Phosphodiesterase 4 Inhibitors

Name
Phosphodiesterase 4 Inhibitors
Accession Number
DBCAT001410
Description

Compounds that specifically inhibit PHOSPHODIESTERASE 4.

Drugs
DrugDrug Description
RoflumilastA selective phosphodiesterase 4 inhibitor indicated to decrease the risk of exacerbations in patients with severe chronic obstructive pulmonary disease (COPD) associated with a history of exacerbations and chronic bronchitis.
PiclamilastPiclamilast (RP-73,401), is a selective PDE4 inhibitor comparable to other PDE4 inhibitors for its anti-inflammatory effects. It has been investigated for its applications to the treatment of conditions such as...
RolipramA phosphodiesterase inhibitor with antidepressant properties.
GSK-256066Gsk256066 has been used in trials studying the treatment and diagnostic of SAR, Asthma, Mild Asthma, Allergic Rhinitis, and Seasonal Allergic Rhinitis, among others.
E-6005E6005 has been used in trials studying the treatment of Atopic Dermatitis.
MK-0873MK-0873 has been used in trials studying the treatment of Rheumatoid Arthritis.
CilomilastInvestigated for use/treatment in chronic obstructive pulmonary disease (COPD).
CrisaboroleA non-steroidal topical medication used for the treatment of mild-moderate atopic dermatitis.
ApremilastA non-steroidal medication used for the treatment of inflammatory conditions such as psoriasis and psoriatic arthritis.
Drugs & Drug Targets
DrugTargetType
RoflumilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
RoflumilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
RoflumilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
RoflumilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Ctarget
RoflumilastCytochrome P450 3A4enzyme
PiclamilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
PiclamilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
PiclamilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Ctarget
PiclamilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
RolipramcAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
RolipramcAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
CilomilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
CilomilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
CrisaborolecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
CrisaborolecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
CrisaborolecAMP-specific 3',5'-cyclic phosphodiesterase 4Ctarget
CrisaborolecAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget
CrisaboroleCytochrome P450 2B6enzyme
CrisaboroleCytochrome P450 2C8enzyme
CrisaboroleCytochrome P450 2C9enzyme
ApremilastPhosphodiesterase isozyme 4target
ApremilastCytochrome P450 3A4enzyme
ApremilastCytochrome P450 2A6enzyme
ApremilastCytochrome P450 1A2enzyme
ApremilastP-glycoprotein 1transporter