Highest Risk QTc-Prolonging Agents

Drugs demonstrating a high risk of QTc interval prolongation in animal or human studies.
DrugDrug NameDrug Indication
DB00204DofetilideFor the maintenance of normal sinus rhythm (delay in time to recurrence of atrial fibrillation/atrial flutter [AF/AFl]) in patients with atrial fibrillation/atrial flutter of greater than one week duration who have been converted to normal sinus rhythm
DB00215CitalopramFor the treatment of depression. Off-label indications include: treatment of mild dementia-associated agitation in nonpsychotic patients, smoking cessation, ethanol abuse, obsessive-compulsive disorder (OCD) in children, and diabetic neuropathy [FDA label].
DB00246ZiprasidoneFor the treatment of schizophrenia and related psychotic disorders.
DB00261AnagrelideFor the treatment of patients with thrombocythemia, secondary to myeloproliferative disorders, to reduce the elevated platelet count and the risk of thrombosis and to ameliorate associated symptoms including thrombo-hemorrhagic events.
DB00280DisopyramideFor the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, ventricular pre-excitation and cardiac dysrhythmias. It is a Class Ia antiarrhythmic drug.
DB00308IbutilideIndicated for the rapid conversion of atrial fibrillation or atrial flutter of recent onset to sinus rhythm.
DB00468QuinineFor the treatment of malaria and leg cramps
DB00472FluoxetineLabeled indication include: major depressive disorder (MDD), moderate to severe bulimia nervosa, obsessive-compulsive disorder (OCD), premenstrual dysphoric disorder (PMDD), panic disorder with or without agoraphobia, and combination treatment with olanzapine for treatment-resistant or bipolar I depression. Unlabeled indications include: selective mutism, mild dementia-associated agitation in nonpsychotic patients, post-traumatic stress disorder (PTSD), social anxiety disorder, chronic neuropathic pain, fibromyalgia, and Raynaud's phenomenon.
DB00489SotalolFor the maintenance of normal sinus rhythm [delay in time to recurrence of atrial fibrillation/atrial flutter (AFIB/AFL)] in patients with symptomatic AFIB/AFL who are currently in sinus rhythm. Also for the treatment of documented life-threatening ventricular arrhythmias.
DB00539ToremifeneFor the treatment of metastatic breast cancer in postmenopausal women with estrogen receptor-positive or receptor-unknown tumors. Toremifene is currently under investigation as a preventative agent for prostate cancer in men with high-grade prostatic intraepithelial neoplasia and no evidence of prostate cancer.
DB00604CisaprideFor the symptomatic treatment of adult patients with nocturnal heartburn due to gastroesophageal reflux disease.
DB00679ThioridazineFor the treatment of schizophrenia and generalized anxiety disorder.
DB00834MifepristoneFor the medical termination of intrauterine pregnancy through 49 days' pregnancy. Also indicated to control hyperglycemia secondary to hypercortisolism in adult patients with endogenous Cushing's syndrome who have type 2 diabetes mellitus or glucose intolerance and are not candidates for surgery or have had unsuccessful surgery.
DB00875FlupentixolFor use in the treatment of schizophrenia and depression
DB00908QuinidineFor the treatment of ventricular pre-excitation and cardiac dysrhythmias
DB01035ProcainamideFor the treatment of life-threatening ventricular arrhythmias.
DB01100PimozideUsed for the suppression of motor and phonic tics in patients with Tourette's Disorder who have failed to respond satisfactorily to standard treatment.
DB01118AmiodaroneIntravenously, for initiation of treatment and prophylaxis of frequently recurring ventricular fibrillation and hemodynamically unstable ventricular tachycardia in patients refractory to other therapy. Orally, for the treatment of life-threatening recurrent ventricular arrhythmias such as recurrent ventricular fibrillation and recurrent hemodynamically unstable ventricular tachycardia.
DB01169Arsenic trioxideFor induction of remission and consolidation in patients with acute promyelocytic leukemia (APL), and whose APL is characterized by the presence of the t(15;17) translocation or PML/RAR-alpha gene expression
DB01175EscitalopramLabeled indications include major depressive disorder (MDD) and generalized anxiety disorder (GAD). Unlabeled indications include treatment of mild dementia-associated agitation in nonpsychotic patients.
DB01184DomperidoneFor management of dyspepsia, heartburn, epigastric pain, nausea, and vomiting.
DB01224QuetiapineFor the treatment of schizophrenia and related psychotic disorders.
DB01267PaliperidoneFor the treatment of schizophrenia.
DB01601LopinavirIndicated in combination with other antiretroviral agents for the treatment of HIV-infection.
DB01624ZuclopenthixolUsed in the management of acute psychoses such as mania or schizophrenia. However, the use of zuclopenthixol acetate in psychiatric emergencies as an alternative to standard treatments (haloperidol, clotiapine, etc.) should be cautioned, since well executed and documented trials of zuclopenthixol acetate for this use have yet to be conducted. Zuclopenthixol acetate is not intended for long-term use.
DB04844TetrabenazineTreatment of hyperkinetic movement disorders like chorea in Huntington's disease, hemiballismus, senile chorea, Tourette syndrome and other tic disorders, and tardive dyskinesia
DB04855DronedaroneManagement of paroxysmal or persistent atrial fibrillation via restoration of normal sinus rhythm.
DB04868NilotinibFor the potential treatment of various leukemias, including chronic myeloid leukemia (CML).
DB04946IloperidoneTreatment of acute schizophrenia.
DB05294VandetanibVandetanib is currently approved as an alternative to local therapies for both unresectable and disseminated disease. Because Vandetanib can prolong the Q-T interval, it is contraindicated for use in patients with serious cardiac complications such as congenital long QT syndrome and uncompensated heart failure.
DB06216AsenapineUsed for treatment in psychosis, schizophrenia and schizoaffective disorders, manic disorders, and bipolar disorders as monotherapy or in combination.
DB06697ArtemetherArtemether and lumefantrine combination therapy is indicated for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum, including malaria acquired in chloroquine-resistant areas. May also be used to treat uncomplicated malaria when the Plasmodium species has not been identified. Indicated for use in adults and children greater than 5 kg.
DB06708LumefantrineLumefantrine and artemether combination therapy is indicated for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum, including malaria acquired in chloroquine-resistant areas. May also be used to treat uncomplicated malaria when the Plasmodium species has not been identified. Indicated for use in adults and children greater than 5 kg.
DB08881VemurafenibVemurafenib is approved since 2011 for the treatment of metastatic melanoma with a mutation on BRAF in the valine located in the exon 15 at codon 600, this mutation is denominated as V600E.[A31270] The V600E mutation, a substitution of glutamic acid for valine, accounts for 54% of the cases of cutaneous melanoma.[A31271] Vemurafenib approval was extended in 2017, for its use as a treatment of adult patients with Erdheim-Chester Disease whose cancer cells present BRAF V600 mutation.[L1013] Erdheim-Chester disease is an extremely rare histiocyte cell disorder that affects large bones, large vessels, central nervous system, as well as, skin and lungs. It is reported an association of Erdheim-Chester disease and V600E mutation.[A31272]
DB09039EliglustatEliglustat is indicated for the long-term treatment of type 1 Gaucher disease in patients who are CYP2D6 extensive metabolizers (EMs), intermediate metabolizers (IMs), or poor metabolizers (PMs) in treatment-naive and treatment-experienced adult patients.
