Diagnostic Agents

DrugDrug NameDrug Indication
DB09067Corticorelin ovine triflutateCorticorelin is indicated for use in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushing's syndrome.
DB00183PentagastrinUsed as a diagnostic aid for evaluation of gastric acid secretory function
DB00272BetazoleFor use clinically to test gastric secretory function.
DB00345Aminohippuric acidUsed to measure effective renal plasma flow (ERPF) and to determine the functional capacity of the tubular excretory mechanism.
DB00403CeruletideCaerulein is used in the treatment of paralytic ileus and as diagnostic aid in pancreatic malfunction.
DB00522BentiromideIndicated as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy.
DB00638InulinHistorically used in an important medical test of renal function, specifically a measure of glomerular filtration rate. Sometimes used to help relieve symptoms of diabetes mellitus - a condition characterised by hyperglycemia and/or hyperinsulinemia.
DB00693FluoresceinFor diagnostic imaging. Primarily indicated in diagnostic fluorescein angiography or angioscopy of the fundus and of the iris vasculature.
DB01011MetyraponeUsed as a diagnostic drug for testing hypothalamic-pituitary ACTH function. Occasionally used in Cushing's syndrome.
DB01124TolbutamideFor treatment of NIDDM (non-insulin-dependent diabetes mellitus) in conjunction with diet and exercise.
DB05381HistamineHistamine phosphate is indicated as a diagnostic aid for evaluation of gastric acid secretory function.
DB05394CorticorelinInvestigated for use/treatment in brain cancer and neurologic disorders.
DB08862CholecystokininFor use as a diagnostic aid for evaluation of gallbladder disorders. It is also used in conjunction with secretin in pancreatic insufficiency [L1634].
DB09142SincalideAs the product Kinevac (FDA), sincalide is used for the following indications: 1) to stimulate gallbladder contraction, as may be assessed by various methods of diagnostic imaging, or to obtain by duodenal aspiration a sample of concentrated bile for analysis of cholesterol, bile salts, phospholipids, and crystals; (2) to stimulate pancreatic secretion (especially in conjunction with secretin) prior to obtaining a duodenal aspirate for analysis of enzyme activity, composition, and cytology; (3) to accelerate the transit of a barium meal through the small bowel, thereby decreasing the time and extent of radiation associated with fluoroscopy and x-ray examination of the intestinal tract.
DB09241Methylene blueIndicated for the treatment of pediatric and adult patients with acquired methemoglobinemia. Other clinical applications of methylene blue include improvement of hypotension associated with various clinical states, an antiseptic in urinary tract infections, treatment of hypoxia and hyperdynamic circulation in cirrhosis of liver and severe hepatopulmonary syndrome, and treatment of ifofosamide induced neurotoxicity.
DB09421ProtirelinNot Available
DB11182Rose bengal free acidIndicated as a diagnostic agent in routine ocular examinations or when superficial conjunctiva or corneal tissue change is suspected, and as an aid in the diagnosis of keratoconjunctivitis sicca, keratitis, abrasions or corrosions as well as the detection of foreign bodies.
DB11577Indigotindisulfonic AcidThis drug was initially used as a kidney function test. The main application of indigo carmine at this time is localizing and visualizing ureteral orifices during cystoscopy and ureteral catheterization procedures [L2215].
DB12656SomatorelinNot Available
DB13074MacimorelinIndicated for the diagnosis of adult growth hormone deficiency (AGHD) [FDA Label].
DB13212PhenolsulfonphthaleinNot Available
DB13215SulfobromophthaleinNot Available
DB13298AlsactideNot Available
DB00010SermorelinFor the treatment of dwarfism, prevention of HIV-induced weight loss
DB00162Vitamin AFor the treatment of vitamin A deficiency.
DB00201CaffeineFor management of fatigue, orthostatic hypotension, and for the short term treatment of apnea of prematurity in infants.
DB00644GonadorelinFor evaluating the functional capacity and response of the gonadotropes of the anterior pituitary also for evaluating residual gonadotropic function of the pituitary following removal of a pituitary tumor by surgery and/or irradiation.
