Antidiarrheals, Intestinal Antiinflammatory/antiinfective Agents

DrugDrug NameDrug Description
DB00635PrednisoneA corticosteroid used to treat inflammation or immune-mediated reactions and to treat endocrine or neoplastic diseases.
DB00681Amphotericin BAn antifungal used to treat fungal infections in neutropenic patients, cryptococcal meningitis in HIV infection, fungal infections, and leishmaniasis.
DB00836LoperamideA long acting antidiarrheal used to control nonspecific diarrhea and chronic diarrhea caused by inflammatory bowel disease, or gastroenteritis.
DB01014BalsalazideAn aminosalicylate used to treat ulcerative colitis.
DB01081DiphenoxylateAn antidiarrheal medication used with atropine to manage diarrhea.
DB01082StreptomycinAn aminoglycoside antibiotic indicated to treat mycobacterium tuberculosis and various non-tuberculosis infections.
DB01220RifaximinA rifamycin-based non-systemic antibiotic used for the treatment of gastrointestinal bacterial infections, such as traveler's diarrhea and irritable bowel syndrome, and reduction of overt hepatic encephalopathy recurrence in adults.
DB01250OlsalazineAn anti-inflammatory agent used in the treatment of inflammatory bowel disease and ulcerative colitis.
DB01421ParomomycinAn aminoglycoside antibiotic used in the treatment of acute and chronic intestinal amebiasis, and as an adjunct for the management of hepatic coma.
DB01501DifenoxinAn antidiarrheal agent used as an adjunct for the management of acute nonspecific diarrhea and acute exacerbations of chronic functional diarrhea.
DB01574AttapulgiteA veterinary antidiarrheal agent used to treat non-infectious diarrhea in animals.
DB01575KaolinA natural ingredient used for the short-term symptomatic treatment of various conditions including diarrhea, skin dryness, and minor skin bleeding.
DB08874FidaxomicinA macrolide antibiotic used to treat diarrhea associated with Clostridium difficile.
DB09278Activated charcoalA gastric decontamination agent used in emergency clinical settings as a antidote to treat poisonings following excessive oral ingestion of certain medications or poisons.
DB11130OpiumA medication used to treat moderate to severe pain.
DB11158PectinPectin is used in food as a gelling agent and stabilizer. As a medical drug, it has obtained a great interest in its potential use as a source of dietary...
DB11696RacecadotrilRacecadotril has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and Acute Gastroenteritis.
DB13248PhthalylsulfathiazolePhthalylsulfathiazole is a broad spectrum antibiotic which is part of the drug class, sulfonamides. It was used as an antibiotic for bowel surgery, and for infections of the colon .
DB13268AcetarsolAn anti infective used to treat a wide variety of infections in the body.
DB13325NifurzideNot Annotated
DB13536BroxyquinolineNot Annotated
DB13580SuccinylsulfathiazoleNot Annotated
DB13654MontmorilloniteNot Annotated
DB13726SulfaguanidineNot Annotated
DB13855NifuroxazideNot Annotated
DB00394Beclomethasone dipropionateAn inhaled corticosteroid used as maintenance treatment in the prophylaxis of asthma attacks.
DB00443BetamethasoneA systemic corticosteroid used to relieve inflammation in various conditions, including but not limited to allergic states, dermatologic disorders, gastrointestinal diseases, and hematological disorders.
DB00512VancomycinA glycopeptide antibiotic used to treat severe but susceptible bacterial infections such as MRSA (methicillin-resistant Staphylococcus aureus) infections.
DB00646NystatinA polyene antifungal used to treat cutaneous and mucocutaneous mycotic infections.
DB00741HydrocortisoneA glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders.
DB00795SulfasalazineAn anti-inflammatory drug used to treat Crohn's disease and rheumatoid arthritis.
DB00803ColistinA polymyxin antibiotic used to treat bacterial infections caused by susceptible Gram negative bacteria.
DB00826NatamycinA macrolide antifungal used to treat fungal infections of the eye.
DB00860PrednisoloneA glucocorticoid used to treat adrenocortical insufficiency, inflammatory conditions, and some cancers.
DB00994NeomycinAn aminoglycoside used to treat a wide variety of infections in the body.
