Conotoxins
- Name
- Conotoxins
- Accession Number
- DBCAT002963
- Description
Peptide neurotoxins from the marine fish-hunting snails of the genus CONUS. They contain 13 to 29 amino acids which are strongly basic and are highly cross-linked by disulfide bonds. There are three types of conotoxins, omega-, alpha-, and mu-. OMEGA-CONOTOXINS inhibit voltage-activated entry of calcium into the presynaptic membrane and therefore the release of ACETYLCHOLINE. Alpha-conotoxins inhibit the postsynaptic acetylcholine receptor. Mu-conotoxins prevent the generation of muscle action potentials. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
- Drugs
Drug Drug Description Ziconotide An N-type calcium channel antagonist used to manage patients with severe chronic pain who cannot tolerate, or who have not responded adequately to other treatments such as intrathecal morphine and systemic analgesics. - Drugs & Drug Targets
Drug Target Type Ziconotide Voltage-dependent N-type calcium channel subunit alpha-1B target Ziconotide Voltage-dependent P/Q-type calcium channel subunit alpha-1A target