- Antiarrhythmic agents
- Accession Number
- DBCAT003297 (DBCAT000520)
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
Drug Drug Description Metoprolol A beta-blocker used in the treatment of hypertension and angina, and used to reduce mortality due to myocardial infarction. Atenolol A synthetic beta-1 selective blocker used in the management of hypertension and chronic angina, and to reduce mortality in known or suspected myocardial infarction in hemodynamically stable patients. Timolol A non-selective beta adrenergic blocker used in the treatment of elevated intraocular pressure in ocular hypertension or open angle glaucoma. Digoxin A cardiac glycoside used in the treatment of mild to moderate heart failure and for ventricular response rate control in chronic atrial fibrillation. Acetyldigitoxin Used for fast digitalization in congestive heart failure. Carteolol A beta adrenergic antagonist used to treat arrhythmia, angina, hypertension, and glaucoma. Propranolol A non-selective beta adrenergic antagonist used to treat hypertension, angina, atrial fibrillation, myocardial infarction, migraine, essential tremor, hypertrophic subaortic stenosis, and pheochromocytoma. Atropine A muscarinic antagonist used to treat poisoning by muscarinic agents, including organophosphates and other drugs. Adenosine A medication used in myocardial perfusion scintigraphy. Magnesium sulfate A drug used to treat convulsions during pregnancy, nephritis in children, magnesium deficiency, and tetany. Verapamil A non-dihydropyridine calcium channel blocker used in the treatment of angina, arrhythmia, and hypertension. Losartan An angiotensin receptor blocker used to treat hypertension and diabetic nephropathy, and is used to reduce the risk of stroke. Moricizine An antiarrhythmic used to treat arrhythmias. Alprenolol For the treatment of hypertension, angina, and arrhythmia Levosimendan For short term treatment of acutely decompensated severe chronic heart failure (CHF). Also being investigated for use/treatment in heart disease. Hyoscyamine For treatment of bladder spasms, peptic ulcer disease, diverticulitis, colic, irritable bowel syndrome, cystitis, and pancreatitis. Also used to treat certain heart conditions, to control the symptoms of Parkinson's disease... Felodipine A calcium channel blocker used to treat hypertension. Tocainide An orally active class 1b antiarrhythmic agent that interferes with cardiac sodium channels and typically used to treat ventricular arrhythmias. Deslanoside For the treatment and management of Congestive cardiac insufficiency, arrhythmias and heart failure. Bretylium A norepinephrine release inhibitor used for the prophylaxis and therapy of ventricular fibrillation, as well as the treatment of life-threatening ventricular arrhythmias. Acebutolol A selective β1-receptor antagonist used for the management of hypertension and ventricular premature beats in adults. Nadolol A non-selective beta-adrenergic antagonist used for the management of arrhythmias, angina pectoris, and hypertension. Metipranolol A beta-adrenergic antagonist used for the reduction of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Encainide A voltage-gated sodium channel blocker used for management of atrial or ventricular fibrillation, atrial flutter, and ventricular tachycardia, that is no longer used due to proarrhythmic adverse effects. Bepridil For the treatment of hypertension, and chronic stable angina (classic effort-associated angina). Practolol Used in the emergency treatment of cardiac arrhythmias. Digitoxin A cardiac glycoside used in the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure. Ajmaline For use as an antiarrhythmic agent. Aprindine Aprindine is a cardiac depressant used in arrhythmias. Oxprenolol A non-selective beta-adrenergic antagonist used to treat hypertension, angina pectoris, arrhythmias, and anxiety. Celiprolol Celiprolol is indicated for the management of mild to moderate hypertension and effort-induced angina pectoris. Azimilide Investigated for use/treatment in arrhythmia and atrial fibrillation. Tedisamil Investigated for use/treatment in arrhythmia, atrial fibrillation, and angina. Cariporide Investigated for use/treatment in cardiac surgery. Sparteine Sparteine is a plant alkaloid derived from Cytisus