DB01003Cromoglicic acidA medication used to treat asthma, allergic reactions of the eyes and nose, as well as other mast cell reactions.
DB01110MiconazoleAn antifungal used to treat fungal infections affecting the vagina, mouth and skin.
DB01172KanamycinAn aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria.
DB01222BudesonideA corticosteroid used in the management of asthma, nasal polyposis, and rhinitis via inhalation, as well as mild to moderate active Crohn's disease and ulcerative colitis via ingestion.
DB09091TixocortolA corticosteroid used for the symptomatic treatment of rhinitis, pharyngitis, and ulcerative colitis.
DB14661Loperamide oxideNot Annotated
DB04941CrofelemerAn antidiarrheal agent used for the symptomatic relief of drug-induced non-infectious diarrhea in adult patients with HIV/AIDS receiving antiretroviral therapy.
DB09272EluxadolineA mixed mu-opioid receptor agonist used to treat irritable bowel syndrome with diarrhea.
DB00781Polymyxin BA polymyxin antibiotic used to treat a wide variety of infections in the body.
DrugDrug NameTargetType
DB00635PrednisoneGlucocorticoid receptortarget
DB00635PrednisoneCytochrome P450 3A4enzyme
DB00635PrednisoneP-glycoprotein 1transporter
DB00635PrednisoneSolute carrier organic anion transporter family member 1A2transporter
DB00635PrednisoneCytochrome P450 2C19enzyme
DB00635PrednisoneSerum albumincarrier
DB00635PrednisoneCorticosteroid 11-beta-dehydrogenase isozyme 1target
DB00635PrednisoneCytochrome P450 3A5enzyme
DB00681Amphotericin BErgosteroltarget
DB00681Amphotericin BCytochrome P450 3A4enzyme
DB00836LoperamideVoltage-dependent P/Q-type calcium channel subunit alpha-1Atarget
DB00836LoperamideMu-type opioid receptortarget
DB00836LoperamideCalmodulintarget
DB00836LoperamidePro-opiomelanocortintarget
DB00836LoperamideDelta-type opioid receptortarget
DB00836LoperamideCytochrome P450 3A4enzyme
DB00836LoperamideP-glycoprotein 1transporter
DB00836LoperamideKappa-type opioid receptortarget
DB00836LoperamideCytochrome P450 2C8enzyme
DB00836LoperamideCytochrome P450 2B6enzyme
DB00836LoperamideCytochrome P450 2D6enzyme
DB00836LoperamideNuclear receptor subfamily 1 group I member 3target
DB01014BalsalazideProstaglandin G/H synthase 1target
DB01014BalsalazideProstaglandin G/H synthase 2target
DB01014BalsalazideArachidonate 5-lipoxygenasetarget
DB01014BalsalazidePeroxisome proliferator-activated receptor gammatarget
DB01014BalsalazideNADPH azoreductaseenzyme
DB01081DiphenoxylateMu-type opioid receptortarget
DB01081DiphenoxylateDelta-type opioid receptortarget
DB01082Streptomycin30S ribosomal protein S12target
DB01082Streptomycin16S ribosomal RNAtarget
DB01082StreptomycinSolute carrier family 22 member 6transporter
DB01082StreptomycinProtein-arginine deiminase type-4target
DB01220RifaximinDNA-directed RNA polymerase subunit betatarget
DB01220RifaximinNuclear receptor subfamily 1 group I member 2target
DB01220RifaximinCytochrome P450 3A4enzyme
DB01220RifaximinCytochrome P450 2C19enzyme
DB01220RifaximinCytochrome P450 2C8enzyme
DB01250OlsalazineInterferon gammatarget
DB01250OlsalazineThiopurine S-methyltransferasetarget
DB01421Paromomycin16S ribosomal RNAtarget
DB01421Paromomycin30S ribosomal protein S10target
DB08874FidaxomicinP-glycoprotein 1transporter
DB08874FidaxomicinRNA polymerase sigma factortarget
DB08874FidaxomicinCytochrome P450 3A4enzyme
DB11130OpiumDelta-type opioid receptortarget
DB11130OpiumKappa-type opioid receptortarget
DB11130OpiumMu-type opioid receptortarget
DB11130OpiumSerum albumincarrier
