Name
SRS-A
Accession Number
DBCAT001900
Description

A group of LEUKOTRIENES; (LTC4; LTD4; and LTE4) that is the major mediator of BRONCHOCONSTRICTION; HYPERSENSITIVITY; and other allergic reactions. Earlier studies described a "slow-reacting substance of ANAPHYLAXIS" released from lung by cobra venom or after anaphylactic shock. The relationship between SRS-A leukotrienes was established by UV which showed the presence of the conjugated triene. (From Merck Index, 11th ed)

Drugs
DrugDrug Description
Leukotriene C4The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates...
Leukotriene D4Leukotriene D4 has been used in trials studying the diagnostic of Asthma and Allergic Rhinitis.
Drugs & Drug Targets
DrugTargetType
Leukotriene C4Solute carrier organic anion transporter family member 1B1transporter
Leukotriene C4Solute carrier organic anion transporter family member 1B3transporter
Leukotriene C4Cysteinyl leukotriene receptor 1target
Leukotriene C4Cysteinyl leukotriene receptor 2target
Leukotriene C4Multidrug resistance-associated protein 1target
Leukotriene D4Cysteinyl leukotriene receptor 1target
Leukotriene D4Cysteinyl leukotriene receptor 2target