Beta-Lactam Antibacterials

DrugDrug NameDrug Indication
DB00301FlucloxacillinUsed to treat bacterial infection by susceptible microorganisms.
DB00319PiperacillinFor the treatment of polymicrobial infections.
DB00415AmpicillinFor treatment of infection (Respiratory, GI, UTI and meningitis) due to E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and other Salmonella, nonpenicillinase-producing N. gononhoeae, H. influenzae, staphylococci, streptococci including streptoc
DB00417PhenoxymethylpenicillinIndicated for the treatment of mild to moderately severe infections due to penicillin G­-sensitive microorganisms, with the use of bacteriological studies (including sensitivity tests) and clinical response.[label] Phenoxymethylpenicillin may be used for the treatment of: - mild to moderate infections of the upper respiratory tract, scarlet fever, and mild erysipelas caused by Streptococcus without bacteremia - mild to moderately severe infections of the respiratory tract caused by Pneumococcus - mild infections of the skin and soft tissues caused by penicillin G-sensitive Staphylococcus - mild to moderately severe infections of the oropharynx caused by Fusospirochetosis, including Vincent’s gingivitis and pharyngitis, usually respond to oral penicillin therapy **Off-label** Indicated for use as prophylaxis against bacterial endocarditis in patients with congenital heart disease or rheumatic or other acquired valvular heart disease when they undergo dental procedures and surgical procedures of the upper respiratory tract.[label]
DB00485DicloxacillinUsed to treat infections caused by penicillinase-producing staphylococci which have demonstrated susceptibility to the drug.
DB00578CarbenicillinFor the treatment of acute and chronic infections of the upper and lower urinary tract and in asymptomatic bacteriuria due to susceptible strains of bacteria.
DB00607NafcillinIndicated in the treatment of infections caused by penicillinase-producing staphylococci which have demonstrated susceptibility to the drug.
DB00713OxacillinUsed in the treatment of resistant staphylococci infections.
DB00739HetacillinHetacillin is a beta-lactam antibiotic prodrug used to treat bacterial infections. In the body it gets converted to ampicillin.
DB00948MezlocillinUsed to treat serious gram–negative infections of the lungs, urinary tract, and skin.
DB01000CyclacillinFor the treatment of bacterial infections caused by susceptible organisms.
DB01060AmoxicillinFor the treatment of infections of the ear, nose, and throat, the genitourinary tract, the skin and skin structure, and the lower respiratory tract due to susceptible (only b-lactamase-negative) strains of Streptococcus spp. (a- and b-hemolytic strains only), S. pneumoniae, Staphylococcus spp., H. influenzae, E. coli, P. mirabilis, or E. faecalis. Also for the treatment of acute, uncomplicated gonorrhea (ano-genital and urethral infections) due to N. gonorrhoeae (males and females).
DB01061AzlocillinFor the treatment of infections caused by Pseudomonas aeruginosa, Escherichia coli, and Haemophilus influenzae.
DB01147CloxacillinUsed to treat infections caused by penicillinase-producing staphylococci, including pneumococci, group A beta-hemolytic streptococci, and penicillin G-sensitive and penicillin G-resistant staphylococci.
DB01163AmdinocillinUsed in the treatment of urinary tract infections caused by some strains of E. coli and klebsiella and enterobacter species. Used mainly against Gram negative organisms.
DB01602BacampicillinFor infections at the following sites: upper and lower respiratory tract; skin and soft tissue; urinary tract and acute uncomplicated gonococcal urethritis, when due to sensitive strains of the following organisms: Gram-positive: streptococci (including S. faecalis and S. pneumoniae) and nonpenicillinase-producing staphylococci; Gram-negative: H. influenzae, N. gonorrhoeae, E. coli, P. mirabilis, Salmonellae and Shigellae.
DB01603MeticillinUsed to treat infections caused by susceptible Gram-positive bacteria, particularly beta-lactamase-producing organisms such as Staphylococcus aureus that would otherwise be resistant to most penicillins.
DB01604Pivampicillinor the treatment of respiratory tract infections (including acute bronchitis, acute exacerbations of chronic bronchitis and pneumonia); ear, nose and throat infections; gynecological infections; urinary tract infections (including acute uncomplicated gonococcal urethritis) when caused by non penicillinase-producing susceptible strains of the following organisms: gram-positive organisms, e.g., streptococci, pneumococci and staphylococci; gram-negative organisms, e.g., H. influenzae, N. gonorrhoeae, E. coli, P. mirabilis.
