Drugs for Functional Gastrointestinal Disorders

DrugDrug NameDrug Description
DB00219OxyphenoniumFor the treatment of visceral spasms
DB00383OxyphencyclimineFor the treatment of peptic ulcer disease and the relief of smooth muscle spasms in gastrointestinal disorders.
DB00424HyoscyamineFor treatment of bladder spasms, peptic ulcer disease, diverticulitis, colic, irritable bowel syndrome, cystitis, and pancreatitis. Also used to treat certain heart conditions, to control the symptoms of Parkinson's disease...
DB00505TridihexethylUsed as an adjunct in the treatment of peptic ulcer disease and in Acquired nystagmus
DB00572AtropineA muscarinic antagonist used to treat poisoning by muscarinic agents, including organophosphates and other drugs.
DB00604CisaprideA medication used to treat heartburn associated with GERD.
DB00725Homatropine methylbromideA muscarinic receptor antagonist used to treat peptic ulcers, gastric ulcers, and duodenal ulcers.
DB00771ClidiniumA synthetic anticholinergic used to treat peptic ulcer disease, colicky abdominal pain, diverticulitis, and IBS.
DB00782PropanthelineAn antimuscarinic agent used to treat urinary incontinence, hyperhidrosis, as well as cramps and spasms of the stomach, intestines, and bladder.
DB00804DicyclomineAn antimuscarinic agent used to treat IBS.
DB00940MethanthelineFor the treatment of peptic ulcer disease, irritable bowel syndrome, pancreatitis, gastritis, biliary dyskinesia, pylorosplasm, and reflex neurogenic bladder in children.
DB00969AlosetronA 5-HT3 antagonist used to treat diarrhea-predominant IBS.
DB00986GlycopyrroniumAn anticholinergic agent used to treat hyperhidrosis, severe drooling, COPD, used with other medications to treat ulcers, and used in anesthesia.
DB01113PapaverineAn alkaloid used to treat many types of smooth muscle spasms such as "vascular spasms" associated with acute myocardial infarction and angina pectoris, as well as "visceral spasms".
DB01184DomperidoneA dopamine receptor antagonist used as a peristaltic stimulant and anti-emetic agent for dyspepsia, indigestion, epigastric pain, nausea, and vomiting.
DB01233MetoclopramideAn antiemetic agent and dopamine D2 antagonist used in the treatment of gastroesophageal reflux disease, prevention of nausea and vomiting, and to stimulate gastric emptying.
DB01425AlizaprideAlizapride is used in the treatment of nausea and vomiting, including postoperative nausea and vomiting.
DB01616AlverineUsed to relieve cramps or spasms of the stomach and intestines. It is also useful in treating irritable bowel syndrome (IBS) and similar conditions. It can also be used to...
DB01625IsopropamideFor the treatment of a wide range of gastrointestinal disorders, including such conditions as peptic ulcer, gastritis, hyperchlorhydria, functional diarrhea, irritable or spastic colon, pyloroduodenal irritability, pylorospasm, acute nonspecific gastroenteritis,...
DB04843MepenzolateA postganglionic parasympathetic inhibitor that was previously approved for improving the healing of gastric ulcers, but has been discontinued.
DB04885CilansetronFor the treatment of symptoms associated with irritable bowel syndrome.
DB04924ItoprideInvestigated for use/treatment in gastrointestinal diseases and disorders (miscellaneous).
DB06706IsomethepteneIsometheptene is a sympathomimetic drug which causes vasoconstriction. It is used for treating migraines and tension headaches.
DB06751DrotaverineUsed in the treatment of functional bowel disorders and alleviating pain in renal colic.
DB06787HexocycliumThe World Health Organization classifies hexocyclium as a drug for functional gastrointestinal disorders . Like other anti-muscarinic agents, hexocyclium was likely used to treat peptic ulcers or diarrhea.
DB08978FentoniumFentonium is an atropine derivative.