scoparius and Lupinus mutabilis which may chelate calcium and magnesium. It is a sodium channel blocker so it falls under the category... Bupranolol Used to manage hypertension and tachycardia. Also used to treat glaucoma. Indenolol Indenolol is a drug of the beta-adrenergic blocker class. Nicorandil Indicated for the prevention and treatment of chronic stable angina pectoris and reduction in the risk of acute coronary syndromes. Melperone For the treatment of schizophrenia, sleep, disorders, agitation and mentally confused states [L1317, L1319, L1322]. Tropisetron For the prevention of nausea and vomiting induced by cytotoxic therapy and postoperative. Talinolol Talinolol has been investigated for the basic science of Gastrointestinal Motility Disorder. Anisodamine Anisodamine has been investigated for the treatment of Intestinal Diseases. Tetrahydropalmatine Tetrahydropalmatine is under investigation in clinical trial NCT02118610 (Treatment of Schizophrenia With L-tetrahydropalmatine (l-THP): a Novel Dopamine Antagonist With Anti-inflammatory and Antiprotozoal Activity). Landiolol Landiolol has been used in trials studying the treatment of Pharmacokinetics/Dynamics Study. Simendan Simendan is under investigation in clinical trial NCT00527059 (Renal Effects of Levosimendan in Patients Admitted With Acute Decompensated Heart Failure). Spiradoline Spiradoline has been investigated for the basic science of Bipolar Depression. Pilsicainide Pilsicainide has been investigated for the treatment of Paroxysmal Atrial Fibrillation. Cicletanine Cicletanine is under investigation for the treatment of Diabetes, Hypokalemia, Hyponatremia, and Arterial Hypertension. Cymarin Not Annotated Cibenzoline Not Annotated Metildigoxin Not Annotated Nizofenone Not Annotated Prajmaline Not Annotated Tiracizine Not Annotated Ethacizine Not Annotated Lorajmine Not Annotated Bunaftine Not Annotated Lorcainide Not Annotated Acetyldigoxin Not Annotated Hydroquinine Not Annotated Tertatolol Tertatolol is a beta blocker. Fosfructose Not Annotated Dofetilide A class III antiarrhythmic drug used for the maintenance of normal sinus rhythm and cardioversion in cases of atrial fibrillation and atrial flutter. Disopyramide A class 1A antiarrhythmic agent used to treat life-threatening ventricular arrhythmias. Lidocaine A local anesthetic used in a wide variety of superficial and invasive procedures. Ibutilide A class III antiarrhythmic agent used to correct atrial fibrillation and atrial flutter, which can be considered as an alternative to cardioversion. Mexiletine A class 1B antiarrhythmic agent used in the treatment of documented ventricular arrhythmias that warrant treatment. Sotalol A methane sulfonanilide beta adrenergic antagonist used to treat life-threatening ventricular arrhythmias and to maintain sinus rhythm in atrial fibrillation or flutter. Quinidine A medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias. Procainamide A medication used to treat life threatening ventricular arrhythmias. Amiodarone A class III antiarrhythmic indicated for the treatment of recurrent hemodynamically unstable ventricular tachycardia and recurrent ventricular fibrillation. Propafenone A Class 1C antiarrhythmic agent used in the management of paroxysmal atrial fibrillation/flutter and ventricular arrhythmias. Flecainide A class Ic antiarrhythmic agent used to manage atrial fibrillation and paroxysmal supraventricular tachycardias (PSVT). Dronedarone An antiarrhythmic agent used in the reduce the risk of hospitalization in patients with paroxysmal or persistent atrial fibrillation. Vernakalant An antiarrhythmic medication used to treat patients with atrial fibrillation. Glimepiride A sulfonylurea drug used to treat type 2 diabetes mellitus. Isradipine A dihydropyridine calcium channel blocker used for the treatment of hypertension. Diltiazem A calcium channel blocker used to treat hypertension and to manage chronic stable angina. Nimodipine A calcium channel blocker used to improve neurological outcomes in patients with subarachnoid hemorrhage due to a ruptured intracranial aneurysm. Nisoldipine A calcium channel blocker used as monotherapy or combined with other drugs for the treatment of hypertension. Nicardipine A calcium channel blocker used for the short-term treatment of