UGT1A1 Inhibitors

DrugDrug NameDrug Indication
DB00173AdenineFor nutritional supplementation, also for treating dietary shortage or imbalance
DB00818PropofolUsed for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.
DB00328IndomethacinFor moderate to severe rheumatoid arthritis including acute flares of chronic disease, ankylosing spondylitis, osteoarthritis, acute painful shoulder (bursitis and/or tendinitis) and acute gouty arthritis.
DB04868NilotinibFor the potential treatment of various leukemias, including chronic myeloid leukemia (CML).
DB06589PazopanibTreatment of advanced renal cell cancer and advanced soft tissue sarcoma (in patients previously treated with chemotherapy)
DB08896RegorafenibRegorafenib is indicated for the treatment of patients with metastatic colorectal cancer (CRC) who have been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF therapy, and, if KRAS wild type, an anti-EGFR therapy. Regorafenib is also indicated for the treatment of patients with locally advanced, unresectable or metastatic gastrointestinal stromal tumor (GIST) who have been previously treated with imatinib mesylate and sunitinib malate.
DB01544FlunitrazepamFor short-term treatment of severe insomnias, that are not responsive to other hypnotics.
DB00530ErlotinibFor the treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of at least one prior chemotherapy regimen. Also for use, in combination with gemcitabine, as the first-line treatment of patients with locally advanced, unresectable or metastatic pancreatic cancer.
DB00398SorafenibSorafenib is indicated for the treatment of unresectable hepatocellular carcinoma and advanced renal cell carcinoma.
DB13874EnasidenibIndicated for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with an isocitrate dehydrogenase-2 (IDH2) mutation.
DB13878PibrentasvirIndicated for the treatment of adult patients with chronic hepatitis C virus (HCV) genotype 1, 2, 3, 4, 5 or 6 infection without cirrhosis or with compensated cirrhosis (Child-Pugh A). MAVYRET is also indicated for the treatment of adult patients with HCV genotype 1 infection, who previously have been treated with a regimen containing an HCV NS5A inhibitor or an NS3/4A protease inhibitor (PI), but not both [FDA Label].
DB13879GlecaprevirIndicated for the treatment of adult patients with chronic hepatitis C virus (HCV) genotype 1, 2, 3, 4, 5 or 6 infection without cirrhosis or with compensated cirrhosis (Child-Pugh A). MAVYRET is also indicated for the treatment of adult patients with HCV genotype 1 infection, who previously have been treated with a regimen containing an HCV NS5A inhibitor or an NS3/4A protease inhibitor (PI), but not both [FDA Label].
DB12332RucaparibIndicated as monotherapy for the treatment of patients with deleterious BRCA mutation (germline and/or somatic) associated advanced ovarian cancer who have been treated with two or more chemotherapies. Select patients for therapy based on an FDA-approved companion diagnostic for rucaparib.
DB11827ErtugliflozinErtugliflozin as a monotherapy is indicated to improve the glycemic control in adult patients with type 2 diabetes.[FDA label] Ertugliflozin, in combination with metformin hydrochloride, is indicated to improve glycemic control in patients with diabetes type 2 who are not controlled on a regimen of ertugliflozin or metformin or in patients who are already treated with both ertugliflozin and metformin.[L1134] The administration of ertugliflozin in combination with sitagliptin is indicated to improve glycemic control in adult patients with type 2 diabetes when treatment with ertugliflozin and sitagliptin is appropriate.[L1135] It is pointed out that the use of ertugliflozin has to be an adjunct therapy to the use of diet and exercise. The type 2 diabetes mellitus is characterized by insulin resistance in muscle and liver, which results in the elevation of glucose levels in blood, or by presence of insulin deficiency. The insulin resistance is related to genetic factors, obesity, sedentary lifestyle or/and aging. This increase in the blood glucose can cause severe damage to kidney, eyes and vascular system.[A31582]
DB12010FostamatinibFostamatinib is indicated for use in the treatment of chronic immune thrombocytopenia (ITP) in patients who have had insufficient response to previous therapy [FDA Label].
DB08930DolutegravirDolutegravir is indicated in combination with other antiretroviral agents for the treatment of patients with HIV-1 infection that comply with the characteristics of being adults or children aged 12 years and older and present at least a weight of 40 kg.[A7520] The FDA combination therapy approval of dolutegravir and rilpivirine is indicated for adults with HIV-1 infections whose virus is currently suppressed (< 50 copies/ml) on a stable regimen for at least six months, without history of treatment failure and no known substitutions associated to resistance to any of the two components of the therapy.[L1031]
DB01026KetoconazoleFor the treatment of the following systemic fungal infections: candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis.
DB00224IndinavirIndinavir is an antiretroviral drug for the treatment of HIV infection.
