Anti-Parkinson Drugs

Name
Anti-Parkinson Drugs
Accession Number
DBCAT002254  (DBCAT000470)
Description

Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists.

ATC Classification
Drugs
DrugDrug Description
BenzatropineAn anticholinergic drug used to treat Parkinson's disease (PD) and extrapyramidal symptoms, except tardive dyskinesia.
RopiniroleA non-ergoline dopamine agonist used to treat the symptoms of Parkinson's disease and Restless Legs Syndrome.
TolcaponeA catechol-O-methyltransferase (COMT) inhibitor used as adjunct therapy in the symptomatic management of idiopathic Parkinson's disease.
TrihexyphenidylAn antispasmodic drug used as an adjunct drug in the management of parkinsonism and as a treatment for extrapyramidal symptoms caused by drugs affecting the central nervous system (CNS).
ProcyclidineAn antispasmodic drug used to treat parkinsonism of various types and in the treatment of extrapyramidal symptoms.
PramipexoleA non-ergot dopamine agonist used to treat the signs and symptoms of idiopathic Parkinson's disease and Restless Legs Syndrome (RLS).
EntacaponeA selective reversible catechol-O-methyltransferase inhibitor for the treatment of Parkinson's disease.
BiperidenA muscarinic receptor antagonist used to treat parkinsonism and control extrapyramidal side effects of neuroleptic drugs.
AmantadineA medication used to treat dyskinesia in Parkinson's patients receiving levodopa, as well as extrapyramidal side effects of medications.
SelegilineA monoamine oxidase inhibitor used to treat major depressive disorder and Parkinson's.
BromocriptineA dopamine D2 receptor agonist used for the treatment of galactorrhea due to hyperprolactinemia and other prolactin-related conditions, as well as in early Parkinsonian Syndrome.
LevodopaA dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism.
DexetimideA muscarinic antagonist that has been used to treat neuroleptic-induced parkinsonism. Benzetimide is the (-)-enantimorph of dexetimide.
PiribedilPiribedil has been investigated in Parkinson's Disease.
BudipineNot Annotated
MelevodopaNot Annotated
ProfenamineAn antidyskinetic phenothiazine used to treat the symptoms of Parkinson's disease.
CabergolineA dopamine receptor agonist used for the treatment of hyperprolactinemic conditions due to various causes.
LisurideFor the management of Parkinson's Disease
ProgabideIndicated for the treatment of epilepsy.
MemantineAn NMDA receptor antagonist used to treat moderate to severe dementia in Alzheimer's.
OrphenadrineA muscarinic antagonist used as an adjunct for the symptomatic relief of musculoskeletal pain and discomfort.
3,5-DinitrocatecholNot Available
PimavanserinA second generation atypical antipsychotic used for the treatment of hallucinations and delusions caused by Parkinson's Disease.
IfenprodilIfenprodil is a selective NMDA receptor (glutamate) antagonist.
OpicaponeA catechol-O-methyltransferase inhibitor used to treat Parkinson's disease in patients currently receiving levodopa and a dopa decarboxylase inhibitor.
BenserazideA medication used to treat Parkinson's disease, parkinsonism, and restless leg syndrome.
MetixeneUsed for the symptomatic treatment of parkinsonism.
ApomorphineA morphine derivative D2 dopamine agonist used to treat hypomobile "off" episodes of advanced Parkinson's disease.
PergolideA long-acting dopamine agonist that is uncommonly used for the management of Parkinson's disease, due to the risk for cardiac valvulopathy.
RasagilineAn irreversible inhibitor of monoamine oxidase used for the symptomatic management of idiopathic Parkinson's disease as initial monotherapy and as adjunct therapy to levodopa.
RotigotineA non-selective dopamine agonist used for the treatment of Parkinson's Disease and Restless Leg Syndrome.
EtilevodopaInvestigated for use/treatment in parkinson's disease.
TropatepineTropatepine has been used in France for its antiparkinsons activities .
DihydroergocryptineNot Annotated
PhenglutarimideNot Annotated
MazaticolNot Annotated
EtybenzatropineNot Annotated
BornaprineNot Annotated
EtanautineNot Annotated
CarbidopaA dopa decarboxylase inhibitor used in combination with levodopa for the symptomatic treatment of idiopathic Parkinson disease and other conditions associated with parkinsonian symptoms.
SafinamideA MAO-B inhibitor used as an add-on treatment to levodopa/carbidopa for Parkinson's disease during "off" episodes.
DexpramipexoleDexpramipexole is under investigation in clinical trial NCT01511029 (Study to Evaluate the QTC Interval in Healthy Volunteers Dosed With Dexpramipexole (QTC = Electrocardiogram (ECG) Interval Measured From the Onset of...
