Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor

DrugDrug NameDrug Indication
DB00299PenciclovirUsed to treat recurrent cold sores on the lips and face from various herpesvirus invections.
DB00577ValaciclovirValacyclovir is a nucleoside analog DNA polymerase inhibitor indicated for [FDA label]: **Adults** • Cold Sores (Herpes Labialis) • Genital Herpes • Treatment of genital herpes lesions in immunocompetent patients (initial or recurrent episode) • Suppression of genital herpes lesions in immunocompetent or HIV-infected patients • Reduction of viral transmission • Herpes Zoster **Pediatric Patients** • Cold Sores (Herpes Labialis) • Chickenpox **Limitations of use** [FDA label] The efficacy and safety of valacyclovir have not been established in immunocompromised patients other than for the suppression of genital herpes in HIV-infected patients.
DB00787AcyclovirFor the treatment and management of herpes zoster (shingles), genital herpes, and chickenpox.
DB00426FamciclovirFor the treatment of acute herpes zoster (shingles). Also for the treatment or suppression of recurrent genital herpes in immunocompetent patients and treatment of recurrent mucocutaneous herpes simplex infections in HIV infected patients.
DrugDrug NameTargetType
DB00299PenciclovirDNA polymerase catalytic subunittarget
DB00299PenciclovirThymidine kinasetarget
DB00577ValaciclovirThymidine kinasetarget
DB00577ValaciclovirDNA polymerase catalytic subunittarget
DB00577ValaciclovirSolute carrier family 15 member 1transporter
DB00577ValaciclovirSolute carrier family 15 member 2transporter
DB00577ValaciclovirSolute carrier family 22 member 8transporter
DB00577ValaciclovirSolute carrier family 22 member 6transporter
DB00577ValaciclovirSodium- and chloride-dependent neutral and basic amino acid transporter B(0+)transporter
DB00577ValaciclovirIleal sodium/bile acid cotransportertransporter
DB00577ValaciclovirGuanylate kinaseenzyme
DB00577ValaciclovirHerpes simplex virus 1target
DB00577ValaciclovirVaricella Zoster Virus (VZV) (Human herpes virus 3)target
DB00577ValaciclovirCytomegalovirustarget
DB00577ValaciclovirHerpes simplex virus 2target
DB00577ValaciclovirEpstein-Barr Virus (EBV) (human herpes virus 4)target
DB00577ValaciclovirThymidine kinaseenzyme
DB00787AcyclovirDNA polymerase catalytic subunittarget
DB00787AcyclovirDNA polymerase catalytic subunittarget
DB00787AcyclovirThymidine kinasetarget
DB00787AcyclovirSolute carrier family 22 member 1transporter
DB00787AcyclovirSolute carrier family 22 member 6transporter
DB00787AcyclovirSolute carrier family 22 member 8transporter
DB00787AcyclovirIleal sodium/bile acid cotransportertransporter
DB00787AcyclovirMultidrug and toxin extrusion protein 1transporter
DB00787AcyclovirMultidrug and toxin extrusion protein 2transporter
DB00426FamciclovirDNA polymerase catalytic subunittarget
DB00426FamciclovirDNA polymerase catalytic subunittarget
DB00426FamciclovirAldehyde oxidaseenzyme
DB00426FamciclovirCytochrome P450 3A4enzyme