Iron Preparations

DrugDrug NameDrug Indication
DB01592IronUsed in preventing and treating iron-deficiency anemia.
DB13220Ferrous aspartateNot Available
DB13381Sodium feredetateNot Available
DB13423Ferric hydroxideNot Available
DB13569Ferrous chlorideNot Available
DB13639Ferrous tartrateNot Available
DB13698Ferrous carbonateNot Available
DB13771Ferric sodium citrateNot Available
DB09517Sodium ferric gluconate complexUsed to replete the total body content of iron during iron deficiency anemia in patients age 6 years and older with chronic kidney disease receiving hemodialysis and receiving supplemental epoetin therapy.
DB00115Cyanocobalamin **Nasal spray** The cyanocobalamin nasal spray is indicated for the maintenance of vitamin B12 concentrations after normalization with intramuscular vitamin B12 therapy in patients with deficiency of this vitamin who have no nervous system involvement [FDA label]. Note: CaloMist [FDA label], the nasal spray form, has not been evaluated for the treatment of newly diagnosed vitamin B12 deficiency. **Injection forms (subcutaneous, intramuscular)** These forms are indicated for vitamin B12 deficiencies due to various causes, with or without neurologic manifestations [F3736]. Vitamin B12 deficiency is frequently caused by malabsorption, which is often associated with the following conditions [L5545]: Addisonian (pernicious) anemia Gastrointestinal pathology, dysfunction, or surgery, including gluten enteropathy or sprue, small bowel bacterial overgrowth, total or partial gastrectomy Fish tapeworm infestation Malignancy of the pancreas or bowel Folic acid deficiency **Oral forms** Vitamin B12 supplements are widely available and indicated in patients who require supplementation for various reasons. Dose requirements for vitamin B12 which are higher than normal (caused by pregnancy, thyrotoxicosis, hemolytic anemia, hemorrhage, malignancy, hepatic and renal disease) can usually be achieved with oral supplementation [L5545]. Oral products of vitamin B12 are not recommended in patients with malabsorption, as these forms are primarily absorbed in the gastrointestinal tract [F3739].
DB09146Iron saccharateIron sucrose is elemental iron as an injection. It replenishes body iron stores in patients with iron deficiency.
DB14488Ferrous gluconateUsed in preventing and treating iron-deficiency anemia.
DB14489Ferrous succinateUsed in preventing and treating iron-deficiency anemia.
DB14490Ferrous ascorbateUsed in preventing and treating iron-deficiency anemia.
DB14491Ferrous fumarateUsed in preventing and treating iron-deficiency anemia.
DB14501Ferrous glycine sulfateUsed in preventing and treating iron-deficiency anemia.
DB13257Ferrous sulfate anhydrousFor the prevention and treatment of iron deficiency anemia [L2252].
DrugDrug NameTargetType
DB01592IronTransferrin receptor protein 1target
DB01592IronEgl nine homolog 1target
DB01592IronHistone deacetylase 8target
DB01592IronAlpha-hemoglobin-stabilizing proteintarget
DB01592IronHemoglobin subunit alphatarget
DB01592IronFrataxin, mitochondrialtarget
DB01592IronFerritin heavy chaintarget
DB01592IronFlap endonuclease 1target
DB01592IronEndonuclease 8-like 1target
DB01592IronEndonuclease 8-like 2target
DB01592IronDNA polymerase betatarget
DB01592IronCeruloplasmintarget
DB01592IronSerotransferrintarget
DB09517Sodium ferric gluconate complexFerritin light chaintarget
DB09517Sodium ferric gluconate complexHemoglobin subunit alphatarget
DB09517Sodium ferric gluconate complexHemoglobin subunit betatarget
DB00115CyanocobalaminMethionine synthase reductasetarget
DB00115CyanocobalaminMethylmalonic aciduria type A protein, mitochondrialtarget
DB00115CyanocobalaminMethylmalonyl-CoA mutase, mitochondrialtarget
DB00115CyanocobalaminMethylmalonic aciduria and homocystinuria type C proteintarget
DB00115CyanocobalaminMethionine synthasetarget
DB00115CyanocobalaminMethylenetetrahydrofolate reductasetarget
DB00115CyanocobalaminProtein amnionlesstransporter
DB00115CyanocobalaminTranscobalamin-1transporter
DB00115CyanocobalaminTranscobalamin-2transporter
DB00115CyanocobalaminCob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrialenzyme
DB00115CyanocobalaminGastric intrinsic factortransporter
DB00115CyanocobalaminCubilintransporter
DB00115CyanocobalaminBifunctional adenosylcobalamin biosynthesis protein CobUenzyme
DB00115CyanocobalaminLow-density lipoprotein receptor-related protein 2transporter
DB00115CyanocobalaminMultidrug resistance-associated protein 1transporter
DB00115CyanocobalaminPancreatic proteasesenzyme
DB09146Iron saccharateHemoglobin subunit alphatarget
DB09146Iron saccharateSerotransferrincarrier
DB14488Ferrous gluconateTransferrin receptor protein 1target
DB14488Ferrous gluconateEgl nine homolog 1target
DB14488Ferrous gluconateHistone deacetylase 8target
DB14488Ferrous gluconateAlpha-hemoglobin-stabilizing proteintarget