DB01356Lithium cationLithium is used as a mood stabilizer, and is used for treatment of depression and mania. It is often used in bipolar disorder treatment.
DB06176RomidepsinFor the treatment of cutaneous T-cell lymphoma (CTCL) or/and peripheral T-cell lymphoma (PTCL) in patients who have received at least one prior systemic therapy. These indications are based on response rate. Clinical benefit such as improvement in overall survival has not been demonstrated.
DB00313Valproic AcidFor treatment and management of seizure disorders, mania, and prophylactic treatment of migraine headache. In epileptics, valproic acid is used to control absence seizures, tonic-clonic seizures (grand mal), complex partial seizures, and the seizures associated with Lennox-Gastaut syndrome.
DB01405TemafloxacinFor the treatment of lower respiratory tract infections, genital and urinary infections like prostatitis, and skin infections.
DB00365GrepafloxacinFor treatment of adults with mild to moderate infections caused by susceptible strains of Haemophilus influenzae, Streptococcus pneumoniae, or Moraxella catarrhalis.
DB00685TrovafloxacinFor treatment of infections caused by susceptible strains of the designated microorganisms in uncomplicated urethral gonorrhea in males and endocervical and rectal gonorrhea in females caused by Neisseria gonorrhoeae as well as non gonoccocal urethritis and cervicitis due to Chlamydia trachomatis.
DB00637AstemizoleAstemizole was indicated for use in the relieving allergy symptoms, particularly rhinitis and conjunctivitis. It has been withdrawn from the market however due to concerns of arrhythmias.
DB01244BepridilFor the treatment of hypertension, and chronic stable angina (classic effort-associated angina).
DB00907CocaineFor the introduction of local (topical) anesthesia of accessible mucous membranes of the oral, laryngeal and nasal cavities.
DB01218HalofantrineFor treatment of Severe malaria
DB01208SparfloxacinFor the treatment of adults with the following infections caused by susceptible strains microorganisms: community-acquired pneumonia (caused by Chlamydia pneumoniae, Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella catarrhalis, Mycoplasma pneumoniae, or Streptococcus pneumoniae) and acute bacterial exacerbations of chronic bronchitis (caused by Chlamydia pneumoniae, Enterobacter cloacae, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Staphylococcus aureus, or Streptococcus pneumoniae).
DB00342TerfenadineFor the treatment of allergic rhinitis, hay fever, and allergic skin disorders.
DB00619ImatinibFor the treatment of Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML), Ph+ acute lymphoblastic leukaemia, myelodysplastic/myeloproliferative diseases, aggressive systemic mastocytosis, hypereosinophilic syndrome and/or chronic eosinophilic leukemia (CEL), dermatofibrosarcoma protuberans, and malignant gastrointestinal stromal tumors (GIST).
DB00530ErlotinibFor the treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of at least one prior chemotherapy regimen. Also for use, in combination with gemcitabine, as the first-line treatment of patients with locally advanced, unresectable or metastatic pancreatic cancer.
DB11730RibociclibKisqali (ribociclib) is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced precision may play a role in ensuring that cancer cells do not continue to replicate uncontrollably.
DB13074MacimorelinIndicated for the diagnosis of adult growth hormone deficiency (AGHD) [FDA Label].
DB12161DeutetrabenazineIndicated for the treatment of chorea associated with Huntington’s disease [FDA Label].
DB00283ClemastineFor the relief of symptoms associated with allergic rhinitis such as sneezing, rhinorrhea, pruritus and acrimation. Also for the management of mild, uncomplicated allergic skin manifestations of urticaria and angioedema. Used as self-medication for temporary relief of symptoms associated with the common cold.
DB09083IvabradineIvabradine's indication by the FDA is to reduce the risk of hospitalization for worsening heart failure in patients with stable, symptomatic chronic heart failure with left ventricular ejection fraction ≤35%, who are in sinus rhythm with resting heart rate ≥70 beats per minute and either are on maximally tolerated doses of beta-blockers or have a contraindication to beta-blocker use.
DrugDrug NameTargetType
DB00204DofetilidePotassium channel subfamily K member 2target
DB00204DofetilidePotassium voltage-gated channel subfamily H member 2target
DB00204DofetilideATP-sensitive inward rectifier potassium channel 12target
DB00204DofetilideCytochrome P450 3A4enzyme
DB00215CitalopramSodium-dependent serotonin transportertarget
DB00215CitalopramCytochrome P450 2C19enzyme
DB00215CitalopramCytochrome P450 2D6enzyme
DB00215CitalopramCytochrome P450 3A4enzyme
DB00215CitalopramMultidrug resistance protein 1transporter
DB00215CitalopramCytochrome P450 1A2enzyme
DB00215CitalopramCytochrome P450 2B6enzyme
DB00215CitalopramCytochrome P450 2E1enzyme
DB00215CitalopramHistamine H1 receptortarget
DB00215CitalopramSodium-dependent dopamine transportertransporter
DB00215CitalopramSodium-dependent noradrenaline transportertransporter
DB00215CitalopramSodium-dependent serotonin transportertransporter
DB00215CitalopramAlpha-1A adrenergic receptortarget
DB00215CitalopramMuscarinic acetylcholine receptor M1target
DB00215Citalopram5-hydroxytryptamine receptor 2Ctarget
DB00246ZiprasidoneAlpha-1A adrenergic receptortarget
DB00246ZiprasidoneD(2) dopamine receptortarget
DB00246Ziprasidone5-hydroxytryptamine receptor 2Ctarget
DB00246ZiprasidoneD(3) dopamine receptortarget
