BSEP/ABCB11 Inhibitors

DrugDrug NameDrug Description
DB01016GlyburideA sulfonylurea used in the treatment of non insulin dependent diabetes mellitus.
DB01586Ursodeoxycholic acidA bile acid used for the treatment of primary biliary cirrhosis (PBC), dissolution of radiolucent gallstones in patients with a functioning gallbladder, and treatment of hepatobiliary disorders associated with cystic fibrosis in pediatric patients.
DB02659Cholic AcidA bile acid used for the treatment of bile acid synthesis disorders due to single enzyme defects and as an adjunctive treatment of peroxisomal disorders with disrupted liver function.
DB00977EthinylestradiolAn estradiol used as a contraceptive.
DB01045RifampicinAn antibiotic used to treat several types of mycobacterial infections including Mycobacterium avium complex, leprosy, and in combination with other antibacterials to treat latent or active tuberculosis.
DB00091CyclosporineA steroid-sparing immunosuppressant used in organ and bone marrow transplants as well as inflammatory conditions such as ulcerative colitis, rheumatoid arthritis, and atopic dermatitis.
DB00845ClofazimineA riminophenazine used to treat leprosy.
DB00206ReserpineFoe the treatment of hypertension
DB00570VinblastineA vinca alkaloid used to treat breast cancer, testicular cancer, neuroblastoma, Hodgkin's and non-Hodgkins lymphoma, mycosis fungoides, histiocytosis, and Kaposi's sarcoma.
DB01026KetoconazoleA broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections.
DB00197TroglitazoneFor the treatment of Type II diabetes mellitus. It is used alone or in combination with a sulfonylurea, metformin, or insulin as an adjunct to diet and exercise.
DB02703Fusidic acidA topical antibacterial agent used to prevent and treat mild to moderate skin infections caused by susceptible bacteria.
DB00559BosentanA dual endothelin receptor antagonist used to treat pulmonary arterial hypertension.
DB06290SimeprevirA direct-acting antiviral agent that inhibits HCV NS3/4A protease to treat chronic hepatitis C virus (HCV) infection in adults with HCV genotype 1 or 4.
DB12070LetermovirAn antiviral medication used to treat CMV infections and disease in adult CMV-seropositive recipients of an allogeneic hematopoietic stem cell transplant (HSCT).
DB00396ProgesteroneA hormone used for a variety of functions, including contraception, control of abnormal uterine bleeding, maintenance of pregnancy, and prevention of endometrial hyperplasia.
DB00932TipranavirA protease inhibitor used to treat HIV-1 resistant to more than 1 protease inhibitor.
DB00257ClotrimazoleA topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis.
DB09078LenvatinibA receptor tyrosine kinase inhibitor used for the treatment of metastatic thyroid cancer, advanced renal cell carcinoma in combination with everolimus, and unresectable hepatocellular carcinoma.
DB00477ChlorpromazineA phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children.
DB00501CimetidineA histamine H2 receptor antagonist used to manage GERD, peptic ulcer disease, and indigestion.
DB01229PaclitaxelA taxoid chemotherapeutic agent used as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast and lung cancer.
DB00908QuinidineA medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias.
DB00675TamoxifenA selective estrogen receptor modulator used to treat estrogen receptor positive breast cancer, reduce the risk of invasive breast cancer following surgery, or reduce the risk of breast cancer in high risk women.
DB14057ValinomycinA cyclododecadepsipeptide ionophore antibiotic produced by Streptomyces fulvissimus and related to the enniatins. It is composed of 3 moles each of L-valine, D-alpha-hydroxyisovaleric acid, D-valine, and L-lactic acid linked alternately...
DB00661VerapamilA calcium channel blocker used for the short-term treatment of angina, arrhythmia, and hypertension.
DB02123Glycochenodeoxycholic AcidA bile salt formed in the liver from chenodeoxycholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed....
DB00199ErythromycinA macrolide antibiotic used to treat and prevent a variety of bacterial infections.
DB00482CelecoxibAn NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, menstrual symptoms, and to reduce polyps is familial adenomatous polyposis.
DB01118AmiodaroneA class III antiarrhythmic indicated for the treatment of recurrent hemodynamically unstable ventricular tachycardia and recurrent ventricular fibrillation.
