Bile Acids and Salts

Steroid acids and salts. The primary bile acids are derived from cholesterol in the liver and usually conjugated with glycine or taurine. The secondary bile acids are further modified by bacteria in the intestine. They play an important role in the digestion and absorption of fat. They have also been used pharmacologically, especially in the treatment of gallstones.
DrugDrug NameDrug Indication
DB02659Cholic AcidOral cholic acid is indicated for: treatment of bile acid synthesis disorders due to single enzyme defects; and as adjunctive treatment of peroxisomal disorders including Zellweger spectrum disorders in patients who exhibit manifestations of liver disease, steatorrhea or complications from decreased fat soluble vitamin absorption.
DB01586Ursodeoxycholic acidThe drug decreases the absorption of cholesterol and is used to dissolve (cholesterol) gallstones in patients as an alternative to a surgical procedure to remove the gallstones.
DB02123Glycochenodeoxycholic AcidNot Available
DB03619Deoxycholic AcidFor improvement in appearance of moderate to severe fullness associated with submental fat in adults.
DB04348Taurocholic AcidNot Available
DB05990Obeticholic acidIndicated for the treatment of primary biliary cholangitis in combination with ursodeoxycholic acid (UDCA) in adults with an inadequate response to UDCA, or as monotherapy in adults unable to tolerate UDCA.
DB06777Chenodeoxycholic acidChenodiol is indicated for patients with radiolucent stones in well-opacifying gallbladders, in whom selective surgery would be undertaken except for the presence of increased surgical risk due to systemic disease or age. Chenodiol will not dissolve calcified (radiopaque) or radiolucent bile pigment stones.
DB08833Taurochenodeoxycholic acidTaurochenodeoxycholic acid is likely indicated as a choleretic and cholagogue. It is also being investigated for its role in inflammation and cancer therapy.
DB08834Tauroursodeoxycholic acidUsed in the treatment of cholesterol gallstones. Tauroursodeoxycholic acid is also being investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis, and Amyotrophic Lateral Sclerosis.
DB08857Bamet-UD2Not Available
DB08858cis-Diamminechlorocholylglycinateplatinum(II)Not Available
DB11622Dehydrocholic acidNo approved therapeutic indications.
DB11789Hyodeoxycholic AcidNot Available
DB11860AramcholNot Available
DB14016Ox bile extractNot Available
DB02691Glycocholic acidNot Available
DrugDrug NameTargetType
DB02659Cholic AcidFerrochelatase, mitochondrialtarget
DB02659Cholic AcidBile salt export pumptransporter
DB02659Cholic AcidMultidrug resistance protein 1transporter
DB02659Cholic AcidMultidrug resistance-associated protein 1transporter
DB02659Cholic AcidSolute carrier organic anion transporter family member 1A2transporter
DB02659Cholic AcidIleal sodium/bile acid cotransportertransporter
DB02659Cholic AcidCanalicular multispecific organic anion transporter 1transporter
DB02659Cholic AcidSolute carrier organic anion transporter family member 1B1transporter
DB02659Cholic AcidCanalicular multispecific organic anion transporter 2transporter
DB02659Cholic AcidMultidrug resistance-associated protein 4transporter
DB02659Cholic AcidSodium/bile acid cotransportertransporter
DB02659Cholic AcidSolute carrier family 22 member 8transporter
DB02659Cholic AcidSolute carrier family 22 member 7transporter
DB02659Cholic AcidSolute carrier organic anion transporter family member 1B3transporter
DB02659Cholic AcidAlcohol dehydrogenase 1Ctarget
DB02659Cholic AcidEstrogen-related receptor gammatarget
DB02659Cholic AcidGastrotropintarget