DB01605PivmecillinamUsed to treat infections due to mecillinam-sensitive organisms such as urinary tract infections, salmonellosis and typhoid fever.
DB01606TazobactamTazobactam is used in combination with piperacillin or ceftolozane to broaden the spectrum of piperacillin antibacterial action, treating susceptible infections. As with any other antibiotic, tazobactam should only be used for infections that are either proven or strongly suspected to be susceptible to the tazobactam containing drug. **Tazobactam-piperacillin** When combined with piperacillin, it is used to treat a variety of infections, including those caused by aerobic and facultative gram-positive and gram-negative bacteria, in addition to gram-positive and gram-negative anaerobes. Some examples of infections treated with piperacillin-tazobactam include cellulitis, diabetic foot infections, appendicitis, and postpartum endometritis infections.[L4417] Certain gram-negative bacilli infections with beta-lactamase producing organisms cannot be treated with piperacillin-tazobactam, due to a gene mutation conferring antibiotic resistance.[A179266] **Tazobactam-ceftolozane** Tazobactam-ceftolozane combined with metronidazole is used to treat complicated urinary tract infections (UTI) and complicated intra-abdominal infections, as well as ventilator-associated bacterial pneumonia and hospital-acquired bacterial pneumonia.[FDA label]. This combination increases efficacy against infections with gram-negative bacilli.[A7657]
DB01607TicarcillinFor the treatment of bacterial infections.
DB08795AzidocillinFor treatment of infection (Respiratory, GI, UTI and meningitis) due to E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and other Salmonella, nonpenicillinase-producing N. gononhoeae, H. influenzae, staphylococci, streptococci including streptoc
DB09319CarindacillinFor the treatment of acute and chronic infections of the upper and lower urinary tract and in asymptomatic bacteriuria (due to susceptible strains Escherichia coli, Proteus mirabilis, Morganella morganii, Providencia rettgeri, Proteus vulgaris, Pseudomonas, Enterobacter, and Enterococci.). Also indicated in the treatment of prostatitis (due to susceptible strains Escherichia coli Enterococcus (S. faecalis), Proteus mirabilis Enterobacter sp.).
DB09320Procaine benzylpenicillinFor the treatment of a number of bacterial infections such as syphilis, anthrax, mouth infections, pneumonia and diphtheria.
DB09324SulbactamSulbactam is currently available in combination products with ampicillin. Within this formulation it is indicated for the treatment of infections due to susceptible strains of the designated microorganisms in the conditions listed below. Skin and Skin Structure Infections caused by beta-lactamase producing strains of Staphylococcus aureus, Escherichia coli, Klebsiella spp. (including K. pneumoniae), Proteus mirabilis, Bacteroides fragilis, Enterobacter spp., and Acinetobacter calcoaceticus. Intra-Abdominal Infections caused by beta-lactamase producing strains of Escherichia coli, Klebsiella spp. (including K. pneumoniae), Bacteroides spp. (including B. fragilis), and Enterobacter spp. Gynecological Infections caused by beta-lactamase producing strains of Escherichia coli, and Bacteroides spp. (including B. fragilis).
DB12127SultamicillinNot Available
DB12343TemocillinNot Available
DB13300EpicillinNot Available
DB13337PheneticillinNot Available
DB13660PropicillinNot Available
DB13686ClometocillinNot Available
DB13693SulbenicillinNot Available
DB13739PenamecillinNot Available
DB13814TalampicillinNot Available
DB13816AspoxicillinNot Available
DB13836MetampicillinNot Available
DB01053BenzylpenicillinFor use in the treatment of severe infections caused by penicillin G-susceptible microorganisms when rapid and high penicillin levels are required such as in the treatment of septicemia, meningitis, pericarditis, endocarditis and severe pneumonia.
DB01598ImipenemFor the treatment of bacterial infections caused by susceptible bacteria.
