Oligonucleotides

Name
Oligonucleotides
Accession Number
DBCAT001720
Description

Polymers made up of a few (2-20) nucleotides. In molecular genetics, they refer to a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe (OLIGONUCLEOTIDE PROBES). (Dorland, 28th ed)

Drugs
DrugDrug Description
MipomersenAn oligonucleotide drug used for the treatment of homozygous familial hypercholesterolemia.
FomivirsenIndicated for the local treatment of cytomegalovirus (CMV) retinitis in patients with acquired immunodeficiency syndrome (AIDS), when other therapy has been ineffective or is considered unsuitable [FDA Label, L1428].
PegaptanibA selective vascular endothelial growth factor (VEGF) antagonist used for the treatment of neovascular (wet) age-related macular degeneration.
GivosiranA 5-aminolevulinic acid synthase-directed small interfering RNA (siRNA) used in the prophylaxis of acute hepatic porphyria.
ViltolarsenAn antisense phosphorodiamidate morpholino oligonucleotide specific for exon 53 of the human DMD gene that is capable of inducing exon 53 skipping to produce a functional truncated dystrophin protein in Duchenne muscular dystrophy patients with specific underlying mutations.
CasimersenAn antisense phosphorodiamidate morpholino oligonucleotide used to treat Duchenne muscular dystrophy patients with mutations amenable to exon 45 skipping.
Adenylyl-(3'-5')-uridine 3'-monophosphateNot Available
LErafAONIntended for the treatment of various forms of cancer.
AGRO100Investigated for use/treatment in cancer/tumors (unspecified), kidney cancer, leukemia (myeloid), and pancreatic cancer.
Egaptivon pegolPlatelet aggregation, thrombosis and acute coronary syndromes
ISS-1018Investigated for use/treatment in colorectal cancer, hepatitis (viral, B), and lymphoma (non-hodgkin's). ISS 1018 is currently being investigated in combination with HBsAg vaccine as a prophylactic treatment for to prevent...
CPG 10101Investigated for use/treatment in hepatitis (viral, C) and viral infection.
NF-kappaB DecoyInvestigated for use/treatment in atopic dermatitis, inflammatory disorders (unspecified), and skin infections/disorders.
TrabedersenInvestigated for use/treatment in brain cancer, colorectal cancer, melanoma, and pancreatic cancer.
EteplirsenAn antisense oligonucleotide used to treat Duchenne muscular dystrophy (DMD) in patients with a confirmed mutation of the DMD gene that is amenable to exon 51 skipping.
AlicaforsenInvestigated for use/treatment in crohn's disease and ulcerative colitis.
PegnivacoginInvestigated for use/treatment in thrombosis, coronary artery disease, and vascular diseases.
G4460Investigated for use/treatment in cancer/tumors (unspecified) and leukemia (myeloid).
AprinocarsenInvestigated for use/treatment in lung cancer.
Lexaptepid pegolLexaptepid pegol has been used in trials studying the treatment of Anemia, Inflammation, Chronic Diseases, End Stage Renal Disease, and Anemia of Chronic Disease.
OblimersenNot Annotated
InotersenAn antisense oligonucleotide used to treat polyneuropathy of hereditary transthyretin-mediated amyloidosis.
CobitolimodCobitolimod is under investigation in clinical trial NCT03178669 (The Efficacy of Cobitolimod in Patients With Moderate to Severe Active Ulcerative Colitis).
GTI-2040GTI-2040 is under investigation in clinical trial NCT00084643 (GTI-2040, Oxaliplatin, and Capecitabine in Treating Patients With Locally Advanced or Metastatic Colorectal Cancer or Other Solid Tumors).
ARC-19499ARC-19499 is under investigation in clinical trial NCT01191372 (First-in-Human and Proof-of-Mechanism Study of ARC19499 Administered to Hemophilia Patients).
RadavirsenRadavirsen is under investigation in clinical trial NCT01375985 (Safety Study of Single Administration Intravenous Treatment for Influenza).
GolodirsenA drug used to treat certain mutations that cause Duchenne muscular dystrophy (DMD).
ISIS 2503ISIS 2503 is under investigation in clinical trial NCT00004193 (ISIS 2503 in Treating Patients With Metastatic And/or Locally Recurrent Colorectal Cancer).
ISIS 104838ISIS 104838 is under investigation in clinical trial NCT00048321 (ISIS 104838, an Inhibitor of Tumor Necrosis Factor, for Active Rheumatoid Arthritis).
VutrisiranA transthyretin-directed small interfering RNA used to treat polyneuropathy associated with hereditary transthyretin-mediated amyloidosis.
MonarsenNot Annotated
RosomidnarNot Available
AgatolimodAgatolimod is under investigation in clinical trial NCT00471471 (Vaccine Therapy in Treating Patients With Recurrent Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery).
AVR118AVR118 represents a new type of biopolymer chemistry that also possesses novel immunomodulator activity. This non-toxic peptide-nucleic acid, which to date has shown no indication of human toxicity, appears to...
IMT504IMT504, a non-CpG 24-mer oligodeoxynucleotide, is an immunomodulatory oligonucleotide currently being investigated as a rabies vaccine.
AVI-7288Not Annotated
Drugs & Drug Targets
DrugTargetType
MipomersenmRNA of ApoB-100target
Fomivirsen30 kDa immediate-early protein 2target
Fomivirsen45 kDa immediate-early protein 2target
PegaptanibVascular endothelial growth factor Atarget
GivosiranALAS1 mRNAtarget
ViltolarsenDMD gene (exon 53 viltolarsen target site)target
CasimersenDMD gene (exon 45 casimersen target site)target
CasimersenCytochrome P450 3A4enzyme
CasimersenCytochrome P450 3A5enzyme
CasimersenCytochrome P450 2C9enzyme
CasimersenCytochrome P450 2C19enzyme
Adenylyl-(3'-5')-uridine 3'-monophosphateDiphtheria toxintarget
LErafAONRAF proto-oncogene serine/threonine-protein kinasetarget
AGRO100NF-kappa-B essential modulatortarget
Egaptivon pegolvon Willebrand factortarget
Egaptivon pegolPlatelet glycoprotein Ib alpha chaintarget
ISS-1018Toll-like receptor 9target
CPG 10101Toll-like receptor 9target
NF-kappaB DecoyNuclear factor NF-kappa-Btarget
TrabedersenTransforming growth factor beta-2target
EteplirsenDMD-001 gene (exon 51 target site)target
G4460Transcriptional activator Mybtarget
AprinocarsenProtein kinase C alpha typetarget
InotersenTransthyretin mRNAtarget
GolodirsenDystrophintarget
VutrisiranTransthyretin mRNAtarget
VutrisiranSerum albumincarrier