Cytochrome P-450 CYP2C9 Inhibitors (weak)

DrugDrug NameDrug Description
DB13174RheinNo approved indication.
DB09120ZucapsaicinA topical analgesic used as an adjunct to relieve severe pain of osteoarthritis of the knee in selected adult patients.
DB01601LopinavirAn HIV-1 protease inhibitor used in combination with ritonavir to treat human immunodeficiency virus (HIV).
DB00208TiclopidineA platelet aggregation inhibitor used in the prevention of conditions associated with thrombi, such as stroke and transient ischemic attacks (TIA).
DB00203SildenafilA phosphodiesterase inhibitor used for the treatment of erectile dysfunction.
DB04911OritavancinAn antibacterial agent used to treat acute bacterial skin and skin structure infections caused by susceptible Gram-positive bacteria.
DB14033Acetyl sulfisoxazoleAcute, recurrent or chronic urinary tract infections (primarily pyelonephritis, pyelitis and cystitis) due to susceptible organisms (usually Escherichia coli, Klebsiella-Enterobacter, staphylococcus, Proteus mirabilis and, less frequently, Proteus vulgaris) in the...
DB13919CandesartanCandesartan is an angiotensin-receptor blocker (ARB) that may be used alone or with other agents to treat hypertension. It is available as a prodrug in the form of Candesartan cilexetil.
DB08816TicagrelorA P2Y12 platelet inhibitor used in patients with a history of myocardial infarction or with acute coronary syndrome (ACS) to prevent future myocardial infarction, stroke and cardiovascular death.
DB00580ValdecoxibA COX-2 inhibitor used to treat osteoarthritis and dysmenorrhoea.
DB00444TeniposideA cytotoxic drug used as an adjunct for chemotherapy induction in the treatment of refractory childhood acute lymphoblastic leukemia.
DB00334OlanzapineAn antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders.
DB14025ClinafloxacinClinafloxacin is a fluoroquinolone antibacterial currently under research. It has been proven to present good antibiotic properties. However, its approval and release have been halted due to the presence of...
DB00582VoriconazoleA triazole compound used to treat fungal infections.
DB00673AprepitantA substance P/neurokinin 1 receptor antagonist used to treat nausea and vomiting caused by chemotherapy and surgery.
DB00661VerapamilA non-dihydropyridine calcium channel blocker used in the treatment of angina, arrhythmia, and hypertension.
DB15328UbrogepantAn oral CGRP antagonist used in the acute treatment of migraine with or without aura.
DrugDrug NameTargetType
DB13174RheinOxysterols receptor LXR-alphatarget
DB13174RheinOxysterols receptor LXR-betatarget
DB13174RheinArylamine N-acetyltransferasetarget
DB13174RheinArachidonate 5-lipoxygenasetarget
DB13174RheinCytochrome P450 1A2enzyme
DB13174RheinCytochrome P450 3A Subfamilyenzyme
DB13174RheinCytochrome P450 2E1enzyme
DB13174RheinCytochrome P450 2C9enzyme
DB13174RheinCytochrome P450 2D6enzyme
DB09120ZucapsaicinTransient receptor potential cation channel subfamily V member 1target
DB09120ZucapsaicinCytochrome P450 1A2enzyme
DB09120ZucapsaicinCytochrome P450 2C19enzyme
DB09120ZucapsaicinCytochrome P450 2C9enzyme
DB09120ZucapsaicinCytochrome P450 2E1enzyme
DB01601LopinavirHuman immunodeficiency virus type 1 proteasetarget
DB01601LopinavirCytochrome P450 3A4enzyme
DB01601LopinavirCytochrome P450 2D6enzyme
DB01601LopinavirCytochrome P450 2C19enzyme
DB01601LopinavirP-glycoprotein 1transporter
DB01601LopinavirCytochrome P450 2B6enzyme
DB01601LopinavirCytochrome P450 2C9enzyme
DB01601LopinavirCytochrome P450 2C8enzyme
DB01601LopinavirCytochrome P450 3A Subfamilyenzyme
DB01601LopinavirSolute carrier organic anion transporter family member 1B1transporter
DB01601LopinavirSolute carrier organic anion transporter family member 1B3transporter
DB01601LopinavirBile salt export pumptransporter
DB00208TiclopidineP2Y purinoceptor 12target
DB00208TiclopidineCytochrome P450 2C19enzyme
DB00208TiclopidineCytochrome P450 2B6enzyme
DB00208TiclopidineCytochrome P450 2C9enzyme