DrugDrug NameTargetType
DB00173AdenineAdenine phosphoribosyltransferasetarget
DB00173AdenineDNAtarget
DB00173AdenineS-methyl-5'-thioadenosine phosphorylasetarget
DB00173AdenineNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferasetarget
DB00173AdenineAcetyl-CoA carboxylase 2target
DB00173AdenineLow molecular weight phosphotyrosine protein phosphatasetarget
DB00173Adenine5'-methylthioadenosine/S-adenosylhomocysteine nucleosidasetarget
DB00173AdeninePeroxisomal trans-2-enoyl-CoA reductasetarget
DB00173AdenineA/G-specific adenine glycosylasetarget
DB00173AdenineNucleoside deoxyribosyltransferase-Itarget
DB00173AdenineSRSF protein kinase 2target
DB00173AdenineHolliday junction ATP-dependent DNA helicase RuvBtarget
DB00173AdenineUDP-glucuronosyltransferase 1-1enzyme
DB00818PropofolCytochrome P450 2B6enzyme
DB00818PropofolUDP-glucuronosyltransferase 1-1enzyme
DB00818PropofolUDP-glucuronosyltransferase 1-9enzyme
DB00818PropofolGamma-aminobutyric acid receptor subunit beta-2target
DB00818PropofolGamma-aminobutyric acid receptor subunit beta-3target
DB00818PropofolSerum albumincarrier
DB00818PropofolSodium channel protein type 4 subunit alphatarget
DB00818PropofolSodium channel protein type 2 subunit alphatarget
DB00818PropofolFatty-acid amide hydrolase 1enzyme
DB00818PropofolCytochrome P450 2C9enzyme
DB00818PropofolUDP-glucuronosyltransferase 1-8enzyme
DB00818PropofolCytochrome P450 2E1enzyme
DB00818PropofolCytochrome P450 1B1enzyme
DB00818PropofolCytochrome P450 1A1enzyme
DB00818PropofolCytochrome P450 1A2enzyme
DB00818PropofolCytochrome P450 2A6enzyme
DB00818PropofolCytochrome P450 2C18enzyme
DB00818PropofolCytochrome P450 2C19enzyme
DB00818PropofolCytochrome P450 2C8enzyme
DB00818PropofolCytochrome P450 2D6enzyme
DB00818PropofolCytochrome P450 3A4enzyme
DB00818PropofolUDP-glucuronosyltransferase 1-6enzyme
DB00818PropofolGABA-A receptor (anion channel)target
DB00328IndomethacinProstaglandin G/H synthase 1target
DB00328IndomethacinProstaglandin G/H synthase 2target
DB00328IndomethacinCytochrome P450 2C19enzyme
DB00328IndomethacinUDP-glucuronosyltransferase 1-9enzyme
DB00328IndomethacinPhospholipase A2, membrane associatedtarget
DB00328IndomethacinProstaglandin reductase 2target
DB00328IndomethacinLactoylglutathione lyasetarget
DB00328IndomethacinProstaglandin D2 receptor 2target
DB00328IndomethacinPeroxisome proliferator-activated receptor gammatarget
DB00328IndomethacinSerum albumincarrier
DB00328IndomethacinCanalicular multispecific organic anion transporter 2transporter
DB00328IndomethacinMultidrug resistance-associated protein 4transporter
DB00328IndomethacinMultidrug resistance-associated protein 6transporter
DB00328IndomethacinMultidrug resistance protein 1transporter
DB00328IndomethacinMultidrug resistance-associated protein 1transporter
DB00328IndomethacinSolute carrier organic anion transporter family member 1A2transporter
DB00328IndomethacinSolute carrier family 22 member 6transporter
DB00328IndomethacinSolute carrier family 22 member 8transporter
DB00328IndomethacinCanalicular multispecific organic anion transporter 1transporter
DB00328IndomethacinATP-binding cassette sub-family C member 11transporter
DB00328IndomethacinSolute carrier family 22 member 11transporter
DB00328IndomethacinSodium/bile acid cotransportertransporter
DB00328IndomethacinSolute carrier family 22 member 7transporter
DB00328IndomethacinCytochrome P450 2C9enzyme
DB00328IndomethacinUDP-glucuronosyltransferase 1-1enzyme
DB00328IndomethacinLiver carboxylesterase 1enzyme
DB00328IndomethacinUDP-glucuronosyltransferase 2B7enzyme
DB00328IndomethacinPeroxisome proliferator-activated receptor alphatarget
DB00328IndomethacinAldo-keto reductase family 1 member C3target
DB04868NilotinibTyrosine-protein kinase ABL1target
DB04868NilotinibMast/stem cell growth factor receptor Kittarget
DB04868NilotinibCytochrome P450 2D6enzyme
DB04868NilotinibCytochrome P450 2C8enzyme
DB04868NilotinibCytochrome P450 2C9enzyme
DB04868NilotinibCytochrome P450 3A4enzyme
DB04868NilotinibMultidrug resistance protein 1transporter
DB04868NilotinibATP-binding cassette sub-family G member 2transporter
DB04868NilotinibUDP-glucuronosyltransferase 1-1transporter
DB04868NilotinibCytochrome P450 2B6enzyme
DB06589PazopanibVascular endothelial growth factor receptor 1target
DB06589PazopanibVascular endothelial growth factor receptor 2target
DB06589PazopanibVascular endothelial growth factor receptor 3target
DB06589PazopanibPlatelet-derived growth factor receptor alphatarget
DB06589PazopanibPlatelet-derived growth factor receptor betatarget
DB06589PazopanibMast/stem cell growth factor receptor Kittarget
DB06589PazopanibCytochrome P450 3A4enzyme
DB06589PazopanibCytochrome P450 2D6enzyme
DB06589PazopanibCytochrome P450 2C8enzyme
DB06589PazopanibCytochrome P450 1A2enzyme
DB06589PazopanibMultidrug resistance protein 1transporter
DB06589PazopanibATP-binding cassette sub-family G member 2transporter
DB06589PazopanibSolute carrier organic anion transporter family member 1B1transporter
DB06589PazopanibUDP-glucuronosyltransferase 1-1transporter
DB06589PazopanibFibroblast growth factor receptor 3target
DB06589PazopanibTyrosine-protein kinase ITK/TSKtarget
