Diagnostic Radiopharmaceuticals

DrugDrug NameDrug Indication
DB09339Indium In-111 imciromab pentetateNot Available
DB00057Indium In-111 satumomab pendetideFor diagnosis of extrahepatic malignant cancers
DB00089Capromab pendetideFor diagnosis of prostate cancer and detection of intra-pelvic metastases.
DB00113Technetium Tc-99m arcitumomabFor imaging colorectal tumors
DB08824Ioflupane I-123Ioflupane I-123 is a SPECT (single photon emission computerized tomography) agent used to distinguish between Parkinson’s syndrome tremors and essential tremor.
DB09137Technetium Tc-99m mebrofeninTechnetium Tc 99m Mebrofenin is indicated as a hepatobiliary imaging agent.
DB09138Technetium Tc-99m medronateTechnetium Tc 99m Medronate is indicated for use as a bone imaging agent to delineate areas of altered osteogenesis.
DB09139Technetium Tc-99m oxidronateTechnetium Tc-99m oxidronate is indicated in adult and pediatric patients to be used in skeletal imaging for diagnosis of areas that can present altered osteogenesis. When administered intravenously, it is able to generate a clear image of the bones which allows the physician to diagnose any bone problem.[L1141] It is important to point out that this drug has to be manipulated only under the service of a nuclear specialist.[L1140] The approved indications for a bone scan are 1) visualization of tumor metastasis in bone, 2) osteomyelitis, 3) fracture, 4) stress fracture, 5) avascular necrosis, 6) osteoporosis and 7) prosthetic joint evaluation. From all the major indications, the detection of a metastatic disease is the most common because it presents a 95% of sensitivity and lesion detection can be done 6 months earlier than with X-ray studies.[L1139]
DB09148Florbetaben (18F)Florbetaben is a radioactive diagnostic agent indicated for Positron Emission Tomography (PET) imaging of the brain to estimate β-amyloid neuritic plaque density in adult patients with cognitive impairment who are being evaluated for Alzheimer’s Disease (AD) and other causes of cognitive decline.
DB09149Florbetapir (18F)Florbetapir 18F is indicated for Positron Emission Tomography (PET) imaging of the brain to estimate β-amyloid neuritic plaque density in adult patients with cognitive impairment who are being evaluated for Alzheimer's Disease (AD) and other causes of cognitive decline.
DB09151Flutemetamol (18F)Flutemetamol F18 is indicated for Positron Emission Tomography (PET) imaging of the brain to estimate β amyloid neuritic plaque density in adult patients with cognitive impairment who are being evaluated for Alzheimer's disease (AD) or other causes of cognitive decline.
DB09160Technetium Tc-99m tetrofosminTechnetium-99m tetrofosmin is indicated for the diagnosis of heart abnormalities by exercise myocardial scintigraphy. The exercise myocardial scintigraphy is an established method for the diagnosis of the severity of coronary artery disease.[A31592] This method allows distinguishing regions of reversible myocardial ischemia in the presence or absence of infarcted myocardium following rest and stress conditions.[L1147] The use of technetium-99m tetrofosmin is mainly used to assess myocardial perfusion in ischemia and infarction.[L1146]
DB09161Technetium Tc-99m sestamibiTechnetium Tc 99m Sestamibi is indicated for: 1) detecting coronary artery disease by localizing myocardial ischemia (reversible defects) and infarction (non-reversible defects); and 2) evaluating myocardial function and developing information for use in patient management decisions.
DB09163Technetium Tc-99m exametazimeTechnetium Tc99m exametazime scintigraphy (with or without methylene blue stabilization) may be useful as an adjunct in the detection of altered regional cerebral perfusion in stroke. Tc99m exametazime without methylene blue stabilization is indicated for leukocyte labeled scintigraphy as an adjunct in the localization of intra-abdominal infection and inflammatory bowel disease.
DB09164Technetium Tc-99m disofeninTechnetium Tc99m Disofenin is indicated as a hepatobiliary imaging agent. Hepatolite is indicated in the diagnosis of acute cholecystitis as well as to rule out the occurrence of acute cholecystitis in suspected patients with right upper quadrant pain, fever, jaundice, right upper quadrant tenderness and mass or rebound tenderness, but not limited to these signs and symptoms.
DB09165Technetium Tc-99m pyrophosphateFor use as a skeletal imaging agent used to demonstrate areas of altered osteogenesis, and a cardiac imaging agent used as an adjunct in the diagnosis of acute myocardial infarction [FDA Label]. May also be used to image gated blood pools and detect gastrointetinal bleeding.
DB09266Technetium Tc-99m tilmanoceptIndicated with or without scintigraphic imaging for lymphatic mapping using a handheld gamma counter to locate lymph nodes draining a primary tumor site in patients with solid tumors for which this procedure is a component of intraoperative management [FDA Label]. Indicated with or without scintigraphic imaging for guiding sentinel lymph node biopsy using a handheld gamma counter in patients with clinically node negative squamous cell carcinoma of the oral cavity, breast cancer or melanoma [FDA Label].
DB09293Iodide I-131Therapeutic solutions of Sodium Iodide-131 are indicated for the treatment of hyperthyroidism and thyroid carcinomas that take up iodine. Palliative effects may be observed in patients with advanced thyroid malignancy if the metastatic lesions take up iodine. It is also indicated for use in performance of the radioactive iodide (RAI) uptake test to evaluate thyroid function.
DB09314Technetium Tc-99m pertechnetateSodium Pertechnetate Tc99m Injection is indicated for use in adults for imaging in the following tissues: thyroid, salivary gland, urinary bladder (for detection of vesico-ureteral reflux), and nasolacrimal drainage system (dacryoscintigraphy). It is indicated for use in children for imaging the following tissues: thyroid and urinary bladder.
