Tumor Suppressor Proteins

Accession Number

DBCAT003114

Description

Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.

Drugs

Drug	Drug Description
Isoxaflutole	Balance has been investigated for the treatment of Chronic Renal Failure and Peritoneal Membrane Disorder.
Erdafitinib	A fibroblast growth factor receptor tyrosine kinase inhibitor used to treat locally advanced or metastatic urothelial carcinoma.
TAK-448	TAK-448 has been used in trials studying the treatment of Prostate Cancer, Low Testosterone, Prostatic Neoplasms, and Hypogonadotropic Hypogonadism.
Kisspeptin-10	Kisspeptin-10 is under investigation in clinical trial NCT03771326 (KP-10 and Insulin Secretion in Men).

Drugs & Drug Targets

Drug	Target	Type
Erdafitinib	Cytochrome P450 2C9	enzyme
Erdafitinib	Cytochrome P450 3A4	enzyme
Erdafitinib	Fibroblast growth factor receptor 1	target
Erdafitinib	Fibroblast growth factor receptor 2	target
Erdafitinib	Fibroblast growth factor receptor 3	target
Erdafitinib	Fibroblast growth factor receptor 4	target
Erdafitinib	P-glycoprotein 1	transporter
Erdafitinib	Solute carrier family 22 member 2	transporter
Erdafitinib	Proto-oncogene tyrosine-protein kinase receptor Ret	target
Erdafitinib	Macrophage colony-stimulating factor 1 receptor	target
Erdafitinib	Platelet-derived growth factor receptor alpha	target
Erdafitinib	Platelet-derived growth factor receptor beta	target
Erdafitinib	Mast/stem cell growth factor receptor Kit	target
Erdafitinib	Vascular endothelial growth factor receptor 2	target
Erdafitinib	alpha1-acid glycoprotein	carrier