Anti-Acne Preparations

DrugDrug NameDrug Description
DB13092MeclocyclineCurrently under investigation for the topical treatment of ulcerative oral mucositis
DB00210AdapaleneA topical retinoid agent used for the treatment of acne vulgaris.
DB00548Azelaic acidA saturated dicarboxylic acid used to treat mild to moderate acne vulgaris.
DB00634SulfacetamideA corticosteroid used to treat inflammatory ocular conditions and acne vulgaris.
DB00755TretinoinA vitamin A derivative used to treat acne vulgaris, certain types of promyelocytic leukemia, and fine wrinkles.
DB00982IsotretinoinA retinoid used to treat severe recalcitrant acne.
DB01190ClindamycinA lincosamide antibiotic used to treat serious infections caused by susceptible anaerobic, streptococcal, staphylococcal, and pneumococcal bacteria.
DB09096Benzoyl peroxideAn antibacterial and anti-inflammatory agent used for the symptomatic treatment of mild to moderate acne vulgaris and rosacea.
DB09353OctasulfurAn ingredient of various cosmetic preparations for its keratolytic, antifungal, and antibacterial properties.
DB11081Aluminum chlorideIndicated for the control of minor hemorrhage during dental restorative procedures. Indicated to reduce underarm perspiration.
DB11085ResorcinolContemporary therapeutic uses for resorcinol primarily revolve around the use of the phenol derivative as an active ingredient in topical antiseptics [L2745, L2744, L2727, F61] or as topical antibacterial skin...
DB11342Aluminum oxideAluminum oxide has a chemical formula Al2O3. It is amphoteric in nature, and is used in various chemical, industrial and commercial applications. It is considered an indirect additive used in...
DB12447NadifloxacinNadifloxacin has been used in trials studying the treatment of Acne Vulgaris.
DB13343TioxoloneNot Annotated
DB13368MotretinideNot Annotated
DB00162Vitamin AA vitamin important for retinal function that is used clinically to correct vitamin A deficiency.
DB00199ErythromycinA macrolide antibiotic used to treat and prevent a variety of bacterial infections.
DB00250DapsoneA sulfone drug used to treat acne vulgaris, Hansen's disease, and dermatitis herpetiformis.
DB00324FluorometholoneAn ophthalmic corticosteroid used for the relief of inflammation located in both the palpebral and bulbar conjunctiva, the cornea, and the anterior segment of the globe of the eye.
DB00446ChloramphenicolA broad spectrum antibiotic that is effective against a variety of susceptible and serious bacterial infections but is not frequently used because of its high risk of bone marrow toxicity.
DB00959MethylprednisoloneA corticosteroid used to treat inflammation or immune reactions across a variety of organ systems, endocrine conditions, and neoplastic diseases.
DB01234DexamethasoneA glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders.
DB04813BithionolBithionol, formerly marketed as an active ingredient in various topical drug products, was shown to be a potent photosensitizer with the potential to cause serious skin disorders. Approvals of the...
DB13356MesulfenNot Annotated
DB12035SarecyclineA tetracycline antibiotic used to treat inflammatory lesions of non-nodular moderate to severe acne vulgaris.
DB12808TrifaroteneA topical retinoid indicated for the treatment of acne vulgaris.
DrugDrug NameTargetType
DB13092MeclocyclineOuter membrane protein Ftransporter
DB13092MeclocyclineOuter membrane porin Ctransporter
DB13092Meclocycline30S ribosomal protein S7target
DB13092MeclocyclineTetX family tetracycline inactivation enzymeenzyme
DB00210AdapaleneRetinoic acid receptor alphatarget
DB00210AdapaleneRetinoic acid receptor RXR-betatarget
DB00210AdapaleneRetinoic acid receptor gammatarget
DB00210AdapaleneRetinoic acid receptor betatarget
DB00210AdapaleneRetinoic acid receptor RXR-gammatarget
DB00210AdapaleneRetinoic acid receptor RXR-alphatarget
DB00210AdapaleneProstaglandin G/H synthase 2target
DB00548Azelaic acid3-oxo-5-alpha-steroid 4-dehydrogenase 2target
DB00548Azelaic acidDNA polymerase Itarget
DB00548Azelaic acidThioredoxin reductasetarget
DB00548Azelaic acidTyrosinasetarget
DB00548Azelaic acid3-oxo-5-beta-steroid 4-dehydrogenasetarget
DB00634SulfacetamideDihydropteroate synthasetarget