DB09018BromoprideBromopride in indicated in the treatment of nausea and vomiting, including PONV (post-operative nausea and vomiting), gastroesophageal reflux disease (GERD/GORD), as well as endoscopy preparation and radiographic studies of the...
DB09089TrimebutineA spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and treatment of postoperative paralytic ileus following abdominal surgery.
DB09090PinaveriumA spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and functional disorders of the biliary tract.
DB09271CimetropiumCimetropium is a semi-synthetic belladonna alkaloid and derivative of scopolamine. It is a potent antimuscarinic and an effective antispasmodic drug. It is also endowed of a direct myolitic action which...
DB09300ButylscopolamineAn antispasmodic and anticholinergic agent used for the symptomatic treatment of abdominal cramping and pain.
DB11315MethscopolamineMethscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh) receptors. Methscopolamine bromide is the most common form of the active ingredient in oral pharmaceutical products. The...
DB12251MoxaverineMoxaverine has been investigated for the treatment of Retina, Ocular Physiology, and Regional Blood Flow.
DB12554MebeverineMebeverine has been investigated for the treatment of Irritable Bowel Syndrome and Post-cholecystectomy Gastrointestinal Spasms.
DB12944PhloroglucinolPhloroglucinol has been used in trials studying the diagnostic of Colonoscopy.
DB13042FenoverineFenoverine has been used in trials studying the treatment of Irritable Bowel Syndrome.
DB13091TiropramideTiropramide is under investigation in clinical trial NCT01629212 (Comparison of the Efficacy and Safety of Tiropramide and Octylonium in the Treatment of Irritable Bowel Syndrome).
DB13254PrifiniumPrifinium is an antimuscarinic agent with antispasmodic and antiemetic properties. It may be useful for the treatment of irritable bowel syndrome .
DB13276IdanpramineNot Annotated
DB13311TrepibutoneNot Annotated
DB13351PiperidolateNot Annotated
DB13361TrimethyldiphenylpropylamineNot Annotated
DB13369BenziloneNot Annotated
DB13380DifemerineNot Annotated
DB13439FenpipraneNot Annotated
DB13476DiisopromineNot Annotated
DB13497ValethamateNot Annotated
DB13500OtiloniumNot Annotated
DB13507PoldineNot Annotated
DB13511CleboprideNot Annotated
DB13531NicofetamideNot Annotated
DB13542BevoniumNot Annotated
DB13581RociverineNot Annotated
DB13666Tiemonium iodideNot Annotated
DB13672DimethylaminopropionylphenothiazineNot Annotated
DB13678DihexyverineNot Annotated
DB13695PenthienateNot Annotated
DB13720DiphemanilUsed in the treatment of peptic ulcer, gastric hyperacidity, and hypermotility in gastritis and pylorospasm, and in the treatment of hyperhidrosis (excessive perspiration).
DB13738CamylofinNot Annotated
DB13759FenpiveriniumNot Annotated
DB13769Emetonium iodideNot Annotated
DB13788ChlorbenzoxamineNot Annotated
DB13819ProxazoleNot Annotated
DB13833MethylatropineNot Annotated
DB13835CaroverineNot Annotated
DB13844PipenzolateNot Annotated
DB13850TimepidiumNot Annotated
DB00209TrospiumAn antimuscarinic agent used to treat the symptoms of overactive bladder (OAB).
DB13505EmeproniumNot Annotated
DB08810CinitaprideIt is indicated to treat gastrointestinal disorders associated with motility disturbances like gastroesophageal reflux disease (GERD), non-ulcer dyspepsia and delayed gastric emptying.
