Bile Acids and Salts

Steroid acids and salts. The primary bile acids are derived from cholesterol in the liver and usually conjugated with glycine or taurine. The secondary bile acids are further modified by bacteria in the intestine. They play an important role in the digestion and absorption of fat. They have also been used pharmacologically, especially in the treatment of gallstones.
DrugDrug NameDrug Description
DB02659Cholic AcidA bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function.
DB01586Ursodeoxycholic acidA bile acid used for the treatment of primary biliary cirrhosis (PBC), dissolution of radiolucent gallstones in patients with a functioning gallbladder, and treatment of hepatobiliary disorders associated with cystic fibrosis in pediatric patients.
DB02123Glycochenodeoxycholic AcidA bile salt formed in the liver from chenodeoxycholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed....
DB03619Deoxycholic acidA cytolytic agent injected subcutaneously to improve the appearance submental fat.
DB04348Taurocholic acidThe product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats...
DB05990Obeticholic acidA bile acid analog and farnesoid X receptor agonist used to treat primary biliary cholangitis in adult patients with inadequate clinical response or intolerance to UDCA.
DB06777Chenodeoxycholic acidA bile acid used for the treatment of primary biliary cirrhosis.
DB08833Taurochenodeoxycholic acidTaurochenodeoxycholic acid is likely indicated as a choleretic and cholagogue. It is also being investigated for its role in inflammation and cancer therapy.
DB08834Tauroursodeoxycholic acidUsed in the treatment of cholesterol gallstones. Tauroursodeoxycholic acid is also being investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis,...
DB08857Bamet-UD2Bamet-UD2 is a novel bile acid-platinum derivative.
DB08858cis-Diamminechlorocholylglycinateplatinum(II)Not Annotated
DB11622Dehydrocholic acidNo approved therapeutic indications.
DB11789Hyodeoxycholic AcidHyodeoxycholic Acid has been used in trials studying the treatment of Hypercholesterolemia.
DB11860AramcholAramchol has been used in trials studying the treatment of HIV, Gallstones, Fatty Liver, Metabolic Syndrome, and Nonalcoholic Steatohepatitis, among others.
DB14016Ox bile extractNot Annotated
DB02691Glycocholic acidThe glycine conjugate of cholic acid. It acts as a detergent to solubilize fats for absorption and is itself absorbed.
DrugDrug NameTargetType
DB02659Cholic AcidFerrochelatase, mitochondrialtarget
DB02659Cholic AcidBile salt export pumptransporter
DB02659Cholic AcidP-glycoprotein 1transporter
DB02659Cholic AcidMultidrug resistance-associated protein 1transporter
DB02659Cholic AcidSolute carrier organic anion transporter family member 1A2transporter
DB02659Cholic AcidIleal sodium/bile acid cotransportertransporter
DB02659Cholic AcidCanalicular multispecific organic anion transporter 1transporter
DB02659Cholic AcidSolute carrier organic anion transporter family member 1B1transporter
DB02659Cholic AcidCanalicular multispecific organic anion transporter 2transporter
DB02659Cholic AcidMultidrug resistance-associated protein 4transporter
DB02659Cholic AcidSodium/bile acid cotransportertransporter
DB02659Cholic AcidSolute carrier family 22 member 8transporter
DB02659Cholic AcidSolute carrier family 22 member 7transporter
DB02659Cholic AcidSolute carrier organic anion transporter family member 1B3transporter
DB02659Cholic AcidAlcohol dehydrogenase 1Ctarget
DB02659Cholic AcidEstrogen-related receptor gammatarget
DB02659Cholic AcidGastrotropintarget