DB00634SulfacetamideDihydropteroate synthase type-1target
DB00634SulfacetamideFolic acid synthesis protein FOL1target
DB00755TretinoinRetinoic acid receptor gammatarget
DB00755TretinoinRetinoic acid receptor RXR-betatarget
DB00755TretinoinRetinal dehydrogenase 1target
DB00755TretinoinRetinoic acid-induced protein 3target
DB00755TretinoinRetinoic acid receptor RXR-gammatarget
DB00755TretinoinNuclear receptor subfamily 0 group B member 1target
DB00755TretinoinRetinal dehydrogenase 2target
DB00755TretinoinRetinoic acid receptor responder protein 1target
DB00755TretinoinCytochrome P450 2C8enzyme
DB00755TretinoinCellular retinoic acid-binding protein 1transporter
DB00755TretinoinCellular retinoic acid-binding protein 2transporter
DB00755TretinoinCytochrome P450 2B6enzyme
DB00755TretinoinCytochrome P450 3A4enzyme
DB00755TretinoinCytochrome P450 3A5enzyme
DB00755TretinoinCytochrome P450 2A6enzyme
DB00755TretinoinCytochrome P450 3A7enzyme
DB00755TretinoinCytochrome P450 2C18enzyme
DB00755TretinoinCytochrome P450 2C9enzyme
DB00755TretinoinCytochrome P450 4A11enzyme
DB00755TretinoinCytochrome P450 1A1enzyme
DB00755TretinoinRetinoic acid receptor alphatarget
DB00755TretinoinRetinoic acid receptor betatarget
DB00755TretinoinLipocalin-1target
DB00755TretinoinOdorant-binding protein 2atarget
DB00755TretinoinRetinol-binding protein 4target
DB00755TretinoinSerum albumincarrier
DB00755Tretinoin[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrialtarget
DB00755TretinoinRetinoic acid receptor RXR-alphatarget
DB00755TretinoinCytochrome P450 26A1target
DB00755TretinoinCytochrome P450 26B1target
DB00755TretinoinCytochrome P450 26C1target
DB00755TretinoinHematopoietic prostaglandin D synthasetarget
DB00982IsotretinoinRetinoic acid receptor alphatarget
DB00982IsotretinoinSerum albumincarrier
DB00982IsotretinoinRetinoic acid receptor gammatarget
DB00982IsotretinoinCytochrome P450 3A4enzyme
DB01190ClindamycinCytochrome P450 3A4enzyme
DB01190ClindamycinCytochrome P450 3A5enzyme
DB01190ClindamycinAlpha-1-acid glycoprotein 1carrier
DB01190ClindamycinP-glycoprotein 1transporter
DB01190Clindamycin50S ribosomal protein L1target
DB11081Aluminum chlorideGlutamate dehydrogenase 1, mitochondrialtarget
DB11085ResorcinolThyroid peroxidasetarget
DB00162Vitamin ARetinol dehydrogenase 12target
DB00162Vitamin ARetinol-binding protein 1target
DB00162Vitamin A11-cis retinol dehydrogenasetarget
DB00162Vitamin ARetinol dehydrogenase 13target
DB00162Vitamin ARetinol-binding protein 3target
DB00162Vitamin ARetinol-binding protein 5carrier
DB00162Vitamin ARetinoid-binding protein 7carrier
DB00162Vitamin ARetinol-binding protein 4carrier
DB00162Vitamin ARetinol-binding protein 2carrier
DB00162Vitamin ARetinal dehydrogenase 2target
DB00162Vitamin ARetinal dehydrogenase 1target
DB00162Vitamin ARetinaldehyde-binding protein 1target
DB00162Vitamin ALecithin retinol acyltransferasetarget
DB00162Vitamin AShort-chain dehydrogenase/reductase 3target
DB00162Vitamin AAldehyde dehydrogenase family 1 member A3target
DB00162Vitamin AAll-trans-retinol 13,14-reductasetarget
DB00162Vitamin ARetinol dehydrogenase 11target
DB00162Vitamin ADehydrogenase/reductase SDR family member 4target
DB00162Vitamin ARetinol dehydrogenase 14target
DB00162Vitamin ARetinol dehydrogenase 8target
DB00162Vitamin ACytochrome P450 26A1enzyme
DB00162Vitamin AApolipoprotein Dtarget
DB00162Vitamin AHematopoietic prostaglandin D synthasetarget
DB00162Vitamin ASerum albumincarrier
DB00199Erythromycin23S ribosomal RNAtarget
DB00199ErythromycinCytochrome P450 3A4enzyme
DB00199ErythromycinCytochrome P450 3A7enzyme
DB00199ErythromycinP-glycoprotein 1transporter
DB00199ErythromycinSolute carrier organic anion transporter family member 1B1transporter
DB00199ErythromycinMotilin receptortarget
DB00199ErythromycinPotassium voltage-gated channel subfamily H member 2target
DB00199ErythromycinCytochrome P450 3A5enzyme
DB00199ErythromycinSolute carrier organic anion transporter family member 1B3transporter
DB00199ErythromycinBile salt export pumptransporter
DB00199ErythromycinCanalicular multispecific organic anion transporter 1transporter
DB00199ErythromycinSolute carrier organic anion transporter family member 1A2transporter