DrugDrug NameTargetType
DB00219OxyphenoniumMuscarinic acetylcholine receptor M1target
DB00383OxyphencyclimineMuscarinic acetylcholine receptor M1target
DB00383OxyphencyclimineMuscarinic acetylcholine receptor M2target
DB00383OxyphencyclimineMuscarinic acetylcholine receptor M3target
DB00424HyoscyamineMuscarinic acetylcholine receptor M1target
DB00424HyoscyamineMuscarinic acetylcholine receptor M2target
DB00424HyoscyamineMuscarinic acetylcholine receptor M3target
DB00424HyoscyamineMuscarinic acetylcholine receptor M4target
DB00505TridihexethylMuscarinic acetylcholine receptor M1target
DB00505TridihexethylMuscarinic acetylcholine receptor M2target
DB00505TridihexethylMuscarinic acetylcholine receptor M3target
DB00572AtropineMuscarinic acetylcholine receptor M2target
DB00572AtropineMuscarinic acetylcholine receptor M1target
DB00572AtropineMuscarinic acetylcholine receptor M4target
DB00572AtropineMuscarinic acetylcholine receptor M5target
DB00572AtropineMuscarinic acetylcholine receptor M3target
DB00572AtropineGlycine receptor subunit alpha-1target
DB00572AtropineNeuronal acetylcholine receptor subunit alpha-4target
DB00572AtropineNeuronal acetylcholine receptor subunit beta-2target
DB00572AtropineBile salt export pumptransporter
DB00604Cisapride5-hydroxytryptamine receptor 4target
DB00604Cisapride5-hydroxytryptamine receptor 3Atarget
DB00604CisapridePotassium voltage-gated channel subfamily H member 2target
DB00604Cisapride5-hydroxytryptamine receptor 2Atarget
DB00604CisaprideCytochrome P450 3A4enzyme
DB00604CisaprideCytochrome P450 3A5enzyme
DB00604CisaprideCytochrome P450 3A7enzyme
DB00604CisaprideCytochrome P450 2A6enzyme
DB00604CisaprideCytochrome P450 2B6enzyme
DB00604CisaprideCytochrome P450 2C19enzyme
DB00604CisaprideCytochrome P450 2C8enzyme
DB00604CisaprideCytochrome P450 2C9enzyme
DB00604CisaprideCytochrome P450 2D6enzyme
DB00725Homatropine methylbromideMuscarinic acetylcholine receptor M2target
DB00725Homatropine methylbromideMuscarinic acetylcholine receptor M1target
DB00725Homatropine methylbromideMuscarinic acetylcholine receptor M4target
DB00725Homatropine methylbromideMuscarinic acetylcholine receptor M5target
DB00725Homatropine methylbromideMuscarinic acetylcholine receptor M3target
DB00771ClidiniumMuscarinic acetylcholine receptor M1target
DB00782PropanthelineMuscarinic acetylcholine receptor M1target
DB00804DicyclomineMuscarinic acetylcholine receptor M1target
DB00804DicyclomineMuscarinic acetylcholine receptor M2target
DB00940MethanthelineMuscarinic acetylcholine receptor M1target
DB00940MethanthelineHistamine H2 receptortarget
DB00969Alosetron5-hydroxytryptamine receptor 3Atarget
DB00969AlosetronCytochrome P450 1A2enzyme
DB00969AlosetronCytochrome P450 2C9enzyme
DB00969AlosetronCytochrome P450 3A4enzyme
DB00969AlosetronCytochrome P450 2E1enzyme
DB00986GlycopyrroniumMuscarinic acetylcholine receptor M1target
DB00986GlycopyrroniumMuscarinic acetylcholine receptor M3target
DB00986GlycopyrroniumMuscarinic acetylcholine receptor M2target
DB01113PapaverinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB01113PapaverinecAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Atarget
DB01184DomperidoneDopamine D2 receptortarget
DB01184DomperidoneCytochrome P450 3A4enzyme
DB01184DomperidoneCytochrome P450 3A5enzyme
