Antiemetics and Antinauseants

DrugDrug NameDrug Description
DB00377PalonosetronA serotonin antagonist used in the prophylaxis or management of vomiting that results from emetogenic chemotherapy, and for the management of postoperative nausea and vomiting.
DB00470DronabinolA synthetic delta-9-THC used in the treatment of anorexia and weight loss in HIV patients as well as nausea and vomiting in cancer chemotherapy.
DB00486NabiloneA synthetic delta-9-THC used in the treatment of anorexia and weight loss in HIV patients as well as nausea and vomiting in cancer chemotherapy.
DB00673AprepitantA substance P/neurokinin 1 receptor antagonist used to treat nausea and vomiting caused by chemotherapy and surgery.
DB00747ScopolamineAn anticholinergic used to treat excessive salivation, colicky abdominal pain, bradycardia, diverticulitis, IBS, and motion sickness.
DB00757DolasetronAn antinauseant and antiemetic used in chemotherapy and postoperatively.
DB00889GranisetronA 5HT3 antagonist used to treat nausea and vomiting in cancer therapy and postoperatively.
DB00904OndansetronA serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting in cancer chemotherapy and postoperatively.
DB06634CasopitantInvestigated for use/treatment in urinary incontinence and adverse effects (chemotherapy).
DB11386ChlorobutanolNo approved therapeutic indications on its own.
DB11699TropisetronFor the prevention of nausea and vomiting induced by cytotoxic therapy and postoperative.
DB13519Cerium oxalateNot Annotated
DB13591MetopimazineNot Annotated
DB09291RolapitantA neurokinin-1 (NK-1) receptor antagonist used in combination with other antiemetics for the prevention of delayed nausea and vomiting associated with emetogenic chemotherapy.
DrugDrug NameTargetType
DB00377Palonosetron5-hydroxytryptamine receptor 3Atarget
DB00377PalonosetronCytochrome P450 2D6enzyme
DB00377PalonosetronCytochrome P450 3A4enzyme
DB00377PalonosetronCytochrome P450 1A2enzyme
DB00470DronabinolCannabinoid receptor 1target
DB00470DronabinolCytochrome P450 3A4enzyme
DB00470DronabinolCytochrome P450 2C9enzyme
DB00470DronabinolCannabinoid receptor 2target
DB00470DronabinolP-glycoprotein 1transporter
DB00470DronabinolATP-binding cassette sub-family G member 2transporter
DB00470DronabinolProstaglandin G/H synthase 1enzyme
DB00486NabiloneCannabinoid receptor 2target
DB00486NabiloneCannabinoid receptor 1target
DB00486NabiloneCytochrome P450 2E1enzyme
DB00486NabiloneCytochrome P450 2C8enzyme
DB00486NabiloneCytochrome P450 2C9enzyme
DB00673AprepitantNeurokinin 1 receptortarget
DB00673AprepitantCytochrome P450 3A4enzyme
DB00673AprepitantCytochrome P450 2C9enzyme
DB00673AprepitantCytochrome P450 2C19enzyme
DB00747ScopolamineMuscarinic acetylcholine receptor M1target
DB00747ScopolamineSucrase-isomaltase, intestinaltarget
DB00747ScopolamineMuscarinic acetylcholine receptor M2target
DB00747ScopolamineMuscarinic acetylcholine receptor M3target
DB00747ScopolamineMuscarinic acetylcholine receptor M4target
DB00747ScopolamineMuscarinic acetylcholine receptor M5target
DB00747ScopolamineP-glycoprotein 1transporter
DB00747ScopolamineNeuronal acetylcholine receptor subunit alpha-4target
DB00747ScopolamineNeuronal acetylcholine receptor subunit beta-2target
DB00757Dolasetron5-hydroxytryptamine receptor 3Atarget
DB00757DolasetronCytochrome P450 3A4enzyme
DB00757DolasetronCytochrome P450 2D6enzyme
DB00757DolasetronCytochrome P450 2C9enzyme
DB00889Granisetron5-hydroxytryptamine receptor 3Atarget
DB00889GranisetronCytochrome P450 3A4enzyme
DB00889GranisetronCytochrome P450 1A1enzyme
DB00904Ondansetron5-hydroxytryptamine receptor 3Atarget
DB00904OndansetronCytochrome P450 3A4enzyme
DB00904OndansetronCytochrome P450 1A2enzyme
DB00904OndansetronCytochrome P450 2D6enzyme
DB00904OndansetronCytochrome P450 3A5enzyme
DB00904OndansetronCytochrome P450 3A7enzyme
DB00904Ondansetron5-hydroxytryptamine receptor 4target
DB00904Ondansetron5-hydroxytryptamine receptor 1Atarget
DB00904Ondansetron5-hydroxytryptamine receptor 1Btarget
DB00904OndansetronMu-type opioid receptortarget
DB00904OndansetronCytochrome P450 2C9enzyme
DB00904OndansetronCytochrome P450 2E1enzyme
DB06634CasopitantCytochrome P450 3A4target
DB06634CasopitantNeurokinin 1 receptortarget
DB11386ChlorobutanolPotassium voltage-gated channel subfamily H member 2target
DB11699Tropisetron5-hydroxytryptamine receptor 3Atarget
DB09291RolapitantNeurokinin 1 receptortarget
DB09291RolapitantCytochrome P450 2D6enzyme
DB09291RolapitantCytochrome P450 3A4enzyme
DB09291RolapitantATP-binding cassette sub-family G member 2transporter
DB09291RolapitantP-glycoprotein 1transporter