DB00653Magnesium sulfateUsed for immediate control of life-threatening convulsions in the treatment of severe toxemias (pre-eclampsia and eclampsia) of pregnancy and in the treatment of acute nephritis in children. Also indicated for replacement therapy in magnesium deficiency, especially in acute hypomagnesemia accompanied by signs of tetany similar to those of hypocalcemia. Also used in uterine tetany as a myometriat relaxant.
DB01638SorbitolUsed as a non-stimulant laxative via an oral suspension or enema.
DB03793Benzoic AcidNot Available
DB11735GalactoseThere are limited therapeutic uses for which galactose is formally indicated. Some predominant indications include (a) the use of galactose to facilitate the construction of structurally and immunologically effective attenuated vaccines [T188, L2633], and (b) the role galactose plays as an essential element in the formation of lactulose - a synthetic disaccharide indicated for the treatment of constipation and/or hepatic encephalopathy (HE); hepatic coma [L2632]. Nevertheless, there are many studies looking into a variety of possible uses for galactose, including the use of the monosaccharide sugar for accelerating senescence in mice, rats, and Drosophila [A32853, A32854], the proposed association between galactose in consumed milk and ovarian cancer [A32855, A32856], a possible role in the therapy of focal segmental glomerulosclerosis [A32858], among various others. Regardless, none of these proposed indications have yet been formally elucidated for practical use.
DB09532Secretin humanIndicated for the stimulation of: - pancreatic secretions, including bicarbonate, to aid in the diagnosis of pancreatic exocrine dysfunction [FDA Label]. - gastrin secretion to aid in the diagnosis of gastrinoma [FDA Label]. - pancreatic secretions to facilitate the identification of the ampulla of Vater and accessory papilla during endoscopic retrograde cholangiopancreatography (ERCP) [FDA Label].
DB15263ThyrotropinNot Available
DrugDrug NameTargetType
DB09067Corticorelin ovine triflutateCorticotropin-releasing factor receptor 1target
DB00183PentagastrinGastrin/cholecystokinin type B receptortarget
DB00183PentagastrinCholinesteraseenzyme
DB00272BetazoleHistamine H2 receptortarget
DB00345Aminohippuric acidSolute carrier family 22 member 2transporter
DB00345Aminohippuric acidSolute carrier family 22 member 5transporter
DB00345Aminohippuric acidSolute carrier family 22 member 6transporter
DB00345Aminohippuric acidSolute carrier family 22 member 8transporter
DB00345Aminohippuric acidCanalicular multispecific organic anion transporter 1transporter
DB00345Aminohippuric acidSolute carrier family 22 member 4transporter
DB00345Aminohippuric acidSolute carrier family 22 member 11transporter
DB00345Aminohippuric acidSolute carrier organic anion transporter family member 3A1transporter
DB00345Aminohippuric acidSolute carrier organic anion transporter family member 1B1transporter
DB00345Aminohippuric acidMultidrug resistance-associated protein 1transporter
DB00345Aminohippuric acidSolute carrier organic anion transporter family member 1A2transporter
DB00345Aminohippuric acidMonocarboxylate transporter 1transporter
DB00345Aminohippuric acidSolute carrier family 22 member 7transporter
DB00403CeruletideCholecystokinin receptor type Atarget
DB00522BentiromideSerine protease hepsintarget
DB00638InulinCycloinulo-oligosaccharide fructanotransferasetarget
DB00693FluoresceinIg kappa chain V-II region RPMI 6410target
DB00693FluoresceinDNAtarget
DB00693FluoresceinSolute carrier family 22 member 6transporter
DB00693FluoresceinBile salt export pumptransporter
DB00693FluoresceinMultidrug resistance-associated protein 1transporter