DB02659Cholic AcidCytochrome c oxidase subunit 4 isoform 1, mitochondrialtarget
DB02659Cholic AcidCytochrome c oxidase subunit 1target
DB02659Cholic AcidCytochrome c oxidase subunit 2target
DB02659Cholic AcidCytochrome c oxidase subunit 3target
DB02659Cholic AcidCytochrome c oxidase subunit 5A, mitochondrialtarget
DB02659Cholic AcidCytochrome c oxidase subunit 5B, mitochondrialtarget
DB02659Cholic AcidCytochrome c oxidase subunit 6Ctarget
DB02659Cholic AcidCytochrome c oxidase subunit 7B, mitochondrialtarget
DB02659Cholic AcidCytochrome c oxidase subunit 7C, mitochondrialtarget
DB02659Cholic AcidCytochrome c oxidase subunit 8A, mitochondrialtarget
DB02659Cholic AcidCytochrome c oxidase subunit 6A2, mitochondrialtarget
DB02659Cholic AcidCytochrome c oxidase subunit 6B1target
DB02659Cholic AcidCytochrome c oxidase subunit 7A1, mitochondrialtarget
DB02659Cholic AcidPhospholipase A2target
DB02659Cholic AcidLiver carboxylesterase 1target
DB02659Cholic AcidFatty acid-binding protein, livercarrier
DB02659Cholic AcidFerrochelatasetarget
DB02659Cholic AcidCholoylglycine hydrolasetarget
DB02659Cholic AcidBile acid receptortarget
DB02659Cholic AcidG-protein coupled bile acid receptor 1target
DB01586Ursodeoxycholic acidAldo-keto reductase family 1 member C2target
DB01586Ursodeoxycholic acidBile salt export pumptransporter
DB01586Ursodeoxycholic acidSolute carrier organic anion transporter family member 1A2transporter
DB01586Ursodeoxycholic acidCanalicular multispecific organic anion transporter 1transporter
DB01586Ursodeoxycholic acidMultidrug resistance-associated protein 4transporter
DB01586Ursodeoxycholic acidIleal sodium/bile acid cotransportertransporter
DB01586Ursodeoxycholic acidSodium/bile acid cotransportertransporter
DB01586Ursodeoxycholic acidCytochrome P450 2E1enzyme
DB01586Ursodeoxycholic acidBile acid receptortarget
DB02123Glycochenodeoxycholic Acid7-alpha-hydroxysteroid dehydrogenasetarget
DB02123Glycochenodeoxycholic AcidBile salt export pumptransporter
DB02123Glycochenodeoxycholic AcidSolute carrier organic anion transporter family member 1A2transporter
DB02123Glycochenodeoxycholic AcidIleal sodium/bile acid cotransportertransporter
DB02123Glycochenodeoxycholic AcidSodium/bile acid cotransportertransporter
DB03619Deoxycholic AcidBile salt export pumptransporter
DB03619Deoxycholic AcidSolute carrier organic anion transporter family member 1A2transporter
DB03619Deoxycholic AcidIleal sodium/bile acid cotransportertransporter
DB03619Deoxycholic AcidSodium/bile acid cotransportertransporter
DB03619Deoxycholic AcidSteroid Delta-isomerasetarget
DB03619Deoxycholic AcidPpcAtarget
DB03619Deoxycholic AcidElongation factor Tu GTP-binding domain-containing protein 1target
DB03619Deoxycholic AcidCholoylglycine hydrolasetarget
DB03619Deoxycholic AcidLactaldehyde dehydrogenasetarget
DB03619Deoxycholic AcidAcriflavine resistance protein Btarget
DB03619Deoxycholic AcidCytochrome c oxidase subunit 1target
DB03619Deoxycholic AcidCytochrome c oxidase subunit 2target
DB03619Deoxycholic AcidBile acid receptortarget
DB03619Deoxycholic AcidGlutathione S-transferase Ptarget
DB03619Deoxycholic AcidG-protein coupled bile acid receptor 1target
DB04348Taurocholic AcidBile salt-activated lipasetarget
DB04348Taurocholic AcidGastrotropintarget
DB04348Taurocholic AcidBile salt export pumptransporter
DB04348Taurocholic AcidMultidrug resistance-associated protein 1transporter
DB04348Taurocholic AcidSolute carrier organic anion transporter family member 1A2transporter
DB04348Taurocholic AcidIleal sodium/bile acid cotransportertransporter