DrugDrug NameTargetType
DB01016GlyburideATP-binding cassette sub-family C member 9target
DB01016GlyburideBile salt export pumptarget
DB01016GlyburideATP-binding cassette sub-family A member 1target
DB01016GlyburideCystic fibrosis transmembrane conductance regulatortarget
DB01016GlyburideSulfonylurea receptor 1, Kir6.2target
DB01016GlyburideCytochrome P450 2C9enzyme
DB01016GlyburideCanalicular multispecific organic anion transporter 2transporter
DB01016GlyburideBile salt export pumptransporter
DB01016GlyburideP-glycoprotein 1transporter
DB01016GlyburideMultidrug resistance-associated protein 1transporter
DB01016GlyburideSolute carrier family 15 member 1transporter
DB01016GlyburideSolute carrier organic anion transporter family member 1A2transporter
DB01016GlyburideSolute carrier family 15 member 2transporter
DB01016GlyburideSolute carrier family 22 member 6transporter
DB01016GlyburideCanalicular multispecific organic anion transporter 1transporter
DB01016GlyburideATP-binding cassette sub-family G member 2transporter
DB01016GlyburideSolute carrier family 22 member 7transporter
DB01016GlyburideSolute carrier organic anion transporter family member 2B1transporter
DB01016GlyburideCytochrome P450 2C19enzyme
DB01016GlyburideCytochrome P450 3A4enzyme
DB01016GlyburideSerum albumincarrier
DB01016GlyburideMitochondrial ATP-sensitive potassium channeltarget
DB01016GlyburideCarnitine O-palmitoyltransferase 1, liver isoformtarget
DB01016GlyburideCytochrome P450 3A7enzyme
DB01016GlyburideCytochrome P450 3A5enzyme
DB01016GlyburideTransient receptor potential cation channel subfamily M member 4target
DB01586Ursodeoxycholic acidAldo-keto reductase family 1 member C2target
DB01586Ursodeoxycholic acidBile salt export pumptransporter
DB01586Ursodeoxycholic acidSolute carrier organic anion transporter family member 1A2transporter
DB01586Ursodeoxycholic acidCanalicular multispecific organic anion transporter 1transporter
DB01586Ursodeoxycholic acidMultidrug resistance-associated protein 4transporter
DB01586Ursodeoxycholic acidIleal sodium/bile acid cotransportertransporter
DB01586Ursodeoxycholic acidSodium/bile acid cotransportertransporter
DB01586Ursodeoxycholic acidCytochrome P450 2E1enzyme
DB01586Ursodeoxycholic acidBile acid receptortarget
DB02659Cholic AcidFerrochelatase, mitochondrialtarget
DB02659Cholic AcidBile salt export pumptransporter
DB02659Cholic AcidP-glycoprotein 1transporter
DB02659Cholic AcidMultidrug resistance-associated protein 1transporter
DB02659Cholic AcidSolute carrier organic anion transporter family member 1A2transporter
DB02659Cholic AcidIleal sodium/bile acid cotransportertransporter
DB02659Cholic AcidCanalicular multispecific organic anion transporter 1transporter
DB02659Cholic AcidSolute carrier organic anion transporter family member 1B1transporter
DB02659Cholic AcidCanalicular multispecific organic anion transporter 2transporter
DB02659Cholic AcidMultidrug resistance-associated protein 4transporter
DB02659Cholic AcidSodium/bile acid cotransportertransporter
DB02659Cholic AcidSolute carrier family 22 member 8transporter
DB02659Cholic AcidSolute carrier family 22 member 7transporter
DB02659Cholic AcidSolute carrier organic anion transporter family member 1B3transporter
DB02659Cholic AcidAlcohol dehydrogenase 1Ctarget
DB02659Cholic AcidEstrogen-related receptor gammatarget
DB02659Cholic AcidGastrotropintarget
DB02659Cholic AcidCytochrome c oxidase subunit 4 isoform 1, mitochondrialtarget
DB02659Cholic AcidCytochrome c oxidase subunit 1target
DB02659Cholic AcidCytochrome c oxidase subunit 2target
DB02659Cholic AcidCytochrome c oxidase subunit 3target
DB02659Cholic AcidCytochrome c oxidase subunit 5A, mitochondrialtarget
DB02659Cholic AcidCytochrome c oxidase subunit 5B, mitochondrialtarget
DB02659Cholic AcidCytochrome c oxidase subunit 6Ctarget
DB02659Cholic AcidCytochrome c oxidase subunit 7B, mitochondrialtarget
DB02659Cholic AcidCytochrome c oxidase subunit 7C, mitochondrialtarget
DB02659Cholic AcidCytochrome c oxidase subunit 8A, mitochondrialtarget
DB02659Cholic AcidCytochrome c oxidase subunit 6A2, mitochondrialtarget
DB02659Cholic AcidCytochrome c oxidase subunit 6B1target
DB02659Cholic AcidCytochrome c oxidase subunit 7A1, mitochondrialtarget
DB02659Cholic AcidPhospholipase A2target
DB02659Cholic AcidLiver carboxylesterase 1target
DB02659Cholic AcidFatty acid-binding protein, livercarrier
DB02659Cholic AcidFerrochelatasetarget
DB02659Cholic AcidCholoylglycine hydrolasetarget
DB02659Cholic AcidBile acid receptortarget
DB02659Cholic AcidG-protein coupled bile acid receptor 1target
DB00977EthinylestradiolEstrogen receptor alphatarget
DB00977EthinylestradiolNuclear receptor subfamily 1 group I member 2target
DB00977EthinylestradiolCytochrome P450 3A4enzyme
DB00977EthinylestradiolCytochrome P450 2C8enzyme
