Name
Dioxoles
Accession Number
DBCAT001989
Description
Not Available
Drugs
DrugDrug Description
BrecanavirFor the treatment of HIV-1 infection in combination with other antiretroviral agents.
TroxacitabineInvestigated for use/treatment in leukemia (myeloid).
ORG-34517Investigated for use/treatment in depression.
AmdoxovirInvestigated for use/treatment in HIV infection and acquired immune deficiency syndrome (AIDS) and aids-related infections.
ProtokylolProtokylol is a β-adrenergic receptor agonist used as a bronchodilator in Europe and the United States.
StiripentolAn anticonvulsant agent used with clobazam and valproate as an adjunct to treat refractory generalized tonic-clonic seizures in Dravet syndrome.
LumacaftorA protein chaperone used in combination with ivacaftor for the treatment of cystic fibrosis in patients who are homozygous for the F508del mutation in the CFTR gene.
Piperonyl butoxideA pesticide used as a potentiator ingredient in the treatment of pediculosis (head lice, body lice or crabs) to boost efficacy of treatment.
SaracatinibSaracatinib has been investigated for the treatment of Cancer, Osteosarcoma, Ovarian Cancer, Fallopian Tube Cancer, and Primary Peritoneal Cancer.
PrulifloxacinPrulifloxacin has been investigated for the treatment of Urinary Tract Infection.
PiperineBioperine has been used in trials studying the treatment of Multiple Myeloma and Deglutition Disorders.
PU-H71PU-H71 has been used in trials studying the treatment of LYMPHOMA, Solid Tumors, Metastatic Solid Tumor, and Myeloproliferative Neoplasms (MPN).
DomiodolNot Annotated
anle138banle138b restores hippocampal synaptic and transcriptional plasticity as well as spatial memory in a mouse model for Alzheimer's disease, when given orally before or after the onset of pathology.
TrabectedinAn alkylating agent approved for the treatment of unresectable or metastatic soft tissue sarcoma (liposarcoma or leiomyosarcoma).
AtrasentanInvestigated for use/treatment in prostate cancer and cancer/tumors (unspecified).
TezacaftorA medication used to treat homozygous or heterozygous F508del mutation cystic fibrosis.
CasimiroinCasimiroin is a quinone reductase 2 inhibitor isolated from Casimiroa edulis.
Drugs & Drug Targets
DrugTargetType
BrecanavirHuman immunodeficiency virus type 1 proteasetarget
TroxacitabineDNAtarget
TroxacitabineDeoxycytidine kinaseenzyme
ORG-34517Glucocorticoid receptortarget
ProtokylolBeta-2 adrenergic receptortarget
StiripentolCytochrome P450 2C19enzyme
StiripentolCytochrome P450 2D6enzyme
StiripentolCytochrome P450 3A4enzyme
StiripentolCytochrome P450 1A2enzyme
StiripentolCytochrome P450 2C9enzyme
StiripentolGABA(A) Receptortarget
StiripentolL-lactate dehydrogenase A chaintarget
StiripentolL-lactate dehydrogenase B chaintarget
LumacaftorCytochrome P450 2B6enzyme
LumacaftorCytochrome P450 2C8enzyme
LumacaftorCytochrome P450 2C9enzyme
LumacaftorCytochrome P450 2C19enzyme
LumacaftorSerum albumincarrier
LumacaftorCystic fibrosis transmembrane conductance regulatortarget
LumacaftorCytochrome P450 3A4enzyme
LumacaftorP-glycoprotein 1transporter
SaracatinibCytochrome P450 3A4enzyme
PrulifloxacinCytochrome P450 1A2enzyme
PiperineNuclear receptor subfamily 1 group I member 2target
PiperineCytochrome P450 3A4enzyme
PiperineP-glycoprotein 1transporter
TrabectedinCytochrome P450 3A4enzyme
TrabectedinCytochrome P450 2C9enzyme
TrabectedinCytochrome P450 2D6enzyme
TrabectedinCytochrome P450 2E1enzyme
TrabectedinCytochrome P450 2C19enzyme
TrabectedinDNAtarget
TrabectedinProstaglandin G/H synthase 1enzyme
AtrasentanEndothelin-1 receptortarget
TezacaftorCytochrome P450 3A4enzyme
TezacaftorCytochrome P450 3A5enzyme
TezacaftorCystic fibrosis transmembrane conductance regulatortarget
TezacaftorP-glycoprotein 1transporter
TezacaftorATP-binding cassette sub-family G member 2transporter
CasimiroinRibosyldihydronicotinamide dehydrogenase [quinone]target