Nucleosides and Nucleotides Excl. Reverse Transcriptase Inhibitors

DrugDrug NameDrug Indication
DB00299PenciclovirUsed to treat recurrent cold sores on the lips and face from various herpesvirus invections.
DB00369CidofovirFor the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS)
DB00426FamciclovirFor the treatment of acute herpes zoster (shingles). Also for the treatment or suppression of recurrent genital herpes in immunocompetent patients and treatment of recurrent mucocutaneous herpes simplex infections in HIV infected patients.
DB00577ValaciclovirFor the treatment or suppression of cold sores (herpes labialis), herpes zoster (shingles), genital herpes in immunocompetent individuals, and recurrent genital herpes in HIV-infected individuals.
DB00811RibavirinIndicated for the treatment of chronic Hepatitis C virus (HCV) infection in combination with other antiviral agents with the intent to cure or achieve a sustained virologic response (SVR). Typically added to improve SVR and reduce relapse rates [A19644]. The addition of ribavirin in Technivie therapy indicated for treating HCV genotype 1a and 4 infections is recommended in patients with or without cirrhosis. Resistance: viral genetic determinants resulting in variable response to ribavirin therapy has not been yet determined.
DB01610ValganciclovirValganciclovir is an antiviral medication used for the treatment of cytomegalovirus infections.
DB00194VidarabineFor treatment of chickenpox - varicella, herpes zoster and herpes simplex
DB00249IdoxuridineFor use in keratoconjunctivitis and keratitis caused by herpes simplex virus.
DB00787AcyclovirFor the treatment and management of herpes zoster (shingles), genital herpes, and chickenpox.
DB01004GanciclovirFor induction and maintenance in the treatment of cytomegalovirus (CMV) retinitis in immunocompromised patients, including patients with acquired immunodeficiency syndrome (AIDS). Also used in the treatment of severe cytomegalovirus (CMV) disease, including CMV pneumonia, CMV gastrointestinal disease, and disseminated CMV infections, in immunocompromised patients.
DB03312BrivudineNot Available
DrugDrug NameTargetType
DB00299PenciclovirDNA polymerase catalytic subunittarget
DB00299PenciclovirThymidine kinasetarget
DB00369CidofovirThymidine phosphorylaseenzyme
DB00369CidofovirDNA polymerase catalytic subunittarget
DB00369CidofovirSolute carrier family 22 member 6transporter
DB00426FamciclovirAldehyde oxidaseenzyme
DB00426FamciclovirCytochrome P450 3A4enzyme
DB00426FamciclovirDNA polymerase catalytic subunittarget
DB00426FamciclovirDNA polymerase catalytic subunittarget
DB00577ValaciclovirThymidine kinasetarget
DB00577ValaciclovirDNA polymerase catalytic subunittarget
DB00577ValaciclovirSolute carrier family 15 member 1transporter
DB00577ValaciclovirSolute carrier family 15 member 2transporter
DB00577ValaciclovirSolute carrier family 22 member 8transporter
DB00577ValaciclovirSolute carrier family 22 member 6transporter
DB00577ValaciclovirSodium- and chloride-dependent neutral and basic amino acid transporter B(0+)transporter
DB00577ValaciclovirIleal sodium/bile acid cotransportertransporter
DB00811RibavirinAdenosine kinaseenzyme
DB00811RibavirinRNA-directed RNA polymerase Ltarget
DB00811RibavirinEctonucleotide pyrophosphatase/phosphodiesterase family member 1target
DB00811RibavirinRNA-directed RNA polymerase catalytic subunittarget
DB00811RibavirinCytosolic purine 5'-nucleotidasetarget
DB00811RibavirinInosine-5'-monophosphate dehydrogenase 1target
DB00811RibavirinGenome polyproteintarget
DB00811RibavirinInosine-5'-monophosphate dehydrogenase 2target
DB00811RibavirinEquilibrative nucleoside transporter 1transporter
DB00811RibavirinSolute carrier family 28 member 3transporter
DB01610ValganciclovirDNAtarget
DB01610ValganciclovirSolute carrier family 15 member 1transporter
DB01610ValganciclovirSolute carrier family 15 member 2transporter
DB01610ValganciclovirSodium- and chloride-dependent neutral and basic amino acid transporter B(0+)transporter
DB00194VidarabineAdenosine deaminaseenzyme
DB00194VidarabineDNAtarget
DB00194VidarabineDNA polymerase catalytic subunittarget
DB00194VidarabineThymidine kinasetarget
DB00194VidarabineThymidine kinasetarget
DB00249IdoxuridineThymidine kinasetarget
DB00249IdoxuridineDNAtarget
DB00787AcyclovirDNA polymerase catalytic subunittarget
DB00787AcyclovirDNA polymerase catalytic subunittarget
DB00787AcyclovirThymidine kinasetarget
DB00787AcyclovirSolute carrier family 22 member 1transporter
DB00787AcyclovirSolute carrier family 22 member 6transporter
DB00787AcyclovirSolute carrier family 22 member 8transporter
DB00787AcyclovirIleal sodium/bile acid cotransportertransporter
DB00787AcyclovirMultidrug and toxin extrusion protein 1transporter
DB00787AcyclovirMultidrug and toxin extrusion protein 2transporter
DB01004GanciclovirDNA polymerase catalytic subunittarget
DB01004GanciclovirThymidine kinasetarget
DB01004GanciclovirDNAtarget
DB01004GanciclovirSolute carrier family 22 member 1transporter
DB01004GanciclovirSolute carrier family 22 member 6transporter
DB01004GanciclovirSolute carrier family 22 member 8transporter
DB01004GanciclovirSolute carrier family 22 member 7transporter
DB01004GanciclovirMultidrug and toxin extrusion protein 1transporter
DB01004GanciclovirMultidrug and toxin extrusion protein 2transporter
DB03312BrivudineThymidine kinasetarget