DB00977EthinylestradiolBile salt export pumptransporter
DB00977EthinylestradiolSodium/bile acid cotransportertransporter
DB00977EthinylestradiolCanalicular multispecific organic anion transporter 1transporter
DB00977EthinylestradiolP-glycoprotein 1transporter
DB00977EthinylestradiolSex hormone-binding globulintarget
DB00977EthinylestradiolUDP-glucuronosyltransferase 1-1enzyme
DB00977EthinylestradiolCytochrome P450 2C19enzyme
DB01045RifampicinDNA-directed RNA polymerase subunit betatarget
DB01045RifampicinNuclear receptor subfamily 1 group I member 2target
DB01045RifampicinCytochrome P450 3A4enzyme
DB01045RifampicinCytochrome P450 1A2enzyme
DB01045RifampicinCytochrome P450 2C8enzyme
DB01045RifampicinUDP-glucuronosyltransferase 1-1enzyme
DB01045RifampicinCytochrome P450 2C9enzyme
DB01045RifampicinCytochrome P450 2B6enzyme
DB01045RifampicinCytochrome P450 2C19enzyme
DB01045RifampicinCanalicular multispecific organic anion transporter 2transporter
DB01045RifampicinMultidrug resistance-associated protein 5transporter
DB01045RifampicinP-glycoprotein 1transporter
DB01045RifampicinCanalicular multispecific organic anion transporter 1transporter
DB01045RifampicinSolute carrier organic anion transporter family member 2B1transporter
DB01045RifampicinBile salt export pumptransporter
DB01045RifampicinMultidrug resistance-associated protein 1transporter
DB01045RifampicinSolute carrier organic anion transporter family member 1A2transporter
DB01045RifampicinSolute carrier organic anion transporter family member 1B3transporter
DB01045RifampicinSolute carrier family 22 member 7transporter
DB01045RifampicinSolute carrier organic anion transporter family member 1B1transporter
DB01045RifampicinCytochrome P450 2A6enzyme
DB01045RifampicinCytochrome P450 2E1enzyme
DB01045RifampicinCytochrome P450 3A43enzyme
DB01045RifampicinCytochrome P450 3A7enzyme
DB01045RifampicinSolute carrier family 22 member 6transporter
DB01045RifampicinSolute carrier family 22 member 8transporter
DB01045RifampicinUDP-glucuronosyltransferase 1-9enzyme
DB01045RifampicinCytochrome P450 3A5enzyme
DB01045RifampicinSerum albumincarrier
DB01045Rifampicinalpha1-acid glycoproteincarrier
DB00091CyclosporineCalcium signal-modulating cyclophilin ligandtarget
DB00091CyclosporinePeptidyl-prolyl cis-trans isomerase Atarget
DB00091CyclosporineCalcineurin subunit B type 2target
DB00091CyclosporineCytochrome P450 3A5enzyme
DB00091CyclosporineCytochrome P450 3A4enzyme
DB00091CyclosporineCytochrome P450 3A7enzyme
DB00091CyclosporineP-glycoprotein 1transporter
DB00091CyclosporineCanalicular multispecific organic anion transporter 2transporter
DB00091CyclosporineBile salt export pumptransporter
DB00091CyclosporineSolute carrier organic anion transporter family member 1A2transporter
DB00091CyclosporineIleal sodium/bile acid cotransportertransporter
DB00091CyclosporineSodium/bile acid cotransportertransporter
DB00091CyclosporineSolute carrier family 22 member 6transporter
DB00091CyclosporineMultidrug resistance-associated protein 7transporter
DB00091CyclosporineCanalicular multispecific organic anion transporter 1transporter
DB00091CyclosporineATP-binding cassette sub-family G member 2transporter
DB00091CyclosporineSolute carrier organic anion transporter family member 1B1transporter
DB00091CyclosporineCytochrome P450 2C19enzyme
DB00091CyclosporineCytochrome P450 2C9enzyme
DB00091CyclosporineCytochrome P450 2D6enzyme
DB00091CyclosporinePeptidyl-prolyl cis-trans isomerase F, mitochondrialtarget
DB00091CyclosporineSolute carrier organic anion transporter family member 1B3transporter
DB00845ClofazimineUncharacterized oxidoreductase CzcO-liketarget
DB00845ClofazimineDNAtarget
DB00845ClofazimineBile salt export pumptransporter
DB00845ClofazimineP-glycoprotein 1transporter
DB00845ClofazimineCytochrome P450 3A4enzyme
DB00845ClofazimineBile salt export pumptarget
DB00206ReserpineSynaptic vesicular amine transportertarget
DB00206ReserpineP-glycoprotein 1transporter
DB00206ReserpineSolute carrier family 22 member 1transporter
DB00206ReserpineBile salt export pumptransporter
DB00206ReserpineCanalicular multispecific organic anion transporter 1transporter
DB00206ReserpineSolute carrier family 22 member 2transporter
DB00206ReserpineCytochrome P450 3A5enzyme
DB00206ReserpineChromaffin granule amine transportertarget
DB00206ReserpineBaculoviral IAP repeat-containing protein 5target
DB00206ReserpineSolute carrier organic anion transporter family member 1B1transporter
DB00206ReserpineSolute carrier organic anion transporter family member 2B1transporter
DB00570VinblastineTubulin beta chaintarget
DB00570VinblastineTranscription factor AP-1target
DB00570VinblastineCytochrome P450 3A4enzyme
DB00570VinblastineP-glycoprotein 1transporter
DB00570VinblastineMultidrug resistance-associated protein 1transporter