DB00208TiclopidineCytochrome P450 2D6enzyme
DB00208TiclopidineMyeloperoxidaseenzyme
DB00208TiclopidineCytochrome P450 1A2enzyme
DB00208TiclopidineCytochrome P450 2C8enzyme
DB00208TiclopidineCytochrome P450 2E1enzyme
DB00203SildenafilcGMP-specific 3',5'-cyclic phosphodiesterasetarget
DB00203SildenafilCytochrome P450 2C9enzyme
DB00203SildenafilRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammatarget
DB00203SildenafilRetinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammatarget
DB00203SildenafilCytochrome P450 3A4enzyme
DB00203SildenafilCytochrome P450 3A5enzyme
DB00203SildenafilCytochrome P450 3A7enzyme
DB00203SildenafilMultidrug resistance-associated protein 4transporter
DB00203SildenafilMultidrug resistance-associated protein 5transporter
DB00203SildenafilMultidrug resistance-associated protein 7transporter
DB00203SildenafilCytochrome P450 2C19enzyme
DB00203SildenafilCytochrome P450 2D6enzyme
DB00203SildenafilCytochrome P450 2E1enzyme
DB00203SildenafilSolute carrier organic anion transporter family member 1B1transporter
DB00203SildenafilP-glycoprotein 1transporter
DB04911OritavancinCytochrome P450 3A4enzyme
DB04911OritavancinCytochrome P450 2D6enzyme
DB04911OritavancinCytochrome P450 2C9enzyme
DB04911OritavancinCytochrome P450 2C19enzyme
DB14033Acetyl sulfisoxazoleDihydropteroate synthasetarget
DB14033Acetyl sulfisoxazoleCytochrome P450 2C9enzyme
DB13919CandesartanType-1 angiotensin II receptortarget
DB13919CandesartanCytochrome P450 2C8enzyme
DB13919CandesartanCytochrome P450 2C9enzyme
DB13919CandesartanP-glycoprotein 1transporter
DB13919CandesartanUDP-glucuronosyltransferase 1-3enzyme
DB13919CandesartanProstaglandin G/H synthase 1enzyme
DB13919CandesartanSolute carrier organic anion transporter family member 1B1transporter
DB08816TicagrelorCytochrome P450 3A4enzyme
DB08816TicagrelorP2Y purinoceptor 12target
DB08816TicagrelorP-glycoprotein 1transporter
DB08816TicagrelorCytochrome P450 2D6enzyme
DB08816TicagrelorCytochrome P450 2C9enzyme
DB00580ValdecoxibProstaglandin G/H synthase 2target
DB00580ValdecoxibCytochrome P450 2C9enzyme
DB00580ValdecoxibCytochrome P450 3A4enzyme
DB00580ValdecoxibUDP-glucuronosyltransferase 1-9enzyme
DB00580ValdecoxibCarbonic anhydrase 2target
DB00580ValdecoxibCarbonic anhydrase 3target
DB00444TeniposideDNA topoisomerase 2-alphatarget
DB00444TeniposideCytochrome P450 2C19enzyme
DB00444TeniposideCytochrome P450 2C9enzyme
DB00444TeniposideCytochrome P450 3A4enzyme
DB00444TeniposideMultidrug resistance-associated protein 6transporter
DB00444TeniposideATP-binding cassette sub-family G member 2transporter
DB00444TeniposideCytochrome P450 3A5enzyme
DB00334OlanzapineDopamine D1 receptortarget
DB00334OlanzapineMuscarinic acetylcholine receptor M1target
DB00334OlanzapineMuscarinic acetylcholine receptor M3target
DB00334Olanzapine5-hydroxytryptamine receptor 2Atarget
DB00334OlanzapineDopamine D4 receptortarget
DB00334OlanzapineHistamine H1 receptortarget
DB00334OlanzapineMuscarinic acetylcholine receptor M4target
DB00334OlanzapineMuscarinic acetylcholine receptor M2target
DB00334OlanzapineDopamine D2 receptortarget
DB00334Olanzapine5-hydroxytryptamine receptor 2Ctarget
DB00334OlanzapineDopamine D3 receptortarget
DB00334OlanzapineAlpha-1B adrenergic receptortarget
DB00334OlanzapineCytochrome P450 1A2enzyme
DB00334Olanzapine5-hydroxytryptamine receptor 3Atarget
DB00334Olanzapine5-hydroxytryptamine receptor 6target
DB00334OlanzapineAlpha-1A adrenergic receptortarget
DB00334OlanzapineDopamine D5 receptortarget
DB00334OlanzapineSerum albumincarrier
DB00334OlanzapineAlpha-1-acid glycoprotein 1carrier
DB00334OlanzapineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00334OlanzapineCytochrome P450 2D6enzyme
DB00334OlanzapineP-glycoprotein 1transporter
DB00334OlanzapineCytochrome P450 2C19enzyme
DB00334OlanzapineD(1) dopamine receptortarget
DB00334OlanzapineBeta adrenergic receptortarget
DB00334Olanzapine5-hydroxytryptamine receptor 1target
DB00334OlanzapineGABA-A receptor (benzodiazepine site)target