DB06589PazopanibFibroblast growth factor 1target
DB06589PazopanibSH2B adapter protein 3target
DB08896RegorafenibCytochrome P450 3A4enzyme
DB08896RegorafenibUDP-glucuronosyltransferase 1-9enzyme
DB08896RegorafenibProto-oncogene tyrosine-protein kinase receptor Rettarget
DB08896RegorafenibVascular endothelial growth factor receptor 1target
DB08896RegorafenibVascular endothelial growth factor receptor 2target
DB08896RegorafenibVascular endothelial growth factor receptor 3target
DB08896RegorafenibMast/stem cell growth factor receptor Kittarget
DB08896RegorafenibPlatelet-derived growth factor receptor alphatarget
DB08896RegorafenibPlatelet-derived growth factor receptor betatarget
DB08896RegorafenibFibroblast growth factor receptor 1target
DB08896RegorafenibFibroblast growth factor receptor 2target
DB08896RegorafenibAngiopoietin-1 receptortarget
DB08896RegorafenibDiscoidin domain-containing receptor 2target
DB08896RegorafenibHigh affinity nerve growth factor receptortarget
DB08896RegorafenibEphrin type-A receptor 2target
DB08896RegorafenibRAF proto-oncogene serine/threonine-protein kinasetarget
DB08896RegorafenibSerine/threonine-protein kinase B-raftarget
DB08896RegorafenibCytochrome P450 2C8enzyme
DB08896RegorafenibCytochrome P450 2C9enzyme
DB08896RegorafenibCytochrome P450 2B6enzyme
DB08896RegorafenibCytochrome P450 2C19enzyme
DB08896RegorafenibMitogen-activated protein kinase 11target
DB08896RegorafenibTyrosine-protein kinase FRKtarget
DB08896RegorafenibTyrosine-protein kinase ABL1target
DB08896RegorafenibMultidrug resistance protein 1transporter
DB08896RegorafenibATP-binding cassette sub-family G member 2transporter
DB08896RegorafenibUDP-glucuronosyltransferase 1-1enzyme
DB01544FlunitrazepamGamma-aminobutyric acid receptor subunit alpha-2target
DB01544FlunitrazepamGamma-aminobutyric acid receptor subunit alpha-4target
DB01544FlunitrazepamGamma-aminobutyric acid receptor subunit alpha-5target
DB01544FlunitrazepamGamma-aminobutyric acid receptor subunit alpha-6target
DB01544FlunitrazepamGamma-aminobutyric acid receptor subunit alpha-3target
DB01544FlunitrazepamTranslocator proteintarget
DB01544FlunitrazepamCytochrome P450 2C19enzyme
DB01544FlunitrazepamUDP-glucuronosyltransferase 2B7enzyme
DB01544FlunitrazepamCytochrome P450 1A2enzyme
DB01544FlunitrazepamCytochrome P450 2A6enzyme
DB01544FlunitrazepamCytochrome P450 2B6enzyme
DB01544FlunitrazepamCytochrome P450 2C9enzyme
DB01544FlunitrazepamCytochrome P450 3A4enzyme
DB01544FlunitrazepamCytochrome P450 2E1enzyme
DB01544FlunitrazepamUDP-glucuronosyltransferase 1-1enzyme
DB01544FlunitrazepamUDP-glucuronosyltransferase 1-3enzyme
DB01544FlunitrazepamGamma-aminobutyric acid receptor subunit alpha-1target
DB01544FlunitrazepamGamma-aminobutyric acid receptor subunit beta-3target
DB01544FlunitrazepamGamma-aminobutyric acid receptor subunit gamma-2target
DB00530ErlotinibEpidermal growth factor receptortarget
DB00530ErlotinibCytochrome P450 3A4enzyme
DB00530ErlotinibATP-binding cassette sub-family G member 2transporter
DB00530ErlotinibMultidrug resistance protein 1transporter
DB00530ErlotinibNuclear receptor subfamily 1 group I member 2target
DB00530ErlotinibCytochrome P450 3A5enzyme
DB00530ErlotinibCytochrome P450 1A1enzyme
DB00530ErlotinibCytochrome P450 1A2enzyme
DB00530ErlotinibCytochrome P450 1B1enzyme
DB00530ErlotinibCytochrome P450 2D6enzyme
DB00530ErlotinibCytochrome P450 2C8enzyme
DB00530ErlotinibUDP-glucuronosyltransferase 1-1enzyme
DB00530ErlotinibSerum albumincarrier
DB00530ErlotinibAlpha-1-acid glycoprotein 1carrier
DB00398SorafenibSerine/threonine-protein kinase B-raftarget
DB00398SorafenibReceptor-type tyrosine-protein kinase FLT3target
DB00398SorafenibRAF proto-oncogene serine/threonine-protein kinasetarget
DB00398SorafenibVascular endothelial growth factor receptor 3target
DB00398SorafenibPlatelet-derived growth factor receptor betatarget
DB00398SorafenibMast/stem cell growth factor receptor Kittarget
DB00398SorafenibVascular endothelial growth factor receptor 2target
DB00398SorafenibCytochrome P450 3A4enzyme
DB00398SorafenibUDP-glucuronosyltransferase 1-9enzyme
DB00398SorafenibCytochrome P450 2B6enzyme
DB00398SorafenibCytochrome P450 2C8enzyme
DB00398SorafenibCytochrome P450 3A5enzyme
DB00398SorafenibCytochrome P450 3A7enzyme
DB00398SorafenibCytochrome P450 2C9enzyme
DB00398SorafenibMultidrug resistance-associated protein 4transporter
DB00398SorafenibMultidrug resistance protein 1transporter
DB00398SorafenibCanalicular multispecific organic anion transporter 1transporter
DB00398SorafenibATP-binding cassette sub-family G member 2transporter
DB00398SorafenibCytochrome P450 1A2enzyme
DB00398SorafenibCytochrome P450 2C19enzyme
DB00398SorafenibCytochrome P450 2D6enzyme
DB00398SorafenibUDP-glucuronosyltransferase 1-1enzyme
DB00398SorafenibRalA-binding protein 1transporter
DB00398SorafenibFibroblast growth factor receptor 1target
DB00398SorafenibProto-oncogene tyrosine-protein kinase receptor Rettarget
DB00398SorafenibVascular endothelial growth factor receptor 1target
DB13874EnasidenibCytochrome P450 1A2enzyme
DB13874EnasidenibCytochrome P450 2B6enzyme
DB13874EnasidenibIsocitrate dehydrogenase [NADP], mitochondrialtarget
DB13874EnasidenibCytochrome P450 2C8enzyme