DrugDrug NameTargetType
DB00301FlucloxacillinPenicillin-binding protein 1Atarget
DB00301FlucloxacillinCytochrome P450 3A4enzyme
DB00301FlucloxacillinBile salt export pumptransporter
DB00319PiperacillinSolute carrier family 22 member 6transporter
DB00319PiperacillinPenicillin-binding protein 3target
DB00319PiperacillinPenicillin-binding protein 2Btarget
DB00319PiperacillinPenicillin-binding protein 2atarget
DB00319PiperacillinPenicillin-binding protein 1btarget
DB00319PiperacillinSolute carrier family 22 member 8transporter
DB00415AmpicillinSerum albumincarrier
DB00415AmpicillinSolute carrier family 22 member 5transporter
DB00415AmpicillinSolute carrier family 15 member 1transporter
DB00415AmpicillinSolute carrier family 15 member 2transporter
DB00415AmpicillinPenicillin-binding protein 2atarget
DB00415AmpicillinPenicillin-binding protein 1btarget
DB00415AmpicillinPenicillin-binding protein 3target
DB00415AmpicillinPenicillin-binding protein 1Atarget
DB00415AmpicillinPenicillin-binding protein 2Btarget
DB00415AmpicillinMonocarboxylate transporter 1transporter
DB00415AmpicillinSolute carrier family 15 member 1target
DB00415AmpicillinSolute carrier family 15 member 2target
DB00415AmpicillinAngiopoietin-1 receptortarget
DB00417PhenoxymethylpenicillinPenicillin-binding protein 1Atarget
DB00417PhenoxymethylpenicillinMecA PBP2' (penicillin binding protein 2')target
DB00417PhenoxymethylpenicillinD-alanyl-D-alanine carboxypeptidase DacBtarget
DB00417PhenoxymethylpenicillinPenicillin acylasetarget
DB00417PhenoxymethylpenicillinSolute carrier family 15 member 1target
DB00485DicloxacillinSolute carrier family 15 member 1transporter
DB00485DicloxacillinSolute carrier family 15 member 2transporter
DB00485DicloxacillinPenicillin-binding protein 3target
DB00485DicloxacillinPenicillin-binding protein 1btarget
DB00485DicloxacillinPenicillin-binding protein 2atarget
DB00485DicloxacillinPenicillin-binding protein 3target
DB00485DicloxacillinPenicillin-binding protein 1Atarget
DB00485DicloxacillinPenicillin-binding protein 2Btarget
DB00485DicloxacillinCytochrome P450 3A4enzyme
DB00578CarbenicillinSolute carrier family 22 member 6transporter
DB00578CarbenicillinPenicillin-binding proteintarget
DB00578CarbenicillinCytosolic phospholipase A2enzyme
DB00607NafcillinCytochrome P450 1A2enzyme
DB00607NafcillinCytochrome P450 3A4enzyme
DB00607NafcillinSolute carrier family 22 member 6transporter
DB00607NafcillinPenicillin-binding protein 1btarget
DB00607NafcillinPenicillin-binding protein 2Btarget
DB00607NafcillinPenicillin-binding protein 2atarget
DB00607NafcillinPenicillin-binding protein 3target
DB00607NafcillinPenicillin-binding protein 1Atarget
DB00607NafcillinSerum albumincarrier
DB00713OxacillinPenicillin-binding protein 1Atarget
DB00713OxacillinSolute carrier family 15 member 1transporter
DB00713OxacillinSolute carrier family 15 member 2transporter
DB00713OxacillinPenicillin-binding protein 3target
DB00713OxacillinPenicillin-binding protein 2atarget
DB00713OxacillinPenicillin-binding protein 1Atarget
DB00713OxacillinPenicillin-binding protein 2Btarget
DB00713OxacillinPenicillin-binding protein 1btarget
DB00713OxacillinSolute carrier family 15 member 1target
DB00713OxacillinPenicillin-binding protein 2target
DB00713OxacillinSolute carrier family 15 member 2target
DB00739HetacillinPenicillin-binding protein 2atarget
DB00739HetacillinPenicillin-binding protein 1btarget
DB00739HetacillinPenicillin-binding protein 3target
DB00739HetacillinPenicillin-binding protein 1Atarget
DB00739HetacillinPenicillin-binding protein 2Btarget
DB00948MezlocillinPenicillin-binding protein 1Atarget
DB00948MezlocillinPenicillin-binding protein 2target
DB00948MezlocillinPenicillin-binding protein 3target
DB01000CyclacillinPenicillin-binding protein 1Atarget
DB01000CyclacillinSolute carrier family 22 member 5transporter
DB01000CyclacillinSolute carrier family 15 member 1transporter
DB01000CyclacillinSolute carrier family 15 member 2transporter
DB01000CyclacillinPenicillin-binding protein 1Atarget