hypertension and chronic stable angina. Perhexiline For the management of severe angina pectoris. Nifedipine A dihydropyridine calcium channel blocker indicated for the management of several subtypes of angina pectoris, and hypertension. Mibefradil For the treatment of angina and high blood pressure. Clevidipine A dihydropyridine L-type calcium channel blocker used to lower blood pressure when oral antihypertensive therapy is not feasible or not desirable. Nilvadipine For the management of vasospastic angina, chronic stable angina and hypertension. Fendiline Fendiline is a coronary vasodilator which inhibits calcium function in muscle cells in excitation-contraction coupling. It has been proposed as an antiarrhythmic and antianginal agent. Fendiline is non-selective. Barnidipine Indicated for the treatment of mild to moderate essential hypertension and management of chronic stable angina. Benidipine Benidipine is a potent and long-lasting drug indicated for the treatment of cardiovascular diseases such as hypertension, renoparenchymal hypertension and angina pectoris. Cilnidipine Cilnidipine is indicated for the management of hypertension for end-organ protection. It is reported to be useful in elderly patients and in those with diabetes and albuminuria. Cilnidipine has been... Lacidipine Indicated for the treatment of hypertension either alone or in combination with other antihypertensive agents, including β-adrenoceptor antagonists, diuretics, and ACE-inhibitors . Gallopamil Gallopamil has been used in trials studying the treatment of Asthma. Lidoflazine Not Annotated Pregabalin An anticonvulsant drug used to treat neuropathic pain conditions and fibromyalgia, and for the treatment of partial onset seizures in combination with other anticonvulsants. Amlodipine A calcium channel blocker used to treat hypertension and angina. Lercanidipine For the treatment of Hypertension, management of angina pectoris and Raynaud's syndrome Lamotrigine A phenyltriazine antiepileptic used to treat some types of epilepsy and bipolar I disorder. Cinnarizine For the treatment of vertigo/meniere's disease, nausea and vomiting, motion sickness and also useful for vestibular symptoms of other origins. Nitrendipine For the treatment of mild to moderate hypertension Flunarizine A selective calcium-entry blocker used as migraine prophylaxis in patients with severe and frequent episodes who have not responded adequately to more common treatments. Pinaverium A spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and functional disorders of the biliary tract. Manidipine For the treatment of hypertension. Efonidipine For the treatment of hypertension. Nimesulide For the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old. Prenylamine Prenylamine was withdrawn from the Canadian, US, and UK markets in 1988 due to concerns regarding cardiac arrhythmias. Ziconotide An N-type calcium channel antagonist used to manage patients with severe chronic pain who cannot tolerate, or who have not responded adequately to other treatments such as intrathecal morphine and systemic analgesics. Dotarizine Investigated for use/treatment in migraine and cluster headaches. Tranilast For the treatment of bronchial asthma, keloid and hypertrophic scar, and allergic disorders such as asthma, allergic rhinitis and atopic dermatitis. Eperisone Eperisone is an antispasmodic drug which relaxes both skeletal muscles and vascular smooth muscles, and demonstrates a variety of effects such as reduction of myotonia, improvement of circulation, and suppression... Tolfenamic acid In the information for tolfenamic acid, it is stated that this drug, being an NSAID, is effective in treating the pain associated with the acute attack of migraines in adults. Azelnidipine For the treatment of hypertension. Darodipine Darodipine is a calcium channel blocker. Niguldipine Niguldipine is a calcium channel blocker drug (CCB) with a1-adrenergic antagonist properties. Niludipine Niludipine is a calcium channel blocker. Carboxyamidotriazole Carboxyamidotriazole has been used in trials studying the treatment of Lymphoma, Lung Cancer, Breast Cancer, Kidney Cancer, and Ovarian Cancer, among others. Naftopidil Naftopidil has been investigated for the treatment of Disorder of Urinary Stent. Vinpocetine Vinpocetine