DB00246Ziprasidone5-hydroxytryptamine receptor 1Atarget
DB00246Ziprasidone5-hydroxytryptamine receptor 1Dtarget
DB00246ZiprasidoneHistamine H1 receptortarget
DB00246Ziprasidone5-hydroxytryptamine receptor 2Atarget
DB00246ZiprasidoneD(4) dopamine receptortarget
DB00246Ziprasidone5-hydroxytryptamine receptor 7target
DB00246ZiprasidoneCytochrome P450 3A4enzyme
DB00246ZiprasidoneAlpha-2A adrenergic receptortarget
DB00246ZiprasidoneAlpha-1B adrenergic receptortarget
DB00246ZiprasidoneAlpha-2B adrenergic receptortarget
DB00246ZiprasidoneAlpha-2C adrenergic receptortarget
DB00246ZiprasidoneD(1A) dopamine receptortarget
DB00246ZiprasidoneD(1B) dopamine receptortarget
DB00246ZiprasidoneMuscarinic acetylcholine receptor M1target
DB00246ZiprasidoneMuscarinic acetylcholine receptor M2target
DB00246ZiprasidoneMuscarinic acetylcholine receptor M3target
DB00246ZiprasidoneMuscarinic acetylcholine receptor M4target
DB00246ZiprasidoneMuscarinic acetylcholine receptor M5target
DB00246Ziprasidone5-hydroxytryptamine receptor 1Btarget
DB00246Ziprasidone5-hydroxytryptamine receptor 1Etarget
DB00246Ziprasidone5-hydroxytryptamine receptor 3Atarget
DB00246Ziprasidone5-hydroxytryptamine receptor 6target
DB00246ZiprasidoneCytochrome P450 3A5enzyme
DB00246ZiprasidoneCytochrome P450 3A7enzyme
DB00246ZiprasidoneCytochrome P450 1A2enzyme
DB00246ZiprasidoneCytochrome P450 2D6enzyme
DB00261AnagrelidecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
DB00261AnagrelideCytochrome P450 1A2enzyme
DB00280DisopyramideSodium channel protein type 5 subunit alphatarget
DB00280DisopyramideAlpha-1-acid glycoprotein 1carrier
DB00280DisopyramideCytochrome P450 3A4enzyme
DB00280DisopyramideMuscarinic acetylcholine receptor M1target
DB00280DisopyramideMuscarinic acetylcholine receptor M2target
DB00280DisopyramideMuscarinic acetylcholine receptor M3target
DB00280DisopyramidePotassium voltage-gated channel subfamily D member 2target
DB00280DisopyramidePotassium voltage-gated channel subfamily D member 3target
DB00280DisopyramideSolute carrier family 22 member 2transporter
DB00280DisopyramideSolute carrier family 22 member 1transporter
DB00280DisopyramidePotassium voltage-gated channel subfamily H member 2target
DB00280DisopyramideAlpha-1-acid glycoprotein 2target
DB00280DisopyramideCytochrome P450 1A2enzyme
DB00308IbutilidePotassium voltage-gated channel subfamily H member 6target
DB00308IbutilideVoltage-dependent L-type calcium channel subunit beta-1target
DB00308IbutilideVoltage-dependent calcium channel gamma-1 subunittarget
DB00308IbutilideVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB00308IbutilidePotassium voltage-gated channel subfamily H member 2target
DB00308IbutilideVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB00308IbutilidePotassium channel subfamily K member 1target
DB00308IbutilidePotassium channel subfamily K member 6target
DB00308IbutilideATP-sensitive inward rectifier potassium channel 11target
DB00308IbutilidePotassium voltage-gated channel subfamily H member 7target
DB00468QuininePlatelet glycoprotein IXtarget
DB00468QuinineIntermediate conductance calcium-activated potassium channel protein 4target
DB00468QuinineCytochrome P450 3A4enzyme
DB00468QuinineCytochrome P450 3A5enzyme
DB00468QuinineCytochrome P450 1A1enzyme
DB00468QuinineCytochrome P450 2D6enzyme
DB00468QuinineCytochrome P450 1A2enzyme
DB00468QuinineCytochrome P450 2C8enzyme
DB00468QuinineCytochrome P450 2C9enzyme
DB00468QuinineCytochrome P450 2C19enzyme
DB00468QuinineCytochrome P450 2E1enzyme
DB00468QuinineCytochrome P450 3A7enzyme
DB00468QuinineSolute carrier family 22 member 2transporter
DB00468QuinineSolute carrier family 22 member 1transporter
DB00468QuinineSolute carrier family 22 member 5transporter
DB00468QuinineMultidrug resistance protein 1transporter
DB00468QuinineSolute carrier organic anion transporter family member 1A2transporter
DB00468QuinineSolute carrier family 22 member 4transporter
DB00468QuinineFe(II)-protoporphyrin IXtarget
DB00468QuinineSolute carrier organic anion transporter family member 1B1transporter
DB00472FluoxetineSodium-dependent serotonin transportertarget
DB00472FluoxetineCytochrome P450 2C9enzyme
DB00472FluoxetineCytochrome P450 2D6enzyme
DB00472FluoxetineCYP2B proteinenzyme
DB00472FluoxetineCytochrome P450 1A2enzyme
DB00472FluoxetineCytochrome P450 3A4enzyme
DB00472FluoxetineCytochrome P450 2C19enzyme
DB00472FluoxetineMultidrug resistance protein 1transporter
DB00472FluoxetineCytochrome P450 2B6enzyme
DB00472FluoxetineCytochrome P450 3A5enzyme
DB00472FluoxetineSerum albumincarrier
DB00472FluoxetineAlpha-1-acid glycoprotein 1carrier
DB00472FluoxetinePotassium voltage-gated channel subfamily H member 2target
DB00472Fluoxetine5-hydroxytryptamine receptor 2Ctarget
DB00472FluoxetineCyclin-dependent kinases regulatory subunit 1target
DB00472FluoxetineNeuronal acetylcholine receptor subunit alpha-2target
DB00472FluoxetineNeuronal acetylcholine receptor subunit alpha-3target
DB00472FluoxetineNeuronal acetylcholine receptor subunit beta-4target
DB00489SotalolPotassium voltage-gated channel subfamily H member 2target
DB00489SotalolBeta-1 adrenergic receptortarget
DB00489SotalolBeta-2 adrenergic receptortarget
DB00489SotalolCytochrome P450 2D6enzyme
DB00539ToremifeneEstrogen receptor alphatarget
DB00539ToremifeneCytochrome P450 3A4enzyme
DB00539ToremifeneMultidrug resistance protein 1transporter
DB00539ToremifeneCytochrome P450 1A1enzyme
DB00539ToremifeneSex hormone-binding globulintarget
DB00604Cisapride5-hydroxytryptamine receptor 4target
DB00604Cisapride5-hydroxytryptamine receptor 3Atarget
DB00604CisapridePotassium voltage-gated channel subfamily H member 2target
