Macrophage-Activating Factors
- Name
- Macrophage-Activating Factors
- Accession Number
- DBCAT002879
- Description
Factors secreted by stimulated lymphocytes that prime macrophages to become nonspecifically cytotoxic to tumors. They also modulate the expression of macrophage cell surface Ia antigens. One MAF is INTERFERON-GAMMA. Other factors antigenically distinct from IFN-gamma have also been identified.
- Drugs
Drug Drug Description Interferon gamma-1b A form of recombinant human interferon used to treat infections associated with chronic granulomatous disease and to slow the progression of severe malignant osteopetrosis. - Drugs & Drug Targets
Drug Target Type Interferon gamma-1b Interferon gamma receptor 1 target Interferon gamma-1b Interferon gamma receptor 2 target Interferon gamma-1b Cytochrome P450 1A2 enzyme