Azole Antifungals

Name
Azole Antifungals
Accession Number
DBCAT003230
Description

Not Available

Drugs
DrugDrug Description
BifonazoleAn azole antifungal drug used to treat fungal skin infections, such as dermatomycosis.
FenticonazoleAn imidazole antifungal used to treat a variety of topical fungal infections.
IsoconazoleAn imidazole antifungal used for superficial skin and vaginal infections.
OmoconazoleNot Annotated
AlbaconazoleAlbaconazole has been used in trials studying the basic science of Onychomycosis.
IsavuconazoleIndicated for patients 18 years of age and older for the treatment of invasive aspergillosis [FDA Label]. Indicated for patients 18 years of age and older for the treatment of...
RavuconazoleInvestigated for use/treatment in fungal infections, aspergillosis, candidiasis, and onychomycosis.
AbafunginInvestigated for use/treatment in fungal infections, bacterial infection, skin infections/disorders, and onychomycosis.
FlutrimazoleA topical antifungal used to treat pityriasis capitis and seborrheic dermatitis.
FluconazoleA triazole antifungal used to treat various fungal infections including candidiasis.
OxiconazoleA topical antifungal used to treat a variety of dermatophyte infections.
TerconazoleAn antifungal drug used in the treatment of vulvovaginal candidiasis.
ClotrimazoleA topical broad-spectrum antifungal agent used for the treatment of a wide variety of dermatophyte infections and candidiasis.
VoriconazoleA triazole compound used to treat fungal infections.
ButoconazoleAn imidazole antifungal used to treat vulvovaginal candidiasis.
KetoconazoleA broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections.
MiconazoleAn azole antifungal with broad-spectrum activity used to treat fungal infections affecting the vagina, mouth and skin, including candidiasis.
EconazoleA topical antifungal used to treat tinea pedis, tinea cruris, tinea corporis, cutaneous candidiasis and tinea versicolor.
SertaconazoleA topical antifungal agent used in the treatment of interdigital tinea pedis in immunocompetent patients.
ItraconazoleA triazole antifungal agent used to treat various fungal infections, such as blastomycosis and onychomycosis.
PosaconazoleA triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients.
IsavuconazoniumA triazole antifungal used for the treatment of invasive aspergillosis and mucormycosis.
SulconazoleA topical antifungal agent used for the treatment of tinea cruris, tinea corporis, and tinea versicolor caused by susceptible fungal strains.
LuliconazoleA topical antifungal agent used to treat fungal infections.
EfinaconazoleAn antifungal agent used to treat onychomycosis, a fungal infection of the nail.
TioconazoleAn imidazole antifungal used to treat vulvovaginal candidiasis.
LevoketoconazoleOne of two enantiomeric forms of racemic ketoconazole that strongly inhibits multiple steroidogenic enzymes and is used for the symptomatic treatment of endogenous Cushing's syndrome.
OteseconazoleAn azole antifungal used to prevent recurrent vulvovaginal candidiasis in females who are not of reproductive potential.
Drugs & Drug Targets
DrugTargetType
BifonazoleCytochrome P450 2B6target
BifonazoleCytochrome P450 51target
BifonazoleCytochrome P450 19A1enzyme
BifonazoleCytochrome P450 2E1enzyme
BifonazoleCytochrome P450 3A4enzyme
IsavuconazoleCytochrome P450 3A4enzyme
IsavuconazoleCytochrome P450 3A5enzyme
IsavuconazoleCytochrome P450 2C8enzyme
IsavuconazoleCytochrome P450 2C9enzyme
IsavuconazoleCytochrome P450 2C19enzyme
IsavuconazoleCytochrome P450 2D6enzyme
IsavuconazoleCytochrome P450 2B6enzyme
IsavuconazoleUDP-glucuronosyltransferase 1-9enzyme
IsavuconazoleUDP-glucuronosyltransferase 1-8enzyme
IsavuconazoleP-glycoprotein 1transporter
IsavuconazoleATP-binding cassette sub-family G member 2transporter
IsavuconazoleSolute carrier family 22 member 2transporter
