Polynucleotides

DrugDrug NameDrug Description
DB04895PegaptanibA selective vascular endothelial growth factor (VEGF) antagonist used for the treatment of neovascular (wet) age-related macular degeneration.
DB04932DefibrotideA mixture of single-stranded oligonucleotides used in the treatment of severe hepatic veno-occlusive disease with renal or pulmonary dysfunction following hematopoietic stem-cell transplantation.
DB04973LErafAONIntended for the treatment of various forms of cancer.
DB04998AGRO100Investigated for use/treatment in cancer/tumors (unspecified), kidney cancer, leukemia (myeloid), and pancreatic cancer.
DB05141LY2181308Investigated for use/treatment in cancer/tumors (unspecified) and solid tumors.
DB05165LY2275796Investigated for use/treatment in cancer/tumors (unspecified) and solid tumors.
DB05202Egaptivon pegolPlatelet aggregation, thrombosis and acute coronary syndromes
DB05406GTI-2501Investigated for use/treatment in prostate cancer and solid tumors.
DB05528MipomersenAn oligonucleotide drug used for the treatment of homozygous familial hypercholesterolemia.
DB05530CPG 10101Investigated for use/treatment in hepatitis (viral, C) and viral infection.
DB05798GEM-231Investigated for use/treatment in solid tumors.
DB06014EteplirsenAn antisense oligonucleotide used to treat Duchenne muscular dystrophy (DMD) only in patients who are confirmed to have a specific type of mutation.
DB06094ApatorsenInvestigated for use/treatment in cancer/tumors (unspecified).
DB06184AEG35156Investigated for use/treatment in cancer/tumors (unspecified) and leukemia (myeloid).
DB06224AlicaforsenInvestigated for use/treatment in crohn's disease and ulcerative colitis.
DB06293PegnivacoginInvestigated for use/treatment in thrombosis, coronary artery disease, and vascular diseases.
DB06451AprinocarsenInvestigated for use/treatment in lung cancer.
DB06556EdifoligideInvestigated for use/treatment in cardiac surgery, peripheral vascular disease, and kidney disease.
DB06662AbetimusInvestigated for use/treatment in kidney disease and systemic lupus erythematosus.
DB06759FomivirsenIndicated for the local treatment of cytomegalovirus (CMV) retinitis in patients with acquired immunodeficiency syndrome (AIDS), when other therapy has been ineffective or is considered unsuitable [FDA Label, L1428].
DB12851MiravirsenMiravirsen has been investigated for the treatment of Hepatitis C and Hepatitis C, Chronic.
DB13161NusinersenA medication used to treat spinal muscular atrophy.
DB13688DrisapersenNot Annotated
DB06181IMO-2055Investigated for use/treatment in renal cell carcinoma, solid tumors, and lung cancer.
DB05463ISS-1018Investigated for use/treatment in colorectal cancer, hepatitis (viral, B), and lymphoma (non-hodgkin's). ISS 1018 is currently being investigated in combination with HBsAg vaccine as a prophylactic treatment for to prevent...
DB05559NF-kappaB DecoyInvestigated for use/treatment in atopic dermatitis, inflammatory disorders (unspecified), and skin infections/disorders.
DB15019MongersenMongersen is under investigation in clinical trial NCT02957474 (A Study to Evaluate the Effect of Food, Formulation Strength, and a Proton Pump Inhibitor on GED 0301 Pharmacokinetics in Healthy Adult...
DB15030GTI-2040GTI-2040 is under investigation in clinical trial NCT00084643 (GTI-2040, Oxaliplatin, and Capecitabine in Treating Patients With Locally Advanced or Metastatic Colorectal Cancer or Other Solid Tumors).
DB15067VolanesorsenVolanesorsen is under investigation in clinical trial NCT02639286 (Efficacy, Safety and Tolerability of ISIS 304801 in People With Partial Lipodystrophy With an Open-Label Extension).
DB15285ARC-19499ARC-19499 is under investigation in clinical trial NCT01191372 (First-in-Human and Proof-of-Mechanism Study of ARC19499 Administered to Hemophilia Patients).
DB15369AganirsenAganirsen is under investigation in clinical trial NCT02947867 (Trial of Aganirsen in iCRVO Patients at Risk of Developing NVG).
DB15455CenersenCenersen is under investigation in clinical trial NCT02243124 (A Study of Aezea® (Cenersen) in Transfusion Dependent Anemia Associated With Myelodysplastic Syndrome (MDS)).
DB12578Lexaptepid PegolLexaptepid Pegol has been used in trials studying the treatment of Anemia, Inflammation, Chronic Diseases, End Stage Renal Disease, and Anemia of Chronic Disease.
DB13811OblimersenNot Annotated
DB14713InotersenAn antisense oligonucleotide used to treat polyneuropathy of hereditary transthyretin-mediated amyloidosis.
DB14825DanvatirsenDanvatirsen is under investigation in clinical trial NCT03334617 (Phase II Umbrella Study of Novel Anti-cancer Agents in Patients With NSCLC Who Progressed on an Anti-PD-1/PD-L1 Containing Therapy.).
DB14909ImetelstatImetelstat is under investigation in clinical trial NCT01916187 (Imetelstat Given Intravenously Alone and With Standard 13-Cis-Retinoic Acid in Children With Neuroblastoma).
DB15332RadavirsenRadavirsen is under investigation in clinical trial NCT01375985 (Safety Study of Single Administration Intravenous Treatment for Influenza).
DB01792Adenylyl-(3'-5')-uridine 3'-monophosphateNot Available