DB00250DapsoneInactive dihydropteroate synthase 2target
DB00250DapsoneDihydropteroate synthase 1target
DB00250DapsoneCytochrome P450 2C9enzyme
DB00250DapsoneCytochrome P450 2E1enzyme
DB00250DapsoneCytochrome P450 3A4enzyme
DB00250DapsoneDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00250DapsoneProstaglandin G/H synthase 1enzyme
DB00250DapsoneProstaglandin G/H synthase 2enzyme
DB00250DapsoneCytochrome P450 2C8enzyme
DB00250DapsoneCytochrome P450 2C19enzyme
DB00250DapsoneArylamine N-acetyltransferase 2enzyme
DB00250DapsoneCytochrome P450 3A5enzyme
DB00250DapsoneCytochrome P450 3A7enzyme
DB00250DapsoneMyeloperoxidaseenzyme
DB00250DapsoneCytochrome P450 2C18enzyme
DB00324FluorometholoneCorticosteroid-binding globulincarrier
DB00324FluorometholoneCytochrome P450 3A4enzyme
DB00324FluorometholoneGlucocorticoid receptortarget
DB00324FluorometholoneCytochrome P450 3A5enzyme
DB00446ChloramphenicolComplement decay-accelerating factortarget
DB00446ChloramphenicolDr hemagglutinin structural subunittarget
DB00446ChloramphenicolCytochrome P450 2C19enzyme
DB00446ChloramphenicolCytochrome P450 3A4enzyme
DB00446ChloramphenicolCytochrome P450 3A5enzyme
DB00446ChloramphenicolCytochrome P450 3A7enzyme
DB00446ChloramphenicolSolute carrier family 22 member 6transporter
DB00446Chloramphenicol50S ribosomal protein L16target
DB00446ChloramphenicolChloramphenicol acetyltransferase 3enzyme
DB00446ChloramphenicolChloramphenicol acetyltransferaseenzyme
DB00446ChloramphenicolChloramphenicol 3-O phosphotransferaseenzyme
DB00959MethylprednisoloneGlucocorticoid receptortarget
DB00959MethylprednisoloneCytochrome P450 3A4enzyme
DB00959MethylprednisoloneP-glycoprotein 1transporter
DB00959MethylprednisoloneCytochrome P450 3A Subfamilyenzyme
DB00959MethylprednisoloneCytochrome P450 2A6enzyme
DB00959MethylprednisoloneCytochrome P450 1B1enzyme
DB00959MethylprednisoloneCytochrome P450 2B6enzyme
DB00959MethylprednisoloneCytochrome P450 2C8enzyme
DB00959MethylprednisoloneCytochrome P450 2C9enzyme
DB00959MethylprednisoloneCytochrome P450 2C19enzyme
DB00959MethylprednisoloneAnnexin A1target
DB00959Methylprednisolone20-ketosteroid reductase (20-hydroxysteroid dehydrogenase)enzyme
DB00959Methylprednisolone11beta-hydroxysteroid dehydrogenaseenzyme
DB00959MethylprednisoloneSerum albumincarrier
DB01234DexamethasoneGlucocorticoid receptortarget
DB01234DexamethasoneAnnexin A1target
DB01234DexamethasoneNitric oxide synthase, inducibletarget
DB01234DexamethasoneNuclear receptor subfamily 0 group B member 1target
DB01234DexamethasoneCytochrome P450 3A4enzyme
DB01234DexamethasoneCytochrome P450 3A5enzyme
DB01234DexamethasoneCytochrome P450 3A7enzyme
DB01234DexamethasoneBile salt export pumptransporter
DB01234DexamethasoneP-glycoprotein 1transporter
DB01234DexamethasoneCanalicular multispecific organic anion transporter 1transporter
DB01234DexamethasoneSolute carrier organic anion transporter family member 1A2transporter
DB01234DexamethasoneATP-binding cassette sub-family G member 2transporter
DB01234DexamethasoneSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
DB01234DexamethasoneCytochrome P450 1A1enzyme
DB01234DexamethasoneCytochrome P450 2A6enzyme
DB01234DexamethasoneCytochrome P450 2B6enzyme
DB01234DexamethasoneCytochrome P450 2C19enzyme
DB01234DexamethasoneCytochrome P450 2C8enzyme
DB01234DexamethasoneCytochrome P450 2E1enzyme
DB01234DexamethasoneCytochrome P450 3A43enzyme
DB01234DexamethasoneCytochrome P450 4A11enzyme
DB01234DexamethasoneNuclear receptor subfamily 1 group I member 2target
DB01234DexamethasoneCytochrome P450 11B1, mitochondrialenzyme
DB01234DexamethasoneSerum albumincarrier
DB01234DexamethasoneCorticosteroid 11-beta-dehydrogenase isozyme 2enzyme
DB01234DexamethasoneCorticosteroid 11-beta-dehydrogenase isozyme 1enzyme
DB01234DexamethasoneSolute carrier family 22 member 8transporter
DB12035SarecyclineP-glycoprotein 1transporter
DB12808TrifaroteneCytochrome P450 2C9enzyme
DB12808TrifaroteneCytochrome P450 3A4enzyme
DB12808TrifaroteneCytochrome P450 2C8enzyme
DB12808TrifaroteneCytochrome P450 2B6enzyme
DB12808TrifaroteneRetinoic acid receptor gammatarget
DB12808TrifaroteneRetinoic acid receptor alphatarget
DB12808TrifaroteneRetinoic acid receptor betatarget