IsavuconazoleLanosterol 14-alpha demethylasetarget
IsavuconazolePotassium voltage-gated channel subfamily H member 2target
IsavuconazoleVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
IsavuconazoleG protein-activated inward rectifier potassium channel 2target
IsavuconazoleG protein-activated inward rectifier potassium channel 3target
IsavuconazoleATP-sensitive inward rectifier potassium channel 11target
IsavuconazolePotassium voltage-gated channel subfamily A member 5target
IsavuconazolePotassium voltage-gated channel subfamily D member 3target
IsavuconazolePotassium voltage-gated channel subfamily KQT member 1target
IsavuconazoleSodium channel protein type 5 subunit alphatarget
FluconazoleCytochrome P450 3A4enzyme
FluconazoleCytochrome P450 2C9enzyme
FluconazoleCytochrome P450 2C19enzyme
FluconazoleP-glycoprotein 1transporter
FluconazoleCytochrome P450 51target
FluconazoleCytochrome P450 3A5enzyme
OxiconazoleCytochrome P450 51target
OxiconazoleLanosterol synthasetarget
OxiconazoleCytochrome P450 3A4enzyme
OxiconazoleCytochrome P450 2C19enzyme
OxiconazoleNuclear receptor subfamily 1 group I member 2target
TerconazoleCytochrome P450 51target
ClotrimazoleIntermediate conductance calcium-activated potassium channel protein 4target
ClotrimazoleCytochrome P450 2D6enzyme
ClotrimazoleCytochrome P450 2C8enzyme
ClotrimazoleCytochrome P450 3A4enzyme
ClotrimazoleCytochrome P450 2B6enzyme
ClotrimazoleP-glycoprotein 1transporter
ClotrimazoleCytochrome P450 2A6enzyme
ClotrimazoleCytochrome P450 2C9enzyme
ClotrimazoleCytochrome P450 2E1enzyme
ClotrimazoleCytochrome P450 3A7enzyme
ClotrimazoleCytochrome P450 51target
ClotrimazoleNuclear receptor subfamily 1 group I member 2target
ClotrimazoleHydroxycarboxylic acid receptor 2target
ClotrimazoleBile salt export pumptransporter
ClotrimazoleSolute carrier organic anion transporter family member 1B1transporter
ClotrimazoleSolute carrier organic anion transporter family member 1B3transporter
ClotrimazoleErgosteroltarget
VoriconazoleCytochrome P450 2C19enzyme
VoriconazoleCytochrome P450 3A4enzyme
VoriconazoleCytochrome P450 2C9enzyme
VoriconazoleDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
VoriconazoleDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
VoriconazoleCytochrome P450 3A5enzyme
VoriconazoleCytochrome P450 3A7enzyme
VoriconazoleProstaglandin G/H synthase 1enzyme
VoriconazoleCytochrome P450 51target
VoriconazoleCytochrome P450 2B6enzyme
ButoconazoleErgosteroltarget
KetoconazoleCytochrome P450 3A4enzyme
KetoconazoleCytochrome P450 2C9enzyme
KetoconazoleCytochrome P450 2C19enzyme
KetoconazoleCytochrome P450 3A5enzyme
KetoconazoleCytochrome P450 1A2enzyme
KetoconazoleCytochrome P450 2C8enzyme
KetoconazoleCytochrome P450 1A1enzyme
KetoconazoleCytochrome P450 2D6enzyme
KetoconazoleBile salt export pumptransporter
KetoconazoleP-glycoprotein 1transporter
KetoconazoleCytochrome P450 11B1, mitochondrialenzyme
KetoconazoleCytochrome P450 1B1enzyme
KetoconazoleCytochrome P450 2A6enzyme
KetoconazoleCytochrome P450 2B6enzyme
KetoconazoleLanosterol 14-alpha demethylasetarget
KetoconazoleAndrogen receptortarget
KetoconazoleSteroid 17-alpha-hydroxylase/17,20 lyasetarget
KetoconazoleSteroid 21-hydroxylasetarget
KetoconazolePotassium voltage-gated channel subfamily H member 2target
KetoconazoleNuclear receptor subfamily 1 group I member 2target
KetoconazoleNuclear receptor subfamily 1 group I member 3target
KetoconazoleUDP-glucuronosyltransferase 1-1enzyme
KetoconazoleUDP-glucuronosyltransferase 2B7enzyme
KetoconazoleSolute carrier organic anion transporter family member 1B1transporter
KetoconazoleCytochrome P450 4F12enzyme
KetoconazoleLeukotriene-B(4) omega-hydroxylase 1enzyme
KetoconazoleSerum albumincarrier
KetoconazoleSex hormone-binding globulincarrier
KetoconazoleCytochrome P450 19A1enzyme
KetoconazoleUDP-glucuronosyltransferase 1-7enzyme
