Nitrosoureas

Name
Nitrosoureas
Accession Number
DBCAT002264
Description

Not Available

ATC Classification
Drugs
DrugDrug Description
CarmustineAn alkylating agent used in the treatment of various malignancies, including brain tumours and multiple myeloma, among others.
StreptozocinA nitrosourea antineoplastic agent used in the treatment of metastatic pancreatic islet cell carcinoma.
LomustineAn alkylating agent used as a part of chemotherapeutic regimens for the treatment of primary and metastatic brain tumors as well as refractory or relapsed Hodgkin's disease in addition to surgical and/or radiotherapeutic treatments.
FotemustineAn alkylating agent used in the treatment of metastatic melanoma.
NimustineNimustine has been used in trials studying the treatment of Glioblastoma.
SemustineNot Annotated
RanimustineNot Annotated
Uracil mustardUsed for its antineoplastic properties.
Drugs & Drug Targets
DrugTargetType
CarmustineGlutathione reductase, mitochondrialtarget
CarmustineDNAtarget
CarmustineRNAtarget
StreptozocinDNAtarget
StreptozocinP-glycoprotein 1transporter
StreptozocinSolute carrier family 2, facilitated glucose transporter member 2target
StreptozocinO-GlcNAcase BT_4395target
StreptozocinCytochrome P450 1A1enzyme
StreptozocinCytochrome P450 1A2enzyme
StreptozocinCytochrome P450 2E1enzyme
StreptozocinBifunctional protein NCOATtarget
LomustineDNAtarget
LomustineCytochrome P450 3A4enzyme
LomustineCytochrome P450 2D6enzyme
LomustineStathmin-4target
FotemustineThioredoxin reductase 1, cytoplasmictarget
Uracil mustardDNAtarget