Cytochrome P-450 CYP2C8 Inhibitors (weak)

DrugDrug NameDrug Description
DB12332RucaparibAn anti-cancer agent used to treat recurrent ovarian, fallopian tube, or peritoneal cancer.
DB06589PazopanibAn antineoplastic agent used in the treatment of advanced renal cell cancer and advanced soft tissue sarcoma in patients with prior chemotherapy.
DB08875CabozantinibA tyrosine kinase inhibitor used to treat renal cell carcinoma and hepatocellular carcinoma.
DB01072AtazanavirAn antiviral protease inhibitor used in combination with other antiretrovirals for the treatment of HIV.
DB00857TerbinafineAn allylamine antifungal used to treat dermatophyte infections of toenails and fingernails as well as other fungal skin infections.
DB00533RofecoxibA COX-2 inhibitor NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, primary dysmenorrhea, and migraine attacks.
DB00908QuinidineA medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias.
DB01039FenofibrateA peroxisome proliferator receptor alpha activator used to lower LDL-C, total-C, triglycerides, and Apo B, while increasing HDL-C in hypercholesterolemia, dyslipidemia, and hypertriglyceridemia.
DB01393BezafibrateA lipid-lowering fibrate used in the management of primary and secondary hyperlipidaemia, when there is a lack of clinical improvement following lifestyle modifications or correction of the underlying disorder.
DB00501CimetidineA histamine H2 receptor antagonist used to manage GERD, peptic ulcer disease, and indigestion.
DB01009KetoprofenAn NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, dysmenorrhea, mild to moderate muscle pain, postoperative pain, and postpartum pain.
DB00205PyrimethamineAn antiparasitic drug used in the prevention and treatment of toxoplasmosis and malaria.
DB00208TiclopidineA platelet aggregation inhibitor used in the prevention of conditions associated with thrombi, such as stroke and transient ischemic attacks (TIA).
DB09054IdelalisibAn antineoplastic kinase inhibitor used to treat chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL).
DB05015BelinostatA histone deacetylase (HDAC) inhibitor used for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma (PTCL).
DB13919CandesartanCandesartan is an angiotensin-receptor blocker (ARB) that may be used alone or with other agents to treat hypertension. It is available as a prodrug in the form of Candesartan cilexetil.
DB11632OpicaponeA catechol-O-methyltransferase inhibitor used to treat Parkinson's disease in patients currently receiving levodopa and a dopa decarboxylase inhibitor.
DB01079TegaserodA serotonin-4 (5-HT4) receptor agonist indicated for the treatment of constipation predominant irritable bowel syndrome (IBS-C) specifically in women under the age of 65. There is currently no safety or efficacy data for use of tegaserol in men.
DB05812AbirateroneAn antiandrogen used in the treatment of prostate cancer.
DB15328UbrogepantAn oral CGRP antagonist used in the acute treatment of migraine with or without aura.
DB01060AmoxicillinA penicillin derivative used for the treatment of infections caused by gram-positive bacteria, in particular streptococcal bacteria causing upper respiratory tract infections.