DB00604Cisapride5-hydroxytryptamine receptor 2Atarget
DB00604CisaprideCytochrome P450 3A4enzyme
DB00604CisaprideCytochrome P450 3A5enzyme
DB00604CisaprideCytochrome P450 3A7enzyme
DB00604CisaprideCytochrome P450 2A6enzyme
DB00604CisaprideCytochrome P450 2B6enzyme
DB00604CisaprideCytochrome P450 2C19enzyme
DB00604CisaprideCytochrome P450 2C8enzyme
DB00604CisaprideCytochrome P450 2C9enzyme
DB00604CisaprideCytochrome P450 2D6enzyme
DB00679ThioridazineAlpha-1A adrenergic receptortarget
DB00679ThioridazineD(2) dopamine receptortarget
DB00679Thioridazine5-hydroxytryptamine receptor 2Atarget
DB00679ThioridazineD(1A) dopamine receptortarget
DB00679ThioridazineCytochrome P450 2C19enzyme
DB00679ThioridazineCytochrome P450 2D6enzyme
DB00679ThioridazineAlpha-1B adrenergic receptortarget
DB00679ThioridazinePotassium voltage-gated channel subfamily H member 2target
DB00679ThioridazineCytochrome P450 2C8enzyme
DB00679ThioridazineCytochrome P450 2C9enzyme
DB00679ThioridazineCytochrome P450 2E1enzyme
DB00834MifepristoneProgesterone receptortarget
DB00834MifepristoneGlucocorticoid receptortarget
DB00834MifepristoneCytochrome P450 3A4enzyme
DB00834MifepristoneCytochrome P450 3A5enzyme
DB00834MifepristoneCytochrome P450 3A7enzyme
DB00834MifepristoneMultidrug resistance protein 1transporter
DB00834MifepristoneMultidrug resistance-associated protein 1transporter
DB00834MifepristoneCytochrome P450 2D6enzyme
DB00834MifepristoneProstate-specific antigentarget
DB00834MifepristoneNuclear receptor subfamily 1 group I member 2target
DB00834MifepristoneBile salt export pumptransporter
DB00834MifepristoneCytochrome P450 2C8enzyme
DB00875FlupentixolAlpha-1A adrenergic receptortarget
DB00875FlupentixolD(2) dopamine receptortarget
DB00875FlupentixolD(1A) dopamine receptortarget
DB00875FlupentixolAromatic-L-amino-acid decarboxylaseenzyme
DB00875Flupentixol5-hydroxytryptamine receptor 2Atarget
DB00875FlupentixolMultidrug resistance protein 1transporter
DB00875FlupentixolMuscarinic acetylcholine receptor M1target
DB00908QuinidineSodium channel protein type 5 subunit alphatarget
DB00908QuinidineAlpha-1-acid glycoprotein 1carrier
DB00908QuinidinePotassium voltage-gated channel subfamily H member 2target
DB00908QuinidinePotassium channel subfamily K member 1target
DB00908QuinidinePotassium channel subfamily K member 6target
DB00908QuinidineCytochrome P450 1A2enzyme
DB00908QuinidineCytochrome P450 2E1enzyme
DB00908QuinidineCytochrome P450 1A1enzyme
DB00908QuinidineCytochrome P450 2D6enzyme
DB00908QuinidineCytochrome P450 3A4enzyme
DB00908QuinidineCytochrome P450 3A7enzyme
DB00908QuinidineSolute carrier family 22 member 2transporter
DB00908QuinidineSolute carrier family 22 member 1transporter
DB00908QuinidineSolute carrier family 22 member 5transporter
DB00908QuinidineMultidrug resistance protein 1transporter
DB00908QuinidineSolute carrier organic anion transporter family member 1A2transporter
DB00908QuinidineSolute carrier family 22 member 8transporter
DB00908QuinidineCanalicular multispecific organic anion transporter 1transporter
DB00908QuinidineSolute carrier family 22 member 4transporter
DB00908QuinidineSolute carrier organic anion transporter family member 1B1transporter
DB00908QuinidineCytochrome P450 2B6enzyme
DB00908QuinidineCytochrome P450 2C9enzyme
DB00908QuinidineAlpha-1A adrenergic receptortarget
DB00908QuinidineAlpha-1B adrenergic receptortarget
DB00908QuinidineAlpha-1D adrenergic receptortarget
DB00908QuinidineBile salt export pumptransporter
DB00908QuinidineCytochrome P450 2C8enzyme
DB01035ProcainamideSodium channel protein type 5 subunit alphatarget
DB01035ProcainamideDNA (cytosine-5)-methyltransferase 1target
DB01035ProcainamideCytochrome P450 2D6enzyme
DB01035ProcainamideCholinesteraseenzyme
DB01035ProcainamideSolute carrier family 22 member 2transporter
DB01035ProcainamideSolute carrier family 22 member 1transporter
DB01035ProcainamideSolute carrier family 22 member 3transporter
DB01035ProcainamideSolute carrier family 22 member 5transporter
DB01035ProcainamideSolute carrier family 22 member 4transporter
DB01035ProcainamidePotassium voltage-gated channel subfamily H member 2target
DB01035ProcainamideMultidrug and toxin extrusion protein 1transporter
DB01035ProcainamideMultidrug and toxin extrusion protein 2transporter
DB01100PimozideD(2) dopamine receptortarget
DB01100PimozideCalmodulintarget
DB01100PimozidePotassium voltage-gated channel subfamily H member 2target
DB01100PimozideCytochrome P450 3A4enzyme
DB01100PimozideCytochrome P450 1A2enzyme
DB01100PimozideCytochrome P450 3A5enzyme
DB01100PimozideCytochrome P450 3A7enzyme
DB01100PimozideMultidrug resistance protein 1transporter
DB01100PimozideD(3) dopamine receptortarget
DB01100PimozideCytochrome P450 2D6enzyme
DB01100PimozideCytochrome P450 2E1enzyme
DB01118AmiodaroneBeta-1 adrenergic receptortarget
DB01118AmiodaronePotassium voltage-gated channel subfamily H member 2target
DB01118AmiodaroneCytochrome P450 2C8enzyme
DB01118AmiodaroneCytochrome P450 2C9enzyme
DB01118AmiodaroneCytochrome P450 2D6enzyme
DB01118AmiodaroneVoltage-dependent T-type calcium channel subunit alpha-1Htarget
DB01118AmiodaroneVoltage-dependent calcium channel subunit alpha-2/delta-2target
DB01118AmiodaroneCytochrome P450 3A4enzyme
DB01118AmiodaroneCytochrome P450 1A2enzyme
DB01118AmiodaroneCytochrome P450 3A5enzyme
DB01118AmiodaroneCytochrome P450 3A7enzyme
DB01118AmiodaroneCytochrome P450 1A1enzyme
DB01118AmiodaroneMultidrug resistance protein 1transporter
DB01118AmiodaroneCytochrome P450 2C19enzyme
DB01118AmiodaroneCytochrome P450 2A6enzyme
DB01118AmiodaroneThyroid hormone receptor alphatarget
