Drugs for Functional Gastrointestinal Disorders

DrugDrug NameDrug Indication
DB00219OxyphenoniumFor the treatment of visceral spasms
DB00383OxyphencyclimineFor the treatment of peptic ulcer disease and the relief of smooth muscle spasms in gastrointestinal disorders.
DB00424HyoscyamineFor treatment of bladder spasms, peptic ulcer disease, diverticulitis, colic, irritable bowel syndrome, cystitis, and pancreatitis. Also used to treat certain heart conditions, to control the symptoms of Parkinson's disease and rhinitis.
DB00505TridihexethylUsed as an adjunct in the treatment of peptic ulcer disease and in Acquired nystagmus
DB00572AtropineFor the treatment of poisoning by susceptible organophosphorous nerve agents having anti-cholinesterase activity (cholinesterase inhibitors) as well as organophosphorous or carbamate insecticides.
DB00604CisaprideFor the symptomatic treatment of adult patients with nocturnal heartburn due to gastroesophageal reflux disease.
DB00725Homatropine methylbromideUsed in conjunction with antacids or histamine H2-receptor antagonists in the treatment of peptic ulcers, gastric ulcers and duodenal ulcers, to reduce further gastric acid secretion and delay gastric emptying.
DB00771ClidiniumFor the treatment of peptic ulcer disease and also to help relieve abdominal or stomach spasms or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome.
DB00782PropanthelineFor the treatment of enuresis. It has also been used for hyperhidrosis, and cramps or spasms of the stomach, intestines or bladder.
DB00804DicyclomineFor the treatment of functional bowel/irritable bowel syndrome including Colicky abdominal pain; diverticulitis
DB00940MethanthelineFor the treatment of peptic ulcer disease, irritable bowel syndrome, pancreatitis, gastritis, biliary dyskinesia, pylorosplasm, and reflex neurogenic bladder in children.
DB00969AlosetronOnly for the treatment of symptoms of severe diarrhea-predominant irritable bowel syndrome (IBS) in women with chronic symptoms (generally lasting greater than 6 months) who does not present with anatomic or biochemical GI abnormalities and have not responded to conventional therapy.
DB00986GlycopyrroniumFor use as a preoperative antimuscarinic to reduce salivary, tracheobronchial, and pharyngeal secretions, to reduce the volume and free acidity of gastric secretions and to block cardiac vagal inhibitory reflexes during induction of anesthesia and intubation. Also used to treat chronic obstructive pulmonary disease (COPD).
DB01113PapaverineFor the treatment of impotence and vasospasms.
DB01184DomperidoneFor management of dyspepsia, heartburn, epigastric pain, nausea, and vomiting.
DB01233MetoclopramideFor the treatment of gastroesophageal reflux disease (GERD). It is also used in treating nausea and vomiting, and to increase gastric emptying.
DB01425AlizaprideAlizapride is used in the treatment of nausea and vomiting, including postoperative nausea and vomiting.
DB01616AlverineUsed to relieve cramps or spasms of the stomach and intestines. It is also useful in treating irritable bowel syndrome (IBS) and similar conditions. It can also be used to help relieve period pain. Alverine citrate is also under investigation to increase the cytotoxic effects of the proteasome inhibitor MG132 on breast cancer cells.
DB01625IsopropamideFor the treatment of a wide range of gastrointestinal disorders, including such conditions as peptic ulcer, gastritis, hyperchlorhydria, functional diarrhea, irritable or spastic colon, pyloroduodenal irritability, pylorospasm, acute nonspecific gastroenteritis, biliary dyskinesia and chronic cholelithiasis, duodenitis, gastrointestinal spasm; it may also be used to treat genitourinary spasm.
DB04843MepenzolateFor use as adjunctive therapy in the treatment of peptic ulcer. It has not been shown to be effective in contributing to the healing of peptic ulcer, decreasing the rate of recurrence, or preventing complications.
DB04885CilansetronFor the treatment of symptoms associated with irritable bowel syndrome.
DB04924ItoprideInvestigated for use/treatment in gastrointestinal diseases and disorders (miscellaneous).
DB06706IsomethepteneIsometheptene is a sympathomimetic drug which causes vasoconstriction. It is used for treating migraines and tension headaches.
DB06751DrotaverineUsed in the treatment of functional bowel disorders and alleviating pain in renal colic.
DB06787HexocycliumThe World Health Organization classifies hexocyclium as a drug for functional gastrointestinal disorders [L876]. Like other anti-muscarinic agents, hexocyclium was likely used to treat peptic ulcers or diarrhea.
DB08978FentoniumNot Available
DB09018BromoprideBromopride in indicated in the treatment of nausea and vomiting, including PONV (post-operative nausea and vomiting), gastroesophageal reflux disease (GERD/GORD), as well as endoscopy preparation and radiographic studies of the GI tract.
DB09089TrimebutineIndicated for symptomatic treatment of irritable bowel syndrome (IBS) and treatment of postoperative paralytic ileus following abdominal surgery.
DB09090PinaveriumPinaverium is indicated for the symptomatic treatment of irritable bowel syndrome (IBS) and functional disorders of the biliary tract.
