Beta-Lactam Antibacterials

DrugDrug NameDrug Description
DB00301FlucloxacillinA narrow spectrum penicillin antibiotic that exerts specific activity against Gram positive organisms in skin and soft tissue infections, except those caused by methicillin resistant staphylococcus aureus (MRSA).
DB00319PiperacillinA penicillin antibiotic combined with tazobactam to treat piperacillin-resistant, piperacillin/tazobactam­ susceptible, β-lactamase generating strains of several bacteria.
DB00415AmpicillinA penicillin derivative used for the treatment of a variety of infections caused by gram-positive and gram-negative bacteria as well as some anaerobes.
DB00417PhenoxymethylpenicillinA penicillin antibiotic used to prevent and treat mild to moderately severe infections in the respiratory tract, skin, and soft tissues.
DB00485DicloxacillinA penicillin used to treat penicillinase-producing bacterial infections that are susceptible to the drug.
DB00578CarbenicillinFor the treatment of acute and chronic infections of the upper and lower urinary tract and in asymptomatic bacteriuria due to susceptible strains of bacteria.
DB00607NafcillinA penicillin derivative antibiotic used to treat susceptible staphylococcal infections.
DB00713OxacillinA penicillin antibiotic used to treat a number of susceptible bacterial infections.
DB00739HetacillinHetacillin is a beta-lactam antibiotic prodrug used to treat bacterial infections. In the body it gets converted to ampicillin.
DB00948MezlocillinUsed to treat serious gram–negative infections of the lungs, urinary tract, and skin.
DB01000CyclacillinFor the treatment of bacterial infections caused by susceptible organisms.
DB01060AmoxicillinA penicillin derivative used for the treatment of infections caused by gram-positive bacteria, in particular streptococcal bacteria causing upper respiratory tract infections.
DB01061AzlocillinFor the treatment of infections caused by Pseudomonas aeruginosa, Escherichia coli, and Haemophilus influenzae.
DB01147CloxacillinAn antibiotic agent used for the treatment of beta-hemolytic streptococcal and pneumococcal infections as well as staphylococcal infections.
DB01163AmdinocillinUsed in the treatment of urinary tract infections caused by some strains of E. coli and klebsiella and enterobacter species. Used mainly against Gram negative organisms.
DB01602BacampicillinFor infections at the following sites: upper and lower respiratory tract; skin and soft tissue; urinary tract and acute uncomplicated gonococcal urethritis, when due to sensitive strains of the following...
DB01603MeticillinUsed to treat infections caused by susceptible Gram-positive bacteria, particularly beta-lactamase-producing organisms such as Staphylococcus aureus that would otherwise be resistant to most penicillins.
DB01604PivampicillinAn ampicillin prodrug used to treat a variety of infections.
DB01605PivmecillinamA prodrug of the beta lactam antibiotic mecillinam, indicated for the treatment of uncomplicated urinary tract infections (UTIs).
DB01606TazobactamA beta lactamase inhibitor administered with antibiotics such as piperacillin and ceftolozane to prevent their degradation, resulting in increased efficacy.
DB01607TicarcillinA beta lactam antibiotic used to treat a variety of infections in the body.
DB08795AzidocillinFor treatment of infection (Respiratory, GI, UTI and meningitis) due to E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and other Salmonella, nonpenicillinase-producing N. gononhoeae, H. influenzae, staphylococci, streptococci including...
DB09319CarindacillinA penicillin antibiotic used to treat a variety of infections, but is no longer marketed in the USA.
DB09320Procaine benzylpenicillinA local anesthetic and antibiotic combination for intramuscular injection to treat a variety of bacterial infections while reducing pain from a deep intramuscular injection.
DB09324SulbactamAn beta-lactamase inhibitor antibiotic combined with other antibiotics to treat a variety of susceptible bacterial infections.
DB12127SultamicillinSultamicillin has been used in trials studying the prevention and treatment of Ventilator Associated Pneumonia and Chronic Obstructive Pulmonary Disease (COPD).
DB12343TemocillinTemocillin has been investigated in Infection, Liver Dysfunction, and Urinary Tract Infection.
DB13300EpicillinNot Annotated
DB13337PheneticillinPheneticillin (or phenethicillin) is a penicillin antibiotic which is approved for use internationally.
DB13660PropicillinNot Annotated
DB13686ClometocillinNot Annotated
DB13693SulbenicillinNot Annotated
DB13739PenamecillinNot Annotated
DB13814TalampicillinNot Annotated
DB13816AspoxicillinNot Annotated
DB13836MetampicillinMetampicillin is a penicillin antibiotic prepared by the reaction of ampicillin with formaldehyde. It is hydrolysed in aqueous solution to form ampicillin. Hydrolysis is rapid under acid conditions like the...
DB01053BenzylpenicillinA penicillin used for the treatment of infections caused by gram-positive cocci, in particular streptococcal infections. This form of penicillin is typically used in intravenous or long-acting injectable formulations due to poor oral absorption.
