Gonadotropin-releasing hormone agonist

Name
Gonadotropin-releasing hormone agonist
Accession Number
DBCAT002742  (DBCAT000050, DBCAT002088, DBCAT002435)
Description

A decapeptide that stimulates the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE. GnRH is produced by neurons in the septum PREOPTIC AREA of the HYPOTHALAMUS and released into the pituitary portal blood, leading to stimulation of GONADOTROPHS in the ANTERIOR PITUITARY GLAND.

ATC Classification
Drugs
DrugDrug Description
LeuprolideA protein-based luteinizing hormone agonist used to treat prostate cancer, endometriosis, and precocious puberty.
GoserelinA synthetic analog of luteinizing hormone-releasing hormone used to treat breast cancer and prostate cancer by reducing secretion of gonadotropins from the pituitary.
BuserelinA LHRH agonist used for the palliative treatment of hormone-dependent advanced carcinoma of the prostate gland in males and treatment of endometriosis in females.
TriptorelinA GnRH agonist indicated for the palliative treatment of advanced prostate cancer.
NafarelinA gonadotropin releasing hormone agonist used to treat central precocious puberty.
GonadorelinA synthetic GnRH used to test the function of gonadotropes and the pituitary.
DeslorelinDeslorelin acetate is an injectable gonadotropin releasing hormone super-agonist also known as an LHRH agonist. It stops the production of sex hormones.
HistrelinA GnRH agonist found in subcutaneous implants used for the treatment of pediatric patients with central precocious puberty and the palliative treatment of advanced prostate cancer.
Drugs & Drug Targets
DrugTargetType
LeuprolideGonadotropin-releasing hormone receptortarget
LeuprolideCytochrome P450 3A4enzyme
GoserelinLutropin-choriogonadotropic hormone receptortarget
GoserelinGonadotropin-releasing hormone receptortarget
BuserelinLutropin-choriogonadotropic hormone receptortarget
BuserelinGonadotropin-releasing hormone receptortarget
BuserelinCytochrome P450 19A1enzyme
TriptorelinGonadotropin-releasing hormone receptortarget
NafarelinGonadotropin-releasing hormone receptortarget
NafarelinPutative gonadotropin-releasing hormone II receptortarget
GonadorelinGonadotropin-releasing hormone receptortarget
GonadorelinPutative gonadotropin-releasing hormone II receptortarget
HistrelinGonadotropin-releasing hormone receptortarget