DB13874EnasidenibCytochrome P450 2C9enzyme
DB13874EnasidenibCytochrome P450 2C19enzyme
DB13874EnasidenibCytochrome P450 2D6enzyme
DB13874EnasidenibCytochrome P450 3A4enzyme
DB13874EnasidenibUDP-glucuronosyltransferase 1-1enzyme
DB13874EnasidenibUDP-glucuronosyltransferase 1-3enzyme
DB13874EnasidenibUDP-glucuronosyltransferase 1-4enzyme
DB13874EnasidenibUDP-glucuronosyltransferase 1-9enzyme
DB13874EnasidenibUDP-glucuronosyltransferase 2B7enzyme
DB13874EnasidenibUDP-glucuronosyltransferase 2B15enzyme
DB13874EnasidenibMultidrug resistance protein 1transporter
DB13874EnasidenibATP-binding cassette sub-family G member 2transporter
DB13874EnasidenibSolute carrier family 22 member 6transporter
DB13874EnasidenibSolute carrier organic anion transporter family member 1B1transporter
DB13874EnasidenibSolute carrier family 22 member 2transporter
DB13874EnasidenibSolute carrier organic anion transporter family member 1B3transporter
DB13874EnasidenibSolute carrier family 22 member 8transporter
DB13878PibrentasvirNonstructural Protein 5A (NS5A)target
DB13878PibrentasvirCYP3Aenzyme
DB13878PibrentasvirCytochrome P450 1A2enzyme
DB13878PibrentasvirUDP-glucuronosyltransferase 1-1enzyme
DB13878PibrentasvirMultidrug resistance protein 1transporter
DB13878PibrentasvirATP-binding cassette sub-family G member 2transporter
DB13878PibrentasvirSolute carrier organic anion transporter family member 1B1transporter
DB13878PibrentasvirSolute carrier organic anion transporter family member 1B3transporter
DB13879GlecaprevirCYP3Aenzyme
DB13879GlecaprevirCytochrome P450 1A2enzyme
DB13879GlecaprevirUDP-glucuronosyltransferase 1-1enzyme
DB13879GlecaprevirMultidrug resistance protein 1transporter
DB13879GlecaprevirATP-binding cassette sub-family G member 2transporter
DB13879GlecaprevirSolute carrier organic anion transporter family member 1B1transporter
DB13879GlecaprevirSolute carrier organic anion transporter family member 1B3transporter
DB13879GlecaprevirNS3 proteasetarget
DB12332RucaparibPoly [ADP-ribose] polymerase 1target
DB12332RucaparibPoly [ADP-ribose] polymerase 2target
DB12332RucaparibPoly [ADP-ribose] polymerase 3target
DB12332RucaparibCytochrome P450 2D6enzyme
DB12332RucaparibCytochrome P450 1A2enzyme
DB12332RucaparibCytochrome P450 3A4enzyme
DB12332RucaparibMultidrug resistance protein 1transporter
DB12332RucaparibATP-binding cassette sub-family G member 2transporter
DB12332RucaparibMultidrug and toxin extrusion protein 1transporter
DB12332RucaparibMultidrug and toxin extrusion protein 2transporter
DB12332RucaparibSolute carrier family 22 member 1transporter
DB12332RucaparibMultidrug resistance-associated protein 4transporter
DB12332RucaparibSolute carrier organic anion transporter family member 1B1transporter
DB12332RucaparibSolute carrier organic anion transporter family member 1B3transporter
DB12332RucaparibSolute carrier family 22 member 6transporter
DB12332RucaparibSolute carrier family 22 member 8transporter
DB12332RucaparibCytochrome P450 3A5enzyme
DB12332RucaparibCytochrome P450 3A7enzyme
DB12332RucaparibCytochrome P450 3A43enzyme
DB12332RucaparibCytochrome P450 2C19enzyme
DB12332RucaparibCytochrome P450 2C9enzyme
DB12332RucaparibCytochrome P450 2C8enzyme
DB12332RucaparibUDP-glucuronosyltransferase 1-1enzyme
DB11827ErtugliflozinUDP-glucuronosyltransferase 1-9enzyme
DB11827ErtugliflozinUDP-glucuronosyltransferase 2B7enzyme
DB11827ErtugliflozinSodium/glucose cotransporter 2target
DB11827ErtugliflozinMultidrug resistance protein 1transporter
DB11827ErtugliflozinATP-binding cassette sub-family G member 2transporter
DB11827ErtugliflozinSerum albumincarrier
DB11827ErtugliflozinUDP-glucuronosyltransferase 1-1enzyme
DB11827ErtugliflozinUDP-glucuronosyltransferase 1-4enzyme
DB12010FostamatinibAdenosine receptor A3target
DB12010Fostamatinibvesicular monoamine transporter 2 (VMAT2)target
DB12010FostamatinibFatty-acid amide hydrolase 1target
DB12010FostamatinibEquilibrative nucleoside transporter 1target
DB12010FostamatinibUDP-glucuronosyltransferase 1-1target
DB12010FostamatinibcGMP-specific 3',5'-cyclic phosphodiesterasetarget
DB12010FostamatinibArachidonate 5-lipoxygenasetarget
DB12010FostamatinibCathepsin Starget
DB12010FostamatinibCathepsin L1target
DB12010FostamatinibTyrosine-protein kinase ABL1target
DB12010FostamatinibCalcium-dependent protein kinase 1target
DB12010FostamatinibSerine/threonine-protein kinase PknBtarget
DB12010FostamatinibRibosomal protein S6 kinase alpha-6target
DB12010FostamatinibNon-receptor tyrosine-protein kinase TYK2target
DB12010FostamatinibAtypical kinase COQ8A, mitochondrialtarget
DB12010FostamatinibTyrosine-protein kinase JAK1target
DB12010FostamatinibHepatocyte growth factor receptortarget
DB12010FostamatinibSerine/threonine-protein kinase NIM1target
DB12010FostamatinibSerine/threonine-protein kinase MST4target
DB12010FostamatinibcAMP-dependent protein kinase catalytic subunit alphatarget
DB12010FostamatinibSerine/threonine-protein kinase 24target
DB12010FostamatinibSerine/threonine-protein kinase 3target
DB12010FostamatinibTyrosine-protein kinase Tectarget
DB12010FostamatinibTyrosine-protein kinase SYKtarget
DB12010FostamatinibSerine/threonine-protein kinase 33target