DB00570VinblastineCanalicular multispecific organic anion transporter 1transporter
DB00570VinblastineMultidrug resistance-associated protein 6transporter
DB00570VinblastineBile salt export pumptransporter
DB00570VinblastineTubulin alpha-1A chaintarget
DB00570VinblastineTubulin delta chaintarget
DB00570VinblastineTubulin epsilon chaintarget
DB00570VinblastineTubulin gamma-1 chaintarget
DB00570VinblastineCytochrome P450 2D6enzyme
DB00570VinblastineSolute carrier organic anion transporter family member 1B1transporter
DB01026KetoconazoleCytochrome P450 3A4enzyme
DB01026KetoconazoleCytochrome P450 2C9enzyme
DB01026KetoconazoleCytochrome P450 2C19enzyme
DB01026KetoconazoleCytochrome P450 3A5enzyme
DB01026KetoconazoleCytochrome P450 1A2enzyme
DB01026KetoconazoleCytochrome P450 2C8enzyme
DB01026KetoconazoleCytochrome P450 1A1enzyme
DB01026KetoconazoleCytochrome P450 2D6enzyme
DB01026KetoconazoleBile salt export pumptransporter
DB01026KetoconazoleP-glycoprotein 1transporter
DB01026KetoconazoleCytochrome P450 11B1, mitochondrialenzyme
DB01026KetoconazoleCytochrome P450 1B1enzyme
DB01026KetoconazoleCytochrome P450 2A6enzyme
DB01026KetoconazoleCytochrome P450 2B6enzyme
DB01026KetoconazoleLanosterol 14-alpha demethylasetarget
DB01026KetoconazoleAndrogen receptortarget
DB01026KetoconazoleSteroid 17-alpha-hydroxylase/17,20 lyasetarget
DB01026KetoconazoleSteroid 21-hydroxylasetarget
DB01026KetoconazolePotassium voltage-gated channel subfamily H member 2target
DB01026KetoconazoleNuclear receptor subfamily 1 group I member 2target
DB01026KetoconazoleNuclear receptor subfamily 1 group I member 3target
DB01026KetoconazoleUDP-glucuronosyltransferase 1-1enzyme
DB01026KetoconazoleUDP-glucuronosyltransferase 2B7enzyme
DB01026KetoconazoleSolute carrier organic anion transporter family member 1B1transporter
DB01026KetoconazoleCytochrome P450 4F12enzyme
DB01026KetoconazoleLeukotriene-B(4) omega-hydroxylase 1enzyme
DB01026KetoconazoleSerum albumincarrier
DB01026KetoconazoleSex hormone-binding globulincarrier
DB01026KetoconazoleCytochrome P450 19A1enzyme
DB01026KetoconazoleUDP-glucuronosyltransferase 1-7enzyme
DB00197TroglitazonePeroxisome proliferator-activated receptor gammatarget
DB00197TroglitazoneLong-chain-fatty-acid--CoA ligase 4target
DB00197TroglitazonePlasminogen activator inhibitor 1target
DB00197TroglitazoneEquilibrative nucleoside transporter 1target
DB00197TroglitazoneCytochrome P450 3A4enzyme
DB00197TroglitazoneCytochrome P450 2C19enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 1-1enzyme
DB00197TroglitazoneCytochrome P450 2C8enzyme
DB00197TroglitazoneBile salt export pumptransporter
DB00197TroglitazoneSolute carrier organic anion transporter family member 1B1transporter
DB00197TroglitazoneEstrogen-related receptor gammatarget
DB00197TroglitazoneSteroid hormone receptor ERR1target
DB00197TroglitazoneCytochrome P450 19A1enzyme
DB00197TroglitazoneCytochrome P450 1A1enzyme
DB00197TroglitazoneCytochrome P450 2B6enzyme
DB00197TroglitazoneCytochrome P450 2C9enzyme
DB00197TroglitazoneCytochrome P450 3A5enzyme
DB00197TroglitazoneCytochrome P450 3A7enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 1-3enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 1-4enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 1-6enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 1-7enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 1-8enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 1-9enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 1-10enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 2B7enzyme
DB00197TroglitazoneUDP-glucuronosyltransferase 2B15enzyme
DB00197TroglitazonePeroxisome proliferator-activated receptor deltatarget
DB00197TroglitazonePeroxisome proliferator-activated receptor alphatarget
DB00197TroglitazoneGlutathione S-transferase Ptarget
DB02703Fusidic acidChloramphenicol acetyltransferase 3target
DB02703Fusidic acidChloramphenicol acetyltransferasetarget
DB02703Fusidic acidBile salt export pumptransporter
DB02703Fusidic acidCanalicular multispecific organic anion transporter 1transporter
DB02703Fusidic acidElongation factor Gtarget
DB02703Fusidic acidCytochrome P450 2D6enzyme
DB02703Fusidic acidCytochrome P450 3A4enzyme
DB02703Fusidic acidUDP-glucuronosyltransferase 1-1enzyme
DB02703Fusidic acidATP-binding cassette sub-family G member 2transporter
DB02703Fusidic acidSolute carrier organic anion transporter family member 1B1transporter
DB00559BosentanEndothelin B receptortarget
DB00559BosentanEndothelin-1 receptortarget
DB00559BosentanCytochrome P450 3A4enzyme
DB00559BosentanCytochrome P450 2C9enzyme
DB00559BosentanBile salt export pumptransporter
DB06290SimeprevirNS3 proteasetarget
DB06290SimeprevirSerum albumincarrier
DB06290SimeprevirCytochrome P450 1A2enzyme
DB06290SimeprevirP-glycoprotein 1transporter
DB06290SimeprevirSolute carrier organic anion transporter family member 1B1transporter
