Thiazolidinediones

A group of oral anti-diabetic drugs designed to treat patients with type 2 diabetes. Thiazolidenediones are compounds that act as agonists of the peroxisome proliferator-activated receptor-gamma increasing tissues sensibility (muscle, adiposity tissue, and liver) to insulin action.
DrugDrug NameDrug Indication
DB00412RosiglitazoneRosiglitazone is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
DB01132PioglitazonePioglitazone is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus [FDA Label].
DB09201CiglitazoneNot Available
DB09198LobeglitazoneLobeglitazone was approved by the Ministry of Food and Drug Safety (South Korea) in 2013, and is being monitored by postmarketing surveillance until 2019. Lobeglitazone is not approved for use by either the Food and Drug Administration (USA), Health Canada, or by the European Medicines Agency for use in the management of diabetes.
DB09200RivoglitazoneNot Available
DB09199NetoglitazoneNot Available
DB12781BalaglitazoneNot Available
DB00197TroglitazoneFor the treatment of Type II diabetes mellitus. It is used alone or in combination with a sulfonylurea, metformin, or insulin as an adjunct to diet and exercise.
DrugDrug NameTargetType
DB00412RosiglitazonePeroxisome proliferator-activated receptor gammatarget
DB00412RosiglitazoneCytochrome P450 2C8enzyme
DB00412RosiglitazoneCytochrome P450 2C9enzyme
DB00412RosiglitazoneLong-chain-fatty-acid--CoA ligase 4target
DB00412RosiglitazoneSolute carrier organic anion transporter family member 1B1transporter
DB00412RosiglitazoneProstaglandin G/H synthase 1enzyme
DB00412RosiglitazoneCytochrome P450 1A2enzyme
DB00412RosiglitazoneCytochrome P450 2A6enzyme
DB00412RosiglitazoneCytochrome P450 2D6enzyme
DB00412RosiglitazoneSerum albumincarrier
DB00412RosiglitazonePeroxisome proliferator-activated receptor alphatarget
DB00412RosiglitazonePeroxisome proliferator-activated receptor deltatarget
DB00412RosiglitazoneRetinoic acid receptor RXR-alphatarget
DB00412RosiglitazoneRetinoic acid receptor RXR-betatarget
DB00412RosiglitazoneRetinoic acid receptor RXR-gammatarget
DB00412RosiglitazoneCytochrome P450 3A4enzyme
DB00412RosiglitazoneBile salt export pumptransporter
DB01132PioglitazonePeroxisome proliferator-activated receptor gammatarget
DB01132PioglitazoneCytochrome P450 2C8enzyme
DB01132PioglitazoneCytochrome P450 3A4enzyme
DB01132PioglitazoneSolute carrier organic anion transporter family member 1B3transporter
DB01132PioglitazoneSolute carrier organic anion transporter family member 1B1transporter
DB01132PioglitazoneProstaglandin G/H synthase 1enzyme
DB01132PioglitazoneCytochrome P450 2C9enzyme
DB01132PioglitazonePeroxisome proliferator-activated receptor deltatarget
DB01132PioglitazonePeroxisome proliferator-activated receptor alphatarget
DB01132PioglitazoneAmine oxidase [flavin-containing] Btarget
DB09201CiglitazonePeroxisome proliferator-activated receptor gammatarget
DB09201CiglitazoneCytochrome P450 3A4enzyme
DB09201CiglitazoneCytochrome P450 2C8enzyme
DB09198LobeglitazoneSolute carrier organic anion transporter family member 1B1transporter
DB09198LobeglitazoneSolute carrier organic anion transporter family member 3A1transporter
DB09198LobeglitazoneP-glycoprotein 1transporter
DB09198LobeglitazoneCytochrome P450 1A2enzyme
DB09198LobeglitazoneCytochrome P450 2C9enzyme
DB09198LobeglitazoneCytochrome P450 2C19enzyme
DB09198LobeglitazonePeroxisome proliferator-activated receptor gammatarget
DB09198LobeglitazoneCytochrome P450 3A4enzyme
DB09198LobeglitazoneCytochrome P450 2C8enzyme
DB09200RivoglitazoneCytochrome P450 3A4enzyme
DB09200RivoglitazoneCytochrome P450 2C8enzyme
DB09199NetoglitazoneCytochrome P450 3A4enzyme
DB09199NetoglitazoneCytochrome P450 2C8enzyme
DB12781BalaglitazoneCytochrome P450 3A4enzyme
DB12781BalaglitazoneCytochrome P450 2C8enzyme
DB00197TroglitazonePeroxisome proliferator-activated receptor gammatarget
DB00197TroglitazoneLong-chain-fatty-acid--CoA ligase 4target
DB00197TroglitazonePlasminogen activator inhibitor 1target
DB00197TroglitazoneEquilibrative nucleoside transporter 1target
DB00197TroglitazoneCytochrome P450 3A4enzyme
DB00197TroglitazoneCytochrome P450 2C19enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 1-1enzyme
DB00197TroglitazoneCytochrome P450 2C8enzyme
DB00197TroglitazoneBile salt export pumptransporter
DB00197TroglitazoneSolute carrier organic anion transporter family member 1B1transporter
DB00197TroglitazoneEstrogen-related receptor gammatarget
DB00197TroglitazoneSteroid hormone receptor ERR1target
DB00197TroglitazoneCytochrome P450 19A1enzyme
DB00197TroglitazoneCytochrome P450 1A1enzyme
DB00197TroglitazoneCytochrome P450 2B6enzyme
DB00197TroglitazoneCytochrome P450 2C9enzyme
DB00197TroglitazoneCytochrome P450 3A5enzyme
DB00197TroglitazoneCytochrome P450 3A7enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 1-3enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 1-4enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 1-6enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 1-7enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 1-8enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 1-9enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 1-10enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 2B7enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 2B15enzyme
DB00197TroglitazonePeroxisome proliferator-activated receptor deltatarget
DB00197TroglitazonePeroxisome proliferator-activated receptor alphatarget
DB00197TroglitazoneGlutathione S-transferase Ptarget