Drugs Affecting Bone Structure and Mineralization

Name
Drugs Affecting Bone Structure and Mineralization
Accession Number
DBCAT002165
Description
Not Available
ATC Classification
Drugs
DrugDrug Description
CholecalciferolA form of Vitamin D used in the treatment of specific medical conditions such as refractory rickets, hypoparathyroidism, and familial hypophosphatemia, as well as osteoporosis and chronic kidney disease.
Pamidronic acidA bisphosphonate used to treat Paget's disease, to treat hypercalcemia of malignancy, and to treat osteolytic bone lesions.
Zoledronic acidA bisphosphonate used to treat malignancy associated hypercalcemia, multiple myeloma, and bone metastasis from solid tumors.
Alendronic acidA bisphosphonate drug that prevents osteoclastic bone resorption and is used for the prevention and treatment of osteoporosis.
IbandronateA bisphosphonate used to treat osteoporosis in postmenopausal women.
Clodronic acidA bisphosphonate used to treat osteoporosis in postmenopausal women, hypercalcemia of malignancy, and osteolysis.
Risedronic acidA bisphosphonate used to treat osteoporosis and Paget's disease.
Etidronic acidA bisphosphonate drug that prevents osteoclastic bone resorption; used for the prevention and treatment of osteoporosis.
Tiludronic acidA bisphosphonate used for the treatment of Paget's disease of bone.
CalciumA mineral found in over-the-counter supplements or prescription formulations used for the treatment of specific medical conditions related to calcium deficiency.
AlfacalcidolA vitamin D analogue used for the management of hypocalcemia, secondary hyperparathyroidism, and osteodystrophy in patients with chronic renal failure.
DenosumabA RANK ligand (RANKL) inhibitor used for the management of osteoporosis in patients at high risk for bone fractures.
Strontium ranelateA medication used for the management of severe osteoporosis in high-risk postmenopausal women and adult men.
Eptotermin AlfaA bone morphogenetic protein that is widely expressed during EMBRYONIC DEVELOPMENT. It is both a potent osteogenic factor and a specific regulator of nephrogenesis. Eptotermin Alfa is an ingredient in...
Dibotermin alfaindicated for the treatment of acute tibia fractures in adults, as an adjunct to standard care using open fracture reduction and intramedullary unreamed nail fixation [FDA Label]. indicated for single-level...
IpriflavoneNot Annotated
Aluminum chlorohydrateA compound used as an antiperspirant.
RomosozumabA monoclonal antibody used to treat osteoporosis in postmenopausal women at high risk of fracture, patients who are intolerant of other treatments, or patients who have failed other treatments.
BurosumabA fibroblast growth factor 23 blocking antibody used to treat X-linked hypophosphatemia.
Drugs & Drug Targets
DrugTargetType
CholecalciferolVitamin D-binding proteincarrier
CholecalciferolCholesterol side-chain cleavage enzyme, mitochondrialenzyme
CholecalciferolVitamin D 25-hydroxylaseenzyme
CholecalciferolSterol 26-hydroxylase, mitochondrialenzyme
CholecalciferolCytochrome P450 2J2enzyme
CholecalciferolCytochrome P450 3A4enzyme
CholecalciferolVitamin D3 receptortarget
CholecalciferolCytochrome P450 1A1enzyme
CholecalciferolCytochrome P450 2C8enzyme
Pamidronic acidFarnesyl pyrophosphate synthasetarget
Pamidronic acidHydroxylapatitetarget
Pamidronic acidGeranylgeranyl pyrophosphate synthasetarget
Pamidronic acidCaspase-3target
Pamidronic acidCaspase-9target
Zoledronic acidFarnesyl pyrophosphate synthasetarget
Zoledronic acidGeranylgeranyl pyrophosphate synthasetarget
Zoledronic acidHydroxylapatitetarget
Zoledronic acidMultidrug resistance-associated protein 1transporter
Alendronic acidFarnesyl pyrophosphate synthasetarget
Alendronic acidTyrosine-protein phosphatase non-receptor type 4target
Alendronic acidReceptor-type tyrosine-protein phosphatase Starget
Alendronic acidReceptor-type tyrosine-protein phosphatase epsilontarget
Alendronic acidV-type proton ATPase catalytic subunit Atarget
Alendronic acidHydroxylapatitetarget
IbandronateFarnesyl pyrophosphate synthasetarget
IbandronateHydroxylapatitetarget
IbandronateGeranylgeranyl pyrophosphate synthasetarget
Clodronic acidADP/ATP translocase 2target
Clodronic acidADP/ATP translocase 1target
Clodronic acidADP/ATP translocase 3target
Clodronic acidHydroxylapatitetarget
Clodronic acidProstaglandin G/H synthase 2enzyme
Risedronic acidFarnesyl pyrophosphate synthasetarget
Risedronic acidHydroxylapatitetarget
Risedronic acidProstaglandin G/H synthase 2enzyme
Etidronic acidHydroxylapatitetarget
Etidronic acidReceptor-type tyrosine-protein phosphatase Starget
Etidronic acidV-type proton ATPase catalytic subunit Atarget
Etidronic acidADP/ATP translocase 1target
Etidronic acidADP/ATP translocase 2target
Etidronic acidADP/ATP translocase 3target
Tiludronic acidTyrosine-protein phosphatase non-receptor type 12target
Tiludronic acidV-ATPase Subunitstarget
Tiludronic acidHydroxylapatitetarget
Tiludronic acidAdenosine triphosphate (ATP)target
Tiludronic acidSerum albumincarrier
Tiludronic acidTyrosine-protein phosphatase non-receptor type 6target
Tiludronic acidReceptor-type tyrosine-protein phosphatase epsilontarget
CalciumProtein S100-Btarget
CalciumCalpastatintarget
CalciumCartilage oligomeric matrix proteintarget
CalciumCalmodulintarget
CalciumSpectrin beta chain, non-erythrocytic 1target
CalciumVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
CalciumTroponin C, skeletal muscletarget
CalciumTroponin C, slow skeletal and cardiac musclestarget
CalciumCalcium-transporting ATPase type 2C member 1target
CalciumAmiloride-sensitive amine oxidase [copper-containing]target
CalciumProtein S100-A13target
CalciumAlkaline phosphatase, placental typetarget
CalciumProtein S100-A8target
CalciumProtein S100-A9target
CalciumProtein S100-A2target
CalciumCeruloplasmintarget
CalciumBone morphogenetic protein 4target
CalciumMatrix Gla proteintarget
CalciumProtocadherin-19target
CalciumProgrammed cell death protein 6target
AlfacalcidolVitamin D-binding proteincarrier
AlfacalcidolVitamin D3 receptortarget
Alfacalcidol25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialtarget
AlfacalcidolRetinoic acid receptor RXR-alphatarget
DenosumabTumor necrosis factor ligand superfamily member 11target
Dibotermin alfaBone morphogenetic protein receptor type-1Atarget
Dibotermin alfaBone morphogenetic protein receptor type-2target
RomosozumabSclerostintarget
BurosumabFibroblast growth factor 23target