Fluoroquinolones

Name
Fluoroquinolones
Accession Number
DBCAT002228  (DBCAT000902)
Description

A group of QUINOLONES with at least one fluorine atom and a piperazinyl group.

ATC Classification
Drugs
DrugDrug Description
Technetium Tc-99m ciprofloxacinInvestigated for use/treatment in infectious and parasitic disease (unspecified).
OrbifloxacinOrbifloxacin is a fluoroquinolone antibiotic. It is marketed by Schering-Plough Animal Health and approved for certain infections in dogs.
SarafloxacinSarafloxacin is a quinolone antibiotic drug, which was discontinued by its manufacturer, Abbott Laboratories, before receiving approval for use in the US or Canada.
DifloxacinDifloxacin is a synthetic fluoroquinolone used in veterinary. As an antibacterial, it presents a broad bactericidal spectrum and its effects are dependent on its concentration. However, it presents a reduced...
GrepafloxacinA fluoroquinolone antibiotic used to treat various gram positive and gram negative bacterial infections.
EnoxacinFor the treatment of adults (≥18 years of age) with the following infections caused by susceptible strains of the designated microorganisms: (1) uncomplicated urethral or cervical gonorrhea due to Neisseria...
PefloxacinFor the treatment of uncomplicated gonococcal urethritis in males and for gram-negative-bacterial infections in the gastrointestinal system and the genitourinary tract.
TrovafloxacinAn antibiotic used to treat gonorrhea and chlamydia.
Nalidixic acidA quinolone antibiotic used to treat urinary tract infections.
RosoxacinFor the treatment of bacterial infection of respiratory tract, urinary tract, GI, CNS and immuno compromised patients.
CinoxacinFor the treatment of initial and recurrent urinary tract infections in adults caused by the following susceptible microorganisms: Escherichia coli, Proteus mirabilis, Proteus vulgaris, Klebsiella species (including K. pneumoniae), and...
GatifloxacinA fourth generation fluoroquinolone used to treat a wide variety of infections in the body.
NorfloxacinA broad-spectrum fluoroquinolone antibiotic with variable activity against gram-positive and gram-negative bacteria. Typically reserved for the treatment of UTIs due to accumulation in the urine.
LevofloxacinA fluoroquinolone antibiotic used to treat infections caused by susceptible bacteria of the upper respiratory tract, skin and skin structures, urinary tract, and prostate, as well as for post-exposure treatment of inhaled anthrax and the plague.
GemifloxacinA quinolone antibacterial agent used for the treatment of acute bacterial exacerbation of chronic bronchitis and mild to moderate community-acquired pneumonia caused by susceptible bacteria.
TemafloxacinFor the treatment of lower respiratory tract infections, genital and urinary infections like prostatitis, and skin infections.
FleroxacinFleroxacin is a broad-spectrum antimicrobial fluoroquinolone.
GarenoxacinInvestigated for use/treatment in bacterial infection.
NemonoxacinInvestigated for use/treatment in bacterial infection and pneumonia.
BesifloxacinA fluoroquinolone antibiotic agent used for the treatment of bacterial conjunctivitis.
FlumequineFlumequine is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class used to treat bacterial infections.
PazufloxacinPazufloxacin is under investigation in clinical trial NCT02592096 (Pazufloxacin Mesilate Ear Drops Clinical Trial Protocol).
PrulifloxacinPrulifloxacin has been investigated for the treatment of Urinary Tract Infection.
SitafloxacinNot Annotated
Oxolinic acidNot Annotated
RufloxacinRufloxacin is a quinolone antibiotic.
Pipemidic acidNot Annotated
MoxifloxacinA fluoroquinolone antibiotic used to treat various bacterial infections.
CiprofloxacinA second generation fluoroquinolone used to treat various susceptible bacterial infections.
LomefloxacinA fluoroquinolone used to prevent and treat a wide variety of infections in the body.
OfloxacinAn antibacterial agent used for the treatment of bacterial infections in many parts of the body, including the respiratory tract, kidney, skin, soft tissue, and urinary tract.
SparfloxacinFor the treatment of adults with the following infections caused by susceptible strains microorganisms: community-acquired pneumonia (caused by Chlamydia pneumoniae, Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella catarrhalis, Mycoplasma pneumoniae, or Streptococcus...
DelafloxacinA fluoroquinolone antibiotic used to treat skin and skin structure infections.
FinafloxacinFinafloxacin is indicated for the treatment of acute otitis externa (AOE) with or without an otowick, caused by susceptible strains of Pseudomonas aeruginosa and Staphylococcus aureus in patients age 1...
EnrofloxacinEnrofloxacin is an antibiotic agent from the fluoroquinolone family produced by the Bayer Corporation. Enrofloxacin is approved by the FDA for its veterinary use. Due to the identification of fluoroquinolone-resistant...