DB11130OpiumBeta-2-microglobulincarrier
DB11130OpiumCytochrome P450 2D6enzyme
DB11130OpiumCytochrome P450 3A4enzyme
DB00394Beclomethasone dipropionateCorticosteroid-binding globulincarrier
DB00394Beclomethasone dipropionateGlucocorticoid receptortarget
DB00394Beclomethasone dipropionateCytochrome P450 3A5enzyme
DB00394Beclomethasone dipropionateCytochrome P450 3A4enzyme
DB00394Beclomethasone dipropionateP-glycoprotein 1transporter
DB00394Beclomethasone dipropionateATP-binding cassette sub-family G member 2transporter
DB00394Beclomethasone dipropionateSolute carrier organic anion transporter family member 1B1transporter
DB00394Beclomethasone dipropionateSolute carrier organic anion transporter family member 1B3transporter
DB00443BetamethasoneGlucocorticoid receptortarget
DB00443BetamethasoneCytochrome P450 3A4enzyme
DB00443BetamethasoneP-glycoprotein 1transporter
DB00443BetamethasoneCytochrome P450 19A1enzyme
DB00443BetamethasoneCytochrome P450 3A5enzyme
DB00512VancomycinD-Ala-D-Ala moiety of NAM/NAG peptide subunits of peptidoglycantarget
DB00512VancomycinSerum albumincarrier
DB00512Vancomycinalpha1-acid glycoproteincarrier
DB00512VancomycinHistamine H1 receptorcarrier
DB00646NystatinErgosteroltarget
DB00646NystatinSolute carrier organic anion transporter family member 1B1transporter
DB00646NystatinSolute carrier organic anion transporter family member 1B3transporter
DB00646NystatinCytochrome P450 3A4enzyme
DB00741HydrocortisoneAnnexin A1target
DB00741HydrocortisoneGlucocorticoid receptortarget
DB00741HydrocortisoneSex hormone-binding globulincarrier
DB00741HydrocortisoneCytochrome P450 3A4enzyme
DB00741HydrocortisoneCytochrome P450 3A5enzyme
DB00741HydrocortisoneCytochrome P450 3A7enzyme
DB00741HydrocortisoneP-glycoprotein 1transporter
DB00741HydrocortisoneSolute carrier organic anion transporter family member 1A2transporter
DB00741HydrocortisoneCytochrome P450 11B1, mitochondrialenzyme
DB00741HydrocortisoneCytochrome P450 11B2, mitochondrialenzyme
DB00741HydrocortisoneCytochrome P450 2C8enzyme
DB00741HydrocortisoneCorticosteroid-binding globulincarrier
DB00741HydrocortisoneCorticosteroid 11-beta-dehydrogenase isozyme 2target
DB00741Hydrocortisone3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
DB00741HydrocortisoneSolute carrier family 22 member 8transporter
DB00795SulfasalazineAcetyl-CoA acetyltransferase, mitochondrialtarget
DB00795SulfasalazineCystine/glutamate transportertarget
DB00795SulfasalazineATP-binding cassette sub-family G member 2transporter
DB00795SulfasalazineCanalicular multispecific organic anion transporter 1transporter
DB00795SulfasalazineInhibitor of nuclear factor kappa-B kinase subunit alphatarget
DB00795SulfasalazineInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB00795SulfasalazineProstaglandin G/H synthase 2target
DB00795SulfasalazinePeroxisome proliferator-activated receptor gammatarget
DB00795SulfasalazineProstaglandin G/H synthase 1target
DB00795SulfasalazineArachidonate 5-lipoxygenasetarget
DB00795SulfasalazineProton-coupled folate transportertransporter
DB00795SulfasalazineThromboxane-A synthasetarget
DB00795SulfasalazinePhospholipase A2target
DB00795SulfasalazineSolute carrier organic anion transporter family member 1B1transporter
DB00795SulfasalazineSolute carrier organic anion transporter family member 1B3transporter
DB00795SulfasalazineSolute carrier organic anion transporter family member 2B1transporter
DB00803ColistinBacterial outer membranetarget
DB00826NatamycinErgosteroltarget