DB09271CimetropiumNot Available
DB09300ButylscopolamineUsed to treat abdmoninal cramping and pain [FDA Label].
DB11315MethscopolamineNot Available
DB12251MoxaverineNot Available
DB12554MebeverineNot Available
DB12944PhloroglucinolNot Available
DB13042FenoverineNot Available
DB13091TiropramideNot Available
DB13254PrifiniumNot Available
DB13276IdanpramineNot Available
DB13311TrepibutoneNot Available
DB13351PiperidolateNot Available
DB13361TrimethyldiphenylpropylamineNot Available
DB13369BenziloneNot Available
DB13380DifemerineNot Available
DB13439FenpipraneNot Available
DB13476DiisopromineNot Available
DB13497ValethamateNot Available
DB13500OtiloniumNot Available
DB13507PoldineNot Available
DB13511CleboprideNot Available
DB13531NicofetamideNot Available
DB13542BevoniumNot Available
DB13581RociverineNot Available
DB13666Tiemonium iodideNot Available
DB13672DimethylaminopropionylphenothiazineNot Available
DB13678DihexyverineNot Available
DB13695PenthienateNot Available
DB13720DiphemanilUsed in the treatment of peptic ulcer, gastric hyperacidity, and hypermotility in gastritis and pylorospasm, and in the treatment of hyperhidrosis (excessive perspiration).
DB13738CamylofinNot Available
DB13759FenpiveriniumNot Available
DB13769Emetonium iodideNot Available
DB13788ChlorbenzoxamineNot Available
DB13819ProxazoleNot Available
DB13833MethylatropineNot Available
DB13835CaroverineNot Available
DB13844PipenzolateNot Available
DB13850TimepidiumNot Available
DB00209TrospiumFor the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency, detrusor instability and frequency of micturition.
DB13505EmeproniumNot Available
DB08810CinitaprideIt is indicated to treat gastrointestinal disorders associated with motility disturbances like gastroesophageal reflux disease (GERD), non-ulcer dyspepsia and delayed gastric emptying.
DrugDrug NameTargetType
DB00219OxyphenoniumMuscarinic acetylcholine receptor M1target
DB00383OxyphencyclimineMuscarinic acetylcholine receptor M1target
DB00383OxyphencyclimineMuscarinic acetylcholine receptor M2target
DB00383OxyphencyclimineMuscarinic acetylcholine receptor M3target
DB00424HyoscyamineMuscarinic acetylcholine receptor M1target
DB00424HyoscyamineMuscarinic acetylcholine receptor M2target
DB00424HyoscyamineMuscarinic acetylcholine receptor M3target
DB00424HyoscyamineMuscarinic acetylcholine receptor M4target
DB00505TridihexethylMuscarinic acetylcholine receptor M1target
DB00505TridihexethylMuscarinic acetylcholine receptor M2target
DB00505TridihexethylMuscarinic acetylcholine receptor M3target
DB00572AtropineMuscarinic acetylcholine receptor M2target
DB00572AtropineMuscarinic acetylcholine receptor M1target
DB00572AtropineMuscarinic acetylcholine receptor M4target
DB00572AtropineMuscarinic acetylcholine receptor M5target
DB00572AtropineMuscarinic acetylcholine receptor M3target
DB00572AtropineGlycine receptor subunit alpha-1target
DB00572AtropineNeuronal acetylcholine receptor subunit alpha-4target
DB00572AtropineNeuronal acetylcholine receptor subunit beta-2target
DB00572AtropineBile salt export pumptransporter
DB00604Cisapride5-hydroxytryptamine receptor 4target
DB00604Cisapride5-hydroxytryptamine receptor 3Atarget
DB00604CisapridePotassium voltage-gated channel subfamily H member 2target
DB00604Cisapride5-hydroxytryptamine receptor 2Atarget
DB00604CisaprideCytochrome P450 3A4enzyme
DB00604CisaprideCytochrome P450 3A5enzyme
DB00604CisaprideCytochrome P450 3A7enzyme
DB00604CisaprideCytochrome P450 2A6enzyme
DB00604CisaprideCytochrome P450 2B6enzyme
DB00604CisaprideCytochrome P450 2C19enzyme
DB00604CisaprideCytochrome P450 2C8enzyme
DB00604CisaprideCytochrome P450 2C9enzyme
DB00604CisaprideCytochrome P450 2D6enzyme
DB00725Homatropine methylbromideMuscarinic acetylcholine receptor M2target
DB00725Homatropine methylbromideMuscarinic acetylcholine receptor M1target
DB00725Homatropine methylbromideMuscarinic acetylcholine receptor M4target
DB00725Homatropine methylbromideMuscarinic acetylcholine receptor M5target
DB00725Homatropine methylbromideMuscarinic acetylcholine receptor M3target
DB00771ClidiniumMuscarinic acetylcholine receptor M1target
DB00782PropanthelineMuscarinic acetylcholine receptor M1target
DB00804DicyclomineMuscarinic acetylcholine receptor M1target
