Poly(ADP-ribose) Polymerase Inhibitors

Name
Poly(ADP-ribose) Polymerase Inhibitors
Accession Number
DBCAT001523
Description

Chemicals and drugs that inhibit the action of POLY(ADP-RIBOSE)POLYMERASES.

Drugs
DrugDrug Description
OlaparibA chemotherapeutic agent used to treat recurrent or advanced ovarian cancer and metastatic breast cancer in patients with specific mutations and prior history of chemotherapy.
NiraparibA poly-ADP ribose polymerase inhibitor used to treat recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer responding to platinum based chemotherapy.
RucaparibAn anti-cancer agent used to treat recurrent ovarian, fallopian tube, or peritoneal cancer.
3-MethoxybenzamideNot Available
2-(4-Chlorophenyl)-5-QuinoxalinecarboxamideNot Available
VeliparibNot Available
TalazoparibA poly-ADP ribose polymerase inhibitor used to treat HER2-, BRCA mutated locally advanced or metastatic breast cancer.
IniparibNot Annotated
Drugs & Drug Targets
DrugTargetType
OlaparibPoly [ADP-ribose] polymerase 1target
OlaparibCytochrome P450 3A4enzyme
OlaparibCytochrome P450 2B6enzyme
OlaparibPoly [ADP-ribose] polymerase 2target
OlaparibPoly [ADP-ribose] polymerase 3target
OlaparibCytochrome P450 3A5enzyme
OlaparibP-glycoprotein 1transporter
OlaparibATP-binding cassette sub-family G member 2transporter
NiraparibPoly [ADP-ribose] polymerase 1target
NiraparibPoly [ADP-ribose] polymerase 2target
NiraparibCarboxylesteraseenzyme
NiraparibBeta-glucuronidaseenzyme
RucaparibPoly [ADP-ribose] polymerase 1target
RucaparibPoly [ADP-ribose] polymerase 2target
RucaparibPoly [ADP-ribose] polymerase 3target
RucaparibCytochrome P450 2D6enzyme
RucaparibCytochrome P450 1A2enzyme
RucaparibCytochrome P450 3A4enzyme
RucaparibP-glycoprotein 1transporter
RucaparibATP-binding cassette sub-family G member 2transporter
RucaparibMultidrug and toxin extrusion protein 1transporter
RucaparibMultidrug and toxin extrusion protein 2transporter
RucaparibSolute carrier family 22 member 1transporter
RucaparibMultidrug resistance-associated protein 4transporter
RucaparibSolute carrier organic anion transporter family member 1B1transporter
RucaparibSolute carrier organic anion transporter family member 1B3transporter
RucaparibSolute carrier family 22 member 6transporter
RucaparibSolute carrier family 22 member 8transporter
RucaparibCytochrome P450 3A5enzyme
RucaparibCytochrome P450 3A7enzyme
RucaparibCytochrome P450 3A43enzyme
RucaparibCytochrome P450 2C19enzyme
RucaparibCytochrome P450 2C9enzyme
RucaparibCytochrome P450 2C8enzyme
RucaparibUDP-glucuronosyltransferase 1-1enzyme
3-MethoxybenzamidePoly [ADP-ribose] polymerase 1target
2-(4-Chlorophenyl)-5-QuinoxalinecarboxamidePoly [ADP-ribose] polymerase 1target
VeliparibPoly [ADP-ribose] polymerase 1target
VeliparibPoly [ADP-ribose] polymerase 2target
TalazoparibPoly [ADP-ribose] polymerase 1target
TalazoparibPoly [ADP-ribose] polymerase 2target
TalazoparibP-glycoprotein 1transporter
TalazoparibATP-binding cassette sub-family G member 2transporter
IniparibPoly [ADP-ribose] polymerase 1target