DB02659Cholic AcidCytochrome c oxidase subunit 4 isoform 1, mitochondrialtarget
DB02659Cholic AcidCytochrome c oxidase subunit 1target
DB02659Cholic AcidCytochrome c oxidase subunit 2target
DB02659Cholic AcidCytochrome c oxidase subunit 3target
DB02659Cholic AcidCytochrome c oxidase subunit 5A, mitochondrialtarget
DB02659Cholic AcidCytochrome c oxidase subunit 5B, mitochondrialtarget
DB02659Cholic AcidCytochrome c oxidase subunit 6Ctarget
DB02659Cholic AcidCytochrome c oxidase subunit 7B, mitochondrialtarget
DB02659Cholic AcidCytochrome c oxidase subunit 7C, mitochondrialtarget
DB02659Cholic AcidCytochrome c oxidase subunit 8A, mitochondrialtarget
DB02659Cholic AcidCytochrome c oxidase subunit 6A2, mitochondrialtarget
DB02659Cholic AcidCytochrome c oxidase subunit 6B1target
DB02659Cholic AcidCytochrome c oxidase subunit 7A1, mitochondrialtarget
DB02659Cholic AcidPhospholipase A2target
DB02659Cholic AcidLiver carboxylesterase 1target
DB02659Cholic AcidFatty acid-binding protein, livercarrier
DB02659Cholic AcidFerrochelatasetarget
DB02659Cholic AcidCholoylglycine hydrolasetarget
DB02659Cholic AcidBile acid receptortarget
DB02659Cholic AcidG-protein coupled bile acid receptor 1target
DB01586Ursodeoxycholic acidAldo-keto reductase family 1 member C2target
DB01586Ursodeoxycholic acidBile salt export pumptransporter
DB01586Ursodeoxycholic acidSolute carrier organic anion transporter family member 1A2transporter
DB01586Ursodeoxycholic acidCanalicular multispecific organic anion transporter 1transporter
DB01586Ursodeoxycholic acidMultidrug resistance-associated protein 4transporter
DB01586Ursodeoxycholic acidIleal sodium/bile acid cotransportertransporter
DB01586Ursodeoxycholic acidSodium/bile acid cotransportertransporter
DB01586Ursodeoxycholic acidCytochrome P450 2E1enzyme
DB01586Ursodeoxycholic acidBile acid receptortarget
DB02123Glycochenodeoxycholic Acid7-alpha-hydroxysteroid dehydrogenasetarget
DB02123Glycochenodeoxycholic AcidBile salt export pumptransporter
DB02123Glycochenodeoxycholic AcidSolute carrier organic anion transporter family member 1A2transporter
DB02123Glycochenodeoxycholic AcidIleal sodium/bile acid cotransportertransporter
DB02123Glycochenodeoxycholic AcidSodium/bile acid cotransportertransporter
DB03619Deoxycholic acidBile salt export pumptransporter
DB03619Deoxycholic acidSolute carrier organic anion transporter family member 1A2transporter
DB03619Deoxycholic acidIleal sodium/bile acid cotransportertransporter
DB03619Deoxycholic acidSodium/bile acid cotransportertransporter
DB03619Deoxycholic acidSteroid Delta-isomerasetarget
DB03619Deoxycholic acidPpcAtarget
DB03619Deoxycholic acidElongation factor Tu GTP-binding domain-containing protein 1target
DB03619Deoxycholic acidCholoylglycine hydrolasetarget
DB03619Deoxycholic acidLactaldehyde dehydrogenasetarget
DB03619Deoxycholic acidAcriflavine resistance protein Btarget
DB03619Deoxycholic acidCytochrome c oxidase subunit 1target
DB03619Deoxycholic acidCytochrome c oxidase subunit 2target
DB03619Deoxycholic acidBile acid receptortarget
DB03619Deoxycholic acidGlutathione S-transferase Ptarget
DB03619Deoxycholic acidG-protein coupled bile acid receptor 1target
DB04348Taurocholic acidBile salt-activated lipasetarget
DB04348Taurocholic acidGastrotropintarget
DB04348Taurocholic acidBile salt export pumptransporter
DB04348Taurocholic acidMultidrug resistance-associated protein 1transporter
DB04348Taurocholic acidSolute carrier organic anion transporter family member 1A2transporter
DB04348Taurocholic acidIleal sodium/bile acid cotransportertransporter
