Immunoglobulin Variable Region

The paired immunoglobulin fragments composed of the variable domains of the heavy and light chains.
DrugDrug NameDrug Description
DB04949PexelizumabFor the treatment of inflammation during cardiac surgery.
DB06081CaplacizumabA von Willebrand factor (vWF)-directed antibody fragment used to treat acquired thrombotic thrombocytopenic purpura (aTTP).
DB14891VobarilizumabVobarilizumab is under investigation in clinical trial NCT02101073 (ALX-0061 Phase I Bioavailability Study in Healthy Volunteers).
DB14784GancotamabGancotamab is under investigation in clinical trial NCT02213744 (MM-302 Plus Trastuzumab vs. Chemotherapy of Physician's Choice Plus Trastuzumab in HER2-Positive Locally Advanced/Metastatic Breast Cancer Patients).
DrugDrug NameTargetType
DB06081Caplacizumabvon Willebrand factortarget