DB01598ImipenemA carbapenem antibiotic normally administered with cilastatin to treat a variety of infections.
DrugDrug NameTargetType
DB00301FlucloxacillinPenicillin-binding protein 1Atarget
DB00301FlucloxacillinCytochrome P450 3A4enzyme
DB00301FlucloxacillinBile salt export pumptransporter
DB00319PiperacillinSolute carrier family 22 member 6transporter
DB00319PiperacillinPenicillin-binding protein 3target
DB00319PiperacillinPenicillin-binding protein 2Btarget
DB00319PiperacillinPenicillin-binding protein 2atarget
DB00319PiperacillinPenicillin-binding protein 1btarget
DB00319PiperacillinSolute carrier family 22 member 8transporter
DB00415AmpicillinSerum albumincarrier
DB00415AmpicillinSolute carrier family 22 member 5transporter
DB00415AmpicillinSolute carrier family 15 member 1transporter
DB00415AmpicillinSolute carrier family 15 member 2transporter
DB00415AmpicillinPenicillin-binding protein 2atarget
DB00415AmpicillinPenicillin-binding protein 1btarget
DB00415AmpicillinPenicillin-binding protein 3target
DB00415AmpicillinPenicillin-binding protein 1Atarget
DB00415AmpicillinPenicillin-binding protein 2Btarget
DB00415AmpicillinMonocarboxylate transporter 1transporter
DB00415AmpicillinSolute carrier family 15 member 1target
DB00415AmpicillinSolute carrier family 15 member 2target
DB00415AmpicillinAngiopoietin-1 receptortarget
DB00417PhenoxymethylpenicillinPenicillin-binding protein 1Atarget
DB00417PhenoxymethylpenicillinMecA PBP2' (penicillin binding protein 2')target
DB00417PhenoxymethylpenicillinD-alanyl-D-alanine carboxypeptidase DacBtarget
DB00417PhenoxymethylpenicillinPenicillin acylasetarget
DB00417PhenoxymethylpenicillinSolute carrier family 15 member 1target
DB00485DicloxacillinSolute carrier family 15 member 1transporter
DB00485DicloxacillinSolute carrier family 15 member 2transporter
DB00485DicloxacillinPenicillin-binding protein 3target
DB00485DicloxacillinPenicillin-binding protein 1btarget
DB00485DicloxacillinPenicillin-binding protein 2atarget
DB00485DicloxacillinPenicillin-binding protein 3target
DB00485DicloxacillinPenicillin-binding protein 1Atarget
DB00485DicloxacillinPenicillin-binding protein 2Btarget
DB00485DicloxacillinCytochrome P450 3A4enzyme
DB00578CarbenicillinSolute carrier family 22 member 6transporter
DB00578CarbenicillinPenicillin-binding proteintarget
DB00578CarbenicillinCytosolic phospholipase A2enzyme
DB00607NafcillinCytochrome P450 1A2enzyme
DB00607NafcillinCytochrome P450 3A4enzyme
DB00607NafcillinSolute carrier family 22 member 6transporter
DB00607NafcillinPenicillin-binding protein 1btarget
DB00607NafcillinPenicillin-binding protein 2Btarget
DB00607NafcillinPenicillin-binding protein 2atarget
DB00607NafcillinPenicillin-binding protein 3target
DB00607NafcillinPenicillin-binding protein 1Atarget
DB00607NafcillinSerum albumincarrier
DB00713OxacillinPenicillin-binding protein 1Atarget
DB00713OxacillinSolute carrier family 15 member 1transporter
DB00713OxacillinSolute carrier family 15 member 2transporter
DB00713OxacillinPenicillin-binding protein 3target
DB00713OxacillinPenicillin-binding protein 2atarget
DB00713OxacillinPenicillin-binding protein 1Atarget
DB00713OxacillinPenicillin-binding protein 2Btarget
DB00713OxacillinPenicillin-binding protein 1btarget
DB00713OxacillinSolute carrier family 15 member 1target
DB00713OxacillinPenicillin-binding protein 2target
DB00713OxacillinSolute carrier family 15 member 2target
DB00739HetacillinPenicillin-binding protein 2atarget
DB00739HetacillinPenicillin-binding protein 1btarget
DB00739HetacillinPenicillin-binding protein 3target
DB00739HetacillinPenicillin-binding protein 1Atarget
DB00739HetacillinPenicillin-binding protein 2Btarget
DB00948MezlocillinPenicillin-binding protein 1Atarget
DB00948MezlocillinPenicillin-binding protein 2target
DB00948MezlocillinPenicillin-binding protein 3target
DB01000CyclacillinPenicillin-binding protein 1Atarget
DB01000CyclacillinSolute carrier family 22 member 5transporter
DB01000CyclacillinSolute carrier family 15 member 1transporter
DB01000CyclacillinSolute carrier family 15 member 2transporter
DB01000CyclacillinPenicillin-binding protein 1Atarget
DB01000CyclacillinPenicillin-binding protein 3target