DB01118AmiodaroneThyroid hormone receptor betatarget
DB01118AmiodaronePeroxisome proliferator-activated receptor gammatarget
DB01118AmiodaroneBile salt export pumptransporter
DB01169Arsenic trioxideInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB01169Arsenic trioxideTranscription factor AP-1target
DB01169Arsenic trioxideG1/S-specific cyclin-D1target
DB01169Arsenic trioxideMitogen-activated protein kinase 3target
DB01169Arsenic trioxideMitogen-activated protein kinase 1target
DB01169Arsenic trioxideRAC-alpha serine/threonine-protein kinasetarget
DB01169Arsenic trioxideCytochrome P450 1A1enzyme
DB01169Arsenic trioxideCanalicular multispecific organic anion transporter 1transporter
DB01169Arsenic trioxideThioredoxin reductase 1, cytoplasmictarget
DB01169Arsenic trioxideMultidrug resistance protein 1transporter
DB01169Arsenic trioxideCytochrome P450 1B1enzyme
DB01169Arsenic trioxideCytochrome P450 3A4enzyme
DB01169Arsenic trioxideCyclin-dependent kinase inhibitor 1target
DB01169Arsenic trioxideHistone deacetylase 1target
DB01169Arsenic trioxideProtein PMLtarget
DB01169Arsenic trioxideSerum albumincarrier
DB01175EscitalopramSodium-dependent serotonin transportertarget
DB01175EscitalopramCytochrome P450 3A4enzyme
DB01175EscitalopramCytochrome P450 2D6enzyme
DB01175EscitalopramSodium-dependent dopamine transportertarget
DB01175EscitalopramSodium-dependent noradrenaline transportertarget
DB01175EscitalopramAlpha-1A adrenergic receptortarget
DB01175EscitalopramMuscarinic acetylcholine receptor M1target
DB01175EscitalopramHistamine H1 receptortarget
DB01175EscitalopramCytochrome P450 2C19enzyme
DB01184DomperidoneD(2) dopamine receptortarget
DB01184DomperidoneCytochrome P450 3A4enzyme
DB01184DomperidoneCytochrome P450 3A5enzyme
DB01184DomperidoneCytochrome P450 3A7enzyme
DB01184DomperidoneMultidrug resistance protein 1transporter
DB01184DomperidoneCytochrome P450 1A2enzyme
DB01184DomperidoneCytochrome P450 2B6enzyme
DB01184DomperidoneCytochrome P450 2C8enzyme
DB01184DomperidoneCytochrome P450 2D6enzyme
DB01184DomperidoneD(3) dopamine receptortarget
DB01224Quetiapine5-hydroxytryptamine receptor 2Atarget
DB01224Quetiapine5-hydroxytryptamine receptor 2Ctarget
DB01224QuetiapineD(2) dopamine receptortarget
DB01224Quetiapine5-hydroxytryptamine receptor 1Atarget
DB01224QuetiapineHistamine H1 receptortarget
DB01224QuetiapineCytochrome P450 3A4enzyme
DB01224QuetiapineAlpha-1A adrenergic receptortarget
DB01224QuetiapineAlpha-1B adrenergic receptortarget
DB01224QuetiapineAlpha-1D adrenergic receptortarget
DB01224QuetiapineAlpha-2A adrenergic receptortarget
DB01224QuetiapineAlpha-2B adrenergic receptortarget
DB01224QuetiapineAlpha-2C adrenergic receptortarget
DB01224Quetiapine5-hydroxytryptamine receptor 1Dtarget
DB01224QuetiapineMuscarinic acetylcholine receptor M1target
DB01224QuetiapineMuscarinic acetylcholine receptor M2target
DB01224QuetiapineMuscarinic acetylcholine receptor M3target
DB01224QuetiapineMuscarinic acetylcholine receptor M4target
DB01224QuetiapineMuscarinic acetylcholine receptor M5target
DB01224Quetiapine5-hydroxytryptamine receptor 1Btarget
DB01224Quetiapine5-hydroxytryptamine receptor 1Etarget
DB01224Quetiapine5-hydroxytryptamine receptor 3Atarget
DB01224Quetiapine5-hydroxytryptamine receptor 6target
DB01224Quetiapine5-hydroxytryptamine receptor 7target
DB01224QuetiapineD(1B) dopamine receptortarget
DB01224QuetiapineD(1A) dopamine receptortarget
DB01224QuetiapineD(3) dopamine receptortarget
DB01224QuetiapineD(4) dopamine receptortarget
DB01224QuetiapineCytochrome P450 3A5enzyme
DB01224QuetiapineCytochrome P450 3A7enzyme
DB01224QuetiapineMultidrug resistance protein 1transporter
DB01224QuetiapineCytochrome P450 2C19enzyme
DB01224QuetiapineCytochrome P450 2D6enzyme
DB01267PaliperidoneD(2) dopamine receptortarget
DB01267Paliperidone5-hydroxytryptamine receptor 2Atarget
DB01267PaliperidoneHistamine H1 receptortarget
DB01267PaliperidoneAlpha-1A adrenergic receptortarget
DB01267PaliperidoneAlpha-1B adrenergic receptortarget
DB01267PaliperidoneD(3) dopamine receptortarget
DB01267PaliperidoneD(4) dopamine receptortarget
DB01267PaliperidoneD(1A) dopamine receptortarget
DB01267PaliperidoneAlpha-2A adrenergic receptortarget
DB01267PaliperidoneAlpha-2B adrenergic receptortarget
DB01267PaliperidoneAlpha-2C adrenergic receptortarget
DB01267Paliperidone5-hydroxytryptamine receptor 1Atarget
DB01267Paliperidone5-hydroxytryptamine receptor 1Dtarget
DB01267Paliperidone5-hydroxytryptamine receptor 2Ctarget
DB01267Paliperidone5-hydroxytryptamine receptor 7target
DB01267PaliperidoneCytochrome P450 3A4enzyme
DB01267PaliperidoneCytochrome P450 2D6enzyme
DB01267PaliperidoneCytochrome P450 3A5enzyme
DB01267PaliperidoneMultidrug resistance protein 1transporter
DB01601LopinavirHuman immunodeficiency virus type 1 proteasetarget
DB01601LopinavirCytochrome P450 3A4enzyme
DB01601LopinavirCytochrome P450 2D6enzyme
DB01601LopinavirCytochrome P450 2C19enzyme
DB01601LopinavirMultidrug resistance protein 1transporter
DB01601LopinavirCytochrome P450 2B6enzyme
DB01601LopinavirCytochrome P450 2C9enzyme
DB01601LopinavirCytochrome P450 2C8enzyme
DB01601LopinavirCYP3Aenzyme
DB01601LopinavirSolute carrier organic anion transporter family member 1B1transporter
DB01601LopinavirSolute carrier organic anion transporter family member 1B3transporter
DB01601LopinavirBile salt export pumptransporter
DB01624ZuclopenthixolD(1A) dopamine receptortarget
DB01624ZuclopenthixolD(1B) dopamine receptortarget
DB01624ZuclopenthixolD(2) dopamine receptortarget
DB01624ZuclopenthixolCytochrome P450 2D6enzyme
DB01624ZuclopenthixolAlpha-1A adrenergic receptortarget