DB04348Taurocholic AcidCanalicular multispecific organic anion transporter 1transporter
DB04348Taurocholic AcidSolute carrier organic anion transporter family member 1B1transporter
DB04348Taurocholic AcidCanalicular multispecific organic anion transporter 2transporter
DB04348Taurocholic AcidMultidrug resistance-associated protein 4transporter
DB04348Taurocholic AcidMultidrug resistance protein 1transporter
DB04348Taurocholic AcidSolute carrier family 22 member 6transporter
DB04348Taurocholic AcidMultidrug resistance-associated protein 7transporter
DB04348Taurocholic AcidSolute carrier family 22 member 8transporter
DB04348Taurocholic AcidSolute carrier organic anion transporter family member 4A1transporter
DB04348Taurocholic AcidATP-binding cassette sub-family C member 11transporter
DB04348Taurocholic AcidSolute carrier organic anion transporter family member 1C1transporter
DB04348Taurocholic AcidSolute carrier organic anion transporter family member 3A1transporter
DB04348Taurocholic AcidATP-binding cassette sub-family G member 2transporter
DB04348Taurocholic AcidSolute carrier organic anion transporter family member 2B1transporter
DB04348Taurocholic AcidMonocarboxylate transporter 1transporter
DB04348Taurocholic AcidSodium/bile acid cotransportertransporter
DB04348Taurocholic AcidOrganic solute transporter subunit alphatransporter
DB04348Taurocholic AcidOrganic solute transporter subunit betatransporter
DB04348Taurocholic AcidSolute carrier organic anion transporter family member 1B3transporter
DB04348Taurocholic AcidCystine/glutamate transportertransporter
DB04348Taurocholic AcidBile acid receptortarget
DB05990Obeticholic acidBile acid receptortarget
DB05990Obeticholic acidBile acid-CoA:amino acid N-acyltransferaseenzyme
DB05990Obeticholic acidCytochrome P450 1A2enzyme
DB06777Chenodeoxycholic acidBile acid receptortarget
DB06777Chenodeoxycholic acidSterol 26-hydroxylase, mitochondrialenzyme
DB06777Chenodeoxycholic acidCytochrome P450 3A4enzyme
DB06777Chenodeoxycholic acidUDP-glucuronosyltransferase 2B7enzyme
DB06777Chenodeoxycholic acidNuclear receptor subfamily 1 group I member 2target
DB06777Chenodeoxycholic acidG-protein coupled bile acid receptor 1target
DB06777Chenodeoxycholic acidAldo-keto reductase family 1 member C2target
DB08833Taurochenodeoxycholic acidSolute carrier organic anion transporter family member 1A2transporter
DB08833Taurochenodeoxycholic acidCystine/glutamate transportertransporter
DB08833Taurochenodeoxycholic acidCytochrome P450 3A4enzyme
DB08834Tauroursodeoxycholic acidSolute carrier organic anion transporter family member 1A2transporter
DB08834Tauroursodeoxycholic acidCystine/glutamate transportertransporter
DB08834Tauroursodeoxycholic acidCytochrome P450 3A1enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 3A2enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 2A1enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 2A2enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 2B1enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 2B2enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 2B9enzyme
DB08857Bamet-UD2Solute carrier organic anion transporter family member 1B1transporter
DB08858cis-Diamminechlorocholylglycinateplatinum(II)Solute carrier organic anion transporter family member 1B1transporter
DB02691Glycocholic acidGastrotropintarget
DB02691Glycocholic acidSolute carrier organic anion transporter family member 1A2transporter
DB02691Glycocholic acidSolute carrier organic anion transporter family member 1B1transporter
DB02691Glycocholic acidSolute carrier organic anion transporter family member 1B3transporter