Receptors, Death Domain
- Name
- Receptors, Death Domain
- Accession Number
- DBCAT002968
- Description
A family of cell surface receptors that signal via a conserved domain that extends into the cell CYTOPLASM. The conserved domain is referred to as a death domain due to the fact that many of these receptors are involved in signaling APOPTOSIS. Several DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains of the activated receptors and through a complex series of interactions activate apoptotic mediators such as CASPASES.
- Drugs
Drug Drug Description Onercept Investigated for use/treatment in psoriasis and psoriatic disorders and crohn's disease. Pegsunercept Investigated for use/treatment in rheumatoid arthritis. Asunercept Asunercept is under investigation in clinical trial NCT02853565 (A Study of CAN008 for Newly Diagnosed Glioblastoma Multiforme). - Drugs & Drug Targets
Drug Target Type Onercept Tumor necrosis factor target