Neuromuscular-Blocking Agents (Nondepolarizing)

Drugs that interrupt transmission at the skeletal neuromuscular junction without causing depolarization of the motor end plate. They prevent acetylcholine from triggering muscle contraction and are used as muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvants.
DrugDrug NameDrug Indication
DB04834RapacuroniumUsed in anaesthesia, to aid and enable endotracheal intubation.
DB01226MivacuriumFor inpatients and outpatients, as an adjunct to general anesthesia, to facilitate tracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
DB00732Atracurium besylateFor use, as an adjunct to general anesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
DB00416Metocurine IodideFor use as an anesthesia adjunct to induce skeletal muscle relaxation and to reduce the intensity of muscle contractions in convulsive therapy.
DB00483Gallamine TriethiodideFor use as adjuncts to anesthesia to induce skeletal muscle relaxation and to facilitate the management of patients undergoing mechanical ventilation
DB00728RocuroniumFor inpatients and outpatients as an adjunct to general anesthesia to facilitate both rapid sequence and routine tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
DB01135DoxacuriumUsed to provide skeletal muscle relaxation as an adjunct to general anesthesia, for endotracheal intubation or to facilitate mechanical ventilation.
DB01199TubocurarineUsed as a diagnosis agent for myasthenia gravis, and also to facilitate the intubation after induction of anesthesia in surgical procedure
DB01336MetocurineMetocurine is a muscle relaxant.
DB01337PancuroniumUsed as a muscle relaxant during anesthesia and surgical procedures.
DB01338PipecuroniumUsed as a muscle relaxant during anesthesia and surgical procedures.
DB01339VecuroniumVecuronium is a muscle relaxing agent and is used as an adjunct in general anesthesia.
DB13295AtracuriumNot Available
DB13584GallamineNot Available
DB13648AlcuroniumNot Available
DB00565CisatracuriumFor inpatients and outpatients as an adjunct to general anesthesia, to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation in the ICU.
DrugDrug NameTargetType
DB04834RapacuroniumMuscarinic acetylcholine receptor M2target
DB01226MivacuriumNeuronal acetylcholine receptor subunit alpha-2target
DB01226MivacuriumMuscarinic acetylcholine receptor M2target
DB01226MivacuriumMuscarinic acetylcholine receptor M3target
DB01226MivacuriumCholinesterasetarget
DB00732Atracurium besylateNeuronal acetylcholine receptor subunit alpha-2target
DB00416Metocurine IodideNeuronal acetylcholine receptor subunit alpha-2target
DB00483Gallamine TriethiodideNeuronal acetylcholine receptor subunit alpha-2target
DB00483Gallamine TriethiodideMuscarinic acetylcholine receptor M2target
DB00483Gallamine TriethiodideAcetylcholinesterasetarget
DB00483Gallamine TriethiodideMuscarinic acetylcholine receptor M1target
DB00483Gallamine TriethiodideMuscarinic acetylcholine receptor M5target
DB00728RocuroniumNeuronal acetylcholine receptor subunit alpha-2target
DB00728RocuroniumMuscarinic acetylcholine receptor M2target
DB00728Rocuronium5-hydroxytryptamine receptor 3Atarget
DB00728RocuroniumSolute carrier family 22 member 1transporter
DB00728RocuroniumSolute carrier organic anion transporter family member 1A2transporter
DB01135DoxacuriumNeuronal acetylcholine receptor subunit alpha-2target
DB01135DoxacuriumMuscarinic acetylcholine receptor M2target
DB01135DoxacuriumCholinesteraseenzyme
DB01199TubocurarineNeuronal acetylcholine receptor subunit alpha-2target
DB01199TubocurarineAcetylcholinesterasetarget
DB01199Tubocurarine5-hydroxytryptamine receptor 3Atarget
DB01199TubocurarineSolute carrier family 22 member 1transporter
DB01199TubocurarineSolute carrier family 22 member 2transporter
DB01199TubocurarineNeuronal acetylcholine receptor subunit alpha-7target
DB01199TubocurarineCholinesteraseenzyme
DB01336MetocurineNeuronal acetylcholine receptor subunit alpha-2target
DB01336MetocurineMuscarinic acetylcholine receptor M2target
DB01337PancuroniumNeuronal acetylcholine receptor subunit alpha-2target
DB01337PancuroniumCholinesteraseenzyme
DB01337PancuroniumMuscarinic acetylcholine receptor M2target
DB01337PancuroniumMuscarinic acetylcholine receptor M3target
DB01337PancuroniumSolute carrier family 22 member 1transporter
DB01337PancuroniumSolute carrier family 22 member 2transporter
DB01338PipecuroniumNeuronal acetylcholine receptor subunit alpha-2target
DB01338PipecuroniumMuscarinic acetylcholine receptor M2target
DB01338PipecuroniumMuscarinic acetylcholine receptor M3target
DB01338PipecuroniumCholinesteraseenzyme
DB01339VecuroniumMultidrug resistance protein 1transporter
DB01339VecuroniumNeuronal acetylcholine receptor subunit alpha-2target
DB00565CisatracuriumNeuronal acetylcholine receptor subunit alpha-2target