DrugDrug NameTargetType
DB12332RucaparibPoly [ADP-ribose] polymerase 1target
DB12332RucaparibPoly [ADP-ribose] polymerase 2target
DB12332RucaparibPoly [ADP-ribose] polymerase 3target
DB12332RucaparibCytochrome P450 2D6enzyme
DB12332RucaparibCytochrome P450 1A2enzyme
DB12332RucaparibCytochrome P450 3A4enzyme
DB12332RucaparibP-glycoprotein 1transporter
DB12332RucaparibATP-binding cassette sub-family G member 2transporter
DB12332RucaparibMultidrug and toxin extrusion protein 1transporter
DB12332RucaparibMultidrug and toxin extrusion protein 2transporter
DB12332RucaparibSolute carrier family 22 member 1transporter
DB12332RucaparibMultidrug resistance-associated protein 4transporter
DB12332RucaparibSolute carrier organic anion transporter family member 1B1transporter
DB12332RucaparibSolute carrier organic anion transporter family member 1B3transporter
DB12332RucaparibSolute carrier family 22 member 6transporter
DB12332RucaparibSolute carrier family 22 member 8transporter
DB12332RucaparibCytochrome P450 3A5enzyme
DB12332RucaparibCytochrome P450 3A7enzyme
DB12332RucaparibCytochrome P450 3A43enzyme
DB12332RucaparibCytochrome P450 2C19enzyme
DB12332RucaparibCytochrome P450 2C9enzyme
DB12332RucaparibCytochrome P450 2C8enzyme
DB12332RucaparibUDP-glucuronosyltransferase 1-1enzyme
DB06589PazopanibVascular endothelial growth factor receptor 1target
DB06589PazopanibVascular endothelial growth factor receptor 2target
DB06589PazopanibVascular endothelial growth factor receptor 3target
DB06589PazopanibPlatelet-derived growth factor receptor alphatarget
DB06589PazopanibPlatelet-derived growth factor receptor betatarget
DB06589PazopanibMast/stem cell growth factor receptor Kittarget
DB06589PazopanibCytochrome P450 3A4enzyme
DB06589PazopanibCytochrome P450 2D6enzyme
DB06589PazopanibCytochrome P450 2C8enzyme
DB06589PazopanibCytochrome P450 1A2enzyme
DB06589PazopanibP-glycoprotein 1transporter
DB06589PazopanibATP-binding cassette sub-family G member 2transporter
DB06589PazopanibSolute carrier organic anion transporter family member 1B1transporter
DB06589PazopanibUDP-glucuronosyltransferase 1-1transporter
DB06589PazopanibFibroblast growth factor receptor 3target
DB06589PazopanibTyrosine-protein kinase ITK/TSKtarget
DB06589PazopanibFibroblast growth factor 1target
DB06589PazopanibSH2B adapter protein 3target
DB08875CabozantinibCytochrome P450 3A4enzyme
DB08875CabozantinibCytochrome P450 2C9enzyme
DB08875CabozantinibHepatocyte growth factor receptortarget
DB08875CabozantinibVascular endothelial growth factor receptor 2target
DB08875CabozantinibProto-oncogene tyrosine-protein kinase receptor Rettarget
DB08875CabozantinibCytochrome P450 2C8enzyme
DB01072AtazanavirHuman immunodeficiency virus type 1 proteasetarget
DB01072AtazanavirCytochrome P450 3A4enzyme
DB01072AtazanavirCytochrome P450 2C9enzyme
DB01072AtazanavirP-glycoprotein 1transporter
DB01072AtazanavirMultidrug resistance-associated protein 1transporter
DB01072AtazanavirSerum albumincarrier
DB01072AtazanavirUDP-glucuronosyltransferase 1-1enzyme
DB01072AtazanavirSolute carrier organic anion transporter family member 1B1transporter
DB01072AtazanavirSolute carrier organic anion transporter family member 1B3transporter
DB01072AtazanavirCytochrome P450 2C8enzyme
DB01072AtazanavirBile salt export pumptransporter
DB01072Atazanaviralpha1-acid glycoproteincarrier
DB01072AtazanavirCytochrome P450 1A2enzyme
DB01072AtazanavirSolute carrier organic anion transporter family member 2B1transporter
DB00857TerbinafineSqualene monooxygenasetarget
DB00857TerbinafineCytochrome P450 2D6enzyme