DB04348Taurocholic acidCanalicular multispecific organic anion transporter 1transporter
DB04348Taurocholic acidSolute carrier organic anion transporter family member 1B1transporter
DB04348Taurocholic acidCanalicular multispecific organic anion transporter 2transporter
DB04348Taurocholic acidMultidrug resistance-associated protein 4transporter
DB04348Taurocholic acidP-glycoprotein 1transporter
DB04348Taurocholic acidSolute carrier family 22 member 6transporter
DB04348Taurocholic acidMultidrug resistance-associated protein 7transporter
DB04348Taurocholic acidSolute carrier family 22 member 8transporter
DB04348Taurocholic acidSolute carrier organic anion transporter family member 4A1transporter
DB04348Taurocholic acidATP-binding cassette sub-family C member 11transporter
DB04348Taurocholic acidSolute carrier organic anion transporter family member 1C1transporter
DB04348Taurocholic acidSolute carrier organic anion transporter family member 3A1transporter
DB04348Taurocholic acidATP-binding cassette sub-family G member 2transporter
DB04348Taurocholic acidSolute carrier organic anion transporter family member 2B1transporter
DB04348Taurocholic acidMonocarboxylate transporter 1transporter
DB04348Taurocholic acidSodium/bile acid cotransportertransporter
DB04348Taurocholic acidOrganic solute transporter subunit alphatransporter
DB04348Taurocholic acidOrganic solute transporter subunit betatransporter
DB04348Taurocholic acidSolute carrier organic anion transporter family member 1B3transporter
DB04348Taurocholic acidCystine/glutamate transportertransporter
DB04348Taurocholic acidBile acid receptortarget
DB05990Obeticholic acidBile acid receptortarget
DB05990Obeticholic acidBile acid-CoA:amino acid N-acyltransferaseenzyme
DB05990Obeticholic acidCytochrome P450 1A2enzyme
DB06777Chenodeoxycholic acidBile acid receptortarget
DB06777Chenodeoxycholic acidSterol 26-hydroxylase, mitochondrialenzyme
DB06777Chenodeoxycholic acidCytochrome P450 3A4enzyme
DB06777Chenodeoxycholic acidUDP-glucuronosyltransferase 2B7enzyme
DB06777Chenodeoxycholic acidNuclear receptor subfamily 1 group I member 2target
DB06777Chenodeoxycholic acidG-protein coupled bile acid receptor 1target
DB06777Chenodeoxycholic acidAldo-keto reductase family 1 member C2target
DB08833Taurochenodeoxycholic acidSolute carrier organic anion transporter family member 1A2transporter
DB08833Taurochenodeoxycholic acidCystine/glutamate transportertransporter
DB08833Taurochenodeoxycholic acidCytochrome P450 3A4enzyme
DB08834Tauroursodeoxycholic acidSolute carrier organic anion transporter family member 1A2transporter
DB08834Tauroursodeoxycholic acidCystine/glutamate transportertransporter
DB08834Tauroursodeoxycholic acidCytochrome P450 3A1enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 3A2enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 2A1enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 2A2enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 2B1enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 2B2enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 2B9enzyme
DB08857Bamet-UD2Solute carrier organic anion transporter family member 1B1transporter
DB08858cis-Diamminechlorocholylglycinateplatinum(II)Solute carrier organic anion transporter family member 1B1transporter
DB02691Glycocholic acidGastrotropintarget
DB02691Glycocholic acidSolute carrier organic anion transporter family member 1A2transporter
DB02691Glycocholic acidSolute carrier organic anion transporter family member 1B1transporter
DB02691Glycocholic acidSolute carrier organic anion transporter family member 1B3transporter