Phosphodiesterase 4 Inhibitors
- Name
- Phosphodiesterase 4 Inhibitors
- Accession Number
- DBCAT001410
- Description
Compounds that specifically inhibit PHOSPHODIESTERASE 4.
- Drugs
Drug Drug Description Roflumilast A selective phosphodiesterase-4 inhibitor indicated to decrease the risk of exacerbations in patients with severe chronic obstructive pulmonary disease (COPD) and to treat plaque psoriasis. Piclamilast Piclamilast (RP-73,401), is a selective PDE4 inhibitor comparable to other PDE4 inhibitors for its anti-inflammatory effects. It has been investigated for its applications to the treatment of conditions such as... Rolipram A phosphodiesterase inhibitor with antidepressant properties. GSK-256066 Gsk256066 has been used in trials studying the treatment and diagnostic of SAR, Asthma, Mild Asthma, Allergic Rhinitis, and Seasonal Allergic Rhinitis, among others. E-6005 E6005 has been used in trials studying the treatment of Atopic Dermatitis. MK-0873 MK-0873 has been used in trials studying the treatment of Rheumatoid Arthritis. Cilomilast Investigated for use/treatment in chronic obstructive pulmonary disease (COPD). Crisaborole A non-steroidal topical medication used for the treatment of mild-moderate atopic dermatitis. Apremilast A non-steroidal medication used for the treatment of inflammatory conditions such as psoriasis and psoriatic arthritis. Drotaverine A phosphodiesterase-4 inhibitor used to alleviate gastrointestinal and genitourinary smooth muscle spasms. CC-11050 CC-11050 is under investigation in clinical trial NCT01300208 (To Evaluate the Preliminary Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of CC-11050 in Subjects With Discoid Lupus Erythematosus and Subacute Cutaneous Lupus... Zatolmilast BPN-14770 is under investigation in clinical trial NCT02840279 (A Multiple Ascending Dose Study of BPN14770 in Healthy Young and Elderly Male or Female Subjects). - Drugs & Drug Targets