Drugs for Functional Gastrointestinal Disorders

Name
Drugs for Functional Gastrointestinal Disorders
Accession Number
DBCAT002215
Description
Not Available
ATC Classification
Drugs
DrugDrug Description
OxyphenoniumFor the treatment of visceral spasms
OxyphencyclimineFor the treatment of peptic ulcer disease and the relief of smooth muscle spasms in gastrointestinal disorders.
HyoscyamineFor treatment of bladder spasms, peptic ulcer disease, diverticulitis, colic, irritable bowel syndrome, cystitis, and pancreatitis. Also used to treat certain heart conditions, to control the symptoms of Parkinson's disease...
TridihexethylUsed as an adjunct in the treatment of peptic ulcer disease and in Acquired nystagmus
AtropineA muscarinic antagonist used to treat poisoning by muscarinic agents, including organophosphates and other drugs.
CisaprideA medication used to treat heartburn associated with GERD.
Homatropine methylbromideA muscarinic receptor antagonist used to treat peptic ulcers, gastric ulcers, and duodenal ulcers.
ClidiniumA synthetic anticholinergic used to treat peptic ulcer disease, colicky abdominal pain, diverticulitis, and IBS.
PropanthelineAn antimuscarinic agent used to treat urinary incontinence, hyperhidrosis, as well as cramps and spasms of the stomach, intestines, and bladder.
DicyclomineAn antimuscarinic agent used to treat IBS.
MethanthelineFor the treatment of peptic ulcer disease, irritable bowel syndrome, pancreatitis, gastritis, biliary dyskinesia, pylorosplasm, and reflex neurogenic bladder in children.
AlosetronA 5-HT3 antagonist used to treat diarrhea-predominant IBS.
GlycopyrroniumAn anticholinergic agent used to treat hyperhidrosis, severe drooling, COPD, used with other medications to treat ulcers, and used in anesthesia.
PapaverineAn alkaloid used to treat many types of smooth muscle spasms such as "vascular spasms" associated with acute myocardial infarction and angina pectoris, as well as "visceral spasms".
DomperidoneA dopamine receptor antagonist used as a peristaltic stimulant and anti-emetic agent for dyspepsia, indigestion, epigastric pain, nausea, and vomiting.
MetoclopramideAn antiemetic agent and dopamine D2 antagonist used in the treatment of gastroesophageal reflux disease, prevention of nausea and vomiting, and to stimulate gastric emptying.
AlizaprideAlizapride is used in the treatment of nausea and vomiting, including postoperative nausea and vomiting.
AlverineUsed to relieve cramps or spasms of the stomach and intestines. It is also useful in treating irritable bowel syndrome (IBS) and similar conditions. It can also be used to...
IsopropamideFor the treatment of a wide range of gastrointestinal disorders, including such conditions as peptic ulcer, gastritis, hyperchlorhydria, functional diarrhea, irritable or spastic colon, pyloroduodenal irritability, pylorospasm, acute nonspecific gastroenteritis,...
MepenzolateA postganglionic parasympathetic inhibitor that was previously approved for improving the healing of gastric ulcers, but has been discontinued.
CilansetronFor the treatment of symptoms associated with irritable bowel syndrome.
ItoprideInvestigated for use/treatment in gastrointestinal diseases and disorders (miscellaneous).
IsomethepteneIsometheptene is a sympathomimetic drug which causes vasoconstriction. It is used for treating migraines and tension headaches.
DrotaverineUsed in the treatment of functional bowel disorders and alleviating pain in renal colic.
HexocycliumThe World Health Organization classifies hexocyclium as a drug for functional gastrointestinal disorders . Like other anti-muscarinic agents, hexocyclium was likely used to treat peptic ulcers or diarrhea.
FentoniumFentonium is an atropine derivative.
BromoprideBromopride in indicated in the treatment of nausea and vomiting, including PONV (post-operative nausea and vomiting), gastroesophageal reflux disease (GERD/GORD), as well as endoscopy preparation and radiographic studies of the...
TrimebutineA spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and treatment of postoperative paralytic ileus following abdominal surgery.
PinaveriumA spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and functional disorders of the biliary tract.
CimetropiumCimetropium is a semi-synthetic belladonna alkaloid and derivative of scopolamine. It is a potent antimuscarinic and an effective antispasmodic drug. It is also endowed of a direct myolitic action which...
ButylscopolamineAn antispasmodic and anticholinergic agent used for the symptomatic treatment of abdominal cramping and pain.
MethscopolamineMethscopolamine is a quaternary ammonium derivative of scopolamine and antagonist at muscarininc (mACh) receptors. Methscopolamine bromide is the most common form of the active ingredient in oral pharmaceutical products. The...
MoxaverineMoxaverine has been investigated for the treatment of Retina, Ocular Physiology, and Regional Blood Flow.