DB00804DicyclomineMuscarinic acetylcholine receptor M2target
DB00804DicyclomineCytochrome P450 1A1enzyme
DB00940MethanthelineMuscarinic acetylcholine receptor M1target
DB00940MethanthelineHistamine H2 receptortarget
DB00969Alosetron5-hydroxytryptamine receptor 3Atarget
DB00969AlosetronCytochrome P450 1A2enzyme
DB00969AlosetronCytochrome P450 2C9enzyme
DB00969AlosetronCytochrome P450 3A4enzyme
DB00969AlosetronCytochrome P450 2E1enzyme
DB00986GlycopyrroniumMuscarinic acetylcholine receptor M1target
DB00986GlycopyrroniumMuscarinic acetylcholine receptor M3target
DB00986GlycopyrroniumMuscarinic acetylcholine receptor M2target
DB01113PapaverinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB01113PapaverinecAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Atarget
DB01184DomperidoneD(2) dopamine receptortarget
DB01184DomperidoneCytochrome P450 3A4enzyme
DB01184DomperidoneCytochrome P450 3A5enzyme
DB01184DomperidoneCytochrome P450 3A7enzyme
DB01184DomperidoneMultidrug resistance protein 1transporter
DB01184DomperidoneCytochrome P450 1A2enzyme
DB01184DomperidoneCytochrome P450 2B6enzyme
DB01184DomperidoneCytochrome P450 2C8enzyme
DB01184DomperidoneCytochrome P450 2D6enzyme
DB01184DomperidoneD(3) dopamine receptortarget
DB01233MetoclopramideMuscarinic acetylcholine receptor M1target
DB01233MetoclopramideD(2) dopamine receptortarget
DB01233MetoclopramideCytochrome P450 2D6enzyme
DB01233Metoclopramide5-hydroxytryptamine receptor 4target
DB01233MetoclopramideCytochrome P450 11B1, mitochondrialenzyme
DB01233MetoclopramideCytochrome P450 11B2, mitochondrialenzyme
DB01233MetoclopramideSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
DB01233Metoclopramide5-hydroxytryptamine receptor 3Atarget
DB01233MetoclopramideAcetylcholinesterasetarget
DB01425AlizaprideD(2) dopamine receptortarget
DB01616Alverine5-hydroxytryptamine receptor 1Atarget
DB01625IsopropamideMuscarinic acetylcholine receptor M3target
DB01625IsopropamideMuscarinic acetylcholine receptor M4target
DB04843MepenzolateMuscarinic acetylcholine receptor M1target
DB04843MepenzolateMuscarinic acetylcholine receptor M3target
DB04885Cilansetron5-hydroxytryptamine receptor 3Atarget
DB04924ItoprideD(2) dopamine receptortarget
DB04924ItoprideAcetylcholinesterasetarget
DB06706IsomethepteneAlpha-1A adrenergic receptortarget
DB06706IsomethepteneSynaptic vesicular amine transportertarget
DB06751DrotaverinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DB06751DrotaverineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB06787HexocycliumMuscarinic acetylcholine receptor M1target
DB06787HexocycliumMuscarinic acetylcholine receptor M2target
DB06787HexocycliumMuscarinic acetylcholine receptor M3target
DB06787HexocycliumMuscarinic acetylcholine receptor M4target
DB09018BromoprideD(2) dopamine receptortarget
DB09089TrimebutineMu-type opioid receptortarget
DB09089TrimebutineVoltage-dependent L-type calcium channeltarget
DB09089TrimebutineCalcium-activated potassium channeltarget
DB09089TrimebutineVoltage-dependent T-type calcium channeltarget
DB09089TrimebutineMuscarinic acetylcholine receptor M1target
DB09089TrimebutineMuscarinic acetylcholine receptor M2target
DB09089TrimebutineMuscarinic acetylcholine receptor M3target
DB09089TrimebutineMuscarinic acetylcholine receptor M4target
DB09089TrimebutineCytochrome P450 3A4enzyme
DB09090PinaveriumVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB09090PinaveriumCytochrome P450 3A4enzyme
DB09300ButylscopolamineMuscarinic acetylcholine receptor M3target
DB09300ButylscopolamineMuscarinic acetylcholine receptor M2target
DB13500OtiloniumCytochrome P450 3A4enzyme
DB13581RociverineMuscarinic acetylcholine receptor M1target
DB13581RociverineMuscarinic acetylcholine receptor M2target
DB13581RociverineMuscarinic acetylcholine receptor M3target
DB13581RociverineMuscarinic acetylcholine receptor M4target
DB13581RociverineMuscarinic acetylcholine receptor M5target
DB13720DiphemanilMuscarinic acetylcholine receptor M3target
DB13835CaroverineCytochrome P450 3A4enzyme
DB00209TrospiumMuscarinic acetylcholine receptor M1target
DB00209TrospiumCytochrome P450 2D6enzyme
DB08810Cinitapride5-hydroxytryptamine receptor 1Atarget
DB08810Cinitapride5-hydroxytryptamine receptor 4target
DB08810Cinitapride5-hydroxytryptamine receptor 2Atarget