Drugs & Drug Targets
DrugTargetType
BenzatropineMuscarinic acetylcholine receptor M1target
BenzatropineSodium-dependent dopamine transportertarget
BenzatropineHistamine H1 receptortarget
BenzatropineSerum albumincarrier
BenzatropineSodium-dependent serotonin transportertarget
BenzatropineSodium-dependent noradrenaline transportertarget
RopiniroleDopamine D2 receptortarget
RopiniroleDopamine D3 receptortarget
RopiniroleDopamine D4 receptortarget
RopiniroleCytochrome P450 1A2enzyme
RopiniroleAlpha adrenergic receptortarget
TolcaponeCatechol O-methyltransferasetarget
TolcaponeCytochrome P450 2C9enzyme
TrihexyphenidylMuscarinic acetylcholine receptor M1target
TrihexyphenidylMuscarinic acetylcholine receptor M2target
TrihexyphenidylMuscarinic acetylcholine receptor M3target
TrihexyphenidylMuscarinic acetylcholine receptor M4target
TrihexyphenidylMuscarinic acetylcholine receptor M5target
ProcyclidineMuscarinic acetylcholine receptor M1target
ProcyclidineMuscarinic acetylcholine receptor M2target
ProcyclidineMuscarinic acetylcholine receptor M4target
ProcyclidineMuscarinic acetylcholine receptor M3target
PramipexoleDopamine D3 receptortarget
PramipexoleDopamine D4 receptortarget
PramipexoleDopamine D2 receptortarget
Pramipexole5-hydroxytryptamine receptor 1Atarget
PramipexoleAlpha-2A adrenergic receptortarget
PramipexoleSolute carrier family 22 member 2transporter
PramipexoleSolute carrier family 22 member 1transporter
PramipexoleSolute carrier family 22 member 3transporter
EntacaponeCatechol O-methyltransferasetarget
EntacaponeCatechol O-methyltransferaseenzyme
EntacaponeUDP-glucuronosyltransferase 1-9enzyme
EntacaponeCytochrome P450 2D6enzyme
BiperidenMuscarinic acetylcholine receptor M1target
BiperidenCytochrome P450 2D6enzyme
AmantadineDopamine D2 receptortarget
AmantadineMatrix protein 2target
AmantadineAromatic-L-amino-acid decarboxylaseenzyme
AmantadineAmine oxidase [flavin-containing] Benzyme
AmantadineSolute carrier family 22 member 2transporter
AmantadineSolute carrier family 22 member 1transporter
AmantadineGlutamate receptor ionotropic, NMDA 3Atarget
AmantadineNeuronal acetylcholine receptor subunit alpha-7target
AmantadineNeuronal acetylcholine receptor subunit alpha-4target
AmantadineNeuronal acetylcholine receptor subunit alpha-3target
SelegilineAmine oxidase [flavin-containing] Btarget
SelegilineCytochrome P450 2B6enzyme
SelegilineAmine oxidase [flavin-containing] Atarget
SelegilineCytochrome P450 2A6enzyme
SelegilineCytochrome P450 3A4enzyme
SelegilineP-glycoprotein 1transporter
SelegilineCytochrome P450 1A2enzyme
SelegilineCytochrome P450 2C19enzyme
SelegilineCytochrome P450 2C8enzyme
SelegilineCytochrome P450 2C9enzyme
SelegilineCytochrome P450 2D6enzyme
SelegilineCytochrome P450 2E1enzyme
BromocriptineDopamine D2 receptortarget
BromocriptineCytochrome P450 3A4enzyme
Bromocriptine5-hydroxytryptamine receptor 1Dtarget
BromocriptineAlpha-2A adrenergic receptortarget
BromocriptineDopamine D3 receptortarget
Bromocriptine5-hydroxytryptamine receptor 1Atarget
BromocriptineAlpha-2C adrenergic receptortarget
BromocriptineAlpha-2B adrenergic receptortarget
Bromocriptine5-hydroxytryptamine receptor 2Btarget
BromocriptineDopamine D4 receptortarget
Bromocriptine5-hydroxytryptamine receptor 2Atarget
Bromocriptine5-hydroxytryptamine receptor 1Btarget
Bromocriptine5-hydroxytryptamine receptor 2Ctarget
BromocriptineDopamine D5 receptortarget
BromocriptineDopamine D1 receptortarget
BromocriptineAlpha-1A adrenergic receptortarget
BromocriptineAlpha-1B adrenergic receptortarget
BromocriptineAlpha-1D adrenergic receptortarget
Bromocriptine5-hydroxytryptamine receptor 7target