MiconazoleCytochrome P450 2C9enzyme
MiconazoleCytochrome P450 2D6enzyme
MiconazoleCytochrome P450 3A4enzyme
MiconazoleP-glycoprotein 1transporter
MiconazoleCytochrome P450 51target
MiconazoleNitric oxide synthase, endothelialtarget
MiconazoleNitric oxide synthase, inducibletarget
MiconazoleCytochrome P450 11B1, mitochondrialenzyme
MiconazoleCytochrome P450 2A6enzyme
MiconazoleCytochrome P450 2B6enzyme
MiconazoleCytochrome P450 2C19enzyme
MiconazoleCytochrome P450 2E1enzyme
MiconazoleNuclear receptor subfamily 1 group I member 2target
MiconazoleLanosterol 14-alpha demethylaseenzyme
MiconazoleCytochrome P450 19A1enzyme
MiconazoleCalcium-activated potassium channeltarget
MiconazoleVoltage-gated Potassium Channelstarget
MiconazoleInward rectifier potassium channeltarget
MiconazoleVoltage gated L-type calcium channeltarget
MiconazoleSerum albumincarrier
MiconazoleCytochrome P450 2C8enzyme
EconazoleCytochrome P450 19A1enzyme
EconazoleCytochrome P450 2E1enzyme
EconazoleCytochrome P450 3A4enzyme
EconazoleCytochrome P450 51target
EconazoleNuclear receptor subfamily 1 group I member 2target
SertaconazoleCytochrome P450 51target
ItraconazoleCytochrome P450 3A4enzyme
ItraconazoleCytochrome P450 3A5enzyme
ItraconazoleCytochrome P450 3A7enzyme
ItraconazoleCytochrome P450 2B6enzyme
ItraconazoleP-glycoprotein 1transporter
ItraconazoleCytochrome P450 1A1enzyme
ItraconazoleCytochrome P450 2E1enzyme
ItraconazoleSolute carrier organic anion transporter family member 2B1transporter
ItraconazoleCytochrome P450 3A Subfamilyenzyme
ItraconazoleATP-binding cassette sub-family G member 2transporter
ItraconazoleSerum albumincarrier
ItraconazoleLanosterol 14-alpha demethylasetarget
PosaconazoleCytochrome P450 3A4enzyme
PosaconazoleP-glycoprotein 1transporter
PosaconazoleCytochrome P450 51target
IsavuconazoniumCytochrome P450 3A4enzyme
IsavuconazoniumP-glycoprotein 1transporter
IsavuconazoniumCytochrome P450 3A5enzyme
IsavuconazoniumCholinesteraseenzyme
IsavuconazoniumCytochrome P450 2C8enzyme
IsavuconazoniumCytochrome P450 2C9enzyme
IsavuconazoniumCytochrome P450 2C19enzyme
IsavuconazoniumCytochrome P450 2D6enzyme
IsavuconazoniumCytochrome P450 2B6enzyme
IsavuconazoniumATP-binding cassette sub-family G member 2transporter
IsavuconazoniumSolute carrier family 22 member 2transporter
IsavuconazoniumLanosterol 14-alpha demethylasetarget
IsavuconazoniumSerum albumincarrier
SulconazoleCytochrome P450 1A2enzyme
SulconazoleCytochrome P450 2C9enzyme
SulconazoleCytochrome P450 2D6enzyme
SulconazoleLanosterol 14-alpha demethylasetarget
LuliconazoleCytochrome P450 51target
LuliconazoleCytochrome P450 3A4enzyme
LuliconazoleCytochrome P450 2C19enzyme
EfinaconazoleLanosterol 14-alpha demethylasetarget
TioconazoleLanosterol 14-alpha demethylasetarget
TioconazoleCytochrome P450 19A1enzyme
TioconazoleCytochrome P450 2C19enzyme
TioconazoleCytochrome P450 2E1enzyme
TioconazoleCytochrome P450 3A4enzyme
TioconazoleCytochrome P450 51target
LevoketoconazoleCytochrome P450 11B1, mitochondrialtarget
LevoketoconazoleLanosterol 14-alpha demethylasetarget
LevoketoconazoleCytochrome P450 3A4enzyme
LevoketoconazoleCytochrome P450 3A5enzyme
LevoketoconazoleSteroid 21-hydroxylaseenzyme
LevoketoconazoleP-glycoprotein 1transporter
LevoketoconazoleSteroid 17-alpha-hydroxylase/17,20 lyasetarget
LevoketoconazoleCytochrome P450 11B2, mitochondrialtarget
LevoketoconazoleCholesterol side-chain cleavage enzyme, mitochondrialtarget
LevoketoconazoleSolute carrier family 22 member 2transporter
LevoketoconazoleMultidrug and toxin extrusion protein 1transporter
LevoketoconazoleCytochrome P450 2B6enzyme
LevoketoconazoleCytochrome P450 2C8enzyme
LevoketoconazoleCytochrome P450 1A2enzyme
LevoketoconazoleCytochrome P450 7A1enzyme
LevoketoconazoleCytochrome P450 19A1enzyme
OteseconazoleCytochrome P450 51target
OteseconazoleATP-binding cassette sub-family G member 2transporter