DB00334OlanzapineCytochrome P450 2C9enzyme
DB00334OlanzapineUDP-glucuronosyltransferase 1-4enzyme
DB00334OlanzapineCytochrome P450 3A4enzyme
DB00334OlanzapineCytochrome P450 3A Subfamilyenzyme
DB14025ClinafloxacinCytochrome P450 1A2enzyme
DB14025ClinafloxacinCytochrome P450 2C19enzyme
DB14025ClinafloxacinCytochrome P450 2D6enzyme
DB14025ClinafloxacinCytochrome P450 2C9enzyme
DB00582VoriconazoleCytochrome P450 2C19enzyme
DB00582VoriconazoleCytochrome P450 3A4enzyme
DB00582VoriconazoleCytochrome P450 2C9enzyme
DB00582VoriconazoleDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
DB00582VoriconazoleDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00582VoriconazoleCytochrome P450 3A5enzyme
DB00582VoriconazoleCytochrome P450 3A7enzyme
DB00582VoriconazoleProstaglandin G/H synthase 1enzyme
DB00582VoriconazoleCytochrome P450 51target
DB00582VoriconazoleCytochrome P450 2B6enzyme
DB00673AprepitantNeurokinin 1 receptortarget
DB00673AprepitantCytochrome P450 3A4enzyme
DB00673AprepitantCytochrome P450 2C9enzyme
DB00673AprepitantCytochrome P450 2C19enzyme
DB00661VerapamilATP-sensitive inward rectifier potassium channel 11target
DB00661VerapamilVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
DB00661VerapamilPotassium voltage-gated channel subfamily H member 2target
DB00661VerapamilVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB00661VerapamilCytochrome P450 1A2enzyme
DB00661VerapamilCytochrome P450 3A5enzyme
DB00661VerapamilVoltage-dependent N-type calcium channel subunit alpha-1Btarget
DB00661VerapamilVoltage-dependent P/Q-type calcium channel subunit alpha-1Atarget
DB00661VerapamilSodium-dependent serotonin transportertarget
DB00661VerapamilCytochrome P450 3A4enzyme
DB00661VerapamilP-glycoprotein 1transporter
DB00661VerapamilSolute carrier family 22 member 1transporter
DB00661VerapamilCanalicular multispecific organic anion transporter 2transporter
DB00661VerapamilMultidrug resistance-associated protein 4transporter
DB00661VerapamilSolute carrier family 22 member 5transporter
DB00661VerapamilSolute carrier organic anion transporter family member 1A2transporter
DB00661VerapamilMultidrug resistance-associated protein 7transporter
DB00661VerapamilSolute carrier family 22 member 4transporter
DB00661VerapamilSolute carrier organic anion transporter family member 1B1transporter
DB00661VerapamilCytochrome P450 2C8enzyme
DB00661VerapamilCytochrome P450 2C9enzyme
DB00661VerapamilCytochrome P450 2B6enzyme
DB00661VerapamilCytochrome P450 2C19enzyme
DB00661VerapamilCytochrome P450 2D6enzyme
DB00661VerapamilAlpha-1A adrenergic receptortarget
DB00661VerapamilAlpha-1B adrenergic receptortarget
DB00661VerapamilAlpha-1D adrenergic receptortarget
DB00661VerapamilSerum albumincarrier
DB00661VerapamilAlpha-1-acid glycoprotein 1carrier
DB00661VerapamilCytochrome P450 2C18enzyme
DB00661VerapamilCytochrome P450 2E1enzyme
DB00661VerapamilMultidrug resistance-associated protein 1transporter
DB00661VerapamilMultidrug and toxin extrusion protein 1transporter
DB00661VerapamilMultidrug and toxin extrusion protein 2transporter
DB00661VerapamilVoltage-dependent T-type calcium channel subunit alpha-1Htarget
DB15328UbrogepantP-glycoprotein 1transporter
DB15328UbrogepantATP-binding cassette sub-family G member 2transporter
DB15328UbrogepantCytochrome P450 3A4enzyme
DB15328UbrogepantCytochrome P450 2C8enzyme
DB15328UbrogepantCytochrome P450 2C9enzyme
DB15328UbrogepantCytochrome P450 2D6enzyme
DB15328UbrogepantCytochrome P450 2C19enzyme
DB15328UbrogepantAmine oxidase [flavin-containing] Aenzyme
DB15328UbrogepantUDP-glucuronosyltransferase 1-1enzyme
DB15328UbrogepantSolute carrier organic anion transporter family member 1B1transporter
DB15328UbrogepantSolute carrier organic anion transporter family member 1B3transporter
DB15328UbrogepantSolute carrier family 22 member 6transporter
DB15328UbrogepantSolute carrier family 22 member 2transporter
DB15328UbrogepantCalcitonin gene-related peptide type 1 receptortarget