DB12010FostamatinibSerine/threonine-protein kinase 35target
DB12010FostamatinibSerine/threonine-protein kinase 36target
DB12010FostamatinibSerine/threonine-protein kinase 38target
DB12010FostamatinibSerine/threonine-protein kinase 38-liketarget
DB12010FostamatinibSTE20/SPS1-related proline-alanine-rich protein kinasetarget
DB12010FostamatinibSerine/threonine-protein kinase TAO1target
DB12010FostamatinibSerine/threonine-protein kinase TAO2target
DB12010FostamatinibSerine/threonine-protein kinase TAO3target
DB12010FostamatinibSerine/threonine-protein kinase TBK1target
DB12010FostamatinibAngiopoietin-1 receptortarget
DB12010FostamatinibDual specificity testis-specific protein kinase 1target
DB12010FostamatinibTGF-beta receptor type-1target
DB12010FostamatinibTGF-beta receptor type-2target
DB12010FostamatinibTyrosine-protein kinase receptor Tie-1target
DB12010FostamatinibSerine/threonine-protein kinase tousled-like 1target
DB12010FostamatinibSerine/threonine-protein kinase tousled-like 2target
DB12010FostamatinibTRAF2 and NCK-interacting protein kinasetarget
DB12010FostamatinibNon-receptor tyrosine-protein kinase TNK1target
DB12010FostamatinibActivated CDC42 kinase 1target
DB12010FostamatinibSerine/threonine-protein kinase TNNI3Ktarget
DB12010FostamatinibTestis-specific serine/threonine-protein kinase 1target
DB12010FostamatinibDual specificity protein kinase TTKtarget
DB12010FostamatinibTyrosine-protein kinase TXKtarget
DB12010FostamatinibTyrosine-protein kinase receptor TYRO3target
DB12010FostamatinibSerine/threonine-protein kinase ULK1target
DB12010FostamatinibSerine/threonine-protein kinase ULK2target
DB12010FostamatinibSerine/threonine-protein kinase ULK3target
DB12010FostamatinibWee1-like protein kinasetarget
DB12010FostamatinibTyrosine-protein kinase Yestarget
DB12010FostamatinibMitogen-activated protein kinase kinase kinase 19target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase MLTtarget
DB12010FostamatinibTyrosine-protein kinase ZAP-70target
DB12010FostamatinibAP2-associated protein kinase 1target
DB12010FostamatinibAbelson tyrosine-protein kinase 2target
DB12010FostamatinibActivin receptor type-1target
DB12010FostamatinibActivin receptor type-1Btarget
DB12010FostamatinibAtypical kinase COQ8B, mitochondrialtarget
DB12010FostamatinibALK tyrosine kinase receptortarget
DB12010FostamatinibAnkyrin repeat and protein kinase domain-containing protein 1target
DB12010FostamatinibAurora kinase Atarget
DB12010FostamatinibAurora kinase Btarget
DB12010FostamatinibAurora kinase Ctarget
DB12010FostamatinibTyrosine-protein kinase receptor UFOtarget
DB12010FostamatinibTyrosine-protein kinase Blktarget
DB12010FostamatinibBMP-2-inducible protein kinasetarget
DB12010FostamatinibBone morphogenetic protein receptor type-1Btarget
DB12010FostamatinibBone morphogenetic protein receptor type-2target
DB12010FostamatinibCytoplasmic tyrosine-protein kinase BMXtarget
DB12010FostamatinibSerine/threonine-protein kinase B-raftarget
DB12010FostamatinibTyrosine-protein kinase BTKtarget
DB12010FostamatinibCalcium/calmodulin-dependent protein kinase type 1target
DB12010FostamatinibCalcium/calmodulin-dependent protein kinase type 1Dtarget
DB12010FostamatinibCalcium/calmodulin-dependent protein kinase type 1Gtarget
DB12010FostamatinibCalcium/calmodulin-dependent protein kinase type II subunit alphatarget
DB12010FostamatinibCalcium/calmodulin-dependent protein kinase type II subunit betatarget
DB12010FostamatinibCalcium/calmodulin-dependent protein kinase type II subunit deltatarget
DB12010FostamatinibCalcium/calmodulin-dependent protein kinase type II subunit gammatarget
DB12010FostamatinibCalcium/calmodulin-dependent protein kinase kinase 1target
DB12010FostamatinibCalcium/calmodulin-dependent protein kinase kinase 2target
DB12010FostamatinibPeripheral plasma membrane protein CASKtarget
DB12010FostamatinibKappa-caseintarget
DB12010FostamatinibCyclin-dependent kinase 1target
DB12010FostamatinibSerine/threonine-protein kinase MRCK gammatarget
DB12010FostamatinibCyclin-dependent kinase 4target
DB12010FostamatinibCyclin-dependent kinase-like 1target
DB12010FostamatinibCyclin-dependent kinase-like 2target
DB12010FostamatinibSerine/threonine-protein kinase Chk1target
DB12010FostamatinibSerine/threonine-protein kinase Chk2target
DB12010FostamatinibCitron Rho-interacting kinasetarget
DB12010FostamatinibDual specificity protein kinase CLK1target
DB12010FostamatinibDual specificity protein kinase CLK2target
DB12010FostamatinibDual specificity protein kinase CLK3target
DB12010FostamatinibDual specificity protein kinase CLK4target
DB12010FostamatinibMacrophage colony-stimulating factor 1 receptortarget
DB12010FostamatinibTyrosine-protein kinase CSKtarget
DB12010FostamatinibCasein kinase I isoform alphatarget
DB12010FostamatinibCasein kinase II subunit alphatarget
DB12010FostamatinibCasein kinase II subunit alpha'target
DB12010FostamatinibDeath-associated protein kinase 1target
DB12010FostamatinibDeath-associated protein kinase 2target
DB12010FostamatinibDeath-associated protein kinase 3target
DB12010FostamatinibSerine/threonine-protein kinase DCLK1target
DB12010FostamatinibSerine/threonine-protein kinase DCLK2target
DB12010FostamatinibSerine/threonine-protein kinase DCLK3target