DB06290SimeprevirSolute carrier organic anion transporter family member 1B3transporter
DB06290SimeprevirCytochrome P450 3A4enzyme
DB06290SimeprevirCanalicular multispecific organic anion transporter 1transporter
DB06290SimeprevirATP-binding cassette sub-family G member 2transporter
DB06290SimeprevirSolute carrier organic anion transporter family member 2B1transporter
DB06290SimeprevirSodium/bile acid cotransportertransporter
DB06290SimeprevirBile salt export pumptransporter
DB12070LetermovirUDP-glucuronosyltransferase 1-1enzyme
DB12070LetermovirUDP-glucuronosyltransferase 1-3enzyme
DB12070LetermovirSolute carrier organic anion transporter family member 1B1transporter
DB12070LetermovirSolute carrier organic anion transporter family member 1B3transporter
DB12070LetermovirTripartite terminase subunit 1target
DB12070LetermovirTripartite terminase subunit 2target
DB12070LetermovirTripartite terminase subunit 3target
DB12070LetermovirCytochrome P450 2D6enzyme
DB12070LetermovirCytochrome P450 2C8enzyme
DB12070LetermovirCytochrome P450 2C19enzyme
DB12070LetermovirCytochrome P450 2C9enzyme
DB12070LetermovirCytochrome P450 2B6enzyme
DB12070LetermovirP-glycoprotein 1transporter
DB12070LetermovirATP-binding cassette sub-family G member 2transporter
DB12070LetermovirBile salt export pumptransporter
DB12070LetermovirSolute carrier family 22 member 8transporter
DB12070LetermovirCanalicular multispecific organic anion transporter 1transporter
DB12070LetermovirCytochrome P450 3A4enzyme
DB12070LetermovirCytochrome P450 3A5enzyme
DB12070LetermovirCytochrome P450 3A7enzyme
DB12070LetermovirCytochrome P450 3A43enzyme
DB00396ProgesteroneProgesterone receptortarget
DB00396ProgesteroneEstrogen receptor alphatarget
DB00396ProgesteroneSteroid 17-alpha-hydroxylase/17,20 lyasetarget
DB00396ProgesteroneCytochrome P450 2C19enzyme
DB00396ProgesteroneCytochrome P450 2C9enzyme
DB00396ProgesteroneCytochrome P450 3A4enzyme
DB00396ProgesteroneCytochrome P450 3A5enzyme
DB00396ProgesteroneCytochrome P450 3A7enzyme
DB00396ProgesteroneP-glycoprotein 1transporter
DB00396ProgesteroneSolute carrier family 22 member 2transporter
DB00396ProgesteroneSolute carrier family 22 member 1transporter
DB00396ProgesteroneSolute carrier family 22 member 3transporter
DB00396ProgesteroneBile salt export pumptransporter
DB00396ProgesteroneMultidrug resistance-associated protein 1transporter
DB00396ProgesteroneSodium/bile acid cotransportertransporter
DB00396ProgesteroneSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
DB00396ProgesteroneCytochrome P450 1A1enzyme
DB00396ProgesteroneCytochrome P450 1B1enzyme
DB00396ProgesteroneCytochrome P450 2A6enzyme
DB00396ProgesteroneCytochrome P450 2D6enzyme
DB00396ProgesteroneMineralocorticoid receptortarget
DB00396ProgesteroneKappa-type opioid receptortarget
DB00396ProgesteroneAlpha-1-acid glycoprotein 1target
DB00396ProgesteroneGlucocorticoid receptortarget
DB00396ProgesteroneAndrogen receptortarget
DB00396ProgesteroneSex hormone-binding globulintarget
DB00396ProgesteroneSolute carrier organic anion transporter family member 1B1transporter
DB00396ProgesteroneATP-binding cassette sub-family G member 2transporter
DB00396ProgesteroneEstrogen receptor betatarget
DB00396ProgesteroneSolute carrier organic anion transporter family member 1B3transporter
DB00932TipranavirHuman immunodeficiency virus type 1 proteasetarget
DB00932TipranavirCytochrome P450 3A4enzyme
DB00932TipranavirCytochrome P450 2D6enzyme
DB00932TipranavirCytochrome P450 2C19enzyme
DB00932TipranavirBile salt export pumptransporter
DB00932TipranavirUDP-glucuronosyltransferase 1-1enzyme
DB00932TipranavirSolute carrier organic anion transporter family member 2B1transporter
DB00932TipranavirSolute carrier organic anion transporter family member 1B1transporter
DB00932TipranavirSolute carrier organic anion transporter family member 1B3transporter
DB00257ClotrimazoleIntermediate conductance calcium-activated potassium channel protein 4target
DB00257ClotrimazoleCytochrome P450 2D6enzyme
DB00257ClotrimazoleCytochrome P450 2C8enzyme
DB00257ClotrimazoleCytochrome P450 3A4enzyme
DB00257ClotrimazoleCytochrome P450 2B6enzyme
DB00257ClotrimazoleP-glycoprotein 1transporter
DB00257ClotrimazoleCytochrome P450 2A6enzyme
DB00257ClotrimazoleCytochrome P450 2C9enzyme
DB00257ClotrimazoleCytochrome P450 2E1enzyme
DB00257ClotrimazoleCytochrome P450 3A7enzyme
DB00257ClotrimazoleCytochrome P450 51target
DB00257ClotrimazoleNuclear receptor subfamily 1 group I member 2target
DB00257ClotrimazoleHydroxycarboxylic acid receptor 2target
DB00257ClotrimazoleBile salt export pumptransporter
DB00257ClotrimazoleSolute carrier organic anion transporter family member 1B1transporter
DB00257ClotrimazoleSolute carrier organic anion transporter family member 1B3transporter
DB00257ClotrimazoleErgosteroltarget