DB01624ZuclopenthixolAlpha-2A adrenergic receptortarget
DB01624Zuclopenthixol5-hydroxytryptamine receptor 2Atarget
DB01624ZuclopenthixolHistamine H1 receptortarget
DB01624ZuclopenthixolCytochrome P450 3A4enzyme
DB04844TetrabenazineSynaptic vesicular amine transportertarget
DB04844TetrabenazineCytochrome P450 2D6enzyme
DB04844TetrabenazineD(2) dopamine receptortarget
DB04844TetrabenazineCarbonyl reductase [NADPH] 1enzyme
DB04855DronedaroneAlpha-1A adrenergic receptortarget
DB04855DronedaroneBeta-1 adrenergic receptortarget
DB04855DronedaroneAlpha-1B adrenergic receptortarget
DB04855DronedaroneAlpha-1D adrenergic receptortarget
DB04855DronedaroneAlpha-2A adrenergic receptortarget
DB04855DronedaroneAlpha-2B adrenergic receptortarget
DB04855DronedaroneAlpha-2C adrenergic receptortarget
DB04855DronedaronePotassium voltage-gated channel subfamily H member 2target
DB04855DronedaroneVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB04855DronedaroneVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DB04855DronedaroneVoltage-dependent L-type calcium channel subunit alpha-1Ftarget
DB04855DronedaroneVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB04855DronedaroneVoltage-dependent L-type calcium channel subunit beta-1target
DB04855DronedaroneVoltage-dependent L-type calcium channel subunit beta-2target
DB04855DronedaroneVoltage-dependent L-type calcium channel subunit beta-3target
DB04855DronedaroneVoltage-dependent L-type calcium channel subunit beta-4target
DB04855DronedaroneCytochrome P450 2D6enzyme
DB04855DronedaroneCytochrome P450 3A4enzyme
DB04855DronedaroneMultidrug resistance protein 1transporter
DB04855DronedaroneSodium channel protein type 1 subunit alphatarget
DB04855DronedaronePotassium channel subfamily K member 2target
DB04855DronedaroneSerum albumincarrier
DB04868NilotinibTyrosine-protein kinase ABL1target
DB04868NilotinibMast/stem cell growth factor receptor Kittarget
DB04868NilotinibCytochrome P450 2D6enzyme
DB04868NilotinibCytochrome P450 2C8enzyme
DB04868NilotinibCytochrome P450 2C9enzyme
DB04868NilotinibCytochrome P450 3A4enzyme
DB04868NilotinibMultidrug resistance protein 1transporter
DB04868NilotinibATP-binding cassette sub-family G member 2transporter
DB04868NilotinibUDP-glucuronosyltransferase 1-1transporter
DB04868NilotinibCytochrome P450 2B6enzyme
DB04868NilotinibSolute carrier organic anion transporter family member 1B1transporter
DB04946IloperidoneD(2) dopamine receptortarget
DB04946Iloperidone5-hydroxytryptamine receptor 2Atarget
DB04946IloperidoneCytochrome P450 2D6enzyme
DB04946IloperidoneCytochrome P450 3A4enzyme
DB04946IloperidoneCytochrome P450 3A5enzyme
DB04946IloperidoneCytochrome P450 3A7enzyme
DB04946IloperidoneCytochrome P450 2E1enzyme
DB04946IloperidoneD(3) dopamine receptortarget
DB04946IloperidoneAlpha-1A adrenergic receptortarget
DB04946IloperidoneD(4) dopamine receptortarget
DB04946Iloperidone5-hydroxytryptamine receptor 6target
DB04946Iloperidone5-hydroxytryptamine receptor 7target
DB04946IloperidoneHistamine H1 receptortarget
DB04946IloperidoneD(1A) dopamine receptortarget
DB04946Iloperidone5-hydroxytryptamine receptor 1Atarget
DB04946IloperidoneAlpha-2C adrenergic receptortarget
DB05294VandetanibVascular endothelial growth factor Atarget
DB05294VandetanibEpidermal growth factor receptortarget
DB05294VandetanibMultidrug resistance-associated protein 1transporter
DB05294VandetanibATP-binding cassette sub-family G member 2transporter
DB05294VandetanibProto-oncogene tyrosine-protein kinase receptor Rettarget
DB05294VandetanibDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
DB05294VandetanibDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB05294VandetanibProtein-tyrosine kinase 6target
DB05294VandetanibAngiopoietin-1 receptortarget
DB05294VandetanibAlpha-1-acid glycoprotein 1carrier
DB05294VandetanibSerum albumincarrier
DB05294VandetanibCytochrome P450 3A4enzyme
DB06216Asenapine5-hydroxytryptamine receptor 1Atarget
DB06216Asenapine5-hydroxytryptamine receptor 1Btarget
DB06216Asenapine5-hydroxytryptamine receptor 2Atarget
DB06216Asenapine5-hydroxytryptamine receptor 2Btarget
DB06216Asenapine5-hydroxytryptamine receptor 2Ctarget
DB06216Asenapine5-hydroxytryptamine receptor 6target
DB06216Asenapine5-hydroxytryptamine receptor 7target
DB06216AsenapineAlpha-2A adrenergic receptortarget
DB06216AsenapineAlpha-2B adrenergic receptortarget
DB06216AsenapineAlpha-2C adrenergic receptortarget
DB06216AsenapineAlpha-1A adrenergic receptortarget
DB06216AsenapineD(1A) dopamine receptortarget
DB06216AsenapineD(2) dopamine receptortarget
DB06216AsenapineD(3) dopamine receptortarget
DB06216AsenapineD(4) dopamine receptortarget
DB06216AsenapineHistamine H1 receptortarget
DB06216AsenapineHistamine H2 receptortarget
DB06216AsenapineCytochrome P450 1A2enzyme
DB06216AsenapineCytochrome P450 2D6enzyme
DB06216Asenapine5-hydroxytryptamine receptor 5Atarget
DB06216AsenapineUDP-glucuronosyltransferase 1-4enzyme
DB06216AsenapineCytochrome P450 3A4enzyme
DB06216AsenapineBeta-1 adrenergic receptortarget
DB06216AsenapineBeta-2 adrenergic receptortarget
DB06697ArtemetherCytochrome P450 3A4enzyme
DB06697ArtemetherCytochrome P450 3A5enzyme
DB06697ArtemetherCytochrome P450 2B6enzyme
DB06697ArtemetherCytochrome P450 2C9enzyme
DB06697ArtemetherCytochrome P450 2C19enzyme
DB06697ArtemetherCytochrome P450 2D6enzyme
DB06708LumefantrineCytochrome P450 2D6enzyme
DB06708LumefantrineCytochrome P450 3A4enzyme
DB08881VemurafenibSerum albumincarrier
DB08881VemurafenibAlpha-1-acid glycoprotein 1carrier
DB08881VemurafenibCytochrome P450 1A2enzyme
DB08881VemurafenibCytochrome P450 2D6enzyme
DB08881VemurafenibCytochrome P450 3A4enzyme
