodeoxycholic acidCanalicular multispecific organic anion transporter 1transporter
DB01586Ursodeoxycholic acidMultidrug resistance-associated protein 4transporter
DB01586Ursodeoxycholic acidIleal sodium/bile acid cotransportertransporter
DB01586Ursodeoxycholic acidSodium/bile acid cotransportertransporter
DB01586Ursodeoxycholic acidCytochrome P450 2E1enzyme
DB01586Ursodeoxycholic acidBile acid receptortarget
DB02123Glycochenodeoxycholic Acid7-alpha-hydroxysteroid dehydrogenasetarget
DB02123Glycochenodeoxycholic AcidBile salt export pumptransporter
DB02123Glycochenodeoxycholic AcidSolute carrier organic anion transporter family member 1A2transporter
DB02123Glycochenodeoxycholic AcidIleal sodium/bile acid cotransportertransporter
DB02123Glycochenodeoxycholic AcidSodium/bile acid cotransportertransporter
DB05990Obeticholic acidBile acid receptortarget
DB05990Obeticholic acidBile acid-CoA:amino acid N-acyltransferaseenzyme
DB05990Obeticholic acidCytochrome P450 1A2enzyme
DB06777Chenodeoxycholic acidBile acid receptortarget
DB06777Chenodeoxycholic acidSterol 26-hydroxylase, mitochondrialenzyme
DB06777Chenodeoxycholic acidCytochrome P450 3A4enzyme
DB06777Chenodeoxycholic acidUDP-glucuronosyltransferase 2B7enzyme
DB06777Chenodeoxycholic acidNuclear receptor subfamily 1 group I member 2target
DB06777Chenodeoxycholic acidG-protein coupled bile acid receptor 1target
DB06777Chenodeoxycholic acidAldo-keto reductase family 1 member C2target
DB08833Taurochenodeoxycholic acidSolute carrier organic anion transporter family member 1A2transporter
DB08833Taurochenodeoxycholic acidCystine/glutamate transportertransporter
DB08833Taurochenodeoxycholic acidCytochrome P450 3A4enzyme
DB08834Tauroursodeoxycholic acidSolute carrier organic anion transporter family member 1A2transporter
DB08834Tauroursodeoxycholic acidCystine/glutamate transportertransporter
DB08834Tauroursodeoxycholic acidCytochrome P450 3A1enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 3A2enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 2A1enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 2A2enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 2B1enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 2B2enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 2B9enzyme
DB08857Bamet-UD2Solute carrier organic anion transporter family member 1B1transporter
DB08858cis-Diamminechlorocholylglycinateplatinum(II)Solute carrier organic anion transporter family member 1B1transporter
DB03619Deoxycholic acidBile salt export pumptransporter
DB03619Deoxycholic acidSolute carrier organic anion transporter family member 1A2transporter
DB03619Deoxycholic acidIleal sodium/bile acid cotransportertransporter
DB03619Deoxycholic acidSodium/bile acid cotransportertransporter
DB03619Deoxycholic acidSteroid Delta-isomerasetarget
DB03619Deoxycholic acidPpcAtarget
DB03619Deoxycholic acidElongation factor Tu GTP-binding domain-containing protein 1target
DB03619Deoxycholic acidCholoylglycine hydrolasetarget
DB03619Deoxycholic acidLactaldehyde dehydrogenasetarget
DB03619Deoxycholic acidAcriflavine resistance protein Btarget
DB03619Deoxycholic acidCytochrome c oxidase subunit 1target
DB03619Deoxycholic acidCytochrome c oxidase subunit 2target
DB03619Deoxycholic acidBile acid receptortarget
DB03619Deoxycholic acidGlutathione S-transferase Ptarget
DB03619Deoxycholic acidG-protein coupled bile acid receptor 1target