DB00693FluoresceinCytochrome P450 1A1enzyme
DB01011MetyraponeCamphor 5-monooxygenasetarget
DB01011MetyraponeCytochrome P450 11B2, mitochondrialenzyme
DB01011MetyraponeCytochrome P450 2A6enzyme
DB01011MetyraponeCytochrome P450 3A4enzyme
DB01011MetyraponeCanalicular multispecific organic anion transporter 2transporter
DB01011MetyraponeCytochrome P450 11B1, mitochondrialtarget
DB01011MetyraponeCytochrome P450 11B1, mitochondrialenzyme
DB01011MetyraponeCytochrome P450 2E1enzyme
DB01124TolbutamideATP-sensitive inward rectifier potassium channel 1target
DB01124TolbutamideCytochrome P450 2C19enzyme
DB01124TolbutamideCytochrome P450 2C9enzyme
DB01124TolbutamideCytochrome P450 2C8enzyme
DB01124TolbutamideATP-binding cassette sub-family C member 8target
DB01124TolbutamideSolute carrier family 15 member 1transporter
DB01124TolbutamideSolute carrier organic anion transporter family member 1A2transporter
DB01124TolbutamideSolute carrier family 15 member 2transporter
DB01124TolbutamideSolute carrier family 22 member 6transporter
DB01124TolbutamideSolute carrier organic anion transporter family member 2B1transporter
DB01124TolbutamideCytochrome P450 2C18enzyme
DB01124TolbutamideSerum albumincarrier
DB05381HistamineHistamine H1 receptortarget
DB05381HistamineHistamine H2 receptortarget
DB05381HistamineHistamine H3 receptortarget
DB05381HistamineHistamine N-methyltransferaseenzyme
DB05381HistamineSolute carrier family 22 member 2transporter
DB05381HistamineSolute carrier family 22 member 1transporter
DB05381HistamineSolute carrier family 22 member 3transporter
DB05381HistamineSolute carrier family 22 member 5transporter
DB05381HistamineHistamine H4 receptortarget
DB05381HistamineCytochrome P450 2C9enzyme
DB05381HistamineCytochrome P450 3A4enzyme
DB05381HistamineSynaptic vesicular amine transportertarget
DB05394CorticorelinDopamine beta-hydroxylaseenzyme
DB08862CholecystokininSolute carrier organic anion transporter family member 1B3transporter
DB08862CholecystokininCholecystokinin receptor type Atarget
DB08862CholecystokininRAF proto-oncogene serine/threonine-protein kinasetarget
DB08862CholecystokininMitogen-activated protein kinase 3target
DB08862CholecystokininPro-epidermal growth factortarget
DB08862CholecystokininProtein kinase C beta typetarget
DB08862CholecystokininGastrin/cholecystokinin type B receptortarget
DB08862CholecystokininSolute carrier organic anion transporter family member 1B1transporter
DB08862CholecystokininSolute carrier organic anion transporter family member 2B1transporter
DB09142SincalideSolute carrier organic anion transporter family member 1B3transporter
DB09241Methylene blueGuanylate cyclase soluble subunit alpha-2target
DB09241Methylene blueNitric oxide synthase, braintarget
DB09421ProtirelinThyrotropin Releasing Hormone Receptortarget
DB11182Rose bengal free acidSerum albumincarrier
DB11182Rose bengal free acidLactotransferrincarrier
DB11182Rose bengal free acidSerotransferrincarrier
DB11182Rose bengal free acidLysozyme Cenzyme
DB11577Indigotindisulfonic AcidAryl hydrocarbon receptortarget
DB11577Indigotindisulfonic AcidAlpha adrenergic receptortarget
DB13074MacimorelinGrowth hormone secretagogue receptor type 1target
DB13074MacimorelinCytochrome P450 3A4enzyme
DB00010SermorelinGrowth hormone-releasing hormone receptortarget
DB00162Vitamin ARetinol dehydrogenase 12target
DB00162Vitamin ARetinol-binding protein 1target
DB00162Vitamin A11-cis retinol dehydrogenasetarget
DB00162Vitamin ARetinol dehydrogenase 13target
DB00162Vitamin ARetinol-binding protein 3target
DB00162Vitamin ARetinol-binding protein 5carrier
DB00162Vitamin ARetinoid-binding protein 7carrier