DB08881VemurafenibSerine/threonine-protein kinase B-raftarget
DB08881VemurafenibMultidrug resistance-associated protein 1transporter
DB08881VemurafenibATP-binding cassette sub-family G member 2transporter
DB08881VemurafenibCytochrome P450 2C9enzyme
DB08881VemurafenibCytochrome P450 2C8enzyme
DB08881VemurafenibCytochrome P450 2B6enzyme
DB09039EliglustatCeramide glucosyltransferasetarget
DB09039EliglustatCytochrome P450 2D6enzyme
DB09039EliglustatCytochrome P450 3A4enzyme
DB01356Lithium cationInositol monophosphatase 2target
DB01356Lithium cationInositol monophosphatase 1target
DB01356Lithium cationGlycogen synthase kinase-3 betatarget
DB01356Lithium cationGlutamate receptor 3target
DB06176RomidepsinCytochrome P450 3A4enzyme
DB06176RomidepsinCytochrome P450 3A5enzyme
DB06176RomidepsinMultidrug resistance protein 1transporter
DB06176RomidepsinSolute carrier organic anion transporter family member 1B3transporter
DB06176RomidepsinCytochrome P450 1A1enzyme
DB06176RomidepsinCytochrome P450 2B6enzyme
DB06176RomidepsinCytochrome P450 2C19enzyme
DB06176RomidepsinHistone deacetylase 1target
DB06176RomidepsinHistone deacetylase 2target
DB06176RomidepsinHistone deacetylase 4target
DB06176RomidepsinHistone deacetylase 6target
DB06176RomidepsinMultidrug resistance-associated protein 1target
DB00313Valproic Acid4-aminobutyrate aminotransferase, mitochondrialtarget
DB00313Valproic AcidHistone deacetylase 9target
DB00313Valproic AcidShort/branched chain specific acyl-CoA dehydrogenase, mitochondrialtarget
DB00313Valproic AcidCytochrome P450 2A6enzyme
DB00313Valproic AcidCytochrome P450 2B6enzyme
DB00313Valproic AcidCytochrome P450 2C9enzyme
DB00313Valproic AcidSolute carrier family 22 member 5transporter
DB00313Valproic AcidSolute carrier family 22 member 6transporter
DB00313Valproic AcidSolute carrier family 22 member 8transporter
DB00313Valproic AcidMonocarboxylate transporter 1transporter
DB00313Valproic AcidSolute carrier family 22 member 7transporter
DB00313Valproic AcidCytochrome P450 3A5enzyme
DB00313Valproic AcidUDP-glucuronosyltransferase 1-9enzyme
DB00313Valproic AcidProstaglandin G/H synthase 1enzyme
DB00313Valproic AcidCytochrome P450 1A2enzyme
DB00313Valproic AcidCytochrome P450 2C18enzyme
DB00313Valproic AcidCytochrome P450 2C19enzyme
DB00313Valproic AcidCytochrome P450 2C8enzyme
DB00313Valproic AcidCytochrome P450 3A4enzyme
DB00313Valproic AcidUDP-glucuronosyltransferase 1-4enzyme
DB00313Valproic AcidUDP-glucuronosyltransferase 1-8enzyme
DB00313Valproic AcidUDP-glucuronosyltransferase 1-10enzyme
DB00313Valproic AcidUDP-glucuronosyltransferase 1-6enzyme
DB00313Valproic AcidUDP-glucuronosyltransferase 1-3enzyme
DB00313Valproic AcidUDP-glucuronosyltransferase 2B7enzyme
DB00313Valproic AcidUDP-glucuronosyltransferase 2B15enzyme
DB00313Valproic Acid2-oxoglutarate dehydrogenase, mitochondrialtarget
DB00313Valproic AcidSuccinate-semialdehyde dehydrogenase, mitochondrialtarget
DB00313Valproic AcidSodium channel proteintarget
DB00313Valproic AcidHistone deacetylase 2target
DB00313Valproic AcidPeroxisome proliferator-activated receptor alphatarget
DB00313Valproic AcidPeroxisome proliferator-activated receptor deltatarget
DB00313Valproic AcidPeroxisome proliferator-activated receptor gammatarget
DB00313Valproic AcidSerum albumincarrier
DB00313Valproic AcidUDP-glucuronosyltransferase 1-1enzyme
DB00313Valproic AcidSolute carrier organic anion transporter family member 2B1transporter
DB01405TemafloxacinDNA gyrase subunit Atarget
DB01405TemafloxacinDNA topoisomerase 4 subunit Atarget
DB01405TemafloxacinCytochrome P450 1A2enzyme
DB00365GrepafloxacinDNA gyrase subunit Atarget
DB00365GrepafloxacinDNA topoisomerase 4 subunit Atarget
DB00365GrepafloxacinCytochrome P450 3A4enzyme
DB00365GrepafloxacinCytochrome P450 1A2enzyme
DB00365GrepafloxacinSolute carrier family 22 member 2transporter
DB00365GrepafloxacinSolute carrier family 22 member 5transporter
DB00365GrepafloxacinCanalicular multispecific organic anion transporter 1transporter
DB00365GrepafloxacinMultidrug resistance protein 1transporter
DB00365GrepafloxacinMultidrug resistance-associated protein 1transporter
DB00365GrepafloxacinSolute carrier family 22 member 6transporter
DB00685TrovafloxacinDNA gyrase subunit Atarget
DB00685TrovafloxacinDNA topoisomerase 4 subunit Atarget
DB00685TrovafloxacinDNA topoisomerase 2-alphatarget
DB00685TrovafloxacinCytochrome P450 1A2enzyme
DB00637AstemizoleHistamine H1 receptortarget
DB00637AstemizolePotassium voltage-gated channel subfamily H member 2target
DB00637AstemizoleCytochrome P450 3A4enzyme
DB00637AstemizoleCytochrome P450 3A5enzyme
DB00637AstemizoleCytochrome P450 3A7enzyme
DB00637AstemizoleMultidrug resistance protein 1transporter
DB00637AstemizoleCytochrome P450 2D6enzyme
DB00637AstemizoleCytochrome P450 2J2enzyme
DB00637AstemizolePotassium voltage-gated channel subfamily H member 1target
DB00637AstemizoleMicrotubule-associated protein tautarget
DB00637AstemizoleBile salt export pumptransporter
DB01244BepridilVoltage-dependent P/Q-type calcium channel subunit alpha-1Atarget
DB01244BepridilSodium/potassium-transporting ATPase subunit alpha-1target
DB01244BepridilPotassium voltage-gated channel subfamily KQT member 1target
DB01244BepridilTroponin C, slow skeletal and cardiac musclestarget
DB01244BepridilCalmodulintarget
DB01244BepridilVoltage-dependent T-type calcium channel subunit alpha-1Htarget
DB01244BepridilVoltage-dependent calcium channel subunit alpha-2/delta-2target
DB01244BepridilCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1Btarget
DB01244BepridilCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1Atarget