MebeverineMebeverine has been investigated for the treatment of Irritable Bowel Syndrome and Post-cholecystectomy Gastrointestinal Spasms.
PhloroglucinolPhloroglucinol has been used in trials studying the diagnostic of Colonoscopy.
FenoverineFenoverine has been used in trials studying the treatment of Irritable Bowel Syndrome.
TiropramideTiropramide is under investigation in clinical trial NCT01629212 (Comparison of the Efficacy and Safety of Tiropramide and Octylonium in the Treatment of Irritable Bowel Syndrome).
PrifiniumPrifinium is an antimuscarinic agent with antispasmodic and antiemetic properties. It may be useful for the treatment of irritable bowel syndrome .
IdanpramineNot Annotated
TrepibutoneNot Annotated
PiperidolateNot Annotated
TrimethyldiphenylpropylamineNot Annotated
BenziloneNot Annotated
DifemerineNot Annotated
FenpipraneNot Annotated
DiisopromineNot Annotated
ValethamateNot Annotated
OtiloniumNot Annotated
PoldineNot Annotated
CleboprideNot Annotated
NicofetamideNot Annotated
BevoniumNot Annotated
RociverineNot Annotated
Tiemonium iodideNot Annotated
DimethylaminopropionylphenothiazineNot Annotated
DihexyverineNot Annotated
PenthienateNot Annotated
DiphemanilUsed in the treatment of peptic ulcer, gastric hyperacidity, and hypermotility in gastritis and pylorospasm, and in the treatment of hyperhidrosis (excessive perspiration).
CamylofinNot Annotated
FenpiveriniumNot Annotated
Emetonium iodideNot Annotated
ChlorbenzoxamineNot Annotated
ProxazoleNot Annotated
MethylatropineNot Annotated
CaroverineNot Annotated
PipenzolateNot Annotated
TimepidiumNot Annotated
TrospiumAn antimuscarinic agent used to treat the symptoms of overactive bladder (OAB).
EmeproniumNot Annotated
CinitaprideIt is indicated to treat gastrointestinal disorders associated with motility disturbances like gastroesophageal reflux disease (GERD), non-ulcer dyspepsia and delayed gastric emptying.
Drugs & Drug Targets
DrugTargetType
OxyphenoniumMuscarinic acetylcholine receptor M1target
OxyphencyclimineMuscarinic acetylcholine receptor M1target
OxyphencyclimineMuscarinic acetylcholine receptor M2target
OxyphencyclimineMuscarinic acetylcholine receptor M3target
HyoscyamineMuscarinic acetylcholine receptor M1target
HyoscyamineMuscarinic acetylcholine receptor M2target
HyoscyamineMuscarinic acetylcholine receptor M3target
HyoscyamineMuscarinic acetylcholine receptor M4target
TridihexethylMuscarinic acetylcholine receptor M1target
TridihexethylMuscarinic acetylcholine receptor M2target
TridihexethylMuscarinic acetylcholine receptor M3target
AtropineMuscarinic acetylcholine receptor M2target
AtropineMuscarinic acetylcholine receptor M1target
AtropineMuscarinic acetylcholine receptor M4target
AtropineMuscarinic acetylcholine receptor M5target
AtropineMuscarinic acetylcholine receptor M3target
AtropineGlycine receptor subunit alpha-1target
AtropineNeuronal acetylcholine receptor subunit alpha-4target
AtropineNeuronal acetylcholine receptor subunit beta-2target
AtropineBile salt export pumptransporter
Cisapride5-hydroxytryptamine receptor 4target
Cisapride5-hydroxytryptamine receptor 3Atarget
CisapridePotassium voltage-gated channel subfamily H member 2target
Cisapride5-hydroxytryptamine receptor 2Atarget
CisaprideCytochrome P450 3A4enzyme
CisaprideCytochrome P450 3A5enzyme
CisaprideCytochrome P450 3A7enzyme
CisaprideCytochrome P450 2A6enzyme
CisaprideCytochrome P450 2B6enzyme
CisaprideCytochrome P450 2C19enzyme
CisaprideCytochrome P450 2C8enzyme
CisaprideCytochrome P450 2C9enzyme
CisaprideCytochrome P450 2D6enzyme
Homatropine methylbromideMuscarinic acetylcholine receptor M2target
Homatropine methylbromideMuscarinic acetylcholine receptor M1target
Homatropine methylbromideMuscarinic acetylcholine receptor M4target
Homatropine methylbromideMuscarinic acetylcholine receptor M5target
Homatropine methylbromideMuscarinic acetylcholine receptor M3target
ClidiniumMuscarinic acetylcholine receptor M1target
PropanthelineMuscarinic acetylcholine receptor M1target