DB09078LenvatinibVascular endothelial growth factor receptor 1target
DB09078LenvatinibVascular endothelial growth factor receptor 2target
DB09078LenvatinibVascular endothelial growth factor receptor 3target
DB09078LenvatinibFibroblast growth factor receptor 1target
DB09078LenvatinibFibroblast growth factor receptor 2target
DB09078LenvatinibFibroblast growth factor receptor 3target
DB09078LenvatinibFibroblast growth factor receptor 4target
DB09078LenvatinibPlatelet-derived growth factor receptor alphatarget
DB09078LenvatinibProto-oncogene tyrosine-protein kinase receptor Rettarget
DB09078LenvatinibMast/stem cell growth factor receptor Kittarget
DB09078LenvatinibP-glycoprotein 1transporter
DB09078LenvatinibATP-binding cassette sub-family G member 2transporter
DB09078LenvatinibCytochrome P450 3A4enzyme
DB09078LenvatinibAldehyde oxidaseenzyme
DB09078LenvatinibCytochrome P450 2C8enzyme
DB09078LenvatinibCytochrome P450 2C9enzyme
DB09078LenvatinibCytochrome P450 1A2enzyme
DB09078LenvatinibCytochrome P450 2B6enzyme
DB09078LenvatinibCytochrome P450 2C19enzyme
DB09078LenvatinibSolute carrier family 22 member 6transporter
DB09078LenvatinibSolute carrier family 22 member 8transporter
DB09078LenvatinibSolute carrier family 22 member 2transporter
DB09078LenvatinibSolute carrier organic anion transporter family member 1B1transporter
DB09078LenvatinibBile salt export pumptransporter
DB09078LenvatinibCytochrome P450 2D6enzyme
DB00477ChlorpromazineDopamine D2 receptortarget
DB00477Chlorpromazine5-hydroxytryptamine receptor 2Atarget
DB00477ChlorpromazineCytochrome P450 2D6enzyme
DB00477ChlorpromazineCholinesteraseenzyme
DB00477ChlorpromazineCytochrome P450 1A2enzyme
DB00477ChlorpromazineSerum albumincarrier
DB00477ChlorpromazineP-glycoprotein 1transporter
DB00477ChlorpromazineDopamine D1 receptortarget
DB00477Chlorpromazine5-hydroxytryptamine receptor 1Atarget
DB00477ChlorpromazineAlpha-1A adrenergic receptortarget
DB00477ChlorpromazineAlpha-1B adrenergic receptortarget
DB00477ChlorpromazineCytochrome P450 2E1enzyme
DB00477ChlorpromazineCytochrome P450 3A4enzyme
DB00477ChlorpromazineHistamine H1 receptortarget
DB00477ChlorpromazinePotassium voltage-gated channel subfamily H member 2target
DB00477ChlorpromazineD(1) dopamine receptortarget
DB00477ChlorpromazineDopamine D3 receptortarget
DB00477ChlorpromazineDopamine D4 receptortarget
DB00477ChlorpromazineDopamine D5 receptortarget
DB00477Chlorpromazine5-hydroxytryptamine receptor 2Ctarget
DB00477Chlorpromazine5-hydroxytryptamine 2 receptortarget
DB00477ChlorpromazineAlpha-1 adrenergic receptorstarget
DB00477ChlorpromazineAlpha-2 adrenergic receptorstarget
DB00477ChlorpromazineMuscarinic acetylcholine receptor M1target
DB00477ChlorpromazineMuscarinic acetylcholine receptor M3target
DB00477ChlorpromazineSphingomyelin phosphodiesterasetarget
DB00477ChlorpromazineCalmodulintarget
DB00477Chlorpromazinealpha1-acid glycoproteintarget
DB00477Chlorpromazine5-hydroxytryptamine receptor 6target
DB00477Chlorpromazine5-hydroxytryptamine receptor 7target
DB00477ChlorpromazineHistamine H4 receptortarget
DB00477ChlorpromazineBile salt export pumptransporter
DB00501CimetidineHistamine H2 receptortarget
DB00501CimetidineCytochrome P450 1A2enzyme
DB00501CimetidineCytochrome P450 2D6enzyme
DB00501CimetidineCytochrome P450 2C19enzyme
DB00501CimetidineCytochrome P450 3A4enzyme
DB00501CimetidineCytochrome P450 3A5enzyme
DB00501CimetidineP-glycoprotein 1transporter
DB00501CimetidineSolute carrier family 22 member 2transporter
DB00501CimetidineSolute carrier family 22 member 1transporter
DB00501CimetidineSolute carrier family 22 member 3transporter
DB00501CimetidineSolute carrier family 22 member 5transporter
DB00501CimetidineSolute carrier family 22 member 6transporter
DB00501CimetidineSolute carrier family 22 member 8transporter
DB00501CimetidineMultidrug and toxin extrusion protein 1transporter
DB00501CimetidineSolute carrier family 22 member 4transporter
DB00501CimetidineSolute carrier family 22 member 11transporter
DB00501CimetidineSolute carrier family 22 member 7transporter
DB00501CimetidineCytochrome P450 11B1, mitochondrialenzyme
DB00501CimetidineCytochrome P450 2C8enzyme
DB00501CimetidineCytochrome P450 2C9enzyme
DB00501CimetidineCytochrome P450 2E1enzyme
DB00501CimetidineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00501CimetidineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
DB00501CimetidineBile salt export pumptransporter
DB00501CimetidineMultidrug and toxin extrusion protein 2transporter
DB01229PaclitaxelApoptosis regulator Bcl-2target
DB01229PaclitaxelTubulin beta-1 chaintarget
DB01229PaclitaxelCytochrome P450 2C8enzyme
DB01229PaclitaxelCytochrome P450 3A4enzyme
DB01229PaclitaxelCytochrome P450 3A5enzyme
DB01229PaclitaxelCytochrome P450 3A7enzyme
DB01229PaclitaxelBile salt export pumptransporter
