ACE Inhibitors and Diuretics

DrugDrug NameDrug Indication
DB00492FosinoprilFor treating mild to moderate hypertension, use as an adjunct in treating congestive heart failure, and may be used to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.
DB00542BenazeprilBenazepril is indicated for the treatment of hypertension[A840]. It may be used alone or in combination with thiazide diuretics[FDA Label].
DB00722LisinoprilLisinopril is indicated for the treatment of acute myocardial infarction, hypertension in patients ≥6 years, and as an adjunct therapy for heart failure.[L8384,L8387] A combination product with hydrochlorothiazide is indicated for the treatment of hypertension.[L8390]
DB00881QuinaprilQuinapril is indicated for the treatment of hypertension and as an adjunct therapy in the treatment of heart failure.[L8420] Quinapril in combination with hydrochlorothiazide is indicated for the treatment of hypertension.[L8423]
DB01197CaptoprilFor the treatment of essential or renovascular hypertension (usually administered with other drugs, particularly thiazide diuretics). May be used to treat congestive heart failure in combination with other drugs (e.g. cardiac glycosides, diuretics, β-adrenergic blockers). May improve survival in patients with left ventricular dysfunction following myocardial infarction. May be used to treat nephropathy, including diabetic nephropathy.
DB00178RamiprilFor the management of mild to severe hypertension. May be used to reduce cardiovascular mortality following myocardial infarction in hemodynamically stable individuals who develop clinical signs of congestive heart failure within a few days following myocardial infarction. [FDA Label] To reduce the rate of death, myocardial infarction and stroke in individuals at high risk of cardiovascular events. May be used to slow the progression of renal disease in individuals with hypertension, diabetes mellitus and microalubinuria or overt nephropathy. [T116]
DB00584EnalaprilIndicated for the management of essential or renovascular hypertension [L6586] as monotherapy or in combination with other antihypertensive agents, such as thiazide diuretics, for an additive effect.[label] Indicated for the treatment of symptomatic congestive heart failure, usually in combination with diuretics and digitalis.[label] Indicated for the management of asymptomatic left ventricular dysfunction in patients with an ejection fraction of ≤ to 35 percent to decrease the rate of development of overt heart failure and the incidence of hospitalization for heart failure.[label]
DB00691MoexiprilFor the treatment of hypertension.
DB00790PerindoprilFor the treatment of mild to moderate essential hypertension, mild to moderate congestive heart failure, and to reduce the cardiovascular risk of individuals with hypertension or post-myocardial infarction and stable coronary disease.
DB01340CilazaprilCilazapril is an ACE inhibtor class drug used in the treatment of hypertension and heart failure.
DB13166ZofenoprilNot Available
DB13312DelaprilNot Available
DrugDrug NameTargetType
DB00492FosinoprilAngiotensin-converting enzymetarget
DB00492FosinoprilSolute carrier family 15 member 1transporter
DB00492FosinoprilSolute carrier family 15 member 2transporter
DB00542BenazeprilAngiotensin-converting enzymetarget
DB00542BenazeprilMethylenetetrahydrofolate reductaseenzyme
DB00542BenazeprilSolute carrier family 15 member 1transporter
DB00542BenazeprilSolute carrier family 15 member 2transporter
DB00722LisinoprilAngiotensin-converting enzymetarget
DB00722LisinoprilSolute carrier family 15 member 1transporter
DB00722LisinoprilSolute carrier family 15 member 2transporter
DB00722LisinoprilRenintarget
DB00881QuinaprilAngiotensin-converting enzymetarget
DB00881QuinaprilSolute carrier family 15 member 1transporter
DB00881QuinaprilSolute carrier family 15 member 2transporter
DB00881QuinaprilSolute carrier family 22 member 8transporter
DB00881QuinaprilLiver carboxylesterase 1enzyme
DB00881QuinaprilSerum albumincarrier
DB01197CaptoprilAngiotensin-converting enzymetarget
DB01197CaptoprilSerum albumincarrier
DB01197Captopril72 kDa type IV collagenasetarget
DB01197CaptoprilMatrix metalloproteinase-9target
DB01197CaptoprilP-glycoprotein 1transporter
DB01197CaptoprilSolute carrier family 15 member 1transporter
DB01197CaptoprilSolute carrier family 22 member 6transporter
DB01197CaptoprilLeukotriene A-4 hydrolasetarget
DB01197CaptoprilB1 bradykinin receptortarget
DB00178RamiprilAngiotensin-converting enzymetarget
DB00178RamiprilSolute carrier family 15 member 1transporter
DB00178RamiprilSolute carrier family 15 member 2transporter
DB00178RamiprilCholinesteraseenzyme
DB00178RamiprilB1 bradykinin receptortarget
DB00584EnalaprilAngiotensin-converting enzymetarget
DB00584EnalaprilP-glycoprotein 1transporter
DB00584EnalaprilSolute carrier family 15 member 1transporter
DB00584EnalaprilSolute carrier family 22 member 6transporter
DB00584EnalaprilSolute carrier family 22 member 8transporter
DB00584EnalaprilSolute carrier family 22 member 7transporter
DB00584EnalaprilSolute carrier organic anion transporter family member 1A2transporter
DB00584EnalaprilSerum albumincarrier
DB00691MoexiprilAngiotensin-converting enzymetarget
DB00691MoexiprilSolute carrier family 15 member 1transporter
DB00691MoexiprilSolute carrier family 15 member 2transporter
DB00691MoexiprilAngiotensin-converting enzyme 2target
DB00790PerindoprilAngiotensin-converting enzymetarget
DB00790PerindoprilSolute carrier family 15 member 1transporter
DB00790PerindoprilSolute carrier family 15 member 2transporter
DB00790PerindoprilCholinesteraseenzyme
DB00790PerindoprilSecreted frizzled-related protein 4target
DB01340CilazaprilAngiotensin-converting enzymetarget
DB01340CilazaprilP-glycoprotein 1transporter
DB01340CilazaprilSolute carrier family 15 member 1transporter
DB01340CilazaprilSolute carrier family 15 member 2transporter
DB13166ZofenoprilAngiotensin-converting enzymetarget