DicyclomineMuscarinic acetylcholine receptor M1target
DicyclomineMuscarinic acetylcholine receptor M2target
MethanthelineMuscarinic acetylcholine receptor M1target
MethanthelineHistamine H2 receptortarget
MethanthelineMuscarinic acetylcholine receptor M2target
MethanthelineMuscarinic acetylcholine receptor M3target
MethanthelineMuscarinic acetylcholine receptor M4target
MethanthelineMuscarinic acetylcholine receptor M5target
MethanthelineAcetylcholinesteraseenzyme
Alosetron5-hydroxytryptamine receptor 3Atarget
AlosetronCytochrome P450 1A2enzyme
AlosetronCytochrome P450 2C9enzyme
AlosetronCytochrome P450 3A4enzyme
AlosetronCytochrome P450 2E1enzyme
GlycopyrroniumMuscarinic acetylcholine receptor M1target
GlycopyrroniumMuscarinic acetylcholine receptor M3target
GlycopyrroniumMuscarinic acetylcholine receptor M2target
PapaverinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
PapaverinecAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Atarget
DomperidoneDopamine D2 receptortarget
DomperidoneCytochrome P450 3A4enzyme
DomperidoneCytochrome P450 3A5enzyme
DomperidoneCytochrome P450 3A7enzyme
DomperidoneP-glycoprotein 1transporter
DomperidoneCytochrome P450 1A2enzyme
DomperidoneCytochrome P450 2B6enzyme
DomperidoneCytochrome P450 2C8enzyme
DomperidoneCytochrome P450 2D6enzyme
DomperidoneDopamine D3 receptortarget
MetoclopramideMuscarinic acetylcholine receptor M1target
MetoclopramideDopamine D2 receptortarget
MetoclopramideCytochrome P450 2D6enzyme
Metoclopramide5-hydroxytryptamine receptor 4target
Metoclopramide5-hydroxytryptamine receptor 3Atarget
MetoclopramideCytochrome P450 3A4enzyme
MetoclopramideCytochrome P450 1A2enzyme
MetoclopramideP-glycoprotein 1transporter
MetoclopramideAlpha-1-acid glycoprotein 1carrier
AlizaprideDopamine D2 receptortarget
Alverine5-hydroxytryptamine receptor 1Atarget
IsopropamideMuscarinic acetylcholine receptor M3target
IsopropamideMuscarinic acetylcholine receptor M4target
MepenzolateMuscarinic acetylcholine receptor M1target
MepenzolateMuscarinic acetylcholine receptor M3target
Cilansetron5-hydroxytryptamine receptor 3Atarget
ItoprideDopamine D2 receptortarget
ItoprideAcetylcholinesterasetarget
IsomethepteneAlpha-1A adrenergic receptortarget
IsomethepteneSynaptic vesicular amine transportertarget
DrotaverinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DrotaverineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
HexocycliumMuscarinic acetylcholine receptor M1target
HexocycliumMuscarinic acetylcholine receptor M2target
HexocycliumMuscarinic acetylcholine receptor M3target
HexocycliumMuscarinic acetylcholine receptor M4target
BromoprideDopamine D2 receptortarget
TrimebutineMu-type opioid receptortarget
TrimebutineVoltage-dependent L-type calcium channeltarget
TrimebutineCalcium-activated potassium channeltarget
TrimebutineVoltage-dependent T-type calcium channeltarget
TrimebutineMuscarinic acetylcholine receptor M1target
TrimebutineMuscarinic acetylcholine receptor M2target
TrimebutineMuscarinic acetylcholine receptor M3target
TrimebutineMuscarinic acetylcholine receptor M4target
TrimebutineCytochrome P450 3A4enzyme
PinaveriumVoltage-dependent L-type calcium channel subunit alpha-1Starget
PinaveriumCytochrome P450 3A4enzyme
ButylscopolamineMuscarinic acetylcholine receptor M3target
ButylscopolamineMuscarinic acetylcholine receptor M2target
OtiloniumCytochrome P450 3A4enzyme
RociverineMuscarinic acetylcholine receptor M1target
RociverineMuscarinic acetylcholine receptor M2target
RociverineMuscarinic acetylcholine receptor M3target
RociverineMuscarinic acetylcholine receptor M4target
RociverineMuscarinic acetylcholine receptor M5target
DiphemanilMuscarinic acetylcholine receptor M3target
CaroverineCytochrome P450 3A4enzyme
TrospiumMuscarinic acetylcholine receptor M1target
TrospiumCytochrome P450 2D6enzyme
TrospiumMuscarinic acetylcholine receptor M3target
Cinitapride5-hydroxytryptamine receptor 1Atarget
Cinitapride5-hydroxytryptamine receptor 4target
Cinitapride5-hydroxytryptamine receptor 2Atarget