DB00857TerbinafineCytochrome P450 2C9enzyme
DB00857TerbinafineCytochrome P450 1A2enzyme
DB00857TerbinafineCytochrome P450 3A4enzyme
DB00857TerbinafineCytochrome P450 2C8enzyme
DB00857TerbinafineCytochrome P450 2C19enzyme
DB00857TerbinafineProstaglandin G/H synthase 1enzyme
DB00857TerbinafineSerum albumincarrier
DB00857Terbinafinealpha1-acid glycoproteincarrier
DB00857TerbinafineABC multidrug transporter MDR2transporter
DB00857TerbinafineSqualene monooxygenasetarget
DB00533RofecoxibProstaglandin G/H synthase 2target
DB00533RofecoxibElastintarget
DB00533RofecoxibCytochrome P450 3A4enzyme
DB00533RofecoxibCytochrome P450 1A2enzyme
DB00533RofecoxibMultidrug resistance-associated protein 4transporter
DB00533RofecoxibProstaglandin G/H synthase 1enzyme
DB00533RofecoxibCytochrome P450 2C8enzyme
DB00533RofecoxibCytochrome P450 2C9enzyme
DB00908QuinidineSodium channel protein type 5 subunit alphatarget
DB00908QuinidineAlpha-1-acid glycoprotein 1carrier
DB00908QuinidinePotassium voltage-gated channel subfamily H member 2target
DB00908QuinidinePotassium channel subfamily K member 1target
DB00908QuinidinePotassium channel subfamily K member 6target
DB00908QuinidineCytochrome P450 1A2enzyme
DB00908QuinidineCytochrome P450 2E1enzyme
DB00908QuinidineCytochrome P450 1A1enzyme
DB00908QuinidineCytochrome P450 2D6enzyme
DB00908QuinidineCytochrome P450 3A4enzyme
DB00908QuinidineCytochrome P450 3A7enzyme
DB00908QuinidineSolute carrier family 22 member 2transporter
DB00908QuinidineSolute carrier family 22 member 1transporter
DB00908QuinidineSolute carrier family 22 member 5transporter
DB00908QuinidineP-glycoprotein 1transporter
DB00908QuinidineSolute carrier organic anion transporter family member 1A2transporter
DB00908QuinidineSolute carrier family 22 member 8transporter
DB00908QuinidineCanalicular multispecific organic anion transporter 1transporter
DB00908QuinidineSolute carrier family 22 member 4transporter
DB00908QuinidineSolute carrier organic anion transporter family member 1B1transporter
DB00908QuinidineCytochrome P450 2B6enzyme
DB00908QuinidineCytochrome P450 2C9enzyme
DB00908QuinidineAlpha-1A adrenergic receptortarget
DB00908QuinidineAlpha-1B adrenergic receptortarget
DB00908QuinidineAlpha-1D adrenergic receptortarget
DB00908QuinidineBile salt export pumptransporter
DB00908QuinidineCytochrome P450 2C8enzyme
DB01039FenofibratePeroxisome proliferator-activated receptor alphatarget
DB01039FenofibrateMatrix metalloproteinase-25target
DB01039FenofibrateCytochrome P450 2C8enzyme
DB01039FenofibrateCytochrome P450 2C9enzyme
DB01039FenofibrateNuclear receptor subfamily 1 group I member 2target
DB01039FenofibrateUDP-glucuronosyltransferase 1-9enzyme
DB01039FenofibrateBile salt export pumptransporter
DB01039FenofibrateSerum albumincarrier
DB01039FenofibrateCytochrome P450 2C19enzyme
DB01039FenofibrateCytochrome P450 2A6enzyme
DB01039FenofibrateLiver carboxylesterase 1enzyme
DB01039FenofibrateCarbonyl reductase [NADPH] 1enzyme
DB01039FenofibrateAldo-keto reductase family 1 member C1enzyme
DB01039FenofibrateAldo-keto reductase family 1 member C2enzyme
DB01039FenofibrateAldo-keto reductase family 1 member C3enzyme
DB01039FenofibrateAldose reductaseenzyme
DB01393BezafibratePeroxisome proliferator-activated receptor alphatarget
DB01393BezafibrateSolute carrier organic anion transporter family member 1B1transporter
DB01393BezafibratePeroxisome proliferator-activated receptor deltatarget
DB01393BezafibratePeroxisome proliferator-activated receptor gammatarget
DB01393BezafibrateCytochrome P450 1A1enzyme