BromocriptineP-glycoprotein 1transporter
LevodopaDopamine D1 receptortarget
LevodopaDopamine D2 receptortarget
LevodopaAromatic-L-amino-acid decarboxylaseenzyme
LevodopaSolute carrier family 15 member 1transporter
LevodopaMonocarboxylate transporter 10transporter
LevodopaDopamine D3 receptortarget
LevodopaDopamine D4 receptortarget
LevodopaDopamine D5 receptortarget
LevodopaLarge neutral amino acids transporter small subunit 1transporter
LevodopaLarge neutral amino acids transporter small subunit 2transporter
LevodopaSerum albumincarrier
PiribedilDopamine D2 receptortarget
PiribedilDopamine D3 receptortarget
ProfenamineGlutamate receptor ionotropic, NMDA 3Atarget
ProfenamineMuscarinic acetylcholine receptor M1target
ProfenamineCholinesteraseenzyme
ProfenamineMuscarinic acetylcholine receptor M2target
CabergolineDopamine D2 receptortarget
Cabergoline5-hydroxytryptamine receptor 2Btarget
CabergolineDopamine D3 receptortarget
Cabergoline5-hydroxytryptamine receptor 2Atarget
CabergolineAlpha-2B adrenergic receptortarget
Cabergoline5-hydroxytryptamine receptor 1Dtarget
CabergolineDopamine D4 receptortarget
CabergolineAlpha-2A adrenergic receptortarget
Cabergoline5-hydroxytryptamine receptor 1Atarget
CabergolineAlpha-2C adrenergic receptortarget
CabergolineDopamine D5 receptortarget
CabergolineDopamine D1 receptortarget
Cabergoline5-hydroxytryptamine receptor 1Btarget
Cabergoline5-hydroxytryptamine receptor 2Ctarget
CabergolineCytochrome P450 3A4enzyme
Cabergoline5-hydroxytryptamine receptor 7target
CabergolineAlpha-1A adrenergic receptortarget
CabergolineAlpha-1B adrenergic receptortarget
CabergolineAlpha-1D adrenergic receptortarget
CabergolineBeta-1 adrenergic receptortarget
CabergolineBeta-2 adrenergic receptortarget
CabergolineD(1) dopamine receptortarget
CabergolineP-glycoprotein 1transporter
LisurideDopamine D1 receptortarget
Lisuride5-hydroxytryptamine receptor 1Atarget
LisurideDopamine D2 receptortarget
LisurideAlpha-2A adrenergic receptortarget
LisurideAlpha-2B adrenergic receptortarget
LisurideAlpha-2C adrenergic receptortarget
LisurideDopamine D3 receptortarget
Lisuride5-hydroxytryptamine receptor 1Dtarget
Lisuride5-hydroxytryptamine receptor 2Btarget
Lisuride5-hydroxytryptamine receptor 2Atarget
LisurideDopamine D4 receptortarget
Lisuride5-hydroxytryptamine receptor 2Ctarget
LisurideDopamine D5 receptortarget
Lisuride5-hydroxytryptamine receptor 1Btarget
LisurideCytochrome P450 3A4enzyme
Lisuride5-hydroxytryptamine receptor 7target
ProgabideGamma-aminobutyric acid receptor subunit alpha-1target
ProgabideGamma-aminobutyric acid type B receptor subunit 1target
MemantineCytochrome P450 2B6enzyme
MemantineSolute carrier family 22 member 2transporter
Memantine5-hydroxytryptamine receptor 3Atarget
MemantineAlpha-7 nicotinic cholinergic receptor subunittarget
MemantineCytochrome P450 2A6enzyme
MemantineCytochrome P450 2C19enzyme
MemantineDopamine D2 receptortarget
MemantineGlutamate receptor ionotropic, NMDA 1target
MemantineSodium/hydrogen exchanger 1transporter
MemantineSolute carrier family 22 member 4transporter
MemantineMultidrug and toxin extrusion protein 1transporter
MemantineGlutamate (NMDA) receptortarget
MemantineGABA(A) Receptortarget
MemantineGlycine receptorstarget
OrphenadrineGlutamate receptor ionotropic, NMDA 1target
OrphenadrineGlutamate receptor ionotropic, NMDA 2Dtarget
OrphenadrineGlutamate receptor ionotropic, NMDA 3Btarget
OrphenadrineGlutamate receptor ionotropic, NMDA 3Atarget
OrphenadrineHistamine H1 receptortarget
OrphenadrineCytochrome P450 2B6enzyme
OrphenadrineCytochrome P450 2E1enzyme
OrphenadrineCytochrome P450 3A4enzyme
OrphenadrineSodium-dependent noradrenaline transportertarget