DB12010FostamatinibEpithelial discoidin domain-containing receptor 1target
DB12010FostamatinibDiscoidin domain-containing receptor 2target
DB12010FostamatinibDual specificity tyrosine-phosphorylation-regulated kinase 1Atarget
DB12010FostamatinibDual specificity tyrosine-phosphorylation-regulated kinase 1Btarget
DB12010FostamatinibEpidermal growth factor receptortarget
DB12010FostamatinibEukaryotic translation initiation factor 2-alpha kinase 1target
DB12010FostamatinibInterferon-induced, double-stranded RNA-activated protein kinasetarget
DB12010FostamatinibeIF-2-alpha kinase GCN2target
DB12010FostamatinibEphrin type-A receptor 1target
DB12010FostamatinibEphrin type-A receptor 2target
DB12010FostamatinibEphrin type-A receptor 3target
DB12010FostamatinibEphrin type-A receptor 4target
DB12010FostamatinibEphrin type-A receptor 5target
DB12010FostamatinibEphrin type-A receptor 6target
DB12010FostamatinibEphrin type-A receptor 7target
DB12010FostamatinibEphrin type-A receptor 8target
DB12010FostamatinibEphrin type-B receptor 1target
DB12010FostamatinibEphrin type-B receptor 2target
DB12010FostamatinibEphrin type-B receptor 4target
DB12010FostamatinibEphrin type-B receptor 6target
DB12010FostamatinibReceptor tyrosine-protein kinase erbB-2target
DB12010FostamatinibReceptor tyrosine-protein kinase erbB-4target
DB12010FostamatinibSerine/threonine-protein kinase/endoribonuclease IRE1target
DB12010FostamatinibTyrosine-protein kinase Fertarget
DB12010FostamatinibTyrosine-protein kinase Fes/Fpstarget
DB12010FostamatinibFibroblast growth factor receptor 1target
DB12010FostamatinibFibroblast growth factor receptor 2target
DB12010FostamatinibFibroblast growth factor receptor 3target
DB12010FostamatinibTyrosine-protein kinase Fgrtarget
DB12010FostamatinibVascular endothelial growth factor receptor 1target
DB12010FostamatinibReceptor-type tyrosine-protein kinase FLT3target
DB12010FostamatinibVascular endothelial growth factor receptor 3target
DB12010FostamatinibSerine/threonine-protein kinase mTORtarget
DB12010FostamatinibTyrosine-protein kinase FRKtarget
DB12010FostamatinibTyrosine-protein kinase Fyntarget
DB12010FostamatinibCyclin-G-associated kinasetarget
DB12010FostamatinibGlycogen synthase kinase-3 alphatarget
DB12010FostamatinibGlycogen synthase kinase-3 betatarget
DB12010FostamatinibTyrosine-protein kinase HCKtarget
DB12010FostamatinibHomeodomain-interacting protein kinase 2target
DB12010FostamatinibHomeodomain-interacting protein kinase 3target
DB12010FostamatinibSerine/threonine-protein kinase ICKtarget
DB12010FostamatinibInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB12010FostamatinibInhibitor of nuclear factor kappa-B kinase subunit epsilontarget
DB12010FostamatinibInsulin receptortarget
DB12010FostamatinibInsulin receptor-related proteintarget
DB12010FostamatinibInterleukin-1 receptor-associated kinase 1target
DB12010FostamatinibInterleukin-1 receptor-associated kinase 3target
DB12010FostamatinibInterleukin-1 receptor-associated kinase 4target
DB12010FostamatinibTyrosine-protein kinase ITK/TSKtarget
DB12010FostamatinibTyrosine-protein kinase JAK2target
DB12010FostamatinibTyrosine-protein kinase JAK3target
DB12010FostamatinibVascular endothelial growth factor receptor 2target
DB12010FostamatinibSerine/threonine-protein kinase SIK3target
DB12010FostamatinibMast/stem cell growth factor receptor Kittarget
DB12010FostamatinibSerine/threonine-protein kinase LATS1target
DB12010FostamatinibTyrosine-protein kinase Lcktarget
DB12010FostamatinibLIM domain kinase 1target
DB12010FostamatinibLIM domain kinase 2target
DB12010FostamatinibLeucine-rich repeat serine/threonine-protein kinase 2target
DB12010FostamatinibLeukocyte tyrosine kinase receptortarget
DB12010FostamatinibTyrosine-protein kinase Lyntarget
DB12010FostamatinibDual specificity mitogen-activated protein kinase kinase 2target
DB12010FostamatinibDual specificity mitogen-activated protein kinase kinase 3target
DB12010FostamatinibDual specificity mitogen-activated protein kinase kinase 5target
DB12010FostamatinibDual specificity mitogen-activated protein kinase kinase 6target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase 1target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase 10target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase 11target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase 12target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase 13target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase 15target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase 2target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase 3target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase 4target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase 6target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase 9target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase kinase 1target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase kinase 2target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase kinase 3target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase kinase 4target
DB12010FostamatinibMitogen-activated protein kinase kinase kinase kinase 5target