DB01393BezafibrateCytochrome P450 2C8enzyme
DB01393BezafibrateCytochrome P450 3A4enzyme
DB01393BezafibrateNuclear receptor subfamily 1 group I member 2target
DB01393BezafibrateRetinoic acid receptor RXR-alphatarget
DB01393BezafibrateRetinoic acid receptor RXR-betatarget
DB01393BezafibrateRetinoic acid receptor RXR-gammatarget
DB00501CimetidineHistamine H2 receptortarget
DB00501CimetidineCytochrome P450 1A2enzyme
DB00501CimetidineCytochrome P450 2D6enzyme
DB00501CimetidineCytochrome P450 2C19enzyme
DB00501CimetidineCytochrome P450 3A4enzyme
DB00501CimetidineCytochrome P450 3A5enzyme
DB00501CimetidineP-glycoprotein 1transporter
DB00501CimetidineSolute carrier family 22 member 2transporter
DB00501CimetidineSolute carrier family 22 member 1transporter
DB00501CimetidineSolute carrier family 22 member 3transporter
DB00501CimetidineSolute carrier family 22 member 5transporter
DB00501CimetidineSolute carrier family 22 member 6transporter
DB00501CimetidineSolute carrier family 22 member 8transporter
DB00501CimetidineMultidrug and toxin extrusion protein 1transporter
DB00501CimetidineSolute carrier family 22 member 4transporter
DB00501CimetidineSolute carrier family 22 member 11transporter
DB00501CimetidineSolute carrier family 22 member 7transporter
DB00501CimetidineCytochrome P450 11B1, mitochondrialenzyme
DB00501CimetidineCytochrome P450 2C8enzyme
DB00501CimetidineCytochrome P450 2C9enzyme
DB00501CimetidineCytochrome P450 2E1enzyme
DB00501CimetidineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00501CimetidineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
DB00501CimetidineBile salt export pumptransporter
DB00501CimetidineMultidrug and toxin extrusion protein 2transporter
DB01009KetoprofenProstaglandin G/H synthase 1target
DB01009KetoprofenProstaglandin G/H synthase 2target
DB01009KetoprofenC-X-C chemokine receptor type 1target
DB01009KetoprofenSerum albumincarrier
DB01009KetoprofenMultidrug resistance-associated protein 4transporter
DB01009KetoprofenSolute carrier organic anion transporter family member 1A2transporter
DB01009KetoprofenSolute carrier family 22 member 6transporter
DB01009KetoprofenSolute carrier family 22 member 8transporter
DB01009KetoprofenSolute carrier family 22 member 11transporter
DB01009KetoprofenSolute carrier family 22 member 7transporter
DB01009KetoprofenCytochrome P450 2C9enzyme
DB01009KetoprofenCytochrome P450 2C8enzyme
DB01009KetoprofenUDP-glucuronosyltransferase 1-1enzyme
DB00205PyrimethamineBifunctional dihydrofolate reductase-thymidylate synthasetarget
DB00205PyrimethamineDihydrofolate reductasetarget
DB00205PyrimethamineCytochrome P450 2C8enzyme
DB00205PyrimethamineBeta-hexosaminidase subunit betatarget
DB00205PyrimethamineMultidrug and toxin extrusion protein 1transporter
DB00205PyrimethamineMultidrug and toxin extrusion protein 2transporter
DB00208TiclopidineP2Y purinoceptor 12target
DB00208TiclopidineCytochrome P450 2C19enzyme
DB00208TiclopidineCytochrome P450 2B6enzyme
DB00208TiclopidineCytochrome P450 2C9enzyme
DB00208TiclopidineCytochrome P450 2D6enzyme
DB00208TiclopidineMyeloperoxidaseenzyme
DB00208TiclopidineCytochrome P450 1A2enzyme
DB00208TiclopidineCytochrome P450 2C8enzyme
DB00208TiclopidineCytochrome P450 2E1enzyme
DB09054IdelalisibPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformtarget
DB09054IdelalisibATP-binding cassette sub-family G member 2transporter
DB09054IdelalisibP-glycoprotein 1transporter
DB09054IdelalisibAldehyde oxidaseenzyme
DB09054IdelalisibUDP-glucuronosyltransferase 1-4enzyme
DB09054IdelalisibUDP-glucuronosyltransferase 1-4enzyme