DB01184DomperidoneCytochrome P450 3A7enzyme
DB01184DomperidoneP-glycoprotein 1transporter
DB01184DomperidoneCytochrome P450 1A2enzyme
DB01184DomperidoneCytochrome P450 2B6enzyme
DB01184DomperidoneCytochrome P450 2C8enzyme
DB01184DomperidoneCytochrome P450 2D6enzyme
DB01184DomperidoneDopamine D3 receptortarget
DB01233MetoclopramideMuscarinic acetylcholine receptor M1target
DB01233MetoclopramideDopamine D2 receptortarget
DB01233MetoclopramideCytochrome P450 2D6enzyme
DB01233Metoclopramide5-hydroxytryptamine receptor 4target
DB01233Metoclopramide5-hydroxytryptamine receptor 3Atarget
DB01233MetoclopramideCytochrome P450 3A4enzyme
DB01233MetoclopramideCytochrome P450 1A2enzyme
DB01233MetoclopramideP-glycoprotein 1transporter
DB01233MetoclopramideAlpha-1-acid glycoprotein 1carrier
DB01425AlizaprideDopamine D2 receptortarget
DB01616Alverine5-hydroxytryptamine receptor 1Atarget
DB01625IsopropamideMuscarinic acetylcholine receptor M3target
DB01625IsopropamideMuscarinic acetylcholine receptor M4target
DB04843MepenzolateMuscarinic acetylcholine receptor M1target
DB04843MepenzolateMuscarinic acetylcholine receptor M3target
DB04885Cilansetron5-hydroxytryptamine receptor 3Atarget
DB04924ItoprideDopamine D2 receptortarget
DB04924ItoprideAcetylcholinesterasetarget
DB06706IsomethepteneAlpha-1A adrenergic receptortarget
DB06706IsomethepteneSynaptic vesicular amine transportertarget
DB06751DrotaverinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DB06751DrotaverineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB06787HexocycliumMuscarinic acetylcholine receptor M1target
DB06787HexocycliumMuscarinic acetylcholine receptor M2target
DB06787HexocycliumMuscarinic acetylcholine receptor M3target
DB06787HexocycliumMuscarinic acetylcholine receptor M4target
DB09018BromoprideDopamine D2 receptortarget
DB09089TrimebutineMu-type opioid receptortarget
DB09089TrimebutineVoltage-dependent L-type calcium channeltarget
DB09089TrimebutineCalcium-activated potassium channeltarget
DB09089TrimebutineVoltage-dependent T-type calcium channeltarget
DB09089TrimebutineMuscarinic acetylcholine receptor M1target
DB09089TrimebutineMuscarinic acetylcholine receptor M2target
DB09089TrimebutineMuscarinic acetylcholine receptor M3target
DB09089TrimebutineMuscarinic acetylcholine receptor M4target
DB09089TrimebutineCytochrome P450 3A4enzyme
DB09090PinaveriumVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB09090PinaveriumCytochrome P450 3A4enzyme
DB09300ButylscopolamineMuscarinic acetylcholine receptor M3target
DB09300ButylscopolamineMuscarinic acetylcholine receptor M2target
DB13500OtiloniumCytochrome P450 3A4enzyme
DB13581RociverineMuscarinic acetylcholine receptor M1target
DB13581RociverineMuscarinic acetylcholine receptor M2target
DB13581RociverineMuscarinic acetylcholine receptor M3target
DB13581RociverineMuscarinic acetylcholine receptor M4target
DB13581RociverineMuscarinic acetylcholine receptor M5target
DB13720DiphemanilMuscarinic acetylcholine receptor M3target
DB13835CaroverineCytochrome P450 3A4enzyme
DB00209TrospiumMuscarinic acetylcholine receptor M1target
DB00209TrospiumCytochrome P450 2D6enzyme
DB08810Cinitapride5-hydroxytryptamine receptor 1Atarget
DB08810Cinitapride5-hydroxytryptamine receptor 4target
DB08810Cinitapride5-hydroxytryptamine receptor 2Atarget