DB09315Xenon-133Inhalation of Xenon Xe 133 Gas has proved valuable for the evaluation of pulmonary function and for imaging the lungs. It may also be applied to assessment of cerebral flow.
DB09397Technetium Tc-99m sulfur colloidTechnetium 99m sulfur colloid is indicated as a diagnostic agent in adults for the following tests: localization of lymph nodes draining a primary tumor in patients with breast cancer or malignant melanoma; and evaluation of peritoneo-venous (LeVeen) shunt patency. It is indicated in both adult and pediatric patients for: imaging areas of functioning reticuloendothelial cells in the liver, spleen and bone marrow; and studies of esophageal transit and gastroesophageal reflux, and detection of pulmonary aspiration of gastric contents.
DB09398Fluoride ion F-1818F is used as a bone imaging agent to define areas of altered osteogenic activity. It has been indicated for back pain and otherwise unexplained bone pain, child abuse, abnormal radiographic or laboratory findings, osteomyelitis, trauma, inflammatory and degenerative arthritis, avascular necrosis. Osteonecrosis of the mandible, condylar hyperplasia, and metabolic bone disease are also among the indications for fluoride imaging.
DB09420Iodide I-123Administration of Sodium Iodide I 123 Capsules is indicated as a diagnostic procedure to be used in evaluating thyroid function and/or morphology.
DB09425Indium In-111 pentetatePentetate Indium Disodium In 111 is recommended for use in radionuclide cisternography.
DB09443Krypton Kr 81mNot Available
DB09480Iofetamine I-123Not Available
DB09502Fludeoxyglucose F-18The uptake of 18F-FDG by tissues is a marker for the tissue uptake of glucose, which in turn is closely correlated with certain types of tissue metabolism. Fludeoxyglucose F 18 Injection is indicated in positron emission tomography (PET) imaging for assessment of abnormal glucose metabolism to assist in the evaluation of malignancy in patients with known or suspected abnormalities found by other testing modalities, or in patients with an existing diagnoses of cancer.
DB13183Technetium Tc-99m etifeninNot Available
DB13487Iodine (131I) norcholesterolNot Available
DB13582Ferric (59Fe) citrateNot Available
DB13622Selenium (75Se) norcholesterolNot Available
DB13797Iodocholesterol (131I)Not Available
DB13848Fluorodopa (18F)Not Available
DB13976SulesomabNot Available
DB06704IobenguaneDetection of primary and metastatic pheochromocytoma or neuroblastoma
DB11835Indium In-111 pentetreotideNot Available
DB13146Fluciclovine (18F)Fluciclovine is indicated as a detection agent for positron emission tomography (PET) in men with suspected prostate cancer recurrence based on elevated blood prostate specific antigen (PSA) levels following prior treatment.[A31388] The overexpression of L-type amino acid transporters such as LAT1 and LAT3 that mediate the uptake of essential amino acids has been extensively reported as a tumoral mechanism of cell growth.[A31389]
DrugDrug NameTargetType
DB00057Indium In-111 satumomab pendetideTumor-associated glycoprotein 72 (TAG-72)target
DB00089Capromab pendetideGlutamate carboxypeptidase 2target
DB00113Technetium Tc-99m arcitumomabCarcinoembryonic antigen-related cell adhesion molecule 1target
DB08824Ioflupane I-123Sodium-dependent dopamine transportertransporter
DB09137Technetium Tc-99m mebrofeninSolute carrier organic anion transporter family member 1B1transporter
DB09137Technetium Tc-99m mebrofeninSolute carrier organic anion transporter family member 1B3transporter
DB09139Technetium Tc-99m oxidronateSerum albumincarrier
DB09148Florbetaben (18F)Cytochrome P450 2J2enzyme
DB09148Florbetaben (18F)Leukotriene-B(4) omega-hydroxylase 1enzyme
DB09148Florbetaben (18F)Amyloid beta A4 proteintarget
DB09149Florbetapir (18F)Amyloid beta A4 proteintarget
DB09151Flutemetamol (18F)Amyloid beta A4 proteintarget
DB09160Technetium Tc-99m tetrofosminMultidrug resistance protein 1carrier
DB09161Technetium Tc-99m sestamibiMultidrug resistance protein 1transporter
DB09161Technetium Tc-99m sestamibiMultidrug resistance-associated protein 1transporter
DB09165Technetium Tc-99m pyrophosphateHydroxyapatitetarget
DB09165Technetium Tc-99m pyrophosphateAmorphous calcium phosphatetarget
DB09266Technetium Tc-99m tilmanoceptMacrophage mannose receptor 1target
DB09502Fludeoxyglucose F-18Hexokinase-1enzyme
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 4transporter
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 2transporter
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 1transporter
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 3transporter
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 9transporter
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 5transporter
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 6transporter
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 7transporter
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 8transporter
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 10transporter
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 11transporter
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 12transporter
DB06704IobenguaneSodium-dependent noradrenaline transportertransporter
DB13146Fluciclovine (18F)Neutral amino acid transporter B(0)target
DB13146Fluciclovine (18F)Y+L amino acid transporter 1target
DB13146Fluciclovine (18F)Cationic amino acid transporter 3target
DB13146Fluciclovine (18F)Glutamate (NMDA) receptortarget
DB13146Fluciclovine (18F)Glutamate receptor 1target
DB13146Fluciclovine (18F)Glutamate receptor 2target
DB13146Fluciclovine (18F)Glutamate receptor 3target
DB13146Fluciclovine (18F)Glutamate receptor 4target
DB13146Fluciclovine (18F)Multidrug resistance protein 1transporter
DB13146Fluciclovine (18F)Multidrug resistance-associated protein 4transporter