DB09054IdelalisibCytochrome P450 2C8enzyme
DB09054IdelalisibCytochrome P450 2C19enzyme
DB09054IdelalisibCytochrome P450 2B6enzyme
DB09054IdelalisibCytochrome P450 3A4enzyme
DB09054IdelalisibSolute carrier organic anion transporter family member 1B1transporter
DB09054IdelalisibSolute carrier organic anion transporter family member 1B3transporter
DB09054IdelalisibCytochrome P450 3A5enzyme
DB09054IdelalisibCytochrome P450 3A43enzyme
DB09054IdelalisibCytochrome P450 3A7enzyme
DB05015BelinostatHistone deacetylasetarget
DB05015BelinostatCytochrome P450 1A2enzyme
DB05015BelinostatUDP-glucuronosyltransferase 1-4enzyme
DB05015BelinostatCytochrome P450 2C8enzyme
DB05015BelinostatCytochrome P450 2C9enzyme
DB05015BelinostatP-glycoprotein 1transporter
DB13919CandesartanType-1 angiotensin II receptortarget
DB13919CandesartanCytochrome P450 2C8enzyme
DB13919CandesartanCytochrome P450 2C9enzyme
DB13919CandesartanP-glycoprotein 1transporter
DB13919CandesartanUDP-glucuronosyltransferase 1-3enzyme
DB13919CandesartanProstaglandin G/H synthase 1enzyme
DB13919CandesartanSolute carrier organic anion transporter family member 1B1transporter
DB11632OpicaponeCytochrome P450 2C19enzyme
DB11632OpicaponeCytochrome P450 2C8enzyme
DB11632OpicaponeCatechol O-methyltransferasetarget
DB01079Tegaserod5-hydroxytryptamine receptor 4target
DB01079Tegaserod5-hydroxytryptamine receptor 2Btarget
DB01079Tegaserod5-hydroxytryptamine receptor 2Ctarget
DB01079Tegaserod5-hydroxytryptamine receptor 2Atarget
DB01079TegaserodSodium-dependent serotonin transportertransporter
DB01079TegaserodCytochrome P450 1A2enzyme
DB01079TegaserodCytochrome P450 2C8enzyme
DB01079TegaserodCytochrome P450 2D6enzyme
DB01079TegaserodCytochrome P450 2E1enzyme
DB01079TegaserodATP-binding cassette sub-family G member 2transporter
DB01079TegaserodP-glycoprotein 1transporter
DB05812AbirateroneSteroid 17-alpha-hydroxylase/17,20 lyasetarget
DB05812AbirateroneSerum albumincarrier
DB05812AbirateroneAlpha-1-acid glycoprotein 1carrier
DB05812AbirateroneCytochrome P450 3A4enzyme
DB05812AbirateroneBile salt sulfotransferaseenzyme
DB05812AbirateroneMultidrug resistance-associated protein 1transporter
DB05812AbirateroneCytochrome P450 2D6enzyme
DB05812AbirateroneCytochrome P450 2C8enzyme
DB05812AbirateroneCytochrome P450 1A2enzyme
DB05812AbirateroneCytochrome P450 2C19enzyme
DB05812AbirateroneCytochrome P450 2C9enzyme
DB15328UbrogepantP-glycoprotein 1transporter
DB15328UbrogepantATP-binding cassette sub-family G member 2transporter
DB15328UbrogepantCytochrome P450 3A4enzyme
DB15328UbrogepantCytochrome P450 2C8enzyme
DB15328UbrogepantCytochrome P450 2C9enzyme
DB15328UbrogepantCytochrome P450 2D6enzyme
DB15328UbrogepantCytochrome P450 2C19enzyme
DB15328UbrogepantAmine oxidase [flavin-containing] Aenzyme
DB15328UbrogepantUDP-glucuronosyltransferase 1-1enzyme
DB15328UbrogepantSolute carrier organic anion transporter family member 1B1transporter
DB15328UbrogepantSolute carrier organic anion transporter family member 1B3transporter
DB15328UbrogepantSolute carrier family 22 member 6transporter
DB15328UbrogepantSolute carrier family 22 member 2transporter
DB15328UbrogepantCalcitonin gene-related peptide type 1 receptortarget
DB01060AmoxicillinSolute carrier family 15 member 1transporter
DB01060AmoxicillinSolute carrier family 15 member 2transporter
DB01060AmoxicillinSolute carrier family 22 member 6transporter
DB01060AmoxicillinCytochrome P450 2C8enzyme
DB01060AmoxicillinSerum albumincarrier
DB01060AmoxicillinBeta-lactamase 2enzyme
DB01060AmoxicillinPenicillin binding proteintarget