DB01244BepridilMultidrug resistance protein 1transporter
DB01244BepridilCytochrome P450 2D6enzyme
DB01244BepridilPotassium voltage-gated channel subfamily H member 2target
DB01244BepridilCytochrome P450 3A4enzyme
DB00907CocaineSodium-dependent noradrenaline transportertarget
DB00907CocaineSodium channel protein type 5 subunit alphatarget
DB00907CocaineSodium channel protein type 11 subunit alphatarget
DB00907CocaineSodium channel protein type 10 subunit alphatarget
DB00907CocaineSodium-dependent serotonin transportertarget
DB00907CocaineSodium-dependent dopamine transportertarget
DB00907CocaineCytochrome P450 3A4enzyme
DB00907CocaineMuscarinic acetylcholine receptor M1target
DB00907CocaineMuscarinic acetylcholine receptor M2target
DB00907CocaineCytochrome P450 3A5enzyme
DB00907CocaineCytochrome P450 3A7enzyme
DB00907CocaineCytochrome P450 2D6enzyme
DB00907CocaineSolute carrier family 22 member 2transporter
DB00907CocaineCytochrome P450 2C8enzyme
DB00907CocaineCytochrome P450 2C9enzyme
DB00907CocaineSigma non-opioid intracellular receptor 1target
DB00907CocaineLiver carboxylesterase 1target
DB01218HalofantrineFe(II)-protoporphyrin IXtarget
DB01218HalofantrinePotassium voltage-gated channel subfamily H member 2target
DB01218HalofantrineCytochrome P450 3A4enzyme
DB01218HalofantrineCytochrome P450 2D6enzyme
DB01218HalofantrinePlasmepsin-2target
DB01218HalofantrineCytochrome P450 2C8enzyme
DB01218HalofantrineCytochrome P450 3A5enzyme
DB01208SparfloxacinDNA gyrase subunit Atarget
DB01208SparfloxacinDNA topoisomerase 4 subunit Atarget
DB01208SparfloxacinDNA topoisomerase 2-alphatarget
DB01208SparfloxacinSolute carrier family 22 member 5transporter
DB01208SparfloxacinCanalicular multispecific organic anion transporter 1transporter
DB01208SparfloxacinMultidrug resistance protein 1transporter
DB01208SparfloxacinCytochrome P450 1A2enzyme
DB00342TerfenadineHistamine H1 receptortarget
DB00342TerfenadinePotassium voltage-gated channel subfamily H member 2target
DB00342TerfenadineCytochrome P450 3A4enzyme
DB00342TerfenadineCytochrome P450 2C9enzyme
DB00342TerfenadineCytochrome P450 2D6enzyme
DB00342TerfenadineMuscarinic acetylcholine receptor M3target
DB00342TerfenadineCytochrome P450 3A5enzyme
DB00342TerfenadineCytochrome P450 3A7enzyme
DB00342TerfenadineMultidrug resistance protein 1transporter
DB00342TerfenadineCytochrome P450 2C8enzyme
DB00342TerfenadineCytochrome P450 2J2enzyme
DB00342TerfenadineMuscarinic acetylcholine receptor M1target
DB00342TerfenadineMuscarinic acetylcholine receptor M5target
DB00342TerfenadineMuscarinic acetylcholine receptor M4target
DB00342TerfenadineMuscarinic acetylcholine receptor M2target
DB00342TerfenadineBile salt export pumptransporter
DB00619ImatinibPlatelet-derived growth factor receptor betatarget
DB00619ImatinibTyrosine-protein kinase ABL1target
DB00619ImatinibMast/stem cell growth factor receptor Kittarget
DB00619ImatinibRET proto-oncogenetarget
DB00619ImatinibHigh affinity nerve growth factor receptortarget
DB00619ImatinibMacrophage colony-stimulating factor 1 receptortarget
DB00619ImatinibPlatelet-derived growth factor receptor alphatarget
DB00619ImatinibEpithelial discoidin domain-containing receptor 1target
DB00619ImatinibCytochrome P450 3A4enzyme
DB00619ImatinibBCR/ABL fusion protein isoform X9target
DB00619ImatinibCytochrome P450 1A2enzyme
DB00619ImatinibCytochrome P450 2D6enzyme
DB00619ImatinibCytochrome P450 2C9enzyme
DB00619ImatinibCytochrome P450 2C19enzyme
DB00619ImatinibCytochrome P450 3A5enzyme
DB00619ImatinibCytochrome P450 3A7enzyme
DB00619ImatinibSolute carrier family 22 member 1transporter
DB00619ImatinibMultidrug resistance protein 1transporter
DB00619ImatinibSolute carrier family 22 member 2transporter
DB00619ImatinibATP-binding cassette sub-family G member 2transporter
DB00619ImatinibATP-binding cassette sub-family A member 3transporter
DB00619ImatinibProstaglandin G/H synthase 1enzyme
DB00619ImatinibSerum albumincarrier
DB00619ImatinibAlpha-1-acid glycoprotein 1carrier
DB00619ImatinibBile salt export pumptransporter
DB00530ErlotinibEpidermal growth factor receptortarget
DB00530ErlotinibCytochrome P450 3A4enzyme
DB00530ErlotinibATP-binding cassette sub-family G member 2transporter
DB00530ErlotinibMultidrug resistance protein 1transporter
DB00530ErlotinibNuclear receptor subfamily 1 group I member 2target
DB00530ErlotinibCytochrome P450 3A5enzyme
DB00530ErlotinibCytochrome P450 1A1enzyme
DB00530ErlotinibCytochrome P450 1A2enzyme
DB00530ErlotinibCytochrome P450 1B1enzyme
DB00530ErlotinibCytochrome P450 2D6enzyme
DB00530ErlotinibCytochrome P450 2C8enzyme
DB00530ErlotinibUDP-glucuronosyltransferase 1-1enzyme
DB00530ErlotinibSerum albumincarrier
DB00530ErlotinibAlpha-1-acid glycoprotein 1carrier
DB00530ErlotinibSolute carrier organic anion transporter family member 2B1transporter
DB11730RibociclibCyclin-dependent kinase 4target
DB11730RibociclibCyclin-dependent kinase 6target
DB11730RibociclibCytochrome P450 3A4enzyme
DB13074MacimorelinGrowth hormone secretagogue receptor type 1target
DB13074MacimorelinCytochrome P450 3A4enzyme
DB12161DeutetrabenazineSynaptic vesicular amine transportertarget
DB12161DeutetrabenazineCarbonyl reductase [NADPH] 1enzyme
DB12161DeutetrabenazineCarbonyl reductase [NADPH] 3enzyme
DB12161DeutetrabenazineCytochrome P450 2D6enzyme
DB12161DeutetrabenazineCytochrome P450 1A2enzyme
DB12161DeutetrabenazineCytochrome P450 3A5enzyme
DB12161DeutetrabenazineCytochrome P450 3A4enzyme
DB00283ClemastineHistamine H1 receptortarget
DB00283ClemastineCytochrome P450 2D6enzyme
DB09083IvabradineCytochrome P450 3A4enzyme
DB09083IvabradinePotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2target