PradofloxacinPradofloxacin is a 3rd generation fluoroquinolone antibiotic developed by Bayer HealthCare AG, Animal Health GmBH. It was approved by the European Commission in April 2011 for bacterial infections in dogs...
Drugs & Drug Targets
DrugTargetType
Technetium Tc-99m ciprofloxacinDNA gyrase subunit Btarget
Technetium Tc-99m ciprofloxacinDNA topoisomerase 2-betatarget
Technetium Tc-99m ciprofloxacinCytochrome P450 1A2enzyme
OrbifloxacinCytochrome P450 1A2enzyme
SarafloxacinCytochrome P450 1A2enzyme
DifloxacinCytochrome P450 1A2enzyme
DifloxacinCytochrome P450 1A1enzyme
GrepafloxacinDNA gyrase subunit Atarget
GrepafloxacinDNA topoisomerase 4 subunit Atarget
GrepafloxacinCytochrome P450 3A4enzyme
GrepafloxacinCytochrome P450 1A2enzyme
GrepafloxacinSolute carrier family 22 member 2transporter
GrepafloxacinSolute carrier family 22 member 5transporter
GrepafloxacinCanalicular multispecific organic anion transporter 1transporter
GrepafloxacinP-glycoprotein 1transporter
GrepafloxacinMultidrug resistance-associated protein 1transporter
GrepafloxacinSolute carrier family 22 member 6transporter
EnoxacinDNA gyrase subunit Atarget
EnoxacinDNA topoisomerase 4 subunit Atarget
EnoxacinDNA topoisomerase 2-alphatarget
EnoxacinCytochrome P450 1A2enzyme
PefloxacinDNA gyrase subunit Atarget
PefloxacinDNA topoisomerase 4 subunit Atarget
PefloxacinDNA topoisomerase 2-alphatarget
PefloxacinCytochrome P450 1A2enzyme
PefloxacinDNA topoisomerase 1target
TrovafloxacinDNA gyrase subunit Atarget
TrovafloxacinDNA topoisomerase 4 subunit Atarget
TrovafloxacinDNA topoisomerase 2-alphatarget
TrovafloxacinCytochrome P450 1A2enzyme
Nalidixic acidDNAtarget
Nalidixic acidSolute carrier family 22 member 6transporter
Nalidixic acidTryptophan 2,3-dioxygenaseenzyme
Nalidixic acidCytochrome P450 1A2enzyme
RosoxacinDNA topoisomerase 4 subunit Atarget
RosoxacinDNA gyrase subunit Btarget
RosoxacinCytochrome P450 1A2enzyme
CinoxacinDNAtarget
CinoxacinDNA gyrase subunit Atarget
CinoxacinSolute carrier family 22 member 6transporter
CinoxacinCytochrome P450 1A2enzyme
GatifloxacinSerum albumincarrier
GatifloxacinDNA gyrase subunit Atarget
GatifloxacinDNA gyrase subunit Btarget
GatifloxacinDNA topoisomerase 4 subunit Atarget
GatifloxacinDNA topoisomerase 4 subunit Btarget
GatifloxacinCytochrome P450 1A2enzyme
NorfloxacinDNA gyrase subunit Atarget
NorfloxacinDNA topoisomerase 4 subunit Atarget
NorfloxacinDNA topoisomerase 2-alphatarget
NorfloxacinCytochrome P450 1A2enzyme
NorfloxacinCytochrome P450 3A4enzyme
NorfloxacinSolute carrier family 22 member 5transporter
NorfloxacinSolute carrier family 22 member 6transporter
NorfloxacinCytochrome P450 1A1enzyme
LevofloxacinDNA gyrase subunit Atarget
LevofloxacinDNA topoisomerase 4 subunit Atarget
LevofloxacinCytochrome P450 1A2enzyme
LevofloxacinSolute carrier family 22 member 2transporter
LevofloxacinP-glycoprotein 1transporter
LevofloxacinSolute carrier family 22 member 4transporter
LevofloxacinMultidrug and toxin extrusion protein 1transporter
LevofloxacinMultidrug and toxin extrusion protein 2transporter
LevofloxacinCytochrome P450 2C9enzyme
LevofloxacinSerum albumincarrier
LevofloxacinSolute carrier organic anion transporter family member 4C1transporter
LevofloxacinSolute carrier family 22 member 1transporter
LevofloxacinSolute carrier organic anion transporter family member 1A2transporter
GemifloxacinDNA gyrase subunit Atarget
GemifloxacinDNA topoisomerase 4 subunit Atarget
GemifloxacinCytochrome P450 1A2enzyme
TemafloxacinDNA gyrase subunit Atarget
TemafloxacinDNA topoisomerase 4 subunit Atarget