DB12010FostamatinibMitogen-activated protein kinase 10target
DB12010FostamatinibMitogen-activated protein kinase 13target
DB12010FostamatinibMitogen-activated protein kinase 14target
DB12010FostamatinibMitogen-activated protein kinase 15target
DB12010FostamatinibMitogen-activated protein kinase 4target
DB12010FostamatinibMitogen-activated protein kinase 7target
DB12010FostamatinibMitogen-activated protein kinase 9target
DB12010FostamatinibMAP kinase-activated protein kinase 5target
DB12010FostamatinibSerine/threonine-protein kinase MARK1target
DB12010FostamatinibSerine/threonine-protein kinase MARK2target
DB12010FostamatinibMAP/microtubule affinity-regulating kinase 3target
DB12010FostamatinibMAP/microtubule affinity-regulating kinase 4target
DB12010FostamatinibCLIP-associating protein 1target
DB12010FostamatinibMicrotubule-associated serine/threonine-protein kinase 1target
DB12010FostamatinibMegakaryocyte-associated tyrosine-protein kinasetarget
DB12010FostamatinibMaternal embryonic leucine zipper kinasetarget
DB12010FostamatinibTyrosine-protein kinase Mertarget
DB12010FostamatinibMisshapen-like kinase 1target
DB12010FostamatinibMAP kinase-interacting serine/threonine-protein kinase 1target
DB12010FostamatinibMAP kinase-interacting serine/threonine-protein kinase 2target
DB12010FostamatinibMacrophage-stimulating protein receptortarget
DB12010FostamatinibMuscle, skeletal receptor tyrosine-protein kinasetarget
DB12010FostamatinibMyosin light chain kinase, smooth muscletarget
DB12010FostamatinibMyosin light chain kinase 2, skeletal/cardiac muscletarget
DB12010FostamatinibMyosin light chain kinase 3target
DB12010FostamatinibMyosin light chain kinase family member 4target
DB12010FostamatinibMyosin-IIIatarget
DB12010FostamatinibSerine/threonine-protein kinase Nek1target
DB12010FostamatinibSerine/threonine-protein kinase Nek11target
DB12010FostamatinibSerine/threonine-protein kinase Nek2target
DB12010FostamatinibSerine/threonine-protein kinase Nek3target
DB12010FostamatinibSerine/threonine-protein kinase Nek4target
DB12010FostamatinibSerine/threonine-protein kinase Nek5target
DB12010FostamatinibSerine/threonine-protein kinase Nek9target
DB12010FostamatinibHigh affinity nerve growth factor receptortarget
DB12010FostamatinibBDNF/NT-3 growth factors receptortarget
DB12010FostamatinibNT-3 growth factor receptortarget
DB12010FostamatinibNUAK family SNF1-like kinase 1target
DB12010FostamatinibNUAK family SNF1-like kinase 2target
DB12010FostamatinibSerine/threonine-protein kinase OSR1target
DB12010FostamatinibSerine/threonine-protein kinase PAK 1target
DB12010FostamatinibSerine/threonine-protein kinase PAK 2target
DB12010FostamatinibSerine/threonine-protein kinase PAK 3target
DB12010FostamatinibSerine/threonine-protein kinase PAK 4target
DB12010FostamatinibSerine/threonine-protein kinase PAK 6target
DB12010FostamatinibSerine/threonine-protein kinase PAK 5target
DB12010FostamatinibCyclin-dependent kinase 16target
DB12010FostamatinibCyclin-dependent kinase 17target
DB12010FostamatinibPlatelet-derived growth factor receptor alphatarget
DB12010FostamatinibPlatelet-derived growth factor receptor betatarget
DB12010Fostamatinib3-phosphoinositide-dependent protein kinase 1target
DB12010FostamatinibCyclin-dependent kinase 15target
DB12010FostamatinibPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoformtarget
DB12010FostamatinibPhosphatidylinositol 4-kinase betatarget
DB12010FostamatinibPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit betatarget
DB12010FostamatinibPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gammatarget
DB12010FostamatinibPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget
DB12010FostamatinibPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformtarget
DB12010FostamatinibSerine/threonine-protein kinase pim-1target
DB12010FostamatinibSerine/threonine-protein kinase pim-3target
DB12010FostamatinibPhosphatidylinositol 5-phosphate 4-kinase type-2 betatarget
DB12010FostamatinibPhosphatidylinositol 5-phosphate 4-kinase type-2 gammatarget
DB12010FostamatinibMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinasetarget
DB12010FostamatinibSerine/threonine-protein kinase N1target
DB12010FostamatinibSerine/threonine-protein kinase N2target
DB12010FostamatinibSerine/threonine-protein kinase PLK1target
DB12010FostamatinibSerine/threonine-protein kinase PLK2target
DB12010FostamatinibSerine/threonine-protein kinase PLK3target
DB12010FostamatinibSerine/threonine-protein kinase PLK4target
DB12010Fostamatinib5'-AMP-activated protein kinase catalytic subunit alpha-1target
DB12010Fostamatinib5'-AMP-activated protein kinasetarget
DB12010FostamatinibcAMP-dependent protein kinase catalytic subunit betatarget
DB12010FostamatinibProtein kinase C delta typetarget
DB12010FostamatinibProtein kinase C epsilon typetarget
DB12010FostamatinibProtein kinase C gamma typetarget
DB12010FostamatinibProtein kinase C iota typetarget
DB12010FostamatinibProtein kinase C theta typetarget
DB12010FostamatinibSerine/threonine-protein kinase D1target
DB12010FostamatinibcGMP-dependent protein kinase 2target
DB12010FostamatinibSerine/threonine-protein kinase PRP4 homologtarget
DB12010FostamatinibFocal adhesion kinase 1target
