Complement System Proteins

Accession Number

DBCAT002771

Description

Serum glycoproteins participating in the host defense mechanism of COMPLEMENT ACTIVATION that creates the COMPLEMENT MEMBRANE ATTACK COMPLEX. Included are glycoproteins in the various pathways of complement activation (CLASSICAL COMPLEMENT PATHWAY; ALTERNATIVE COMPLEMENT PATHWAY; and LECTIN COMPLEMENT PATHWAY).

Drugs

Drug	Drug Description
Human C1-esterase inhibitor	A C1 inhibitor used to prevent angioedema attacks associated with hereditary angioedema.
Conestat alfa	A recombinant C1INH used for the treatment of acute attacks of hereditary angioedema (HAE) due to C1 esterase inhibitor deficiency in adults.

Drugs & Drug Targets

Drug	Target	Type
Human C1-esterase inhibitor	Complement C1r subcomponent	target
Human C1-esterase inhibitor	Complement C1s subcomponent	target
Human C1-esterase inhibitor	Plasma kallikrein	target
Human C1-esterase inhibitor	Coagulation factor XII	target
Human C1-esterase inhibitor	Prothrombin	target
Human C1-esterase inhibitor	Coagulation factor XI	target
Human C1-esterase inhibitor	Tissue-type plasminogen activator	target
Conestat alfa	Complement C1r subcomponent	target
Conestat alfa	Complement C1s subcomponent	target
Conestat alfa	Plasma kallikrein	target
Conestat alfa	Coagulation factor XII	target
Conestat alfa	Prothrombin	target
Conestat alfa	Coagulation factor XI	target
Conestat alfa	Tissue-type plasminogen activator	target