TemafloxacinCytochrome P450 1A2enzyme
FleroxacinDNA topoisomerase 2-alphatarget
FleroxacinDNA gyrase subunit Atarget
FleroxacinDNA topoisomerase 4 subunit Atarget
GarenoxacinCytochrome P450 1A2enzyme
NemonoxacinCytochrome P450 1A2enzyme
BesifloxacinDNA topoisomerase 4 subunit Atarget
BesifloxacinDNA topoisomerase 4 subunit Atarget
BesifloxacinDNA gyrase subunit Atarget
BesifloxacinDNA gyrase subunit Atarget
BesifloxacinCytochrome P450 1A2enzyme
FlumequineCytochrome P450 1A2enzyme
PazufloxacinCytochrome P450 1A2enzyme
PrulifloxacinCytochrome P450 1A2enzyme
SitafloxacinCytochrome P450 1A2enzyme
Oxolinic acidCytochrome P450 1A2enzyme
RufloxacinCytochrome P450 1A2enzyme
Pipemidic acidCytochrome P450 1A2enzyme
MoxifloxacinDNA gyrase subunit Atarget
MoxifloxacinDNA topoisomerase 4 subunit Atarget
MoxifloxacinDNA topoisomerase 2-alphatarget
MoxifloxacinCytochrome P450 1A2enzyme
CiprofloxacinDNA gyrase subunit Atarget
CiprofloxacinDNA topoisomerase 4 subunit Atarget
CiprofloxacinDNA topoisomerase 2-alphatarget
CiprofloxacinCytochrome P450 1A2enzyme
CiprofloxacinCytochrome P450 3A4enzyme
CiprofloxacinCytochrome P450 3A5enzyme
CiprofloxacinCytochrome P450 3A7enzyme
CiprofloxacinP-glycoprotein 1transporter
CiprofloxacinPotassium voltage-gated channel subfamily H member 2target
CiprofloxacinDNA gyrase subunit Atarget
CiprofloxacinDNA topoisomerase 4 subunit Atarget
CiprofloxacinDNA topoisomerase 4 subunit Btarget
CiprofloxacinDNA gyrase subunit Atarget
CiprofloxacinMultidrug resistance protein MdtKtarget
CiprofloxacinGyrase Atarget
CiprofloxacinDNA gyrase subunit Atarget
CiprofloxacinMultidrug and toxin extrusion protein 1transporter
CiprofloxacinMultidrug and toxin extrusion protein 2transporter
CiprofloxacinSerum albumincarrier
LomefloxacinDNA gyrase subunit Atarget
LomefloxacinDNA topoisomerase 4 subunit Atarget
LomefloxacinDNA topoisomerase 2-alphatarget
LomefloxacinCytochrome P450 1A2enzyme
LomefloxacinSolute carrier family 22 member 5transporter
LomefloxacinCanalicular multispecific organic anion transporter 1transporter
OfloxacinDNA gyrase subunit Atarget
OfloxacinDNA topoisomerase 4 subunit Atarget
OfloxacinDNA topoisomerase 2-alphatarget
OfloxacinCytochrome P450 1A2enzyme
OfloxacinSolute carrier family 22 member 5transporter
OfloxacinMultidrug resistance-associated protein 1transporter
OfloxacinSolute carrier family 22 member 6transporter
OfloxacinCanalicular multispecific organic anion transporter 1transporter
OfloxacinSolute carrier family 22 member 4transporter
OfloxacinBile salt export pumptransporter
SparfloxacinDNA gyrase subunit Atarget
SparfloxacinDNA topoisomerase 4 subunit Atarget
SparfloxacinDNA topoisomerase 2-alphatarget
SparfloxacinSolute carrier family 22 member 5transporter
SparfloxacinCanalicular multispecific organic anion transporter 1transporter
SparfloxacinP-glycoprotein 1transporter
SparfloxacinCytochrome P450 1A2enzyme
DelafloxacinUDP-glucuronosyltransferase 1-1enzyme
DelafloxacinUDP-glucuronosyltransferase 1-3enzyme
DelafloxacinUDP-glucuronosyltransferase 2B15enzyme
DelafloxacinDNA topoisomerase 4 subunit Atarget
DelafloxacinDNA gyrase subunit Atarget
DelafloxacinCytochrome P450 2E1enzyme
DelafloxacinCytochrome P450 2C9enzyme
DelafloxacinCytochrome P450 3A4enzyme
DelafloxacinATP-binding cassette sub-family B member 5transporter
DelafloxacinATP-binding cassette sub-family G member 2transporter
DelafloxacinSerum albumincarrier
FinafloxacinDNA gyrase subunit Atarget
FinafloxacinDNA topoisomerase 4 subunit Atarget
FinafloxacinDNA topoisomerase 2-alphatarget
EnrofloxacinCytochrome P450 1A2enzyme