OrphenadrineSodium channel protein type 10 subunit alphatarget
OrphenadrineCytochrome P450 1A2enzyme
OrphenadrineCytochrome P450 2D6enzyme
3,5-DinitrocatecholCatechol O-methyltransferasetarget
Pimavanserin5-hydroxytryptamine receptor 2Atarget
PimavanserinDopamine D2 receptortarget
IfenprodilGlutamate receptor ionotropic, NMDA 1target
IfenprodilGlutamate receptor ionotropic, NMDA 2Btarget
OpicaponeCytochrome P450 2C19enzyme
OpicaponeCytochrome P450 2C8enzyme
OpicaponeCatechol O-methyltransferasetarget
BenserazideAromatic-L-amino-acid decarboxylasetarget
MetixeneMuscarinic acetylcholine receptortarget
ApomorphineDopamine D2 receptortarget
ApomorphineDopamine D1 receptortarget
ApomorphineDopamine D4 receptortarget
ApomorphineDopamine D3 receptortarget
ApomorphineDopamine D5 receptortarget
ApomorphineAlpha-2C adrenergic receptortarget
ApomorphineAlpha-2B adrenergic receptortarget
Apomorphine5-hydroxytryptamine receptor 2Ctarget
Apomorphine5-hydroxytryptamine receptor 1Atarget
Apomorphine5-hydroxytryptamine receptor 2Atarget
Apomorphine5-hydroxytryptamine receptor 2Btarget
ApomorphineAlpha-2A adrenergic receptortarget
Apomorphine5-hydroxytryptamine receptor 1Dtarget
Apomorphine5-hydroxytryptamine receptor 1Btarget
ApomorphineCatechol O-methyltransferaseenzyme
ApomorphineSulfotransferase 1A1enzyme
ApomorphineSulfotransferase 1A2enzyme
ApomorphineSulfotransferase 1A3/1A4enzyme
ApomorphineEstrogen sulfotransferaseenzyme
ApomorphineSulfotransferase family cytosolic 1B member 1enzyme
ApomorphineCytochrome P450 2B6enzyme
ApomorphineCytochrome P450 2C8enzyme
ApomorphineCytochrome P450 3A4enzyme
ApomorphineCytochrome P450 3A5enzyme
ApomorphineUDP-glucuronosyltransferases (UGTs)enzyme
ApomorphineSerum albumincarrier
ApomorphineSynaptic vesicular amine transportertransporter
PergolideDopamine D2 receptortarget
PergolideDopamine D1 receptortarget
PergolideDopamine D3 receptortarget
Pergolide5-hydroxytryptamine receptor 1Atarget
PergolideAlpha-1A adrenergic receptortarget
PergolideAlpha-2 adrenergic receptorstarget
PergolideAlpha-1B adrenergic receptortarget
PergolideAlpha-1D adrenergic receptortarget
PergolideDopamine D4 receptortarget
PergolideDopamine D5 receptortarget
Pergolide5-hydroxytryptamine receptor 1Btarget
Pergolide5-hydroxytryptamine receptor 1Dtarget
Pergolide5-hydroxytryptamine receptor 2Atarget
Pergolide5-hydroxytryptamine receptor 2Btarget
Pergolide5-hydroxytryptamine receptor 2Ctarget
PergolideCytochrome P450 3A4enzyme
RasagilineApoptosis regulator Bcl-2target
RasagilineAmine oxidase [flavin-containing] Btarget
RasagilineCytochrome P450 1A2enzyme
RotigotineDopamine D3 receptortarget
RotigotineDopamine D5 receptortarget
RotigotineDopamine D4 receptortarget
RotigotineDopamine D2 receptortarget
Rotigotine5-hydroxytryptamine receptor 1Atarget
RotigotineDopamine D1 receptortarget
RotigotineCytochrome P450 2D6enzyme
RotigotineCytochrome P450 3A4enzyme
RotigotineAlpha-2B adrenergic receptortarget
DihydroergocryptineCytochrome P450 3A4enzyme
CarbidopaAromatic-L-amino-acid decarboxylasetarget
SafinamideAmine oxidase [flavin-containing] Btarget
SafinamideAmine oxidase [flavin-containing] Aenzyme
SafinamideATP-binding cassette sub-family G member 2transporter
SafinamideSolute carrier organic anion transporter family member 3A1transporter
SafinamideCytochrome P450 3A4enzyme
SafinamideCytochrome P450 1A1enzyme
SafinamideCytochrome P450 1A2enzyme
SafinamideCytochrome P450 2B6enzyme
SafinamideCytochrome P450 2C9enzyme
SafinamideCytochrome P450 2D6enzyme
SafinamideCytochrome P450 2C19enzyme
SafinamideCytochrome P450 2E1enzyme
SafinamideCytochrome P450 3A5enzyme