DB01229PaclitaxelP-glycoprotein 1transporter
DB01229PaclitaxelMultidrug resistance-associated protein 1transporter
DB01229PaclitaxelMultidrug resistance-associated protein 7transporter
DB01229PaclitaxelCytochrome P450 19A1enzyme
DB01229PaclitaxelCytochrome P450 1B1enzyme
DB01229PaclitaxelSolute carrier organic anion transporter family member 1B3transporter
DB01229PaclitaxelNuclear receptor subfamily 1 group I member 2target
DB01229PaclitaxelMicrotubule-associated protein 4target
DB01229PaclitaxelMicrotubule-associated protein 2target
DB01229PaclitaxelMicrotubule-associated protein tautarget
DB01229PaclitaxelCanalicular multispecific organic anion transporter 1transporter
DB00908QuinidineSodium channel protein type 5 subunit alphatarget
DB00908QuinidineAlpha-1-acid glycoprotein 1carrier
DB00908QuinidinePotassium voltage-gated channel subfamily H member 2target
DB00908QuinidinePotassium channel subfamily K member 1target
DB00908QuinidinePotassium channel subfamily K member 6target
DB00908QuinidineCytochrome P450 1A2enzyme
DB00908QuinidineCytochrome P450 2E1enzyme
DB00908QuinidineCytochrome P450 1A1enzyme
DB00908QuinidineCytochrome P450 2D6enzyme
DB00908QuinidineCytochrome P450 3A4enzyme
DB00908QuinidineCytochrome P450 3A7enzyme
DB00908QuinidineSolute carrier family 22 member 2transporter
DB00908QuinidineSolute carrier family 22 member 1transporter
DB00908QuinidineSolute carrier family 22 member 5transporter
DB00908QuinidineP-glycoprotein 1transporter
DB00908QuinidineSolute carrier organic anion transporter family member 1A2transporter
DB00908QuinidineSolute carrier family 22 member 8transporter
DB00908QuinidineCanalicular multispecific organic anion transporter 1transporter
DB00908QuinidineSolute carrier family 22 member 4transporter
DB00908QuinidineSolute carrier organic anion transporter family member 1B1transporter
DB00908QuinidineCytochrome P450 2B6enzyme
DB00908QuinidineCytochrome P450 2C9enzyme
DB00908QuinidineAlpha-1A adrenergic receptortarget
DB00908QuinidineAlpha-1B adrenergic receptortarget
DB00908QuinidineAlpha-1D adrenergic receptortarget
DB00908QuinidineBile salt export pumptransporter
DB00908QuinidineCytochrome P450 2C8enzyme
DB00675TamoxifenEstrogen receptor alphatarget
DB00675TamoxifenEstrogen receptor betatarget
DB00675TamoxifenCytochrome P450 2C9enzyme
DB00675TamoxifenCytochrome P450 3A4enzyme
DB00675TamoxifenCytochrome P450 2D6enzyme
DB00675TamoxifenCytochrome P450 2C8enzyme
DB00675TamoxifenCytochrome P450 2B6enzyme
DB00675TamoxifenLiver carboxylesterase 1enzyme
DB00675TamoxifenCytochrome P450 3A5enzyme
DB00675TamoxifenCytochrome P450 1A1enzyme
DB00675TamoxifenCytochrome P450 1B1enzyme
DB00675TamoxifenCytochrome P450 2C19enzyme
DB00675TamoxifenDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
DB00675TamoxifenDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00675TamoxifenCytochrome P450 3A7enzyme
DB00675TamoxifenP-glycoprotein 1transporter
DB00675TamoxifenATP-binding cassette sub-family G member 2transporter
DB00675TamoxifenCytochrome P450 19A1enzyme
DB00675TamoxifenCytochrome P450 2A6enzyme
DB00675TamoxifenCytochrome P450 2E1enzyme
DB00675TamoxifenUDP-glucuronosyltransferase 1-10enzyme
DB00675TamoxifenSulfotransferase 1A1enzyme
DB00675TamoxifenCanalicular multispecific organic anion transporter 1transporter
DB00675Tamoxifen3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerasetarget
DB00675TamoxifenProtein kinase Ctarget
DB00675TamoxifenAndrogen receptortarget
DB00675TamoxifenPotassium voltage-gated channel subfamily H member 2target
DB00675TamoxifenNuclear receptor subfamily 1 group I member 2target
DB00675TamoxifenEstrogen-related receptor gammatarget
DB00675TamoxifenSex hormone-binding globulintarget
DB00675TamoxifenBile salt export pumptransporter
DB00675TamoxifenThyroxine-binding globulincarrier
DB00675TamoxifenBile salt sulfotransferaseenzyme
DB00675TamoxifenCytochrome P450 1A2enzyme
DB00675TamoxifenUDP-glucuronosyltransferase 2B7enzyme
DB00675TamoxifenUDP-glucuronosyltransferase 2B17enzyme
DB00675TamoxifenEstrogen sulfotransferaseenzyme
DB00675TamoxifenATP-binding cassette sub-family A member 1transporter
DB00675TamoxifenMitogen-activated protein kinase 8target
DB00675TamoxifenSerum albumincarrier
DB14057ValinomycinBile salt export pumptransporter
DB00661VerapamilSodium channel protein type 5 subunit alphatarget
DB00661VerapamilATP-sensitive inward rectifier potassium channel 11target
DB00661VerapamilVoltage-dependent L-type calcium channel subunit beta-4target
DB00661VerapamilVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
DB00661VerapamilVoltage-dependent L-type calcium channel subunit alpha-1Ftarget
DB00661VerapamilVoltage-dependent L-type calcium channel subunit beta-3target
DB00661VerapamilVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DB00661VerapamilVoltage-dependent L-type calcium channel subunit beta-1target