DB00162Vitamin ARetinol-binding protein 4carrier
DB00162Vitamin ARetinol-binding protein 2carrier
DB00162Vitamin ARetinal dehydrogenase 2target
DB00162Vitamin ARetinal dehydrogenase 1target
DB00162Vitamin ARetinaldehyde-binding protein 1target
DB00162Vitamin ALecithin retinol acyltransferasetarget
DB00162Vitamin AShort-chain dehydrogenase/reductase 3target
DB00162Vitamin AAldehyde dehydrogenase family 1 member A3target
DB00162Vitamin AAll-trans-retinol 13,14-reductasetarget
DB00162Vitamin ARetinol dehydrogenase 11target
DB00162Vitamin ADehydrogenase/reductase SDR family member 4target
DB00162Vitamin ARetinol dehydrogenase 14target
DB00162Vitamin ARetinol dehydrogenase 8target
DB00162Vitamin ACytochrome P450 1A1enzyme
DB00162Vitamin ACytochrome P450 26A1enzyme
DB00162Vitamin AApolipoprotein Dtarget
DB00162Vitamin AHematopoietic prostaglandin D synthasetarget
DB00162Vitamin ASerum albumincarrier
DB00201CaffeineAdenosine receptor A1target
DB00201CaffeinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB00201CaffeineAdenosine receptor A2atarget
DB00201CaffeineCytochrome P450 1A2enzyme
DB00201CaffeineRyanodine receptor 1target
DB00201CaffeineCytochrome P450 3A4enzyme
DB00201CaffeineCytochrome P450 3A5enzyme
DB00201CaffeineCytochrome P450 3A7enzyme
DB00201CaffeineMultidrug resistance protein 1transporter
DB00201CaffeineCytochrome P450 2E1enzyme
DB00201CaffeineCytochrome P450 2C8enzyme
DB00201CaffeineCytochrome P450 2C9enzyme
DB00201CaffeineCytochrome P450 1A1enzyme
DB00201CaffeineCytochrome P450 1B1enzyme
DB00201CaffeineCytochrome P450 2D6enzyme
DB00201CaffeineCyclic nucleotide phosphodiesterasetarget
DB00201CaffeineDNA-dependent protein kinase catalytic subunittarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformtarget
DB00201CaffeinePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformtarget
DB00201CaffeineInositol 1,4,5-trisphosphate receptortarget
DB00201CaffeineSerine-protein kinase ATMtarget
DB00644GonadorelinGonadotropin-releasing hormone receptortarget
DB00644GonadorelinPutative gonadotropin-releasing hormone II receptortarget
DB00653Magnesium sulfateVoltage-dependent calcium channel gamma-1 subunittarget
DB00653Magnesium sulfateVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit beta-1target
DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit beta-2target
DB00653Magnesium sulfateVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB01638SorbitolXylose isomerasetarget
DB01638SorbitolXylose isomerasetarget
DB01638SorbitolXylose isomerasetarget
DB01638SorbitolMalate synthase Gtarget
DB03793Benzoic AcidPeroxiredoxin-5, mitochondrialtarget
DB03793Benzoic AcidHeat-labile enterotoxin B chaintarget
DB03793Benzoic AcidCocaine esterasetarget
DB03793Benzoic AcidHTH-type transcriptional regulator MalTtarget
DB03793Benzoic AcidTautomerase PptAtarget
DB03793Benzoic AcidD-amino-acid oxidasetarget
DB03793Benzoic AcidRibonuclease UK114target
DB03793Benzoic AcidChlorocatechol 1,2-dioxygenasetarget
DB03793Benzoic AcidRas-related protein Rab-9Atarget
DB03793Benzoic AcidHydrogen peroxide-inducible genes activatortarget
DB03793Benzoic Acid2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolasetarget
DB03793Benzoic AcidNon-heme chloroperoxidasetarget
DB03793Benzoic AcidOxygen-insensitive NAD(P)H nitroreductasetarget
DB03793Benzoic AcidHydroxyquinol 1,2-dioxygenasetarget
DB03793Benzoic AcidReplication proteintarget
DB03793Benzoic AcidSolute carrier organic anion transporter family member 2B1transporter
DB03793Benzoic AcidSolute carrier family 22 member 8transporter
DB03793Benzoic AcidMonocarboxylate transporter 1transporter
DB03793Benzoic AcidSolute carrier family 15 member 1target
DB09532Secretin humanSecretin receptortarget