DB01000CyclacillinPenicillin-binding protein 3target
DB01000CyclacillinPenicillin binding protein 2atarget
DB01060AmoxicillinPenicillin-binding protein 1Atarget
DB01060AmoxicillinCytochrome P450 2C19enzyme
DB01060AmoxicillinSolute carrier family 15 member 1transporter
DB01060AmoxicillinSolute carrier family 15 member 2transporter
DB01060AmoxicillinSolute carrier family 22 member 6transporter
DB01061AzlocillinPenicillin-binding protein 1Atarget
DB01147CloxacillinPenicillin-binding protein 1Atarget
DB01147CloxacillinBeta-lactamasetarget
DB01147CloxacillinSerum albumincarrier
DB01147CloxacillinSolute carrier family 15 member 1transporter
DB01147CloxacillinSolute carrier family 15 member 2transporter
DB01147CloxacillinSolute carrier family 22 member 6transporter
DB01147CloxacillinPenicillin-binding protein 2atarget
DB01147CloxacillinPenicillin-binding protein 2Btarget
DB01147CloxacillinPenicillin-binding protein 3target
DB01147CloxacillinD-alanyl-D-alanine carboxypeptidase DacAtarget
DB01163AmdinocillinPenicillin-binding protein 2target
DB01163AmdinocillinPenicillin-binding protein 2atarget
DB01163AmdinocillinPenicillin-binding protein 3target
DB01163AmdinocillinPenicillin-binding protein 1Atarget
DB01163AmdinocillinPenicillin-binding protein 2Btarget
DB01163AmdinocillinPenicillin-binding protein 1btarget
DB01602BacampicillinPenicillin-binding protein 1Atarget
DB01603MeticillinMecA PBP2' (penicillin binding protein 2')target
DB01603MeticillinPenicillin-binding protein 2atarget
DB01603MeticillinPenicillin-binding protein 1btarget
DB01603MeticillinPenicillin-binding protein 2Btarget
DB01603MeticillinPenicillin-binding protein 3target
DB01603MeticillinPenicillin-binding protein 1Atarget
DB01604PivampicillinPenicillin-binding protein 1Atarget
DB01605PivmecillinamPenicillin-binding protein 1Atarget
DB01606TazobactamBeta-lactamase TEMtarget
DB01606TazobactamSolute carrier family 22 member 6transporter
DB01606TazobactamSolute carrier family 22 member 8transporter
DB01606TazobactamBeta-lactamase Ohio-1target
DB01606TazobactamBeta-lactamase SHV-1target
DB01607TicarcillinPenicillin binding protein 2atarget
DB08795AzidocillinPenicillin-binding protein 2atarget
DB08795AzidocillinPenicillin-binding protein 1btarget
DB08795AzidocillinPenicillin-binding protein 3target
DB08795AzidocillinPenicillin-binding protein 1Atarget
DB08795AzidocillinPenicillin-binding protein 2Btarget
DB08795AzidocillinSolute carrier family 22 member 5transporter
DB08795AzidocillinSolute carrier family 15 member 1transporter
DB08795AzidocillinSolute carrier family 15 member 2transporter
DB09319CarindacillinPenicillin-binding proteintarget
DB09324SulbactamBeta-lactamasetarget
DB01053BenzylpenicillinSolute carrier family 22 member 5transporter
DB01053BenzylpenicillinSolute carrier family 15 member 1transporter
DB01053BenzylpenicillinSolute carrier family 15 member 2transporter
DB01053BenzylpenicillinSolute carrier family 22 member 6transporter
DB01053BenzylpenicillinSolute carrier family 22 member 8transporter
DB01053BenzylpenicillinSolute carrier family 22 member 4transporter
DB01053BenzylpenicillinSolute carrier family 22 member 11transporter
DB01053BenzylpenicillinSolute carrier organic anion transporter family member 2B1transporter
DB01053BenzylpenicillinSolute carrier organic anion transporter family member 4A1transporter
DB01053BenzylpenicillinSolute carrier organic anion transporter family member 3A1transporter
DB01053BenzylpenicillinSolute carrier organic anion transporter family member 1B1transporter
DB01053BenzylpenicillinPenicillin-binding protein 3target
DB01053BenzylpenicillinBeta-lactamase TEMtarget
DB01053BenzylpenicillinSolute carrier family 22 member 8target
DB01053BenzylpenicillinSolute carrier family 15 member 1target
DB01053BenzylpenicillinSolute carrier family 15 member 2target
DB01598ImipenemBeta-lactamasetarget
DB01598ImipenemPenicillin-binding protein 1Atarget
DB01598ImipenemPenicillin-binding protein 1Btarget
DB01598ImipenemPenicillin-binding protein 2target
DB01598ImipenemPenicillin-binding protein 3target