DB00826NatamycinCytochrome P450 3A4enzyme
DB00860PrednisoloneCorticosteroid-binding globulincarrier
DB00860PrednisoloneCytochrome P450 3A4enzyme
DB00860PrednisoloneGlucocorticoid receptortarget
DB00860PrednisoloneSolute carrier organic anion transporter family member 1A2transporter
DB00860PrednisoloneP-glycoprotein 1transporter
DB00860PrednisoloneSerum albumincarrier
DB00994Neomycin30S ribosomal protein S12target
DB00994Neomycin16S ribosomal RNAtarget
DB00994NeomycinExtracellular calcium-sensing receptortarget
DB01003Cromoglicic acidCalcium-activated potassium channel subunit alpha-1target
DB01003Cromoglicic acidProtein S100-Ptarget
DB01110MiconazoleCytochrome P450 2C9enzyme
DB01110MiconazoleCytochrome P450 2D6enzyme
DB01110MiconazoleCytochrome P450 3A4enzyme
DB01110MiconazoleP-glycoprotein 1transporter
DB01110MiconazoleCytochrome P450 51target
DB01110MiconazoleNitric oxide synthase, endothelialtarget
DB01110MiconazoleNitric oxide synthase, inducibletarget
DB01110MiconazoleCalcium-activated potassium channel subunit alpha-1target
DB01110MiconazoleCalcium-activated potassium channel subunit beta-1target
DB01110MiconazoleCalcium-activated potassium channel subunit beta-2target
DB01110MiconazoleCalcium-activated potassium channel subunit beta-3target
DB01110MiconazoleCalcium-activated potassium channel subunit beta-4target
DB01110MiconazoleIntermediate conductance calcium-activated potassium channel protein 4target
DB01110MiconazoleSmall conductance calcium-activated potassium channel protein 1target
DB01110MiconazoleSmall conductance calcium-activated potassium channel protein 2target
DB01110MiconazoleSmall conductance calcium-activated potassium channel protein 3target
DB01110MiconazolePotassium voltage-gated channel subfamily H member 2target
DB01110MiconazolePotassium voltage-gated channel subfamily H member 6target
DB01110MiconazolePotassium voltage-gated channel subfamily H member 7target
DB01110MiconazoleCytochrome P450 11B1, mitochondrialenzyme
DB01110MiconazoleCytochrome P450 2A6enzyme
DB01110MiconazoleCytochrome P450 2B6enzyme
DB01110MiconazoleCytochrome P450 2C19enzyme
DB01110MiconazoleCytochrome P450 2E1enzyme
DB01110MiconazoleNuclear receptor subfamily 1 group I member 2target
DB01110MiconazoleLanosterol 14-alpha demethylaseenzyme
DB01110MiconazoleCytochrome P450 19A1enzyme
DB01172Kanamycin30S ribosomal protein S12target
DB01172Kanamycin16S ribosomal RNAtarget
DB01172KanamycinAminoglycoside 2'-N-acetyltransferaseenzyme
DB01172KanamycinKanamycin nucleotidyltransferaseenzyme
DB01172KanamycinAminoglycoside 3'-phosphotransferaseenzyme
DB01222BudesonideGlucocorticoid receptortarget
DB01222BudesonideCytochrome P450 3A4enzyme
DB01222BudesonideCytochrome P450 3A5enzyme
DB01222BudesonideBile salt export pumptransporter
DB01222BudesonideP-glycoprotein 1transporter
DB09091TixocortolGlucocorticoid receptortarget
DB09091TixocortolHistone deacetylase 2target
DB04941CrofelemerCystic fibrosis transmembrane conductance regulatortarget
DB04941CrofelemerAnoctamin-1target
DB09272EluxadolineMu-type opioid receptortarget
DB09272EluxadolineDelta-type opioid receptortarget
DB09272EluxadolineKappa-type opioid receptortarget
DB09272EluxadolineSolute carrier organic anion transporter family member 1B1transporter
DB09272EluxadolineCanalicular multispecific organic anion transporter 1transporter
DB09272EluxadolineSolute carrier family 22 member 8transporter
DB00781Polymyxin BBacterial outer membranetarget
DB00781Polymyxin BSolute carrier family 15 member 2transporter