DB00661VerapamilVoltage-dependent L-type calcium channel subunit beta-2target
DB00661VerapamilPotassium voltage-gated channel subfamily H member 2target
DB00661VerapamilVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB00661VerapamilVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB00661VerapamilVoltage-dependent T-type calcium channel subunit alpha-1Itarget
DB00661VerapamilCytochrome P450 1A2enzyme
DB00661VerapamilCytochrome P450 3A5enzyme
DB00661VerapamilVoltage-dependent N-type calcium channel subunit alpha-1Btarget
DB00661VerapamilVoltage-dependent P/Q-type calcium channel subunit alpha-1Atarget
DB00661VerapamilSodium-dependent serotonin transportertarget
DB00661VerapamilCytochrome P450 3A4enzyme
DB00661VerapamilP-glycoprotein 1transporter
DB00661VerapamilSolute carrier family 22 member 1transporter
DB00661VerapamilCanalicular multispecific organic anion transporter 2transporter
DB00661VerapamilMultidrug resistance-associated protein 4transporter
DB00661VerapamilSolute carrier family 22 member 5transporter
DB00661VerapamilMultidrug resistance-associated protein 1transporter
DB00661VerapamilSolute carrier organic anion transporter family member 1A2transporter
DB00661VerapamilMultidrug resistance-associated protein 7transporter
DB00661VerapamilCanalicular multispecific organic anion transporter 1transporter
DB00661VerapamilSolute carrier family 22 member 4transporter
DB00661VerapamilATP-binding cassette sub-family G member 2transporter
DB00661VerapamilSolute carrier organic anion transporter family member 1B1transporter
DB00661VerapamilCytochrome P450 2C8enzyme
DB00661VerapamilCytochrome P450 2C9enzyme
DB00661VerapamilCytochrome P450 2B6enzyme
DB00661VerapamilCytochrome P450 2C19enzyme
DB00661VerapamilCytochrome P450 2D6enzyme
DB00661VerapamilAlpha-1A adrenergic receptortarget
DB00661VerapamilAlpha-1B adrenergic receptortarget
DB00661VerapamilAlpha-1D adrenergic receptortarget
DB00661VerapamilBile salt export pumptransporter
DB02123Glycochenodeoxycholic Acid7-alpha-hydroxysteroid dehydrogenasetarget
DB02123Glycochenodeoxycholic AcidBile salt export pumptransporter
DB02123Glycochenodeoxycholic AcidSolute carrier organic anion transporter family member 1A2transporter
DB02123Glycochenodeoxycholic AcidIleal sodium/bile acid cotransportertransporter
DB02123Glycochenodeoxycholic AcidSodium/bile acid cotransportertransporter
DB00199Erythromycin23S ribosomal RNAtarget
DB00199ErythromycinCytochrome P450 3A4enzyme
DB00199ErythromycinCytochrome P450 3A7enzyme
DB00199ErythromycinP-glycoprotein 1transporter
DB00199ErythromycinSolute carrier organic anion transporter family member 1B1transporter
DB00199ErythromycinMotilin receptortarget
DB00199ErythromycinPotassium voltage-gated channel subfamily H member 2target
DB00199ErythromycinCytochrome P450 3A5enzyme
DB00199ErythromycinSolute carrier organic anion transporter family member 1B3transporter
DB00199ErythromycinBile salt export pumptransporter
DB00199ErythromycinCanalicular multispecific organic anion transporter 1transporter
DB00199ErythromycinSolute carrier organic anion transporter family member 1A2transporter
DB00482CelecoxibProstaglandin G/H synthase 2target
DB00482Celecoxib3-phosphoinositide-dependent protein kinase 1target
DB00482CelecoxibCytochrome P450 2C9enzyme
DB00482CelecoxibCytochrome P450 2D6enzyme
DB00482CelecoxibMultidrug resistance-associated protein 4transporter
DB00482CelecoxibCytochrome P450 3A4enzyme
DB00482CelecoxibCytochrome P450 2C8enzyme
DB00482CelecoxibCarbonic anhydrase 2target
DB00482CelecoxibCarbonic anhydrase 3target
DB00482CelecoxibBile salt export pumptransporter
DB00482CelecoxibCadherin-11target
DB00482CelecoxibP-glycoprotein 1transporter
DB00482CelecoxibATP-binding cassette sub-family G member 2transporter
DB01118AmiodaroneBeta-1 adrenergic receptortarget
DB01118AmiodaronePotassium voltage-gated channel subfamily H member 2target
DB01118AmiodaroneCytochrome P450 2C8enzyme
DB01118AmiodaroneCytochrome P450 2C9enzyme
DB01118AmiodaroneCytochrome P450 2D6enzyme
DB01118AmiodaroneVoltage-dependent T-type calcium channel subunit alpha-1Htarget
DB01118AmiodaroneVoltage-dependent calcium channel subunit alpha-2/delta-2target
DB01118AmiodaroneCytochrome P450 3A4enzyme
DB01118AmiodaroneCytochrome P450 1A2enzyme
DB01118AmiodaroneCytochrome P450 1A1enzyme
DB01118AmiodaroneP-glycoprotein 1transporter
DB01118AmiodaroneCytochrome P450 2C19enzyme
DB01118AmiodaroneCytochrome P450 2A6enzyme
DB01118AmiodaroneThyroid hormone receptor alphatarget
DB01118AmiodaroneThyroid hormone receptor betatarget
DB01118AmiodaronePeroxisome proliferator-activated receptor gammatarget
DB01118AmiodaroneBile salt export pumptransporter
DB01118AmiodaroneSolute carrier family 22 member 2transporter
DB01118AmiodaroneCytochrome P450 2J2enzyme