Drug Resistance, Multiple

All categories
Name
Drug Resistance, Multiple
Accession Number
DBCAT001768
Description

Not Available

Drugs
DrugDrug Description
ElacridarFor the treatment of solid tumors.
ZosuquidarInvestigated for use/treatment in leukemia (myeloid) and myelodysplastic syndrome.
TariquidarInvestigated for use/treatment in ovarian cancer, lung cancer, and breast cancer.
ValspodarValspodar has been used in trials studying the treatment of Cancer, Sarcoma, Leukemia, Lymphoma, and Breast Cancer, among others.
LaniquidarLaniquidar has been used in trials studying the treatment of Breast Cancer.
ONT-093ONT-093 is an orally bioavailable inhibitor of P-glycoprotein (P-gp). In pre-clinical studies, ONT-093 could inhibit P-gp and reverse multidrug resistance at nM concentrations with no effect on paclitaxel pharmacokinetics.
Reversin 121Reversin 121 is a hydrophobic peptide chemosensitizer that can reverse P-glycoprotein-mediated multidrug resistance.
Drugs & Drug Targets
DrugTargetType
ElacridarP-glycoprotein 1target
ElacridarATP-binding cassette sub-family G member 2transporter
ElacridarP-glycoprotein 1transporter
ZosuquidarP-glycoprotein 1target
TariquidarP-glycoprotein 1target
TariquidarP-glycoprotein 1transporter
ValspodarSolute carrier organic anion transporter family member 1B1transporter
ValspodarSolute carrier organic anion transporter family member 1B3transporter
ValspodarP-glycoprotein 1transporter
LaniquidarP-glycoprotein 1transporter
ONT-093P-glycoprotein 1target
ONT-093P-glycoprotein 1transporter
Reversin 121P-glycoprotein 1target