DB01000CyclacillinPenicillin binding protein 2atarget
DB01060AmoxicillinPenicillin-binding protein 1Atarget
DB01060AmoxicillinSolute carrier family 15 member 1transporter
DB01060AmoxicillinSolute carrier family 15 member 2transporter
DB01060AmoxicillinSolute carrier family 22 member 6transporter
DB01061AzlocillinPenicillin-binding protein 1Atarget
DB01147CloxacillinPenicillin-binding protein 1Atarget
DB01147CloxacillinBeta-lactamasetarget
DB01147CloxacillinSerum albumincarrier
DB01147CloxacillinSolute carrier family 15 member 1transporter
DB01147CloxacillinSolute carrier family 15 member 2transporter
DB01147CloxacillinSolute carrier family 22 member 6transporter
DB01147CloxacillinPenicillin-binding protein 2atarget
DB01147CloxacillinPenicillin-binding protein 2Btarget
DB01147CloxacillinPenicillin-binding protein 3target
DB01147CloxacillinD-alanyl-D-alanine carboxypeptidase DacAtarget
DB01163AmdinocillinPenicillin-binding protein 2target
DB01163AmdinocillinPenicillin-binding protein 2atarget
DB01163AmdinocillinPenicillin-binding protein 3target
DB01163AmdinocillinPenicillin-binding protein 1Atarget
DB01163AmdinocillinPenicillin-binding protein 2Btarget
DB01163AmdinocillinPenicillin-binding protein 1btarget
DB01602BacampicillinPenicillin-binding protein 1Atarget
DB01603MeticillinMecA PBP2' (penicillin binding protein 2')target
DB01603MeticillinPenicillin-binding protein 2atarget
DB01603MeticillinPenicillin-binding protein 1btarget
DB01603MeticillinPenicillin-binding protein 2Btarget
DB01603MeticillinPenicillin-binding protein 3target
DB01603MeticillinPenicillin-binding protein 1Atarget
DB01604PivampicillinPenicillin-binding protein 1Atarget
DB01605PivmecillinamPenicillin-binding protein 1Atarget
DB01606TazobactamBeta-lactamase TEMtarget
DB01606TazobactamSolute carrier family 22 member 6transporter
DB01606TazobactamSolute carrier family 22 member 8transporter
DB01606TazobactamBeta-lactamase Ohio-1target
DB01606TazobactamBeta-lactamase SHV-1target
DB01607TicarcillinPenicillin binding protein 2atarget
DB08795AzidocillinPenicillin-binding protein 2atarget
DB08795AzidocillinPenicillin-binding protein 1btarget
DB08795AzidocillinPenicillin-binding protein 3target
DB08795AzidocillinPenicillin-binding protein 1Atarget
DB08795AzidocillinPenicillin-binding protein 2Btarget
DB08795AzidocillinSolute carrier family 22 member 5transporter
DB08795AzidocillinSolute carrier family 15 member 1transporter
DB08795AzidocillinSolute carrier family 15 member 2transporter
DB09319CarindacillinPenicillin-binding proteintarget
DB09324SulbactamBeta-lactamasetarget
DB01053BenzylpenicillinSolute carrier family 22 member 5transporter
DB01053BenzylpenicillinSolute carrier family 15 member 1transporter
DB01053BenzylpenicillinSolute carrier family 15 member 2transporter
DB01053BenzylpenicillinSolute carrier family 22 member 6transporter
DB01053BenzylpenicillinSolute carrier family 22 member 8transporter
DB01053BenzylpenicillinSolute carrier family 22 member 4transporter
DB01053BenzylpenicillinSolute carrier family 22 member 11transporter
DB01053BenzylpenicillinSolute carrier organic anion transporter family member 2B1transporter
DB01053BenzylpenicillinSolute carrier organic anion transporter family member 4A1transporter
DB01053BenzylpenicillinSolute carrier organic anion transporter family member 3A1transporter
DB01053BenzylpenicillinSolute carrier organic anion transporter family member 1B1transporter
DB01053BenzylpenicillinPenicillin-binding protein 3target
DB01053BenzylpenicillinBeta-lactamase TEMtarget
DB01053BenzylpenicillinSolute carrier family 22 member 8target
DB01053BenzylpenicillinSolute carrier family 15 member 1target
DB01053BenzylpenicillinSolute carrier family 15 member 2target
DB01598ImipenemPenicillin-binding protein 1Atarget
DB01598ImipenemPenicillin-binding protein 1Btarget
DB01598ImipenemPenicillin-binding protein 2target
DB01598ImipenemPenicillin-binding protein 3target
DB01598ImipenemDipeptidase 1enzyme
DB01598ImipenemPenicillin-binding protein 4target
DB01598ImipenemBeta-lactamase SHV-1enzyme
DB01598ImipenemBeta-lactamase TEMenzyme
DB01598ImipenemBeta-lactamase CTX-Menzyme
DB01598ImipenemBeta-lactamase (KPC-2)enzyme