DB14488Ferrous gluconateHemoglobin subunit alphatarget
DB14488Ferrous gluconateFrataxin, mitochondrialtarget
DB14488Ferrous gluconateFerritin heavy chaintarget
DB14488Ferrous gluconateFlap endonuclease 1target
DB14488Ferrous gluconateEndonuclease 8-like 1target
DB14488Ferrous gluconateEndonuclease 8-like 2target
DB14488Ferrous gluconateDNA polymerase betatarget
DB14488Ferrous gluconateCeruloplasmintarget
DB14488Ferrous gluconateSerotransferrintarget
DB14489Ferrous succinateTransferrin receptor protein 1target
DB14489Ferrous succinateEgl nine homolog 1target
DB14489Ferrous succinateHistone deacetylase 8target
DB14489Ferrous succinateAlpha-hemoglobin-stabilizing proteintarget
DB14489Ferrous succinateHemoglobin subunit alphatarget
DB14489Ferrous succinateFrataxin, mitochondrialtarget
DB14489Ferrous succinateFerritin heavy chaintarget
DB14489Ferrous succinateFlap endonuclease 1target
DB14489Ferrous succinateEndonuclease 8-like 1target
DB14489Ferrous succinateEndonuclease 8-like 2target
DB14489Ferrous succinateDNA polymerase betatarget
DB14489Ferrous succinateCeruloplasmintarget
DB14489Ferrous succinateSerotransferrintarget
DB14490Ferrous ascorbateTransferrin receptor protein 1target
DB14490Ferrous ascorbateEgl nine homolog 1target
DB14490Ferrous ascorbateHistone deacetylase 8target
DB14490Ferrous ascorbateAlpha-hemoglobin-stabilizing proteintarget
DB14490Ferrous ascorbateHemoglobin subunit alphatarget
DB14490Ferrous ascorbateFrataxin, mitochondrialtarget
DB14490Ferrous ascorbateFerritin heavy chaintarget
DB14490Ferrous ascorbateFlap endonuclease 1target
DB14490Ferrous ascorbateEndonuclease 8-like 1target
DB14490Ferrous ascorbateEndonuclease 8-like 2target
DB14490Ferrous ascorbateDNA polymerase betatarget
DB14490Ferrous ascorbateCeruloplasmintarget
DB14490Ferrous ascorbateSerotransferrintarget
DB14491Ferrous fumarateTransferrin receptor protein 1target
DB14491Ferrous fumarateEgl nine homolog 1target
DB14491Ferrous fumarateHistone deacetylase 8target
DB14491Ferrous fumarateAlpha-hemoglobin-stabilizing proteintarget
DB14491Ferrous fumarateHemoglobin subunit alphatarget
DB14491Ferrous fumarateFrataxin, mitochondrialtarget
DB14491Ferrous fumarateFerritin heavy chaintarget
DB14491Ferrous fumarateFlap endonuclease 1target
DB14491Ferrous fumarateEndonuclease 8-like 1target
DB14491Ferrous fumarateEndonuclease 8-like 2target
DB14491Ferrous fumarateDNA polymerase betatarget
DB14491Ferrous fumarateCeruloplasmintarget
DB14491Ferrous fumarateSerotransferrintarget
DB14501Ferrous glycine sulfateTransferrin receptor protein 1target
DB14501Ferrous glycine sulfateEgl nine homolog 1target
DB14501Ferrous glycine sulfateHistone deacetylase 8target
DB14501Ferrous glycine sulfateAlpha-hemoglobin-stabilizing proteintarget
DB14501Ferrous glycine sulfateHemoglobin subunit alphatarget
DB14501Ferrous glycine sulfateFrataxin, mitochondrialtarget
DB14501Ferrous glycine sulfateFerritin heavy chaintarget
DB14501Ferrous glycine sulfateFlap endonuclease 1target
DB14501Ferrous glycine sulfateEndonuclease 8-like 1target
DB14501Ferrous glycine sulfateEndonuclease 8-like 2target
DB14501Ferrous glycine sulfateDNA polymerase betatarget
DB14501Ferrous glycine sulfateCeruloplasmintarget
DB14501Ferrous glycine sulfateSerotransferrintarget
DB13257Ferrous sulfate anhydrousSerotransferrintransporter
DB13257Ferrous sulfate anhydrousFerritin light chaintransporter
DB13257Ferrous sulfate anhydrousFerritin heavy chaintransporter
DB13257Ferrous sulfate anhydrousDivalent metal ion transporter 1transporter
DB13257Ferrous sulfate anhydrousIron binding protein FbpAtransporter
DB13257Ferrous sulfate anhydrousNADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrialenzyme
DB13257Ferrous sulfate anhydrousSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialenzyme
DB13257Ferrous sulfate anhydrousXanthine dehydrogenase/oxidaseenzyme
DB13257Ferrous sulfate anhydrousAconitate hydratase, mitochondrialenzyme
DB13257Ferrous sulfate anhydrousCytochrome P450 4A11enzyme
DB13257Ferrous sulfate anhydrousSulfite oxidase, mitochondrialenzyme
DB13257Ferrous sulfate anhydrousMyeloperoxidaseenzyme
DB13257Ferrous sulfate anhydrousCatalaseenzyme
DB13257Ferrous sulfate anhydrousNitric oxide synthase, inducibleenzyme
DB13257Ferrous sulfate anhydrousProstaglandin G/H synthase 1enzyme
DB13257Ferrous sulfate anhydrousProstaglandin G/H synthase 2enzyme
DB13257Ferrous sulfate anhydrousTryptophan 5-hydroxylase 1enzyme
DB13257Ferrous sulfate anhydrousProlyl 4-hydroxylase subunit alpha-1enzyme
DB13257Ferrous sulfate anhydrousRibonucleoside-diphosphate reductase large subunitenzyme
DB13257Ferrous sulfate anhydrousPterin-4-alpha-carbinolamine dehydrataseenzyme
DB13257Ferrous sulfate anhydrousTrimethyllysine dioxygenase, mitochondrialenzyme
DB13257Ferrous sulfate anhydrousCeruloplasminenzyme
DB13257Ferrous sulfate anhydrousFree radicalstarget