has been investigated for the treatment of Epilepsy. Bencyclane A vasodilator agent found to be effective in a variety of peripheral circulation disorders. It has various other potentially useful pharmacological effects. Its mechanism may involve block of calcium channels. Otilonium Not Annotated Terodiline Not Annotated Caroverine Not Annotated WIN 55212-2 WIN 55,212-2 is a chemical described as an aminoalkylindole derivative, which produces effects similar to those of cannabinoids such as tetrahydrocannabinol (THC) but has an entirely different chemical structure. It... Seletracetam Investigated for use/treatment in epilepsy. Bioallethrin Bioallethrin was used for lice and scabies infestation. Other pyrethroids are now used in place of bioallethrin. Zonisamide A sulfonamide anticonvulsant used to treat partial seizures. Loperamide A long acting antidiarrheal used to control nonspecific diarrhea and chronic diarrhea caused by inflammatory bowel disease, or gastroenteritis. Trimethadione An anticonvulsant agent indicated for the control of treatment-refractory petit mal seizures. Ethosuximide An anticonvulsant used to treat petit mal seizures. Methsuximide A succinimide anticonvulsant that increases the seizure threshold. Primarily used for childhood absence seizures. Functions by suppressing paroxysmal spike-and-wave patterns associated with lapses of consciousness in absence seizures. Fluspirilene An antipsychotic agent used in the treatment of schizophrenia. Cyclandelate A vasodilator used for the treatment of various blood vessel diseases, such as claudication and arteriosclerosis. Trimebutine A spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and treatment of postoperative paralytic ileus following abdominal surgery. Fish oil A source of essential fatty acids used as a source of calories in parenteral nutrition and as a dietary supplement. Nylidrin A vasodilator used to treat patients with peripheral vascular disorders, and elderly patients with symptoms associated with organic mental disorders. Agmatine Agmatine is being studied experimentally for several indications such as cardioprotection, diabetes, decreased kidney function, neuroprotection (stroke, severe CNS injuries, epilepsy, glaucoma, and neuropathic pain), and psychiatric conditions (depression, anxiety,... Aranidipine Aranidipine has been used for many years to treat angina pectoris and hypertension. Levomenthol An organic compound used to treat mild to moderate muscle and joint pain. Penfluridol Not Annotated Betaxolol A cardioselective beta blocking agent commonly used to treat hypertension and elevated intraocular pressure (when administered ophthalmically). Bisoprolol A beta-1 adrenergic blocking agent used to prevent myocardial infarction and heart failure and to treat mild to moderate hypertension. Esmolol A cardioselective beta-adrenergic blocker used for the short-term control of ventricular rate and heart rate in various types of tachycardia, including perioperative tachycardia and hypertension. Nebivolol A beta blocking agent used to treat hypertension and aid in the management of heart failure. Dexverapamil Not Annotated Emopamil Prevents renal injury after warm & cold ischemia. Lomerizine Used to treat migraines. Tetrandrine Not Annotated Dexniguldipine Not Annotated Fosinoprilat Fosinoprilat is the active phosphinic acid metabolite of prodrug fosinopril, which is activated by esterases in vivo. It binds zinc with phosphinic acid group. Xylometazoline A direct acting sympathomimetic agent used for the symptomatic treatment of nasal congestion and minor inflammation due to allergies or colds. Dexpropranolol Not Available Fasudil Fasudil has been investigated in Carotid Stenosis. Hydroquinidine Hydroquinidine is under investigation in clinical trial NCT00927732 (Hydroquinidine Versus Placebo in Patients With Brugada Syndrome). Carvedilol A non selective beta-adrenergic antagonist used to treat mild to severe chronic heart failure, hypertension, and left ventricular dysfunction following myocardial infarction in clinically stable patients. SOR-C13 SOR-C13 is under investigation in clinical trial NCT01578564 (Safety and Tolerability Study of SOR-C13 in Subjects With Advanced Cancers Commonly Known to Express the TRPV6 Channel).
- Drugs & Drug Targets