DB12010FostamatinibProtein-tyrosine kinase 2-betatarget
DB12010FostamatinibProtein-tyrosine kinase 6target
DB12010FostamatinibRAF proto-oncogene serine/threonine-protein kinasetarget
DB12010FostamatinibProto-oncogene tyrosine-protein kinase receptor Rettarget
DB12010FostamatinibSerine/threonine-protein kinase RIO1target
DB12010FostamatinibSerine/threonine-protein kinase RIO2target
DB12010FostamatinibSerine/threonine-protein kinase RIO3target
DB12010FostamatinibReceptor-interacting serine/threonine-protein kinase 1target
DB12010FostamatinibReceptor-interacting serine/threonine-protein kinase 2target
DB12010FostamatinibReceptor-interacting serine/threonine-protein kinase 4target
DB12010FostamatinibRho-associated protein kinase 2target
DB12010FostamatinibProto-oncogene tyrosine-protein kinase ROStarget
DB12010FostamatinibRibosomal protein S6 kinase alpha-1target
DB12010FostamatinibRibosomal protein S6 kinase alpha-3target
DB12010FostamatinibSerine/threonine-protein kinase SBK1target
DB12010FostamatinibUncharacterized serine/threonine-protein kinase SBK3target
DB12010FostamatinibSerine/threonine-protein kinase Sgk3target
DB12010FostamatinibSerine/threonine-protein kinase SIK1target
DB12010FostamatinibSerine/threonine-protein kinase SIK2target
DB12010FostamatinibSTE20-like serine/threonine-protein kinasetarget
DB12010FostamatinibSNF-related serine/threonine-protein kinasetarget
DB12010FostamatinibProto-oncogene tyrosine-protein kinase Srctarget
DB12010FostamatinibTyrosine-protein kinase Srmstarget
DB12010FostamatinibSerine/threonine-protein kinase 10target
DB12010FostamatinibSerine/threonine-protein kinase 16target
DB12010FostamatinibSerine/threonine-protein kinase 17Atarget
DB12010FostamatinibSerine/threonine-protein kinase 17Btarget
DB12010FostamatinibSerine/threonine-protein kinase 32Atarget
DB12010FostamatinibCytochrome P450 3A4enzyme
DB12010FostamatinibATP-binding cassette sub-family G member 2transporter
DB12010FostamatinibATP-binding cassette sub-family B member 5transporter
DB12010FostamatinibUDP-glucuronosyltransferase 1-9enzyme
DB08930DolutegravirUDP-glucuronosyltransferase 1-1enzyme
DB08930DolutegravirCYP3Aenzyme
DB08930DolutegravirIntegrasetarget
DB08930DolutegravirMultidrug resistance protein 1carrier
DB08930DolutegravirSolute carrier family 22 member 2transporter
DB08930DolutegravirUDP-glucuronosyltransferase 1-3enzyme
DB08930DolutegravirUDP-glucuronosyltransferase 1-9enzyme
DB08930DolutegravirATP-binding cassette sub-family G member 2transporter
DB08930DolutegravirMultidrug and toxin extrusion protein 1transporter
DB08930DolutegravirMultidrug and toxin extrusion protein 2transporter
DB08930DolutegravirSolute carrier family 22 member 6transporter
DB08930DolutegravirSolute carrier family 22 member 8transporter
DB01026KetoconazoleCytochrome P450 3A4enzyme
DB01026KetoconazoleCytochrome P450 2C9enzyme
DB01026KetoconazoleCytochrome P450 2C19enzyme
DB01026KetoconazoleCytochrome P450 3A5enzyme
DB01026KetoconazoleCytochrome P450 1A2enzyme
DB01026KetoconazoleCytochrome P450 2C8enzyme
DB01026KetoconazoleCytochrome P450 1A1enzyme
DB01026KetoconazoleCytochrome P450 2D6enzyme
DB01026KetoconazoleCytochrome P450 3A7enzyme
DB01026KetoconazoleBile salt export pumptransporter
DB01026KetoconazoleMultidrug resistance protein 1transporter
DB01026KetoconazoleSolute carrier organic anion transporter family member 1A2transporter
DB01026KetoconazoleCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DB01026KetoconazoleCytochrome P450 11B1, mitochondrialenzyme
DB01026KetoconazoleCytochrome P450 1B1enzyme
DB01026KetoconazoleCytochrome P450 26A1enzyme
DB01026KetoconazoleCytochrome P450 2A6enzyme
DB01026KetoconazoleCytochrome P450 2B6enzyme
DB01026KetoconazoleLanosterol 14-alpha demethylaseenzyme
DB01026KetoconazoleLanosterol 14-alpha demethylasetarget
DB01026KetoconazoleAndrogen receptortarget
DB01026Ketoconazole17-hydroxylasetarget
DB01026KetoconazoleSteroid 21-hydroxylasetarget
DB01026Ketoconazole11-hydroxylasetarget
DB01026KetoconazoleCytochrome P450 19A1target
DB01026KetoconazolePotassium voltage-gated channel subfamily H member 2target
DB01026KetoconazoleNuclear receptor subfamily 1 group I member 2target
DB01026KetoconazoleNuclear receptor subfamily 1 group I member 3target
DB01026KetoconazoleUDP-glucuronosyltransferase 1-1enzyme
DB01026KetoconazoleUDP-glucuronosyltransferase 2B7enzyme
DB00224IndinavirHuman immunodeficiency virus type 1 proteasetarget
DB00224IndinavirCytochrome P450 3A4enzyme
DB00224IndinavirCytochrome P450 3A5enzyme
DB00224IndinavirCytochrome P450 3A7enzyme
DB00224IndinavirMultidrug resistance protein 1transporter
DB00224IndinavirSolute carrier family 22 member 1transporter
DB00224IndinavirMultidrug resistance-associated protein 1transporter
DB00224IndinavirSolute carrier organic anion transporter family member 1A2transporter
DB00224IndinavirSolute carrier organic anion transporter family member 1B1transporter
DB00224IndinavirCanalicular multispecific organic anion transporter 1transporter
DB00224IndinavirCytochrome P450 2C19enzyme
DB00224IndinavirCytochrome P450 2C9enzyme
DB00224IndinavirCytochrome P450 2D6enzyme
DB00224IndinavirUDP-glucuronosyltransferase 1-1enzyme